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  • 1
    Electronic Resource
    Electronic Resource
    Circulating hepatocyte membrane-specific autoantibodies in chronic active hepatitis type B (1984)
    Springer
    Digestive diseases and sciences 29 (1984), S. 620-624 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sera from two groups of untreated HBsAg-positive patients with chronic active hepatitis on liver biopsy were tested for antibodies to liver cell membrane antigens (liver-specific protein, LSP; and liver membrane antigen, LM-Ag). Among the 14 HBeAg-positive cases, seven (50%) were positive for anti-LSP, whereas only two (13%) of 15 anti-HBe-positive cases circulated this antibody. Liver membrane autoantibody (LMA) was detected only in two sera from delta-positive patients (1 HBeAg positive and 1 anti-HBe positive). Anti-LSP-positive patients presented transaminase values significantly higher than those of the negative cases. Our data do not support the hypothesis that a liver-specific autoimmune mechanism plays a significant role in the immunopathogenesis of liver cell necrosis in anti-HBe-positive chronic active hepatitis type B. The relationship between hepatocyte necrosis and anti-LSP antibody response is confirmed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01347294
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cardiovascular lesions in chronic pancreatitis (1982)
    Springer
    Digestive diseases and sciences 27 (1982), S. 716-722 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We prospectively investigated fifty-four consecutive patients with proven chronic pancreatitis and 54 control subjects for the presence of cardiovascular lesions. Clinical and laboratory evidence of arterial involvement was found in 18 patients (33%) and in five controls (9%) (P〈0.01). Electrocardiographic alterations indicating coronary heart disease were found in eight patients and in three controls, and peripheral symptoms and signs indicating obliterative atherosclerotic disease of the lower extremities were found in 12 patients (two had associated electrocardiographic changes) and in two controls. No significant differences in the prevalence of the major vascular risk factors were observed between patients with vascular lesions and those without, and between patients and control subjects. It is concluded that patients with chronic pancreatitis have more frequent cardiovascular lesions which tend to develop at an earlier age, compared to the general population. The possibility that chronic pancreatitis may favor the development of these lesions is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01393767
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    Paper (German National Licenses)
    Fulltext
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