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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Inc
    Journal of the American Ceramic Society 88 (2005), S. 0 
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Core-shell particles have attracted much research attention in recent years because of the great potential in protection, modification, and functionalization of the core particles with suitable shell materials to achieve specific physical, chemical, and biological performance. A general approach for preparation of core-shell particles possessing complete and smooth shells is presented. The shell layer was constructed by introducing nanoparticles of desired shell material, prepared with the reverse micelle process, onto the core particle surface via layer-by-layer electrostatic adsorption, hydrophilic and hydrophobic interactions, and subsequent sintering. The proposed process is illustrated by coating silica spheres with four different shell materials, including Ag, CdS, ZnS, and TiO2. The successful formation of complete and smooth shell was examined with a novel light scattering intensity decay method and also by direct observation of scanning electron microscope and transmission electron microscope images.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2016-01-15
    Description: Communication between cells and extracellular environments is of interest because of its critical roles in cell development and differentiation. Particularly, this signal transduction is commonly believed to rely on the contact and binding of the participating molecules/proteins, suggesting that the binding distance needed is less than a few nanometers. However, it is difficult to precisely match the rapidly binding interaction which depends on the probability of molecular collision in living systems, raising a hypothesis that another mechanism exists, could promote this signal communication, and remains unknown. Here we report that a long-range signal delivery over 10- μ m and 20- μ m polydimethylsiloxane (PDMS) barriers can be observed in microfluidically tetracycline (Tet) inducible expression systems. Results show that a significant increment of the long-range induced green fluorescent protein in human embryonic kidney 293T (HEK 293T) cells by the stimulation of Tet is demonstrated, and that such a signal induction is not dominated by Tet diffusion and displays a specific bindingless property. In addition, our experimental results, combined with theoretical modeling, suggest that this communication exhibits a bump-shaped characteristic depending on barrier thickness, materially structural property, surface roughness, and agonist concentration. It strongly relies on the PDMS barrier to delivery signal; therefore, we call such a mechanism as “wired” cell communication instead of wireless. These results could ignite interests in the novel and “wired” cell communication, which we call it X-signal , and in the use of such systems for the study of cellular biology and development of new drug.
    Print ISSN: 0021-8979
    Electronic ISSN: 1089-7550
    Topics: Physics
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