Keywords:
Ribosomes.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (298 pages)
Edition:
1st ed.
ISBN:
9780128167342
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6734396
DDC:
571.6/58
Language:
English
Note:
Intro -- Emerging Concepts in Ribosome Structure, Biogenesis, and Function -- Copyright -- Contents -- Contributors -- Chapter 1: Introduction to ribosome factory, origin, and evolution of translation -- What are ribosomes? -- Basic components and structure of the ribosome -- Functions of ribosome -- Ribosome biogenesis and assembly -- Ribosomal gene mutations and ribosomopathies -- Inhibition of ribosome biogenesis -- Summary and conclusions -- References -- Chapter 2: Ribosome structure -- Introduction -- Structure of prokaryotic ribosome -- Structure of eukaryotic ribosome -- Novel features of the 80S Ribosome's structure -- Eukaryote-specific protein tails -- Expansion segments -- Intersubunit bridges -- Structure of mitochondrial ribosome -- Summary and conclusions -- References -- Chapter 3: rDNA gene structure, transcription, and its coregulation -- Introduction -- Organization and regulation of ribosomal RNA genes -- Processing and maturation of pre-rRNA -- Organization and regulation of RNA pol III promoter -- Summary and conclusions -- References -- Chapter 4: Ribosome proteins-Their balanced production -- Introduction -- Structure of ribosomes -- Ribosomal proteins -- Nomenclature of RPs -- The function of ribosomal proteins -- The 40S small subunit ribosomal proteins -- The 60S large subunit ribosomal proteins -- Eukaryotic mitochondrial ribosome or mitoribosomes -- Extra ribosomal functions of ribosomal proteins -- Balanced production of RPs -- At the transcription level -- At the translational level -- At the posttranslational level -- Summary and conclusions -- References -- Chapter 5: Ribosome diversity -- Introduction -- Variation in r-protein complement -- Paralogues of r-proteins -- R-protein posttranslational modifications -- Ribosome-associated factors -- Contribution of rRNA alternatives in ribosome diversity.
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Modifications of rRNA contribute to ribosome diversity -- Special ribosomes of mitochondria -- Congenital anomalies and mutations of ribosomal proteins -- Summary and conclusions -- References -- Chapter 6: Ribosome cycle-Assembly, degradation, and recycling -- Introduction -- Ribosome assembly -- The pathways and steps of ribosome assembly -- Assembly of small subunit of ribosome (40S subunit) -- Assembly of large subunit of ribosome (60S subunit) -- Degradation of the ribosome and ribosomal proteins -- Ubiquitination-Selective degradation of ribosomal proteins -- Ribophagy-Selective degradation of ribosome -- Ribosome recycling -- Splitting of 80S ribosome -- ABCE1-dependent 80S ribosome splitting -- Initiation of translation by post-TCs -- Summary and conclusions -- References -- Chapter 7: Ribosomal biogenesis in eukaryotes -- Introduction -- Yeast as an eukaryotic model to study ribosome biogenesis -- Preinitiation complex formation -- Control of rDNA transcription -- Processing of pre-rRNA -- Coordination of folding and processing of pre-rRNA -- Roles of the ribosomal proteins -- Role of ribosome assembly factors -- Maturation of ribosomal subunits -- Maturation of the 40S subunit -- Maturation of the pre-60S subunit -- Modifications of pre-RNA -- snoRNPs and rRNA modifications -- Summary and conclusions -- References -- Further reading -- Chapter 8: Ribosome biogenesis in prokaryotes -- Introduction -- Escherichia coli as a model organism to study ribosome biogenesis -- r-RNA gene structure, transcription, and posttranscriptional processing -- Regulation of rrn expression -- Structure of the ribosomal protein-coding genes, the operons and regulation of expression -- Modification of RPs -- Assembly of ribosome -- Assembly of 30S subunit -- Assembly of 50S subunit.
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Differences in protein composition of the ribosome from exponential and stationary bacterial growth phases -- Role of ions in ribosome assembly -- Proteins facilitating ribosome assembly -- RNA helicases -- Chaperones -- GTPases -- Association and dissociation of ribosomal subunits -- Ribosome degradation, modifications, and recycling -- Ribosomal rejuvenation -- Ribosomal quality control -- Rescue of stalled ribosomes on mRNAs with defective or no stop codon -- Ribosome biogenesis in archaebacteria -- Summary and conclusions -- References -- Chapter 9: Translation-Process and control -- The process of translation -- Translation initiation -- Recycling of ribosomes -- Formation of 43S complex -- Initiator aa-tRNA recognition -- Formation of the eIF2-GTP ternary complex -- Attachment of 43S complexes to mRNA -- Recognition of initiation codon -- Scanning model -- Ribosome scanning of mRNA 5 ′ UTRs -- Noncanonical translation initiation in eukaryotes -- Internal ribosome entry sites -- Cellular IRESs -- Ribosomal shunting -- Joining of subunits -- Reinitiation, initiation at non-AUG codons and leaky scanning -- Translation elongation -- Decoding of mRNA -- EF-Tu in translation elongation -- Peptide bond transfer and translocation -- The hybrid state models of translocation -- " α -ϵ" model for translocation -- Termination of translation -- Control of translation -- Aminoacyl tRNA and translation elongation -- Modifications in tRNAs -- Codon usage bias and stability of transcripts -- Ribosome stalling -- Ribosome profiling -- Application of ribosome profiling -- Insights into mechanism of translation -- Insights into translation of noncoding RNAs, especially lncRNA -- Expansion of translatome -- Limitations of ribosome profiling -- References -- Chapter 10: Inhibitors of ribosome biogenesis in prokaryotes and eukaryotes -- Introduction.
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Prokaryotic ribosome biogenesis and inhibitors -- Ribosome biosynthesis and assembly -- Inhibitors of ribosome biogenesis in prokaryotes -- Ribosome biogenesis can be the target of cold stress -- Lamotrigine is the most promising cold sensitive chemical compound -- Antibiotics that target ribosome biogenesis -- Eukaryotic ribosome biogenesis and inhibitors -- Ribosome biosynthesis -- Ribosome biogenesis inhibitors-Chemical probes -- Examples of inhibitors -- Rbin-1 -- Diazaborine -- Ribosome biogenesis inhibitors and cancer -- Ribosome biogenesis has a highly variable turnaround in cancer cells -- Conclusions -- References -- Chapter 11: Ribosomopathies-A tree of pathologies with many roots and branches! -- Introduction -- Diamond-Blackfan anemia -- Other ribosomopathies -- Suspected ribosomopathies -- Is cancer a ribosomopathy? -- Conclusions -- References -- Chapter 12: Ribosomal profiling-Diversity and applications -- Introduction -- Tools and techniques of ribosome profiling -- Sample preparation -- RNase protection assay -- Isolation of ribosome footprints -- High throughput sequencing -- Bioinformatics analysis -- Other critical parameters -- Quality control of mRNA -- Canonical decay of mRNA and connections to translation elongation -- Nonsense-mediated decay of mRNA -- No-go decay of mRNAs with disruptions within the ORF -- Nonstop decay of mRNAs -- Degradation of truncated mRNAs -- Understanding the mechanism and regulation of translation -- Ribosome profiling of initiating ribosomes -- Ribosome profiling of elongating ribosomes -- Ribosome profiling of translation termination -- Diversity and applications of ribosome profiling -- Effect of stress on translation -- Cell cycle and translation regulation -- Ribosome profiling during viral infections -- Ribosome profiling during parasitic infections -- Ribosome profiling in Escherichia coli.
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Summary and conclusions -- References -- Index.
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