GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Lipid Composition in Scrapie-Infected Mouse Brain: Prion Infection Increases the Levels of Dolichyl Phosphate and Ubiquinone (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 66 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The neutral and phospholipid composition of mouse brain infected with scrapie prions was investigated. During the later stages of this disease, the level of dolichol decreased by 30% whereas the level of dolichyl phosphate increased by 30%. In terminally ill mice, there was also a 2.5-fold increase in both total ubiquinone and its reduced form. Furthermore, α-tocopherol was elevated at this stage by 50%. In contrast, no changes were observed in phospholipid amount, in phospholipid composition, and in phosphatidylethanolamine plasmalogen content during the entire disease process. The fatty acid and aldehyde composition of individual phospholipids remained unaltered as well. No modifications could be detected in cholesterol content. Thus, the majority of membrane lipids in scrapie-infected mouse brain are modified in neither quantity nor structure, but specific changes occur to a few polyisoprenoid lipids. This specificity indicates that, although prions accumulate in lysosomes, the infection process is not associated with a general membrane destruction caused by lysosomal enzyme leakage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66010277.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Ubiquinone-10 Protects Neurons from Virus-Induced Degeneration (1994)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 63 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Cultured neurons from rat dorsal root ganglia and cerebral cortex were infected with Sendai virus, which gives a productive replication with lysis of most neurons, and with the RW strain of mumps virus, which undergoes defective replication causing degeneration of only 30–40% of the neurons within 5 days after initial infection. In Sendai virus-infected cells the amount of polyisoprenoid lipids was enhanced. In mumps virus-infected cultures there were transient reductions in the contents of cholesterol, dolichol, and ubiquinone-9 in the cultures, whereas the reduction in the ubiquinone-10 level was progressive, reaching 20% of its original value 21 days after infection. Treatment of mumps virus-infected cultures with ubiquinone-10 protected the neurons from degeneration, whereas no effects were observed on exposure to ubiquinone-9. Linolenic acid (18:3) and arachidonic acid (20:4), but not myristic acid (14:0) and palmitic acid (16:0), also had significant neuroprotective effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.63020634.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    NMDA-Receptor Antagonist Prevents Measles Virus-induced Neurodegeneration (1991)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 3 (1991), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: N-methyl-d-aspartate (NMDA) receptors represent a major subtype of excitatory amino acid receptors in the mammalian brain. In addition to their physiological role, NMDA receptors have been linked to the occurrence of nerve cell death in several neurodegenerataive diseases. The hamster neurotropic (HNT) strain of measles virus causes non-inflammatory encephalopathy in mice. This is associated with neuronal loss in areas CA1 and CA3 of the hippocampus. Systemic treatment with the non-competitive NMDA receptor antagonist 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclo-hepten-5,10-imine maleate (MK-801) prevented this cellular necrosis. Thus, a virus may have indirect neurodegenerative effects in the brain due to activation of NMDA receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1991.tb00812.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Exposure to interferon-γ during synaptogenesis increases inhibitory activity after a latent period in cultured rat hippocampal neurons (2004)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 19 (2004), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Certain disorders of the nervous system may have their origin in disturbances in the development of synaptic connections and network structure that may not become overt until later in life. As inflammatory cytokines can influence synaptic activity in neuronal cultures, we analysed whether cytokine exposure during synaptogenesis can lead to imbalances in a neuronal network. Short-term application of interferon-γ (IFN-γ), but not tumour necrosis factor-α, during peak synaptogenesis (but not before or after) in Sprague–Dawley rat hippocampal cultures, caused both a decrease in the frequency of spontaneous excitatory postsynaptic currents (EPSCs) and an increase in the frequency of spontaneous inhibitory postsynaptic currents (IPSCs). These effects were only detected in recordings made weeks later. This was not due to a depression of glutamatergic synapses or to a change in the relative number of neurons containing glutamic acid decarboxylase (GAD). There was an increase in the average amplitude of miniature IPSCs, and in GAD-expressing neurons the amplitude of miniature EPSCs were larger as well as the responses to glutamate. This indicates that IFN-γ-treatment induced increased inhibition via postsynaptic changes. These effects of IFN-γ treatment were not observed when neuronal nitric oxide synthase was inhibited. Our study therefore shows that exposure to IFN-γ during a restricted period of development, which coincides with the peak of excitatory synaptogenesis, can cause progressive changes in synaptic activity in the network. Thus, cytokine exposure at a critical period of development may constitute a ‘hit-and-run’ mechanism for certain nervous system disorders that become manifest after a latency period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0953-816X.2004.03445.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Perturbation of the synaptic release machinery in hippocampal neurons by overexpression of SNAP-25 with the Semliki Forest virus vector (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have examined whether the Semliki Forest virus (SFV) expression vector can be used to manipulate the exocytotic machinery in cultured hippocampal neurons. Autaptic responses were recorded in individually identified neurons which overexpressed either a non-synaptic protein, the transferrin receptor, or the synaptic SNARE protein SNAP-25 (synaptosomal-associated protein of 25 kDA). In neurons overexpressing the transferrin receptor, autaptic responses occurred in a similar proportion and had similar amplitudes (12–18 h postinfection) as in uninfected control neurons. With increasing time after the infection, an increasing proportion of the transferrin receptor-overexpressing neurons showed changes in the shape of the cell body, but the autaptic responses appeared normal as long as recordings could be performed (up to 30 h postinfection). In contrast, in SNAP-25-overexpressing neurons, the proportion of responding cells was reduced 12–18 h after the infection, and the amplitude of the autaptic current in responding neurons was also reduced. The sensitivity to exogenously applied glutamate was, however, unchanged. Biochemical analysis showed that 50% of the overexpressed SNAP-25 was palmitoylated. The levels of two other SNAREs, syntaxin and synaptobrevin (also called vesicle-associated membrane protein), were not affected. Our results indicate that the SFV vector can provide an effective tool to study the function of proteins participating in neurotransmitter release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00614.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Distinct Effects of Clostridial Toxins on Activity-dependent Modulation of Autaptic Responses in Cultured Hippocampal Neurons (1997)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 9 (1997), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Clostridial neurotoxins proteolyse specific proteins implicated in synaptic vesicle exocytosis, but their actions on the release machinery in functional synapses is not well understood. Here we examine the effects of botulinum toxin A (BoNT/A) and tetanus toxin (TeTx) on autaptic transmission in cultured rat hippocampal neurons using whole-cell voltage clamp recordings. The proportion of cells responding to stimulation with an excitatory postsynaptic current (EPSC) and the magnitude of the remaining responses decreased gradually with increasing concentration of either toxin. However, the activity-dependent modulation (5 Hz repetitive stimulation) of EPSCs remaining after toxin inhibition differed markedly between the two toxins. The TeTx inhibition was associated with a persistent activity-dependent depression similar to that in control cells. In contrast, the BoNT/A inhibition was accompanied by a reversal of the modulation into facilitation, resembling that induced by lowering of the calcium concentration. These results demonstrate a difference between BoNT/A and TeTx in their mode of inhibition of synaptic vesicle exocytosis, which suggests that they exert their preferential actions at distinct steps of the release process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1997.tb01535.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Functional Disturbances during Slow Viral Infections of the Central Nervous System (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 724 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb38892.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization (1979)
    Springer
    Acta neuropathologica 48 (1979), S. 215-217 
    Details
    ISSN: 1432-0533
    Keywords: Herpes simplex virus ; Visna virus ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled “bystander effect” of a cell-mediated immune response (bystander demyelination).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690522
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Delayed radiation lesions of the human spinal cord (1967)
    Springer
    Acta neuropathologica 9 (1967), S. 34-44 
    Details
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über die pathologischen Befunde bei fünf Erwachsenen mit cervicaler Myelopathie nach Röntgenbestrahlung von Hypopharynx-Carcinomen berichtet. Die Befunde zeigten weitgehende Übereinstimmung mit jenen früherer Beobachtungen, doch wurden in allen Fällen Teleangiektasien angetroffen. Die Pathogenese der Röntgenspätschädigung des Rückenmarks wird unter Berücksichtigung experimenteller Befunde diskutiert. Eine Gefäßschädigung — vorwiegend durch Schädigung der Gefäßendothelzellen — wird als wichtigster pathogenetischer Faktor angenommen.
    Notes: Summary A report is given on patho-anatomical findings in five adult patients with cervical myelopathy following X-irradiation of hypopharyngeal cancer. The findings were largely consistent with those of earlier reports; however, telangiectases were found in all cases. The pathogenesis of the damage is briefly discussed in relation to experimental work on postirradiation lesions of the central nervous system. A vascular lesion is held to be the most important pathogenetic factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688156
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Morphological studies of the neural spread of herpes simplex virus to the central nervous system (1970)
    Springer
    Acta neuropathologica 16 (1970), S. 54-63 
    Details
    ISSN: 1432-0533
    Keywords: Herpes Simplex Virus ; Axoplasmic Transport ; Encephalo-myelitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Herpes simplex-Virus wurde intradermal in die Pfote des Hinterbeines sowie i.m. in den M. gastrocnemius von 12 Tage alten Saugmäusen inoculiert. Die Entwicklung der resultierenden Läsionen im Nervus ischiadicus, in den Spinalwurzeln, Spinalganglien und im Rückenmark wurde untersucht. Nach intradermaler Inoculation folgten die Läsionen den sensorischen Fasern, während nach intramuskulärer Inoculation sich hauptsächlich Läsionen in motorischen Faserm fanden. Ultramikroskopisch waren Herpes simplex-Virus-ähnliche Partikel in Schwann-Zellen und Nervenzellen dieser Faserbündel zu sehen. Die Annahme ist begründet, daß ein Hauptmechanismus für die neurale Ausbreitung des Herpes simplex-Virus ein direkter Transport des Infektionserregers in den Axonen ist.
    Notes: Summary Herpes simplex virus was inoculated intradermally into the pad of the hind leg and intramuscularly into the gastrocnemius muscle of twelve-day-old suckling mice. The development of the resulting lesions in the sciatic nerve, spinal roots, dorsal ganglia and spinal cord was studied. After intradermal inoculations the lesions followed the sensory fibres, while after intramuscular inoculation lesions corresponding to the motor fibres were seen as a prominent feature. Ultrastructurally herpes simplex virus-like particles were seen in Schwann cells and neurones in these fibre tracts. It is reasonable to suppose that a main mechanism for the neural spread of herpes simplex virus in mice is a direct transport of the infectious agent within axons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686964
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...