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  • 1
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 69 (1996), S. 2324-2326 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Asymmetrically confined multiple quantum well laser structures have recently been very successful in reaching high modulation bandwidths up to 26 GHz, reported in the InGaAs/InGaAlAs material system. We have measured the effective carrier transport time in structures of this kind by performing parasitic-free optical modulation experiments. The result is one specific transport time for each confinement layer width. We show that down to layer widths of about 100 nm this effective time for both types of carriers is given by a pure diffusion process for InGaAs/InGaAlAs. Finally, a diffusion constant for the barrier/confinement carriers results in InGaAlAs material which is in very good agreement with reported mobilities. © 1996 American Institute of Physics.
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  • 2
    ISSN: 1432-2161
    Keywords: Key words Echinococcosis ; Bone ; Soft tissue ; Liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. The present study demonstrates the osseous and soft tissue manifestations of alveolar echinococcosis (AE). Patients. We report on eight patients with AE with bone or soft tissue involvement confirmed at biopsy or needle cytology. Results. All eight patients showed hepatic involvement. Four exhibited infiltration of the spine as a result of direct spread of the hepatic primary lesion; distant metastases were observed in only three of these patients. Calcifications, which are typical for hepatic manifestations of the disease, were observed in soft tissue in only two of eight cases (25%); we observed no instances of endovesicular daughter cysts. Conclusion. AE manifests itself in the vertebral column as a form of spondylitis and in soft tissue presents similar to an abscess. Since in most of these cases spread of the disease per continuitatem from the liver is present, the diagnosis is easily made from the characteristic hepatic findings.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 34 (1995), S. 73-78 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract We have characterized a series of 69 independent mutants at the endogenoushprt locus of human TK6 lymphoblasts and over 200 independent S 1-deficient mutants of the humanxhamster hybrid cell line AL arising spontaneously or following low-fluence exposures to densely ionizing Fe ions (600 MeV/amu, linear energy transfer = 190 keV/µm). We find that large deletions are common. The entirehprt gene (〉44 kb) was missing in 19/39 Fe-induced mutants, while only 2/30 spontaneous mutants lost the entirehprt coding sequence. When the gene of interest (S1 locus = M1C1 gene) is located on a nonessential human chromosome 11, multilocus deletions of several million base pairs are observed frequently. The S1 mutation frequency is more than 50-fold greater than the frequency ofhprt mutants in the same cells. Taken together, these results suggest that low-fluence exposures to Fe ions are often cytotoxic due to their ability to create multilocus deletions that may often include the loss of essential genes. In addition, the tumorigenic potential of these HZE heavy ions may be due to the high potential for loss of tumor suppressor genes. The relative insensitivity of thehprt locus to mutation is likely due to tight linkage to a gene that is required for viability.
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Adolescence 3 (1980), S. 165-173 
    ISSN: 0140-1971
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Adolescence 5 (1982), S. 51-62 
    ISSN: 0140-1971
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 242 (1987), S. 683-685 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Der retrospektive statistische Vergleich von operativer und konservativer Behandlung bei klinisch gleichartigen Patientenkollektiven mit vorzeitiger Zervixreifung in der 15.–35. SSW konnten den Beweis der grundsätzlichen Überlegenheit der operativen Therapieform nicht erbringen. Aufgrund der höheren perinatalen Morbidität in der operativen Behandlungsgruppe ist die großzügige Handhabung der therapeutischen Cerclage bei unselektiver Indikation zu überdenken. Die Analyse der Untergruppen und prospektive Studien müssen zeigen, ob die operative Therapie bei bestimmter Indikationsstellung, z.B. vorzeitige Zervixreifung vor der 24. SSW, Vorteile bietet.
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  • 7
    ISSN: 1432-1084
    Keywords: Key words: Papilloma ; Breast ; MRM ; Galactography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was evaluation of MRI alone and in combination with mammography and galactography in the diagnosis of intraductal papillomas. From 1994 to 1998, a total of 48 women presenting with pathologic mammary secretion underwent galactography and magnetic resonance mammography (MRM). Thirty-five patients aged 16–71 years (average age 46 years) subsequently underwent surgery or diagnostic puncture and the histologic findings were compared with the results of the radiologic examination. Histology revealed papillomas in 16 cases. In 6 of these patients, there was associated malignant degeneration. Malignancy without associated papilloma was observed in 3 cases. Galactography displayed a sensitivity of 94 % and a specificity of 79 % with five false-positive findings and one false-negative finding in the recognition of intraductal papillomas. Malignant processes were detected by mammography/galactography in only one instance. Magnetic resonance mammography visualized pathologic contrast medium uptake in 8 of 9 cases of malignant disease (sensitivity 89 %). One patient with in situ ductal carcinoma escaped detection with MRM. Papillomas showed no or below-the-threshold-lying contrast uptakes with no specific sign suggestive of papilloma. Galactography in combination with mammography remains the primary diagnostic procedure in cases of pathologic mammary secretion or suspected papilloma. The addition of MRI permits exclusion of malignant disease with a high degree of certainty; thus, expectant management in individual cases with negative findings appears justified.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European radiology 10 (2000), S. 802-805 
    ISSN: 1432-1084
    Keywords: Key words: Gastrointestinal bleeding ; Embolization ; Interventional therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Retrospective evaluation of interventional embolization therapy in the treatment of gastrointestinal hemorrhage over a long-term observation period from 1989 to 1997. Included in the study were 35 patients (age range 18–89 years) with gastrointestinal bleeding (GI) referred for radiological intervention either primarily or following unsuccessful endoscopy or surgery. Sources of GI bleeding included gastric and duodenal ulcers (n = 7), diverticula (n = 3), erosion of the intestinal wall secondary to malignancy (n = 6), vascular malformations (n = 4), and hemorrhoids (n = 2), as well as from postoperative (n = 6), posttraumatic (n = 2), postinflammatory (n = 4) or unknown (n = 1) causes. Ethibloc (12 cases) or metal coils (14 cases) were predominantly used as embolisates. In addition, combinations of tissue adhesive and gelfoam particles and of coils and Ethibloc were used (six cases). Finally, polyvinyl alcohol particles, a coated stent, and an arterial wire dissection were utilized in one case each. Bleeding was stopped completely in 29 of 35 cases (83 %). In one case (3 %) the source of bleeding was recognized but the corresponding vessel could not be catheterized. In five other cases (14 %) there was partial success with reduced, though still persistent, bleeding. The rate of complications was 14 %, including four instances of intestinal ischemia with fatal outcome in the first years, and, later, one partial infarction of the spleen without serious consequences. Gastrointestinal hemorrhage can be controlled in a high percentage of patients, including the seriously ill and those who had previously undergone surgery, with the use of minimally invasive interventional techniques. The availability of minicoils instead of fluid embolization agents has reduced the risk of serious complications.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Radiologe 39 (1999), S. 790-794 
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Intraarterielle Chemotherapie ; Mammakarzinom ; Mitoxantron ; Thromboembolie ; Key words Intraarterial chemotherapy ; Breast cancer ; Mitoxantrone ; Thromboembolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A general review of the results and technique of intraarterial chemotherapy in cases of breast cancer is given. The remission rate for untreated primary tumors is nearly 100%, for completely treated local relapses approximately 70%. The complication rate is quite low using an intraarterial well-tolerated cytostatic agent such as mitoxantrone. However, thromboembolism of the vertebral artery facing the internal mammary artery may occur. The indication for intraarterial chemotherapy should always be set by an interdisciplinary board.
    Notes: Zusammenfassung In der vorliegenden Arbeit werden Technik und Ergebnisse der intraarteriellen Chemotherapie beim Mammakarzinom übersichtsartig beschrieben. Die Remissionsraten für einen unbehandelten Primärtumor liegen bei nahezu 100%, beim ausbehandelten Lokalrezidiv bei ca. 70%. Unter Verwendung eines intraarteriell gut verträglichen Zytostatikums wie Mitoxantron sind die Komplikationsraten gering, zu fürchten ist vor allem eine Thromboembolie in die gegenüber der A. mammaria interna gelegene A. vertebralis. Die Indikation zur intraarteriellen Chemotherapie sollte immer interdisziplinär gestellt werden.
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  • 10
    ISSN: 1432-2102
    Keywords: Schlüsselwörter Fortgeschrittenes Zervixkarzinom ; Blutung ; Embolisationsbehandlung ; Key words Cervix uteri ; Advanced carcinoma ; Hemorrhage ; Embolization treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Purpose: Retrospective evaluation of percutaneous interventional treatment of locally advanced cervical carcinoma. Materials and methods: Since 1991, 13 patients with advanced tumor disease have been referred to our department for diagnosis and therapy of an acute blood loss. In all patients (age 40–88 years, mean 61 years) hemorrhage was detected by decrease in red blood cell count. In all cases patients suffered from locally advanced or recurrent disease after surgery and/or additional radio- or chemotherapy. Embolization was performed by transfemoral access using minicoils in most cases, liquid agents less often and a covered vascular stent in one patient. Results: The site of the hemorrhage or the blood pooling of the tumor could be seen in all cases angiographically. Twenty-seven treatment cycles (2.1 per patient) were performed at intervals of 3 days to 6 months. The maximum time of follow-up and additional treatments if necessary was 1 year. In 9 of 13 patients (69%) the bleeding could be stopped immediately with a single treatment or initial treatment via both iliac arteries. One patient (7,7%) died during therapy because of an uncontrollable bleeding and consecutive decrease in red blood cells count. The remaining three patients (23%) showed slight persistent or recurrent bleeding, which could be managed interventionally until the following episode. There were two complications (15%) during therapy, representing a coil misplacement and a coil wash-out, which both could be managed interventionally. Conclusion: Hemorrhage following locally advanced or recurrent cervical carcinoma can be stopped interventionally in about 70% of cases. Even in partial success it is possible to manage the acute life-threatening situation. Follow-up examinations of up to 1 year justify this therapeutic concept.
    Notes: Zusammenfassung Ziel der vorliegenden Arbeit war die retrospektive Auswertung und Darstellung der Bedeutung interventioneller Methoden in der Behandlung von Patienten mit lokal fortgeschittenem Zervixkarzinom. Seit 1991 wurden uns 13 Patientinnen mit fortgeschrittener Tumorerkrankung und akuten Blutungen zur radiologischen Evaluierung und ggf. Intervention vorgestellt. Bei allen Patienten in einem Alter zwischen 40 und 88 Jahren (Durchschnitt: 61 J.) waren Blutungen mit deutlichem Hb-Abfall bis hin zur vitalen Bedrohung aufgetreten. In allen Fällen handelte es sich um Karzinome der Zervix uteri im fortgeschrittenem Stadium oder um Rezidive nach initialer Operation mit begleitender Radio- bzw. Chemotherapie. Bei allen Patienten konnten die Blutungsareale oder das Pooling des Kontrastmittel im Tumor angiographisch lokalisiert werden. Insgesamt erfolgten 27 Embolisationstherapien (2,1 pro Patient) in Abständen von 3 Tagen bis zu 6 Monaten und maximal über einen zeitlichen Verlauf von über 1 Jahr. In 9 von 13 Fällen konnte durch eine solitäre Behandlung bzw. eine zweizeitige Therapie über beide Iliakalarterien die Blutung akut zum Stillstand gebracht werden (69%). Eine Patientin verstarb noch während der Embolisation infolge des Blutverlustes (7,7%). Die anderen 3 Patientinnen zeigten abgeschwächt persistierende oder frühzeitig rezidivierende Blutungen (23%). Als Embolisate wurden vorwiegend Spiralen, selten flüssige Embolisate und einmal ein ummantelter Stent verwendet. Periinterventionelle Komplikationen traten in zwei Fällen auf. Hier gelang es sowohl eine fehlplazierte Spirale, als auch eine Embolisatverschleppung interventionell zu bergen. In etwa 70% können Tumorblutungen bei Zervixkarzinomen interventionell beherrscht werden. Auch wenn nur ein Teilerfolg zu verzeichnen ist, kann zumindest die lebensbedrohliche Akutsituation meist abgewendet werden. Daß z.T. Verläufe über 1 Jahr ohne Möglichkeit einer weiteren kurativen Behandlung der Tumoren vorliegen, rechtfertigt unserer Meinung nach diesen Therapiansatz.
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