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  • 1
    Electronic Resource
    Electronic Resource
    A new digital all-sky imager experiment for optical auroral studies in conjunction with the Scandinavian twin auroral radar experiment (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 578-584 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Studies of the relationship between the optical aurorae and the ionospheric electric fields, as observed by the bi-static Scandinavian twin auroral coherent backscatter radar experiment (STARE) and the tri-static European incoherent backscatter radar facility (EISCAT), are to be undertaken in Scandinavia. For this purpose, an unmanned and fully automatic low-light-level television camera system, coupled to an all-sky lens, has been constructed. A personal computer controls all aspects of the instrument, operating it for all dark and moon-free periods. Monochrome optical data, usually at 557.7 nm, are pre-processed in real time at the recording site. The transformed images are stored digitally to magneto-optical disk with a temporal and spatial resolution directly compatible with the STARE radar data, thus making comparisons easy. Simultaneous TV recordings to tape may be made on a campaign basis. The camera has been calibrated for all gain settings, thereby permitting auroral images to be recalled in any sequence with the same absolute intensity scale. Modem communication permits remote control, trouble shooting and quick-look data transfers. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1148697
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  • 2
    Electronic Resource
    Electronic Resource
    Bedeutung eines intakten Magnesiumhaushalts (2000)
    Springer
    Der Urologe 39 (2000), S. 64-70 
    Details
    ISSN: 1433-0563
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: In beinahe allen Fachgebieten der Medizin ist das Interesse an Magnesium in den letzten Jahren gestiegen. Magnesium ist für den lebenden Organismus ein essentieller Mineralstoff, der in ausreichenden Mengen zugeführt werden muß. Die klinische Bedeutung der Magnesiumüberladung bzw. -intoxikation ist eher gering. Ein Magnesiummangel beim Menschen tritt jedoch häufig auf und kann trotz normaler Ernährung nicht immer komplett ausgeglichen werden. Als primären Effekt eines Magnesiummangels beobachtet man eine Reduktion von Enzymaktivitäten mit Schrittmacheraufgaben in den Stoffwechselwegen der Energieproduktion. Die beeinträchtigte Energieproduktion wirkt sich auf die Membranfunktion, die intrazelluläre Kalzium-Relokation, Elektrolytengradienten, die Bildung von sekundären Botenstoffen und auf Syntheseaufgaben der Zelle aus. Daraus resultieren Konsequenzen für die Funktion der Organe und das Ausmaß der Reaktion des menschlichen Körpers auf äußeren und inneren Streß. Im Krankheitszustand begrenzt der eingeschränkte Energiestatus die Prognose des Patienten und verstärkt klinische Zeichen der Krankheit, wie z.B. Arrhythmien, Hypertonie, Präeklampsie, allergische Reaktionen und andere. Der Stellenwert einer oralen oder parenteralen Magnesiumtherapie ist bekanntlich bei einer Vielzahl von Erkrankungen gut dokumentiert. Hierzu stehen verschiedene Magnesiumpräparate oder supportive Maßnahmen zur Verfügung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001200050012
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  • 3
    Electronic Resource
    Electronic Resource
    A gas-lens telescope (1991)
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 547-548 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] One of the simplest gas lenses consists of an electrically heated pipe through which air is drawn (see Fig. la). Air at room temperature in the centre of the pipe has a higher refractive index than the warm air at the boundary. A refractive index gradient results which brings rays of laser light or ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/353547a0
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  • 4
    Electronic Resource
    Electronic Resource
    Extrapolating EISCAT Pedersen conductances to other parts of the sky using ground-based TV auroral images (1998)
    Springer
    Annales geophysicae 16 (1998), S. 583-588 
    Details
    ISSN: 0992-7689
    Keywords: Atmospheric composition and structure (airglow and aurora) ; Magnetospheric physics (auroral phenomena, instruments and techniques)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Ionospheric conductivity is not very easily measured directly. Incoherent scatter radars perhaps offer the best method but can only measure at one point in the sky at any one time and are limited in their time resolution. Statistical models of average conductivity are available but these may not be applied to individual case studies such as substorms. There are many instances where a real-time estimate of ionospheric conductivity over a large field-of-view is highly desirable at a high temporal and spatial resolution. We show that it is possible to make a reasonable estimate of the noctural height-integrated Pedersen conductivity, or conductance, with a single all-sky TV camera operating at 557.7 nm. This is not so in the case of the Hall conductance where at least two auroral wavelengths should be imaged in order to estimate additionally the energy of the precipitating particles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-998-0583-y
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  • 5
    Electronic Resource
    Electronic Resource
    Ion-neutral coupling in the high-latitude F-layer from incoherent scatter and Fabry-Perot interferometer measurements (2000)
    Springer
    Annales geophysicae 18 (2000), S. 1145-1153 
    Details
    ISSN: 0992-7689
    Keywords: Ionosphere
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Since the auroral ionosphere provides an important energy sink for the magnetosphere, ionosphere-thermosphere coupling must be investigated when considering the energy budget of the ionosphere-magnetosphere coupling. We present the first Scandinavian ground-based study of high-latitude F-region ion-neutral frictional heating where ion velocity and temperature are measured by the EISCAT incoherent scatter radar as well as neutral wind and temperature being measured simultaneously by a Fabry-Perot interferometer. A geomagnetically active period (Kp = 7- - 5-) and quiet period (Kp = 0+ - 0) were studied. Neglecting the neutral wind can result in errors of frictonal heating estimates of 60% or more in the F-layer. About 96% of the local ion temperature enhancement over the neutral temperature is accounted for by ion-neutral frictional heating.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-000-1145-0
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  • 6
    Electronic Resource
    Electronic Resource
    Optical tomography of the aurora and EISCAT (1998)
    Springer
    Annales geophysicae 16 (1998), S. 1332-1342 
    Details
    ISSN: 0992-7689
    Keywords: Tomography ; Aurora ; EISCAT ; Ionosphere ; Conductivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract Tomographic reconstruction of the three-dimensional auroral are emission is used to obtain vertical and horizontal distributions of the optical auroral emission. Under the given experimental conditions with a very limited angular range and a small number of observers, algebraic reconstruction methods generally yield better results than transform techniques. Different algebraic reconstruction methods are tested with an auroral are model and the best results are obtained with an iterative least-square method adapted from emission-computed tomography. The observation geometry used during a campaign in Norway in 1995 is tested with the are model and root-mean-square errors, to be expected under the given geometrical conditions, are calculated. Although optimum geometry was not used, root-mean-square errors of less than 2% for the images and of the order of 30% for the distribution could be obtained. The method is applied to images from real observations. The correspondence of original pictures and projections of the reconstructed volume is discussed, and emission profiles along magnetic field lines through the three-dimensionally reconstructed arc are calibrated into electron density profiles with additional EISCAT measurements. Including a background profile and the temporal changes of the electron density due to recombination, good agreement can be obtained between measured profiles and the time-sequence of calculated profiles. These profiles are used to estimate the conductivity distribution in the vicinity of the EISCAT site. While the radar can only probe the ionosphere along the radar beam, the three-dimensional tomography enables conductivity estimates in a large area around the radar site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00585-998-1332-y
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  • 7
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    Temsirolimus for Newly Diagnosed Glioblastoma (2016)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2016-10-08
    Description: Purpose: EORTC 26082 assessed the activity of temsirolimus in patients with newly diagnosed glioblastoma harboring an unmethylated O6 methylguanine-DNA-methyltransferase ( MGMT ) promoter. Experimental Design: Patients ( n = 257) fulfilling eligibility criteria underwent central MGMT testing. Patients with MGMT unmethylated glioblastoma ( n = 111) were randomized 1:1 between standard chemo-radiotherapy with temozolomide or radiotherapy plus weekly temsirolimus (25 mg). Primary endpoint was overall survival at 12 months (OS12). A positive signal was considered 〉38 patients alive at 12 months in the per protocol population. A noncomparative reference arm of 54 patients evaluated the assumptions on OS12 in a standard-treated cohort of patients. Prespecified post hoc analyses of markers reflecting target activation were performed. Results: Both therapies were administered per protocol with a median of 13 cycles of maintenance temsirolimus. Median age was 55 and 58 years in the temsirolimus and standard arms, the WHO performance status 0 or 1 for most patients (95.5%). In the per protocol population, 38 of 54 patients treated with temsirolimus reached OS12. The actuarial 1-year survival was 72.2% [95% confidence interval (CI), 58.2–82.2] in the temozolomide arm and 69.6% (95% CI, 55.8–79.9) in the temsirolimus arm [hazard ratio (HR) 1.16; 95% CI, 0.77–1.76; P = 0.47]. In multivariable prognostic analyses of clinical and molecular factors, phosphorylation of mTORSer2448 in tumor tissue (HR 0.13; 95% CI, 0.04–0.47; P = 0.002), detected in 37.6%, was associated with benefit from temsirolimus. Conclusions: Temsirolimus was not superior to temozolomide in patients with an unmethylated MGMT promoter. Phosphorylation of mTORSer2448 in the pretreatment tumor tissue may define a subgroup benefitting from mTOR inhibition. Clin Cancer Res; 22(19); 4797–806. ©2016 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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  • 8
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    Induction therapy of AML with ara-C plus daunorubicin versus ara-C plus gemtuzumab ozogamicin: a randomized phase II trial in elderly patients (2012)
    Oxford University Press
    Details
    Publication Date: 2012-04-03
    Description: Background: Chemotherapy for elderly patients with acute myeloid leukemia (AML) results in a median overall survival (OS) of ≤1 year. Elderly patients often present with cardiac comorbidity. Gemtuzumab ozogamicin (GO) is active in elderly (≥60 years) patients with relapsed AML with low cardiac toxicity. Patients and methods: This randomized phase II study compared a standard combination of ara-C and daunorubicin (DNR; 7+3) versus ara-C plus gemtuzumab ozogamicin (7+GO) as the first course of induction therapy. Primary objectives were comparison of blast clearance on day 16, event-free survival (EFS), and remission duration. OS, complete remission (CR), and tolerability were secondary objectives. Results: One hundred and nineteen patients with de novo AML, treatment-related AML, AML with a history of myelodysplastic syndrome (MDS), or high-risk MDS entered the study. Median age of 115 patients (intent-to-treat population) was 69 years. Protocol outlined a second course 7+3 for patients without blast clearance and two courses of high-dose ara-C consolidation upon CR. Both treatments were equally effective in blast clearance, CR, EFS, remission duration, or OS (median: 7+3, 9 months; 7+GO, 10 months). Induction death rate was higher in the GO group due to veno-occlusive disease. Conclusion: The study did not show significant superiority of 7+GO over standard 7+3.
    Print ISSN: 0923-7534
    Electronic ISSN: 1569-8041
    Topics: Medicine
    Published by Oxford University Press
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  • 9
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    Geomagnetic lunar and solar daily variations during the last 100 years (2014)
    In:  Journal of Geophysical Research
    Details
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/article
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  • 10
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    Evidence for stratospheric sudden warming effects on the upper thermosphere derived from satellite orbital decay data during 1967-2013 (2015)
    In:  Geophysical Research Letters
    Details
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/article
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