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  • 1
    Online Resource
    Online Resource
    Dalrymple Trough : an active oblique-slip oceancontinent boundary in the northwest Indian Ocean (2008)
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    In: Earth and planetary science letters, Amsterdam [u.a.] : Elsevier, 1966, 272(2008), 1/2, Seite 437-445, 1385-013X
    In: volume:272
    In: year:2008
    In: number:1/2
    In: pages:437-445
    Description / Table of Contents: The Dalrymple Trough marks part of the transform plate boundary between India and Arabia in the northern Arabian Sea. Oblique extension is presently active across this portion of the boundary at a rate of a few millimetres per year, and seismic reflection profiles across the trough confirm that it is an extensional structure. We present new swath bathymetric and wide-angle seismic data from the trough. The bathymetric data show that the trough is bounded by a single, steep, 3-km-high scarp to the southeast and a series of smaller, en-echelon scarps to the northwest. Wide-angle seismic data show that a typical oceanic crustal velocity structure is present to the northwest, with a crustal thickness of ~ 6 km. There is an abrupt change in crustal thickness and velocity structure at the northwestern edge of the trough, and the trough itself is underlain by 12-km-thick crust interpreted as thinned continental crust. Therefore we infer that Dalrymple Trough is an unusual obliquely extending plate boundary at which continental crust and oceanic crust are juxtaposed. The extensional deformation is focused on a single major fault in the continental lithosphere, but distributed over a region ~ 60 km wide in the oceanic lithosphere.
    Type of Medium: Online Resource
    Pages: graph. Darst
    ISSN: 1385-013X
    DOI: 10.1016/j.epsl.2008.05.007
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Placental infiltration in congenital neuroblastoma: a case study with ultrastructure (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 4 (1980), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Examination of a large, oedematous placenta of a still-born infant showed an extensive infiltration of chorionic villi by malignant cells; the nature of these was not apparent by light microscopy. Ultrastructural examination of these cells showed the presence of cytoplasmic granules whose size and appearance were consistent with those characteristically present in neuroblastomas. Whereas no necropsy was carried out on the still-born infant, it may be assumed, in keeping with the available data, that the placental metastases were derived from a congenital neuroblastoma. Infiltration of the villous stroma by metastatic neuroblastoma observed in the present case was not reported previously as in all other known instances the metastatic neuroblastomatous cells were confined to the lumina of the chorionic vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1980.tb02933.x
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  • 3
    Electronic Resource
    Electronic Resource
    Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice (2000)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 12 (2000), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Somatostatin (SRIF) controls many physiological and pathological processes in the central nervous system but the respective roles of the five receptor isotypes (sst1–5) that mediate its effects are yet to be defined. In the present study, we attempted to identify functions of the sst2 receptor using mice with no functional copy of this gene (sst2 KO mice). In contrast with control 129Sv/C57Bl6 mice, sst2 mRNA was no longer detectable in the brain of sst2 KO mice; 125I-labeled Tyr0DTrp8-SRIF14 binding was also greatly reduced in almost all brain structures except for the hippocampal CA1 area, demonstrating that sst2 accounts for most SRIF binding in mouse brain. Invalidation of this subtype generated an increased anxiety-related behaviour in a number of behavioural paradigms, while locomotor and exploratory activity was decreased in stress-inducing situations. No major motor defects could be detected. sst2 KO mice also displayed increased release of pituitary ACTH, a main regulator of the stress response. Thus, somatostatin, via sst2 receptor isotype pathways, appears involved in the modulation of locomotor, exploratory and emotional reactivity in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2000.00249.x
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  • 4
    Electronic Resource
    Electronic Resource
    Diazepam-induced changes on sleep and the EEG spectrum in mice: role of the α3-GABAA receptor subtype (2003)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 17 (2003), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Benzodiazepines reduce EEG slow-wave activity in non-REM sleep by potentiating GABAergic neurotransmission at GABAA receptors via a modulatory binding site. However, the mechanisms of action underlying the effects of benzodiazepines on sleep and the sleep EEG are still unknown. Slow waves during sleep are generated by the corticothalamic system and synchronized by the inhibitory GABAergic neurons of the reticular thalamic nucleus. This region contains exclusively α3-containing GABAA receptors. We investigated the role of these receptors in the mediation of diazepam effects on the sleep EEG by studying point-mutated mice in which the α3-GABAA receptor is diazepam-insensitive [α3(H126R)]. Sleep was recorded for 12 h after i.p. injection of 3 mg/kg diazepam or vehicle at light onset in α3(H126R) and wild-type controls (n = 13–17 per genotype). The main effect was a marked reduction of slow-wave activity (EEG power density in 0.75–4.00 Hz) in non-REM sleep and a concomitant increase in frequencies above 15.00 Hz in non-REM sleep and waking in both genotypes. Neither effect of diazepam differed significantly between the genotypes. Despite the exclusive expression of α3-containing GABAA receptors in the reticular thalamic nucleus, these receptors do not seem to be critical for the mediation of the effects of diazepam on the sleep EEG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2003.02651.x
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  • 5
    Electronic Resource
    Electronic Resource
    Surface migration of oxygen and metal atoms during the oxidation of copper and silver
    Amsterdam : Elsevier
    Surface Science 2 (1964), S. 376-380 
    Details
    ISSN: 0039-6028
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0039-6028(64)90077-9
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  • 6
    Electronic Resource
    Electronic Resource
    Networks of epitaxial dislocations on untouched copper crystals
    Amsterdam : Elsevier
    Surface Science 3 (1965), S. 421-423 
    Details
    ISSN: 0039-6028
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0039-6028(65)90010-5
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  • 7
    Electronic Resource
    Electronic Resource
    Surface structures on spherical copper crystals after adsorption of oxygen
    Amsterdam : Elsevier
    Surface Science 8 (1967), S. 223-232 
    Details
    ISSN: 0039-6028
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0039-6028(67)90084-2
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  • 8
    Electronic Resource
    Electronic Resource
    Fourier finite-difference migration for steeply dipping reflectors with complex overburden (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 43 (1995), S. 0 
    Details
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: The improvement in accuracy and efficiency of wave-equation migration techniques is an ongoing topic of research. The main problem is the correct imaging of steeply dipping reflectors in media with strong lateral velocity variations. We propose an improved migration method which is based on cascading phase-shift and finite-difference operators for downward continuation. Due to these cascaded operators we call this method‘Fourier finite-difference migration’(FFD migration).In our approach we try to generalize and improve the split-step Fourier migration method for strong lateral velocity variations using an additional finite-difference correction term. Like most of the current migration methods in use today, our method is based on the one-way wave equation. It is solved by first applying the square-root operator but using a constant velocity at each depth step which has to be the minimum velocity. In a second step, the approximate difference between the correct square-root operator and this constant-velocity squareroot operator (the error made in the first step) is implemented as an implicit FD migration scheme, part of which is the split-step Fourier correction term.Some practical aspects of the new FFD method are discussed. Its performance is compared with that of split-step and standard FD migration schemes. First applications to synthetic and real data sets are presented. They show that the superiority of FFD migration becomes evident by migrating steeply dipping reflectors with complex overburden having strong lateral velocity variations. If velocity is laterally constant, FFD migration has the accuracy of the phase-shift method. The maximum migration angle is velocity adaptive, in contrast to conventional FD migration schemes. It varies laterally depending on the local level of velocity variation. FFD migration is more efficient than higher-order implicit FD schemes. These schemes use two cascaded downward-continuation steps in order to attain comparable migration performance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2478.1995.tb00289.x
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  • 9
    Electronic Resource
    Electronic Resource
    Is the management of hepatitis C patients appropriate? A population-based study (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : In order for hepatitis C patients to receive antiviral treatment, they must reach medical care.Aim : To assess the proportion of patients reaching medical care after hepatitis C diagnosis in a general population (1 006 171 inhabitants) in France.Methods : Between 1994 and 1999, 1508 cases were diagnosed, of which 1251 were eligible for the study.Results : Two-hundred and two patients did not have any medical care; among them, 55.4% had normal alanine transferase, 58.4% had risk factors related to lifestyle and 22.8% were alcoholics. Amongst the 1049 other patients, 41.6% had a liver biopsy, 25.0% were treated. Treatment was more often carried out in males than in females (OR: 1.59; P = 0.001), and in patients under 65 than in older patients (OR: 2.22; P 〈 0.008). Among non-treatment reasons, alcoholism (P = 0.001), drug-addiction (P = 0.04) and escaping monitoring (P = 0.04) were more frequent in males than in females, whereas normal alanine transferase was more frequent in females than in males (P = 0.004). Amongst 278 patients with a Metavir score 〉A1F1, 71 (25.5%) did not undergo treatment.Conclusion : In a general population, one patient in six did not receive on-going health care; a quarter of patients with a Metavir score 〉A1F1 did not receive any treatment. These results showed insufficient clinical management, which could compromise the effectiveness of treatment in general population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02393.x
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  • 10
    Electronic Resource
    Electronic Resource
    Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of clinical periodontology 25 (1998), S. 0 
    Details
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. 48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test). Subgingival plaque and swab samples from tongue, tonsils, and buccal mucosa were taken at baseline, 10 days and 3, 6, 9, and 12 months. A. actinomycetemcomitans was detected in the oral cavity, i.e., subgingival plaque and/or mucous membranes. Less frequently in test patients compared to controls at 9 and 12 months (p〈0.01. whereas, the intraoral detection frequency of P. gingivalis was significantly reduced only 10 days following therapy (p〈0.001). At any time after therapy. A. actinomycetemcomitans was not detected intraorally in 5 of 10 (50%) test and 1 of 13 (8%) control patients harboring this pathogen at baseline; P. gingivalis was not detected in only 1 of 18 (6%) test and none of the 17 control patients harboring this pathogen at baseline. Although the data indicated that the assessed antimicrobial therapy may suppress A. actinomycetemcomitans from the entire oral cavity below detectable levels over a minimum of 12 months. P. gingivalis persisted or reoccurred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-051X.1998.tb02356.x
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