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  • 1
    Electronic Resource
    Electronic Resource
    Immune thrombocytopenia associated with hemorrhagic diathesis due to ibuprofen administration (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 413-415 
    Details
    ISSN: 1432-1440
    Keywords: Ibuprofen thrombocytopenia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Acute thrombocytopenic purpura temporally related to the oral administration of ibuprofen developed in a patient with ankylosing spondylitis. Clinical manifestations, with sudden onset occurring within t2 h of drug ingestion and rapid increase of platelet counts following discontinuation of the drug, were characteristic of an antibody-mediated immune pathomechanism. Immunological studies demonstrated IgM and IgG antibodies in the patient's serum that were capable of binding to allogenic platelets in the presence of a metabolite preparation. This finding suggested that an ibuprofen metabolite, rather then the drug itself, was the antigenic agent responsible for the immune reaction. Despite its widespread therapeutic use, ibuprofen has not been described previously as causing immune-mediated thrombocytopenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186632
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  • 2
    Electronic Resource
    Electronic Resource
    Platelet autoantibodies (IgG, IgM, IgA) against glycoproteins IIb/IIIa and Ib/IX in patients with thrombocytopenia (1996)
    Springer
    Annals of hematology 72 (1996), S. 280-285 
    Details
    ISSN: 1432-0584
    Keywords: Key words Autoimmune diseases ; Thrombocytopenia ; Platelet antibodies ; Autoimmune thrombocytopenic purpura ; AITP ; MAIPA assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Autoimmune thrombocytopenic purpura (AITP) is most frequently induced by platelet-specific autoantibodies against epitopes on platelet GP Ib/IX or GP IIb/IIIa. These antibodies are reliably detected on the patients' autologous platelets. So far, studies on the characterization of platelet autoantibodies have been restricted to IgG antibodies. We used the monoclonal antibody immobilization of platelet antigens assay (MAIPA) in a modified version to detect GP-specific IgG, IgM, and IgA antibodies. Platelets of 46.2% of patients carried elevated amounts of IgG antibodies. IgM and IgA antibodies were observed less frequently and showed only weak OD signals in the MAIPA assay. Circulating IgG antibodies in serum were found in 11.5% of patients. Circulating IgM autoantibodies were observed in 8.9% and IgA antibodies in no patient with AITP. Results of direct MAIPA assay were compared with the reactivity of eluates in the platelet adhesion immunofluorescence assay and were found to be highly concordant. Patients with AITP in remission carried high percentages of anti-GP IIb/IIIa. Findings made in this study suggest that autoantibodies of the IgM and IgA classes play only a minor role in the pathogenesis of AITP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050173
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  • 3
    Electronic Resource
    Electronic Resource
    Platelet survival determined with51Cr Versus111In (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 84-89 
    Details
    ISSN: 1432-1440
    Keywords: Thrombocytopenia ; Platelet survival ; 51Cr ; 111In
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Optimal labelling conditions of human platelets with111In-oxine were determined in vitro. Based on this optimized technique, platelet mean life span (MLS) and platelet sequestration site were comparatively evaluated in 79 patients with two labels,51Cr (n=26) and111In (n=53). Patients were subgrouped according to clinical criteria as autoimmune thrombocytopenic purpura (AITP) (group 1;n=49), hypersplenism (2;n=12), impaired thrombopoiesis (3;n=3), unclassified thrombocytopenia (4;n=6), and nonthrombocytopenic patients (5;n=9). In patients with AITP and hypersplenism the mean values for the MLS determined either with51Cr or with111In were lowered but the difference was not statistically significant, neither for group 1 (18.6 h vs 17.3 h;P〉0.2) nor for group 2 (94.7 vs 122.3 h;P〉0.2). The correlation between MLS and platelet counts in patients with AITP was significant for both labels (P〈0.001). The 15 min recovery tended to be higher with111In in all groups, but the difference was significant (P〈0.05) only for group 1. The sequestration sites were similar with both labels. We conclude that, contrary to previous reports, platelet survival studies yield similar results with both the51Cr and111In methods. Due to its distinct advantages111In is the label of choice for investigation of platelet kinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733073
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  • 4
    Electronic Resource
    Electronic Resource
    Posttransfusion purpura (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 1198-1203 
    Details
    ISSN: 1432-1440
    Keywords: Posttransfusion purpura ; Thrombocytopenia ; Blood transfusion ; Platelet antibodies ; HLA antigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen cases of posttransfusion purpura (PTP) which were diagnosed in Germany and Austria from 1977–1985 are described. All patients were women with a mean age of 58.6 years (range, 36–77 years). All but one had been pregnant and received blood transfusions 2 to 12 days prior to the onset of PTP. The thrombocytopenic purpura was always severe with a nadir of platelet counts below 10×109/l and lasted between 3 and 60 days. All patients recovered from PTP. Optimal therapy consisted of administration of high-dose IgG. Twelve of the 13 patients had developed platelet-specific Zwa antibodies (eight of them together with HLA antibodies), in one Zwa positive individual only HLA antibodies were detectable. Five of six HLA-DR typed patients carried DR3 which is considered an immunogenetic risk factor in PTP. Clinical awareness of this rare, but serious iatrogenic transfusion complication is prerequisite for prompt diagnosis and improved therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01728461
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  • 5
    Electronic Resource
    Electronic Resource
    High-dose IgG for post-transfusion purpura-revisited (1988)
    Springer
    Annals of hematology 57 (1988), S. 163-167 
    Details
    ISSN: 1432-0584
    Keywords: Post-transfusion purpura ; High-dose IgG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Therapy for post-transfusion purpura (PTP) is controversial. We have evaluated the effect of high-dose IgG (HDIgG) in 11 PTP cases investigated in our institution and summarized the clinical data of 8 additional cases reported in the literature. Two of these 19 cases had to be eliminated from the analysis (1 patient received a total dose of less than 30 g of IgG; 1 patient died 2 days after starting HDIgG therapy from congestive heart failure). Out of a total of 17 cases, 16 had good or excellent response reaching normal platelet values within few days; only one failure was observed. Five patients relapsed, but attained complete remission after a second course (dose) of IgG. Total doses per course ranged between 52 and 180 g of IgG. Five different IgG preparations were used and seemed similarly effective. No adverse reactions were observed. We conclude that HDIgG is the treatment of choice for PTP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319544
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  • 6
    Electronic Resource
    Electronic Resource
    Identification of the target platelet glycoprotein in autoimmune thrombocytopenia occurring after allogeneic bone marrow transplantation (1989)
    Springer
    Annals of hematology 58 (1989), S. 151-153 
    Details
    ISSN: 1432-0584
    Keywords: Autoimmune thrombocytopenia ; Platelet glycoproteins ; Marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report the case of a patient who developed autoimmune thrombocytopenia after allogeneic bone marrow transplantation from her HLA-identical sister. An IgG autoantibody was detected that bound to the platelet glycoprotein IIb/IIIa and to the HLA class I proteins. Immunoprecipitation studies with radiolabeled platelets revealed additional antibody binding sites on proteins of 214 kDa molecular weight under nonreduced conditions and 65 and 56 kDa molecular weight under reduced conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320436
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  • 7
    Electronic Resource
    Electronic Resource
    Cyclophosphamide-induced immune thrombocytopenia in a patient with ovarian carcinoma successfully treated with intravenous gamma globulin (1983)
    Springer
    Annals of hematology 46 (1983), S. 165-169 
    Details
    ISSN: 1432-0584
    Keywords: ITP ; Cyclophosphamide-induced thrombocytopenia ; Intravenous gamma globulin therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 55 year-old patient with ovarian carcinoma (stage IIb) is described in whom an ITP-like syndrome developed in coincidence with a high-dose cyclophosphamide therapy successfully treated by high-dose intravenous gamma glubulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320276
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  • 8
    Electronic Resource
    Electronic Resource
    A new concept for the effector mechanism of intravenous immunoglobulin in hemocytopenias (1984)
    Springer
    Annals of hematology 48 (1984), S. 353-356 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319962
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  • 9
    Electronic Resource
    Electronic Resource
    Treatment of autoimmune thrombocytopenic purpura with rhesus antibodies (anti-Rh0(D)) (1984)
    Springer
    Annals of hematology 49 (1984), S. 29-35 
    Details
    ISSN: 1432-0584
    Keywords: Autoimmune thrombocytopenic purpura ; Anti-Rh0(D) treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary There is evidence that blockade of the reticuloendothelial system (RES) by sequestration of autologous red blood cells (RBC) leads to an elevation of platelet counts in immune thrombocytopenia. To substantiate this hypothesis, 10 Rh0(D)-positive adult patients (9 female, 1 male) with chronic autoimmune thrombocytopenic purpura (ITP) (1 to 21 years duration) were treated with low doses of intravenous IgG-anti-Rh0(D) (200 to 1,000 μg per dose; 300 to 3,600 μg per course; administration within 1 to 5 days). All patients improved clinically as indicated by cessation of bleeding. In eight out of ten patients there was a rise in platelet count. Platelet increments were excellent (〉100×109/l) in one, good (50−100×109/l) in three, fair (20−50×109/l) in two and low (10−20×109/l) in two patients. Splenectomized patients (N=4) had a poorer response than non-splenectomized patients (N=6) with mean increments of 16×109/l (range 5−43×109/l) versus 60×109/l (range 10−110×109/l). The increase in platelet counts persisted for seven to over 150 days. Transient and slight signs of haemolysis developed in seven out of ten patients (haemoglobin remained stable; increase of lactate dehydrogenase (〉250 IU/l) in four, decrease of haptoglobin (〈60 mg/dl) in five patients). The direct antiglobulin test became positive in all cases due to IgG1 without complement fixation. We conclude that the interaction of antibody-coated RBC with macrophages (and, probably, other means of RBC alteration) is a feasible therapeutic approach in selected cases of ITP and related conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320381
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  • 10
    Electronic Resource
    Electronic Resource
    Book reviews (1985)
    Springer
    Annals of hematology 50 (1985), S. 315-318 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319759
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