Electronic Resource
Oxford, U.K. and Cambridge, USA
:
Blackwell Publishing Ltd
Histopathology
34 (1999), S. 0
ISSN:
1365-2559
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
To determine the variation in p53 protein expression in phyllodes tumours and fibroadenomas of the breast.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsFifteen phyllodes tumours (six malignant, nine benign) and 20 fibroadenomas were examined for p53 expression by immunohistochemistry. Five of the six malignant phyllodes tumours showed moderate or strong p53 positivity at sites of peri-epithelial stromal condensation and atypia. All 20 fibroadenomas, nine benign phyllodes tumours and one malignant phyllodes tumour showed either negativity or focal weak nuclear positivity of scattered stromal cells.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsIncreased p53 immunoreactivity is present in malignant phyllodes tumours in contrast to benign phyllodes tumours and fibroadenomas. Malignant phyllodes tumours display a distinctive pattern of p53 immunostaining which may be of diagnostic value. These findings suggest that p53 protein may be important in the progression of benign to malignant phyllodes tumours.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2559.1999.00666.x
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