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  • 1
    Online Resource
    Online Resource
    Biologic Effects of Light 1998 : Proceedings of a Symposium Basel, Switzerland November 1-3 1998. (1999)
    New York, NY :Springer,
    Details
    Keywords: Light-Physiological effect-Congresses. ; Photobiology-Congresses. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (461 pages)
    Edition: 1st ed.
    ISBN: 9781461550518
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6493903
    DDC: 612/.01444
    Language: English
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    GEOMAR EBL
  • 2
    Electronic Resource
    Electronic Resource
    Xeroderma Pigmentosum (1986)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 25 (1986), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1986.tb04522.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    New Form of Molecular Defect in Xeroderma Pigmentosum (1970)
    [s.l.] : Nature Publishing Group
    Nature 228 (1970), S. 361-362 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Skin grafts, 0-2-0-3 mm thick, were cut from unaffected skin with a dermatome and divided into small pieces (2x2 mm). These pieces were irradiated with an unfilteredxenon lamp6 at various energies (total output: 2'I x 106 erg cm~2 s-1, measured by a compensated thermopile 'CAI'; Kipp & Zonen). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/228361a0
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Risk factors of the cutaneous melanoma phenotype (1981)
    Springer
    Archives of dermatological research 270 (1981), S. 33-36 
    Details
    ISSN: 1432-069X
    Keywords: Prolonged erythema ; SCE ; Malignant melanoma ; Überlanges UV-Erythem ; SCE ; Malignes Melanom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Von 20 Melanompatienten zeigen 85% eine überlange Persistenz eines deutlichen Erythems durch 8 MED mit 300 nm±10 nm (Kontrollgruppe nur 34%). Dieses Phänomen ist nicht mit den Hauttyp korreliert und kann zur prospektiven Identifizierung von Risikopatienten für Melanome und Lichtkarzinome (92%) Anwendung finden. Die Zahl spontaner und UV-C-induzierter „sister chromatid exchanges” (SCE) pro Metaphase ist in peripheren Leukozyten von Melanompatienten signifikant höher als bei der Kontrolle. Es wird der Versuch formuliert, ein „Risikospektrum” des Melanom-Phänotyps abzustecken.
    Notes: Summary Of 20 melanoma patients 85% show a prolonged erythema persistence after a marked test erythema of 8 MED with 300 nm±10 nm (control group only 34%). This phenomenon does not correlate with the skin type and is useful in identifying high-risk patients prone to melanoma and light-induced skin cancer (92%). The spontaneous and the UV-C-induced number of sister chromatid exchanges (SCE) per metaphase was significantly higher in peripheral leukocytes of melanoma patients than in normal controls. The attempt was made to establish a “risk-spectrum” of cutaneous melanoma phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00417147
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Langerhans cells enclosing sunburn cells in acute UV erythema in vivo (1999)
    Springer
    Archives of dermatological research 291 (1999), S. 303-305 
    Details
    ISSN: 1432-069X
    Keywords: Key words Langerhans cells ; Sunburn cells ; UV ; erythema ; Apoptosis ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050413
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Das Pigmentierte Xerodermoid (1971)
    Springer
    Archives of dermatological research 241 (1971), S. 33-43 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das pigmentierte Xerodermoid ist eine dem Xeroderma pigmentosum sehr ähnliche Hautkrankheit. Bei beiden ist die Haut verstärkt lichtempfindlich und es besteht auch eine verminderte Überlebensrate von UV bestrahlten Lymphocyten. Während beim Xeroderma pigmentosum ein Mangel der UV spezifischen Endonuclease des Excisionsrepair-Systems vorliegt, scheint der Defekt beim pigmentierten Xerodermoid im Ablauf derjenigen Erholungsvorgänge zu liegen, die sich bei der Rekombination auswirken. Bei gesunden menschlichen Epidermiszellen kann ein gleichsinniger Effekt durch Coffein erreicht werden; eine Substanz, von der man weiß, daß sie die Rekombination hemmt.
    Notes: Summary Pigmented Xerodermoid is a skin disease similar to Xeroderma pigmentosum. In both traits the skin has an increased light sensitivity and the lymphocytes show a decreased survival rate after UV irradiation. In Xeroderma pigmentosum a defect of endonuclease in the excision repair system can be demonstrated, while in pigmented Xerodermoid the defect seems to be located in the recovery process during recombination. In normal human epidermal cells one can imitate a similar effect by coffein, a substance influencing recombination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00604134
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Pigmented xerodermoid and XP-variants (1980)
    Springer
    Archives of dermatological research 269 (1980), S. 329-330 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406427
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Clinicopathological and prognostic relevance of Rap1-GAP expression in melanocytic tumors (1997)
    Springer
    Archives of dermatological research 289 (1997), S. 573-577 
    Details
    ISSN: 1432-069X
    Keywords: Key words Rap1-GAP ; Melanocytic tumors ; Melanoma pathogenesis ; Melanoma progression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rap1-GAP protein has been identified as an inactivator of Rap1 activity, a putative endogenous antagonist of Ras proteins. The Rap1-GA1 locus maps to 1p36.1–35, the region which may harbor a gene for familial melanoma. In the present immunohistochemical study we analyzed the clinicopathological and prognostic relevance of Rap1-GAP expression in 60 benign and 103 malignant melanocytic tumors. Cytoplasmic immunoreactivity was detected in the cells of 27/60 nevi (45%) and 59/103 melanomas (57%). In the latter group the frequency of Rap1-GAP expression increased ( P 〈 0.05) with the thickness of primary tumors and was highest in metastatic lesions. Rap1-GAP protein was detected in 15/19 subsequently recurring primary melanomas (79%) but only in 32/67 tumors (47%) of patients who remained free of disease ( P 〈 0.05) for at least 6 years. Five out of six recurring thin melanomas (〈 2 mm) were found to be immunoreactive. Although being no indicator for malignant transformation of melanocytic lesions, Rap1-GAP overexpression may represent a useful marker for identifying thin high-risk melanomas. Cytoplasmic expression of Rap1-GAP has also been observed in the cells of skin appendages and in keratinocytes, particularly in suprabasal layers of the epidermis. Therefore, Rap1-GAP is likely to be associated with cellular growth and/or differentiation. However, the present study did not provide evidence that this gene, despite its chromosomal localization, represents an early melanoma gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050242
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Acrokeratoelastoidosis (1973)
    Springer
    Human genetics 〈Berlin〉 17 (1973), S. 357-358 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Acrokeratoelastoidosis is a peculiar palmo-plantar keratosis which was first described in 1952 by the Brasilian dermatologist Costa. Since then several patients have been observed, most of them in South America. During the past year we have had occasion to observe this disease in a large German kindred as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00273193
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Stellungnahme und Empfehlungen der Kommission malignes Melanom der Deutschen Dermatologischen Gesellschaft zur Diagnostik, Behandlung und Nachsorge des malignen Melanoms der Haut (1994)
    Springer
    Der Hautarzt 45 (1994), S. 285-291 
    Details
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Diagnostik – Prognose – Stadieneinteilung – Behandlung – Nachsorge – Malignes Melanom ; Key words: Diagnosis – Prognosis – Classification – Treatment – Follow-up – Melanoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary. The Melanoma Committee of the German Dermatological Society has prepared this position paper on prognostic factors, classification and clinical staging of cutaneous malignant melanoma and has recommended guidelines for diagnosis, treatment and follow-up. The aim is to achieve a consensus procedure for dealing with this tumour.
    Notes: Zusammenfassung. Die Kommission malignes Melanom der Deutschen Dermatologischen Gesellschaft hat zur Frage der prognostischen Faktoren der Klassifikation und der klinischen Stadieneinteilung des malignen Melanoms der Haut Stellung bezogen und für den deutschsprachigen Raum ein einheitliches Vorgehen zur Diagnose, Therapie und Nachsorge empfohlen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001050050071
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    Paper (German National Licenses)
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