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  • 1
    Online Resource
    Online Resource
    Chicago :University of Chicago Press,
    Keywords: Science and state. ; Electronic books.
    Description / Table of Contents: No detailed description available for "The Changing Frontier".
    Type of Medium: Online Resource
    Pages: 1 online resource (441 pages)
    Edition: 1st ed.
    ISBN: 9780226286860
    Series Statement: National Bureau of Economic Research Conference Report
    DDC: 338.9/26
    Language: English
    Note: Intro -- Contents -- Preface -- Introduction by Adam B. Jaffe and Benjamin F. Jones -- The Organization of Scientific Research -- The Geography of Innovation -- Entrepreneurship and Market-Based Innovation -- Historical Perspective on Science Institutions and Paradigms -- Concluding Comments -- References -- I. The Organization of Scientific Research -- 1. Why and Wherefore of Increased Scientific Collaboration by Richard B. Freeman, Ina Ganguli, and Raviv Murciano-Goroff -- 1.1 The Growing Trend of International Collaboration -- 1.2 Survey of Corresponding Authors -- 1.3 Collaborations over Distance -- 1.4 Survey Evidence -- 1.5 Toward an Economics of Scientific Collaborations -- Appendix -- 2. The (Changing) Knowledge Production Function: Evidence from the MIT Department of Biology for 1970-2000 by Annamaria Conti and Christopher C. Liu -- 2.1 Introduction -- 2.2 Empirical Setting -- 2.3 Trends in Scientific Productivity of Graduate Students and Postdocs -- 2.4 Conclusions and Policy Implications -- References -- 3. Collaboration, Stars, and the Changing Organization of Science: Evidence from Evolutionary Biology by Ajay Agrawal, John McHale, and Alexander Oettl -- 3.1 Introduction -- 3.2 Data -- 3.3 Participation: A Broadening Base -- 3.5 Collaboration: Increasing across Distance and Rank -- 3.6 Improved Collaboration Technology and the Distributionof Scientific Output: An Integrating Model -- 3.7 Discussion: Normative Implications of Star Location -- References -- Comment by Julia Lane -- References -- 4. Credit History: The Changing Nature of Scientific Credit by Joshua S. Gans and Fiona Murray -- 4.1 Introduction -- 4.2 Credit and the Organization of Science -- 4.3 Credit History -- 4.4 Formal Model -- 4.5 Some Implications -- 4.6 Conclusions and Future Directions -- References -- II. The Geography of Innovation. , 5. The Rise of International Coinvention by Lee Branstetter, Guangwei Li, and Fransisco Veloso -- 5.1 Introduction -- 5.2 Background -- 5.3 Data Sources and Trends -- 5.4 Empirical Model and Results -- 5.5 Peering inside Coinvention: Lessons from Interviews of Multinational R& -- D Personnel -- 5.6 Conclusions and Implications -- References -- 6. Information Technology and the Distribution of Inventive Activity by Chris Forman, Avi Goldfarb, and Shane Greenstein -- 6.1 Introduction -- 6.2 Data -- 6.3 Empirical Strategy and Results -- Conclusion -- References -- III. Entrepreneurship and Market-Based Innovation -- 7. Innovation and Entrepreneurship in Renewable Energy by Ramana Nanda, Ken Younge, and Lee Fleming -- 7.1 Introduction -- 7.2 Data -- 7.3 Results -- 7.4 Venture Capital Financing of Renewable Energy Start- Ups -- Appendix B: New Measure of Novelty -- References -- 8. Economic Value Creation in Mobile Applications by Timothy F. Bresnahan, Jason P. Davis, and Pai-Ling Yin -- 8.1 Introduction -- 8.2 Innovation in Platform-Based Industries -- 8.3 Matching Apps to Customers: App Store Rankings -- 8.4 Data -- 8.5 App Success is Highly Concentrated -- 8.6 Short-Run Dynamics -- 8.7 "Top List" Implications for Market Development -- 8.8 The Economic Return to the Development of New Apps -- 8.9 Developer Behavior: Platform Choice and Multihoming -- 8.10 Alternative Equilibrium Scenarios -- 8.11 Conclusion -- References -- 9. State Science Policy Experiments by Maryann Feldman and Laura Lanahan -- 9.1 Background on State Science Policy -- 9.2 Methods -- 9.3 Empirical Results -- 9.4 Discussion -- 9.5 Reflective Conclusions -- References -- IV. Historical Perspectives on Science Institutions and Paradigms -- 10. The Endless Frontier: Reaping What Bush Sowed? by Paula Stephan -- 10.1 Introduction. , 10.2 The Scientific Landscape Circa the 1940s and The Endless Frontier -- 10.3 Early Years of the NIH and the NSF -- 10.4 The University Response to Capacity Building: The 1960s -- 10.5 The 1970s-2012 -- 10.6 Taking Stock -- 10.7 Stresses to the System -- 10.8 Concluding Thoughts -- Appendix -- References -- Comment by Bruce A. Weinberg -- References -- 11. Algorithms and the Changing Frontier by Hezekiah Agwara, Philip Auerswald, and Brian Higginbotham -- 11.1 Introduction -- 11.2 Changing Frontiers in the United States -- 11.3 Production Recipes, Standards, and Interoperability -- 11.4 Globalization Is Really Standardization -- 11.5 Using Quality Management Standards to Map the Movement of the Algorithmic Frontier -- 11.6 Algorithms and the Process of Discovery -- 11.7 Conclusion -- Appendix: ISO Management Standards (ISO 2012) -- References -- Comment by Timothy Simcoe -- Algorithmic Production -- Standards and Globalization -- Concluding Thoughts -- References -- Contributors -- Author Index -- Subject Index.
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  • 2
    Keywords: Energy policy ; Energy and state ; Fossil fuels ; Climate change ; Forestry management ; Environmental management ; Air pollution ; Environment
    Description / Table of Contents: This book is a product of the initial phase of a broader study evaluating the voluntary and regulatory compliance protocols that are used to account for the contributions of forests in U.S.-based greenhouse gas (GHG) mitigation programs. The research presented here is particularly concerned with these protocols’ use of the USDA Forest Service’s Forest Inventory and Analysis (FIA) data to describe forest conditions, ownership, and management scenarios, and is oriented towards providing regulators and other interested parties with an objective comparison of the options, uncertainties, and opportunities available to offset GHG emissions through forest management. Chapters focus on the protocols for recognizing forest carbon offsets in the California carbon cap-and-trade program, as described in the Compliance Offset Protocol; U.S. Forest Projects (California Air Resources Board, 2011). Readers will discover the protocols used for quantifying the offset of GHG emissions through forest-related project activity. As such, its scope includes a review of the current methods used in voluntary and compliance forest protocols, an evaluation of the metrics used to assign baselines and determine additionality in the forest offset protocols, an examination of key quantitative and qualitative components and assumptions, and a discussion of opportunities for modifying forest offset protocols, in light of the rapidly changing GHG-related policy and regulatory environment. Finally, the report also discusses accounting and policy issues that create potential barriers to participation in the California cap-and-trade program, and overall programmatic additionality in addressing the needs of a mitigation strategy
    Type of Medium: Online Resource
    Pages: Online-Ressource (XIV, 72 p. 3 illus., 2 illus. in color, online resource)
    ISBN: 9783319524344
    Series Statement: SpringerBriefs in Environmental Science
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 14 (1978), S. 0 
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: : Micro-relief surface depression storage is one of the dynamic components of the rainfall-runoff process. The quantification of the effect of rainfall intensity and duration on the micro-relief was the subject of this study. Micro-relief measurements were made on 88 soil bin samples before and after the application of simulated rainfdl events. The surface depression changes are described with empirical equations, using basic rainfall, surface hydrology, and soil parameters and their cross products as independent variables. A rainfall-runoff model demonstrates the value of a dynamic description of the surface depression storage function.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science, Ltd
    Molecular microbiology 40 (2001), S. 0 
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: FtsZ is required throughout the cell division process in eubacteria and in archaea. We report the isolation of novel mutants of the FtsZ gene in Caulobacter crescentus. Clusters of charged amino acids were changed to alanine to minimize mutations that affect protein folding. Molecular modelling indicated that all the clustered-charged-to-alanine mutations had altered amino acids at the surface of the protein. Of 13 such mutants, four were recessive-lethal, three were dominant-lethal, and six had no discernible phenotype. An FtsZ depletion strain of Caulobacter was constructed to analyse the phenotype of the recessive-lethal mutations and used to show that they blocked cell division at distinct stages. One mutation blocked the initiation of cell division, two mutations blocked cell division randomly, and one mutation blocked both early and late stages of cell division. The effect of the recessive mutations on the subcellular localization of FtsZ was determined. Models to explain the various mutant phenotypes are discussed. This is the first set of recessive alleles of ftsZ blocked at different stages of cell division.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 12 (1976), S. 0 
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: : Micro-relief surface depression storage is one of the components of the rainfall-runoff process. The quantification of surface depression storage values and a depth-storage model to describe the storage was the subject of this study. Point measurement data were collected on 258 surfaces of 5 soils and three artificial surfaces. Five methods of computing storage, 15 depth-storage models, two depth increments, and six grid spacings were investigated. The 1-inch grid computational method, 0.1-inch depth increment, and 1-inch grid spacings were recommended. The surface depression storage function is best described by the model S = aDb, which relates surface depression storage as a function of depth with two equation parameters. Equations for describing the surface depression storage model parameters have been developed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 13 (1901), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2014-03-22
    Description: The Journal of Organic Chemistry DOI: 10.1021/jo402708j
    Print ISSN: 0022-3263
    Electronic ISSN: 1520-6904
    Topics: Chemistry and Pharmacology
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  • 8
    Publication Date: 2013-12-17
    Description: ABSTRACT Maternal choline intake during gestation may influence placental function and fetal health outcomes. Specifically, we previously showed that supplemental choline reduced placental and maternal circulating concentrations of the anti-angiogenic factor, fms-like tyrosine kinase-1 (sFLT1), in pregnant women as well as sFLT1 production in cultured human trophoblasts. The current study aimed to quantify the effect of choline on a wider array of biomarkers related to trophoblast function and to elucidate possible mechanisms. Immortalized HTR-8/SVneo trophoblasts were cultured in different choline concentrations (8, 13 and 28 [control] µM) for 96-h and markers of angiogenesis, inflammation, apoptosis, and blood vessel formation were examined. Choline insufficiency altered the angiogenic profile, impaired in vitro angiogenesis, increased inflammation, induced apoptosis, increased oxidative stress, and yielded greater levels of protein kinase C (PKC) isoforms δ and ϵ possibly through increases in the PKC activators 1-stearoyl-2-arachidonoyl-sn-glycerol and 1-stearoyl-2-docosahexaenoyl-sn-glycerol. Notably, the addition of a PKC inhibitor normalized angiogenesis and apoptosis, and partially rescued the aberrant gene expression profile. Together these results suggest that choline inadequacy may contribute to placental dysfunction and the development of disorders related to placental insufficiency by activating PKC. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 9
    Publication Date: 2018-02-23
    Description: Sensors, Vol. 18, Pages 641: Experimental L-Band Airborne SAR for Oil Spill Response at Sea and in Coastal Waters Sensors doi: 10.3390/s18020641 Authors: Cathleen Jones Benjamin Holt Satellite synthetic aperture radar (SAR) is frequently used during oil spill response efforts to identify oil slick extent, but suffers from the major disadvantages of potential long latency between when a spill occurs and when a satellite can image the site and an inability to continuously track the spill as it develops. We show using data acquired with the Uninhabited Aerial Vehicle SAR (UAVSAR) instrument how a low noise, high resolution, L-band SAR could be used for oil spill response, with specific examples of tracking slick extent, position and weathering; determining zones of relatively thicker or more emulsified oil within a slick; and identifying oil slicks in coastal areas where look-alikes such as calm waters or biogenic slicks can confound the identification of mineral oil spills. From these key points, the essential features of an airborne SAR system for operational oil spill response are described, and further research needed to determine SAR’s capabilities and limitations in quantifying slick thickness is discussed.
    Electronic ISSN: 1424-8220
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Published by MDPI Publishing
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  • 10
    Publication Date: 2013-03-09
    Description: Drained thermokarst lake basins accumulate significant amounts of soil organic carbon in the form of peat, which is of interest to understanding carbon cycling and climate change feedbacks associated with thermokarst in the Arctic. Remote sensing is a tool useful for understanding temporal and spatial dynamics of drained basins. In this study, we tested the application of high-resolution X-band Synthetic Aperture Radar (SAR) data of the German TerraSAR-X satellite from the 2009 growing season (July–September) for characterizing drained thermokarst lake basins of various age in the ice-rich permafrost region of the northern Seward Peninsula, Alaska. To enhance interpretation of patterns identified in X-band SAR for these basins, we also analyzed the Normalized Difference Vegetation Index (NDVI) calculated from a Landsat-5 Thematic Mapper image acquired on July 2009 and compared both X-band SAR and NDVI data with observations of basin age. We found significant logarithmic relationships between (a) TerraSAR-X backscatter and basin age from 0 to 10,000 years, (b) Landat-5 TM NDVI and basin age from 0 to 10,000 years, and (c) TerraSAR-X backscatter and basin age from 50 to 10,000 years. NDVI was a better indicator of basin age over a period of 0–10,000 years. However, TerraSAR-X data performed much better for discriminating radiocarbon-dated basins (50–10,000 years old). No clear relationships were found for either backscatter or NDVI and basin age from 0 to 50 years. We attribute the decreasing trend of backscatter and NDVI with increasing basin age to post-drainage changes in the basin surface. Such changes include succession in vegetation, soils, hydrology, and renewed permafrost aggradation, ground ice accumulation and localized frost heave. Results of this study show the potential application of X-band SAR data in combination with NDVI data to map long-term succession dynamics of drained thermokarst lake basins.
    Electronic ISSN: 2072-4292
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by MDPI Publishing
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