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  • 1
    Online-Ressource
    Online-Ressource
    San Diego :Elsevier,
    Schlagwort(e): Environmental toxicology. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (725 pages)
    Ausgabe: 1st ed.
    ISBN: 9780128004807
    Sprache: Englisch
    Anmerkung: Front Cover -- Wildlife Toxicity Assessments for Chemicals of Military Concern -- Copyright -- Disclaimer -- Contents -- Editor Biographies -- Author Biographies -- Acknowledgements -- Part I: Introduction -- Chapter 1: Characterizing Potential for Toxicity: Estimating Risks to Wildlife -- Introduction -- History of wildlife toxicity reference values -- Recent advances in toxicity reference value derivation -- Important research needs -- References -- Part II: Methodological Derivations -- Chapter 2: Methods for Derivation of Wildlife Toxicity Values for Use in Ecological Risk Assessments -- Introduction -- Data collection and literature search -- Identifying relevant studies -- Toxicity profile preparation -- Derivation of toxicity reference values -- Assigning a confidence level -- Creation of the toxicity reference value report -- References -- Part III: Wildlife Toxicity Assessments of Explosives -- Chapter 3: Wildlife Toxicity Assessment for 2,4,6-Trinitrotoluene (TNT) -- Introduction -- Environmental Fate and Transport -- Summary of mammalian toxicity -- Mammalian Oral Toxicity: Acute/Subacute -- Mammalian Oral Toxicity: Subchronic -- Mammalian Oral Toxicity: Chronic -- Studies Relevant for Mammalian TRV Development for Ingestion Exposures -- Summary of avian toxicity -- Avian Oral Toxicity: Acute -- Avian Oral Toxicity: Subchronic -- Studies Relevant for Avian TRV Development for Ingestion Exposures -- Summary of amphibian toxicity -- Amphibian Toxicity -- Amphibian Microcosm Study -- Relevance for Amphibian TRV Development -- Summary of reptilian toxicity -- Reptilian Toxicity: Acute and Subacute -- Reptilian Toxicity: Subchronic -- Recommended toxicity reference values -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for Mammalian Foraging Guilds -- Toxicity Reference Values for Birds -- TRVs for Amphibians. , TRVs for Reptiles -- References -- Chapter 4: Wildlife Toxicity Assessment for 1,3,5-Trinitrohexahydro-1,3,5-Triazine (RDX) -- Introduction -- Toxicity profile -- Environmental Fate and Transport -- Mammalian Toxicity -- Mammalian Oral Toxicity: Acute -- Mammalian Oral Toxicity: Subacute -- Mammalian Toxicity: Subchronic -- Mammalian Oral Toxicity: Chronic -- Mammalian Oral Toxicity: Other -- Studies Relevant to Mammalian TRV Development: RDX Ingestion Exposures -- Mammalian Inhalation Toxicity -- Mammalian Dermal Toxicity -- Summary of Avian Toxicology -- Avian Oral Toxicity: Acute -- Avian Oral Toxicity: Subacute -- Avian Oral Toxicity: Subchronic -- Avian Oral Toxicity: Chronic -- Avian Oral Toxicity: Other -- Studies Relevant for Avian TRV Development: RDX Ingestion Exposures -- Avian Inhalation Toxicity -- Avian Dermal Toxicity -- Amphibian Toxicology -- Reptilian Toxicology -- Recommended toxicity reference values -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for the Class Mammalia -- TRVs for Inhalation Exposures for the Class Mammalia -- TRVs for Dermal Exposures for the Class Mammalia -- Toxicity Reference Values for Birds -- TRVs for Ingestion Exposures for the Class Aves -- Toxicity Reference Values for Amphibians -- Toxicity Reference Values for Reptiles -- Important research needs -- References -- Chapter 5: Wildlife Toxicity Assessment for High Melting Explosive (HMX) -- Introduction -- Environmental fate and transport -- Toxicity profile -- Summary of Mammalian Toxicity -- Mammalian Oral Toxicity: Acute -- Mammalian Oral Toxicity: Subacute -- Mammalian Toxicity: Subchronic -- Mammalian Oral Toxicity: Chronic -- Mammalian Oral Toxicity: Other -- Studies Relevant for Mammalian TRV Development for Ingestion Exposures -- Mammalian Inhalation Toxicity -- Mammalian Dermal Toxicity -- Mammalian Toxicity: Other. , Summary of Avian Toxicology -- Avian Oral Toxicity: Acute -- Avian Oral Toxicity: Subchronic -- Avian Oral Toxicity: Chronic -- Avian Oral Toxicity: Other -- Avian Inhalation Toxicity -- Avian Dermal Toxicity -- Summary of Amphibian Toxicology -- Summary of Reptilian Toxicology -- Recommended toxicity reference values -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for the Class Mammalia -- TRVs for Ingestion Exposures for Mammalian Foraging Guilds -- TRVs for Inhalation Exposures for the Class Mammalia -- TRVs for Dermal Exposures for the Class Mammalia -- Toxicity Reference Values for Birds -- TRVs for Ingestion Exposures for the Class Aves -- Toxicity Reference Values for Amphibians -- TRVs for Soil Exposures for the Class Amphibia -- Toxicity Reference Values for Reptiles -- TRVs for Ingestion Exposures for the Class Reptilia -- Important research needs -- References -- Chapter 6: Wildlife Toxicity Assessment for 2,4-Dinitrotoluene and 2,6-Dinitrotoluene -- Introduction -- Toxicity profile -- Environmental Fate and Transport -- Mammalian toxicity -- Mammalian Oral Toxicity -- Mammalian Oral Toxicity: Acute -- Mammalian Oral Toxicity: Subacute -- Mammalian Oral Toxicity: Subchronic -- Mammalian Oral Toxicity: Chronic -- Mammalian Oral Toxicity: Other -- Studies Relevant for Mammalian TRV Development for Ingestion Exposures -- 2,4-Dinitrotoluene -- 2,6-Dinitrotoluene -- Mammalian Toxicity: Inhalation -- Mammalian Toxicity: Dermal -- Summary of avian toxicity -- Avian Toxicity Oral: Acute -- 2,4-Dinitrotoluene -- 2,6-Dinitrotoluene -- Avian Toxicity Oral: Subacute -- 2,4-Dinitrotoluene -- 2,6-Dinitrotoluene -- Avian Toxicity Oral: Subchronic -- 2,4-Dinitrotoluene -- 2,6-Dinitrotoluene -- Avian Toxicity Oral: Chronic -- Studies Relevant for Avian TRV Development for Ingestion Exposures -- Avian Toxicity: Inhalation. , Avian Toxicity: Dermal -- Summary of amphibian toxicity -- Amphibian Toxicity Oral: Acute -- 2,4-Dinitrotoluene/2,6-Dinitrotoluene -- Amphibian Toxicity Oral: Subchronic -- Amphibian Toxicity Oral: Chronic -- Studies Relevant for Amphibian TRV Development for Ingestion Exposures -- Amphibian Toxicity: Dermal/Oral/Respiratory -- 2,4-Dinitrotoluene/2,6-Dinitrotoluene -- Summary of reptilian toxicity -- Reptilian Oral Toxicity: Acute -- Reptilian Oral Toxicity: Subacute -- Reptilian Oral Toxicity: Subchronic -- Reptilian Toxicity Oral: Chronic -- Studies Relevant for Reptilian TRV Development for Ingestion Exposures -- Reptilian Toxicity: Inhalation -- Reptilian Toxicity: Dermal -- Recommended toxicity reference values -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for the Class Mammalia -- 2,4-Dinitrotoluene -- 2,6-Dinitrotoluene -- TRVs for Inhalation Exposures for the Class Mammalia -- TRVs for Dermal Exposures for the Class Mammalia -- Toxicity Reference Values for Birds -- TRVs for Ingestion Exposures for the Class Aves -- 2,4-Dinitrotoluene -- 2,6-Dinitrotoluene -- Toxicity Reference Values for Amphibians -- TRVs for Ingestion Exposures for the Class Amphibia -- TRVs for Dermal Exposures for the Class Amphibia -- Toxicity Reference Values for Reptiles -- TRVs for Ingestion Exposures for the Class Reptilia -- 2,4-Dinitrotoluene -- Important research needs -- References -- Chapter 7: Wildlife Toxicity Assessment for Nitroguanidine -- Introduction -- Toxicity profile -- Environmental Fate and Transport -- Summary of Mammalian Toxicology -- Mammalian Oral Toxicity: Acute -- Mammalian Oral Toxicity: Subacute -- Mammalian Oral Toxicity: Subchronic -- Mammalian Oral Toxicity: Chronic -- Mammalian Oral Toxicity: Other -- Studies Relevant for Mammalian TRV Development for Ingestion Exposures -- Mammalian Inhalation Toxicity. , Mammalian Dermal Toxicity -- Summary of Avian Toxicology -- Summary of Amphibian Toxicology -- Summary of Reptilian Toxicology -- Recommended toxicity reference values -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for the Class Mammalia -- TRVs for Ingestion Exposures for Mammalian Foraging Guilds -- TRVs for Inhalation Exposures for the Class Mammalia -- TRVs for Dermal Exposures for the Class Mammalia -- Toxicity Reference Values for Birds -- Toxicity Reference Values for Amphibians -- Toxicity Reference Values for Reptiles -- Important research needs -- References -- Chapter 8: Wildlife Toxicity Assessment for 1,3-Dinitrobenzene -- Introduction -- Toxicity profile -- Environmental Fate and Transport -- Summary of mammalian toxicity -- Mammalian Oral Toxicity: Acute -- Mammalian Oral Toxicity: Subacute -- Mammalian Oral Toxicity: Subchronic -- Mammalian Oral Toxicity: Chronic -- Mammalian Oral Toxicity: Other -- Studies relevant for mammalian toxicity reference value development for ingestion exposures -- Mammalian Inhalation Toxicity -- Mammalian Dermal Toxicity -- Summary of avian toxicity -- Avian Oral Toxicity: Acute -- Avian Oral Toxicity: Subchronic -- Avian Oral Toxicity: Chronic -- Avian Oral Toxicity: Other -- Avian Inhalation Toxicity -- Avian Dermal Toxicity -- Summary of amphibian toxicity -- Summary of reptilian toxicity -- Recommended toxicity reference values -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for the Class Mammalia -- TRVs for Inhalation Exposures for the Class Mammalia -- TRVs for Dermal Exposures for the Class Mammalia -- TRVs for Birds -- TRVs for Amphibians -- TRVs for Reptiles -- Important research needs -- References -- Chapter 9: Wildlife Toxicity Assessment for 1,3,5-Trinitrobenzene (TNB) -- Introduction -- Toxicity profile -- Environmental Fate and Transport. , Summary of Mammalian Toxicity.
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  • 2
    Online-Ressource
    Online-Ressource
    Newark :John Wiley & Sons, Incorporated,
    Schlagwort(e): Ammunition. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (275 pages)
    Ausgabe: 1st ed.
    ISBN: 9783527816644
    Sprache: Englisch
    Anmerkung: Cover -- Title Page -- Copyright -- Contents -- Preface -- Chapter 1 Introduction and Overview -- 1.1 Introduction -- 1.2 Legislative Impact -- 1.3 NATO Studies -- 1.4 New Ingredients and Compositions -- 1.5 Toxicology -- 1.6 Life‐Cycle Analysis -- 1.7 Managing Contamination and Clean‐Up -- 1.8 Disposal Now and in the Future -- 1.9 Recycling -- 1.10 Conclusions -- References -- Chapter 2 General Introduction to Ammunition Demilitarization* -- 2.1 Part one - Logistics, Costs, and Management -- 2.1.1 Introduction -- 2.1.2 Context of Demilitarization -- 2.1.2.1 The Scale of the Issue -- 2.1.2.2 Factors Influencing Demilitarization -- 2.1.3 Demilitarization Process -- 2.1.3.1 Basic Stages of Demilitarization -- 2.1.3.2 Demilitarization Facilities -- 2.1.4 Demilitarization Techniques -- 2.1.4.1 Demilitarization Techniques and Processes -- 2.1.4.2 Maturity and Use of Demilitarization Techniques -- 2.1.5 Summary -- 2.2 Part Two - Environmental Issues and Demilitarization -- 2.2.1 Introduction -- 2.2.2 Demilitarization Process -- 2.2.2.1 Technical and Environmental Issues -- 2.2.2.2 Open Burning (OB) and Open Detonation (OD) -- 2.2.2.3 Open Burning -- 2.2.2.4 Open Detonation -- 2.2.2.5 Examples of Cost and CO2 in Demilitarization Options -- 2.2.3 Design for Demilitarization (DFD) -- 2.2.3.1 NATO AOP 4518 (Revised 2018) -- 2.2.3.2 A Munition Manager's Perspective of Disposal Plans -- 2.2.3.3 Future Trends -- References -- Chapter 3 Assessment and Sustainment of the Environmental Health of Military Live‐fire Training Ranges -- 3.1 Introduction -- 3.2 Background and Context -- 3.3 Munition‐Related Contaminants -- 3.4 Surface Soil Characterization in Live‐fire Training Ranges -- 3.4.1 Safety Aspects -- 3.4.2 Data Quality and Sampling Objectives -- 3.4.3 Importance of Soil Sample Processing to Ensure Representativeness -- 3.4.4 How Clean is Clean?. , 3.4.5 Risk to the Receptors Through the Transport of Munitions Constituents -- 3.5 Methodology for the Precise Measurements of MC Sources -- 3.5.1 Explosive Footprints in Impact Areas -- 3.5.2 Firing Positions -- 3.6 Tailored Management Practices: Mitigation and Remediation -- 3.6.1 Mitigation Measures -- 3.6.1.1 Analytical Tool and Adsorption Method for MCs in Aqueous Samples -- 3.6.1.2 Thermal Treatment of Shoulder Rocket Propellant‐Contaminated Surface and Subsurface Soils -- 3.7 Emerging Constituents -- 3.8 Conclusion -- References -- Chapter 4 Greener Munitions -- 4.1 Background and Context -- 4.2 Munitions Constituents of Concern -- 4.3 Source of Munitions Constituents -- 4.4 Greener Munitions Development Approach -- 4.5 RIGHTTRAC -- 4.5.1 Energetic Formulation Selection -- 4.5.1.1 Main Explosive Charge -- 4.5.1.2 Performance -- 4.5.1.3 IM Properties -- 4.5.1.4 Fate, Transport, and Toxicity -- 4.5.2 Main Propellant Charge -- 4.5.2.1 Performance -- 4.5.2.2 Modular Charges -- 4.5.2.3 IM Properties -- 4.5.2.4 Fate, Transport, and Toxicity -- 4.5.3 Field Demonstration -- 4.5.3.1 Final Selection -- 4.5.3.2 Gun Testing -- 4.5.3.3 Detonation Residues -- 4.5.4 Life‐Cycle Analysis -- 4.5.5 Summary -- 4.6 New Enhanced and Green Plastic Explosive for Demolition and Ordnance Disposal -- 4.6.1 PETN Option -- 4.6.1.1 Performance -- 4.6.1.2 Deposition Rate -- 4.6.1.3 Fate, Transport, and Toxicity -- 4.6.2 HMX Option -- 4.6.3 Summary -- 4.7 Conclusions -- References -- Chapter 5 Pyrotechnics and The Environment -- 5.1 Introduction -- 5.2 Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) -- 5.3 Qualification -- 5.4 Civilian Studies -- 5.5 Production -- 5.6 Site Location -- 5.7 Production -- 5.8 Raw Materials Acquisition and Quality Control -- 5.9 Specific Materials Production -- 5.10 Heavy Metals -- 5.11 Perchlorates and Chlorates. , 5.12 Smokes -- 5.13 Volatilization Smokes -- 5.14 Magnesium Teflon Viton (MTV) Countermeasures -- 5.15 Resins, Binders, and Solvents -- 5.16 Storage -- 5.17 Packaging Waste -- 5.18 Usage and Disposal -- 5.19 Heavy Metals -- 5.20 Perchlorates and Chlorates -- 5.21 Smokes -- 5.21.1 Obscurant Smokes -- 5.21.2 Volatilization Smokes -- 5.21.3 MTV -- 5.22 Disposal and Waste Burning -- 5.23 The Future? -- 5.24 Suitably Qualified and Experienced Person (SQEP) Issues -- 5.25 Integration -- Acknowledgements -- References -- Chapter 6 Munitions in the Sea -- 6.1 Introduction -- 6.2 The Controlling Factors -- 6.2.1 Environmental Aspects -- 6.2.2 Corrosion -- 6.2.3 Fate and Transport of Constituents -- 6.2.4 Sea‐Disposal Process -- 6.3 Tools for Assessment and Remediation -- 6.3.1 Acoustic Sensors -- 6.3.2 EM Sensors -- 6.3.3 Optical Sensors -- 6.3.4 Platforms -- 6.3.5 Navigation and Positioning -- 6.3.6 Remediation -- 6.4 The Outstanding Problems -- 6.4.1 Technical Aspects -- 6.4.1.1 Location -- 6.4.1.2 Detection -- 6.4.1.3 Monitoring -- 6.4.1.4 Handling -- 6.4.2 Environmental Aspects -- 6.4.2.1 Chemical Degradation of MEC -- 6.4.2.2 Long‐Term and Long‐Distance Transport -- 6.4.2.3 Ecotoxicological Aspects -- 6.4.3 Geopolitical Aspects -- 6.5 Moving Forward -- 6.5.1 Global Collaboration -- 6.5.2 Recent Global EU and NATO Efforts -- 6.5.3 Advantages of Joint Efforts -- Glossary -- Acknowledgements -- References -- Chapter 7 Environmental Assessment of Military Systems with the Life‐Cycle Assessment Methodology -- 7.1 Overview of the Life‐Cycle Assessment Methodology -- 7.1.1 Life‐Cycle Thinking -- 7.1.2 Life‐Cycle Assessment -- 7.1.3 Purpose of Life‐Cycle Assessment Studies -- 7.2 The Four Phases of the LCA Methodology Applied to a Case Study -- 7.2.1 Goal and Scope -- 7.2.1.1 Functional Unit -- 7.2.1.2 System Boundaries -- 7.2.2 Life‐Cycle Inventory. , 7.2.3 Life‐Cycle Impact Assessment -- 7.2.3.1 Life‐Cycle Impact Assessment Methods -- 7.2.3.2 Life‐Cycle Impact Assessment Software -- 7.2.3.3 Life‐Cycle Impact Assessment of the Case Study -- 7.3 Limitations of Life‐Cycle Assessment -- 7.4 Conclusions -- References -- Chapter 8 Integrating the 'One Health' Approach in the Design of Sustainable Munition Systems -- 8.1 General Background -- 8.2 Munition Compounds and Aetiology of Environmental, Safety, and Occupational Health Issues: Lessons Learnt -- 8.3 Core Operational ESOH Data: Needs and Requirements -- 8.3.1 Life Cycle Environmental Assessment -- 8.3.2 Bridging Communication Between Research and Acquisition -- 8.3.3 ESOH Data Requirements -- 8.3.3.1 Approaches -- 8.4 Current and Evolving Regulatory Interests -- 8.5 Case Studies and Cost Analysis -- 8.5.1 M116, 117, 118 Simulators -- 8.5.2 M‐18 Violet Smoke -- 8.5.3 Cost and Time Considerations -- 8.6 Summary -- Acknowledgements -- References -- Chapter 9 Overview of REACH Regulation and Its Implications for the Military Sector -- 9.1 Introduction -- 9.2 Regulation for Hazard Substances -- 9.2.1 Overview of Previous Legislation Concerning Hazard Substances in the European Union -- 9.2.2 Overview of REACH Regulation -- 9.2.3 Discussion of REACH Regulation -- 9.3 Conclusions -- References -- Chapter 10 Development and Integration of Environmental, Safety, and Occupational Health Information -- 10.1 Introduction -- 10.2 Phased Approach to a Toxicology Data Requirement -- 10.3 Research, Development, Testing, and Evaluation -- 10.3.1 Conception -- 10.3.2 Synthesis -- 10.3.3 Testing/Demonstration -- 10.3.4 Acquisition -- 10.3.5 Engineering and Manufacturing -- 10.3.6 Demilitarization -- 10.4 Other Data Requirements -- 10.4.1 Environmental -- 10.4.1.1 Fate and Transport -- 10.4.1.2 Ecotoxicity -- 10.4.1.3 Field Monitoring -- 10.4.1.4 Disposal. , 10.4.1.5 Occupational - Industrial Hygiene -- 10.4.2 Regulatory -- 10.4.2.1 Toxic Substance Control Act -- 10.4.2.2 REACH -- 10.4.3 Integrating Weight‐of‐Evidence into Decision‐Making -- 10.5 Concluding Remarks -- Acknowledgements -- References -- Chapter 11 Research Priorities and the Future -- 11.1 Introduction -- 11.2 Greener Munitions -- 11.3 Studies and Their Effect -- 11.4 The Problems and the Changing Requirements -- 11.4.1 Land Management and History -- 11.5 Security Issues and Their Impact on Requirement -- 11.6 Future Options and Needs in a Changing Political Landscape -- 11.7 Conclusions -- References -- Index -- EULA.
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  • 3
    Online-Ressource
    Online-Ressource
    Milton :Taylor & Francis Group,
    Schlagwort(e): Perfluorinated chemicals-Bioaccumulation. ; Electronic books.
    Beschreibung / Inhaltsverzeichnis: Understanding Risk to Wildlife from Exposures to Per- and Polyfluorinated Alkyl Substances (PFAS) provides the most recent summary of toxicity data relevant to mammals, birds, reptiles, and amphibians and provides values for use in risk assessment applications.
    Materialart: Online-Ressource
    Seiten: 1 online resource (177 pages)
    Ausgabe: 1st ed.
    ISBN: 9781000375886
    DDC: 363.7384
    Sprache: Englisch
    Anmerkung: Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Foreword -- Preface -- Acknowledgments -- Authors -- Chapter 1 Introduction -- Derivation of Toxicity Reference Values (TRVs) -- Chapter 2 Perfluorooctanoic acid (PFOA) -- Perfluorooctanoic Acid and Its Uses -- Toxicological Effects of PFOA on Wildlife -- Environmental Fate and Transport -- Bioaccumulation and Elimination -- Mammalian Oral Toxicity -- Mammalian Oral Toxicity - Acute -- Mammalian Oral Toxicity - Acute: Effects on Hormones -- Mammalian Oral Toxicity - Acute: Endocrine Effects -- Mammalian Oral Toxicity - Acute: Neurotoxicity -- Mammalian Oral Toxicity - Sub-Chronic -- Mammalian Oral Toxicity -Sub-Chronic: Developmental Toxicity -- Mammalian Oral Toxicity - Subchronic: Endocrine Effects -- Mammalian Oral Toxicity - Sub-Chronic: Immunotoxicity -- Mammalian Oral Toxicity - Sub-Chronic: Effects on Enzymes -- Mammalian Oral Toxicity - Chronic -- Mammalian Oral Toxicity - Chronic: Reproduction -- Mammalian Oral Toxicity - Chronic: Hormone Effects -- Mammalian Oral Toxicity - Chronic: Enzyme Effects -- Mammalian Inhalation Toxicity -- Mammalian Inhalation Toxicity - Acute -- Mammalian Inhalation Toxicity - Sub-Chronic -- Dermal Toxicity -- Dermal Toxicity - Acute -- Dermal Toxicity - Acute: Immunotoxicity -- Dermal Toxicity - Sub-Chronic -- Mammalian Toxicity - Other -- Mammalian Toxicity - Other: Endocrine Disruption -- Mammalian Toxicity - Other: Genotoxicity/Mutagenicity -- Mammalian Toxicity - Other: Effects on Enzymes -- Mammalian Toxicity - Other: Immunotoxicity -- Mammalian Toxicity - Other: Estrogenic Response -- Summary of Avian Toxicology -- Summary of Amphibian Toxicology -- Summary of Reptilian Toxicology -- Recommended Toxicity Reference Values (TRVs) -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for Mammalian Species. , TRVs for PFOA Inhalation Exposures for the Class Mammalia -- Toxicity Reference Values for Birds -- Toxicity Reference Values for Amphibians -- Toxicity Reference Values for Reptiles -- Important Research Needs -- Chapter 3 Perfluorooctane Sulfonate (PFOS) -- Perfluorooctane Sulfonate and Its Uses -- Toxicological Effects of PFOS on Wildlife -- Environmental Fate and Transport -- Bioaccumulation and Elimination -- Mammalian Oral Toxicity -- Mammalian Oral Toxicity - Acute and Sub-Acute -- Mammalian Oral Toxicity - Sub-Chronic -- Mammalian Oral Toxicity: Developmental/Reproductive Effects -- Mammalian Oral Toxicity: Chronic Toxicity - Non-Carcinogenic Effects -- Mammalian Inhalation Toxicity -- Mammalian Inhalation Toxicity: Acute -- Mammalian Sub-Acute Inhalation -- Mammalian Sub-Chronic Inhalation -- Mammalian Chronic inhalation -- Mammalian Dermal/Ocular Toxicity -- Mammalian Toxicity - Other: Genotoxicity/Mutagenicity -- Mammalian Toxicity - Other Systems and Effects -- Immunotoxicity and PFOS -- Summary of Avian Toxicology -- Acute Toxicity -- Sub-Chronic Toxicity in Avian Species -- Chronic Toxicity in Avian Species -- Reproductive Studies in Avian Species -- Toxicity of PFOS in Amphibians -- Summary of Reptilian Toxicity -- Toxicity Reference Values for Mammals -- TRVs for Ingestion Exposures for the Class Mammalia -- TRV for Inhalation Exposure for Mammalian Species -- TRV for Dermal Exposure for the Class Mammalia -- Toxicity Reference Values for Avian Species -- Toxicity Reference Values for Amphibians -- Toxicity Reference Values for Reptiles. -- Important Research Needs -- Chapter 4 Perfluorohexane Sulfonate (PFHxS) -- Chapter 5 Perfluororoheptanoic Acid (PFHpA) -- Mammalian Toxicity -- Amphibian Toxicity -- Avian Toxicity -- Chapter 6 Perfluorononanoic Acid (PFNA) -- Mammalian Toxicity -- Toxicity to Other Animal Classes. , Chapter 7 Perfluorobutane Sulfonate (PFBS) -- Introduction -- Environmental Fate and Transport -- Bioaccumulation and Elimination -- Mammalian Oral Toxicity -- Mammalian Oral Toxicity - Acute/Sub-Acute -- Mammalian Oral Toxicity - Sub-Chronic -- Mammalian Oral Toxicity - Chronic -- Mammalian Toxicity - Other -- Mammalian Toxicity - Other: Mutagenicity -- Mammalian Toxicity - Other: Endocrine Effects -- Mammalian Inhalation Toxicity -- Mammalian Dermal Toxicity -- Avian PFBS Toxicity -- Amphibian PFBS Toxicity -- Reptilian PFBS Toxicity -- Recommended PFBS Toxicity Reference Values -- PFBS Toxicity Reference Values for Mammals -- PFBS Toxicity Reference Values for Mammals - Oral -- PFBS Toxicity Reference Values for Mammals - Dermal -- PFBS Toxicity Reference Values for Avian Species -- PFBS Toxicity Reference Values for Amphibians -- PFBS Toxicity Reference Values for Reptiles -- Future Research Directions -- Chapter 8 6:2 Fluorotelomer Sulfonate (6:2 FTS) -- Mammalian Toxicity -- Amphibian Toxicity -- Chapter 9 Perfluorodecanoic Acid (PFDA) -- Mammalian Toxicity -- Conclusions -- References -- Index.
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  • 4
    Digitale Medien
    Digitale Medien
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Microbiology 53 (1999), S. 103-128 
    ISSN: 0066-4227
    Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Thema: Biologie
    Notizen: Abstract Energy taxis is widespread in motile bacteria and in some species is the only known behavioral response. The bacteria monitor their cellular energy levels and respond to a decrease in energy by swimming to a microenvironment that reenergizes the cells. This is in contrast to classical Escherichia coli chemotaxis in which sensing of stimuli is independent of cellular metabolism. Energy taxis encompasses aerotaxis (taxis to oxygen), phototaxis, redox taxis, taxis to alternative electron acceptors, and chemotaxis to a carbon source. All of these responses share a common signal transduction pathway. An environmental stimulus, such as oxygen concentration or light intensity, modulates the flow of reducing equivalents through the electron transport system. A transducer senses the change in electron transport, or possibly a related parameter such as proton motive force, and initiates a signal that alters the direction of swimming. The Aer and Tsr proteins in E. coli are newly recognized transducers for energy taxis. Aer is homologous to E. coli chemoreceptors but unique in having a PAS domain and a flavin-adenine dinucleotide cofactor that is postulated to interact with a component of the electron transport system. PAS domains are energy-sensing modules that are found in proteins from archaea to humans. Tsr, the serine chemoreceptor, is an independent transducer for energy taxis, but its sensory mechanism is unknown. Energy taxis has a significant ecological role in vertical stratification of microorganisms in microbial mats and water columns. It plays a central role in the behavior of magnetotactic bacteria and also appears to be important in plant-microbe interactions.
    Materialart: Digitale Medien
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  • 5
    ISSN: 1365-2958
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie , Medizin
    Notizen: PAS domains sense oxygen, redox potential and light, and are implicated in behaviour, circadian rhythmicity, development and metabolic regulation. Although PAS domains are widespread in archaea, bacteria and eukaryota, the mechanism of signal transduction has been elucidated only for the bacterial photo sensor PYP and oxygen sensor FixL. We investigated the signalling mechanism in the PAS domain of Aer, the redox potential sensor and aerotaxis transducer in Escherichia coli. Forty-two residues in Aer were substituted using cysteine-replacement mutagenesis. Eight mutations resulted in a null phenotype for aerotaxis, the behavioural response to oxygen. Four of them also led to the loss of the non-covalently bound FAD cofactor. Three mutant Aer proteins, N34C, F66C and N85C, transmitted a constant signal-on bias. One mutation, Y111C, inverted signalling by the transducer so that positive stimuli produced negative signals and vice versa. Residues critical for signalling were mapped onto a three-dimensional model of the Aer PAS domain, and an FAD-binding site and ‘active site’ for signal transduction are proposed.
    Materialart: Digitale Medien
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  • 6
    Digitale Medien
    Digitale Medien
    [s.l.] : Nature Publishing Group
    Nature 307 (1984), S. 558-560 
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] The EGFP precursor sequence was searched against 1,081 sequences (-120,000 residues) in the 1978 Dayhoff Atlas4 and about 800 sequences (-160,000 residues) in Newat5. The search identified bovine factors X and IX (in the Dayhoff Atlas), and human factors X and IX and bovine protein C (in Newat) as ...
    Materialart: Digitale Medien
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  • 7
    Digitale Medien
    Digitale Medien
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 1365-1367 
    ISSN: 1399-0047
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Notizen: Integrin α1β1 is one of the main collagen receptors in many cell types. A fast large-scale production, purification and crystallization method for the integrin α1 I domain is reported here. The α1 I domain was crystallized using the vapour-diffusion method with a reservoir solution containing a mixture of PEG 4000, sodium acetate, glycerol and Tris–HCl buffer. The crystals beong to the C2 space group, with unit-cell parameters a = 74.5, b = 81.9, c = 37.3 Å, α = γ = 90.0, β = 90.8°. The crystals diffract to 2.0 Å and a 94.2% complete data set to 2.2 Å has been collected from a single crystal with an Rmerge of 5.8%.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    ISSN: 1574-6968
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Bacterial aerotaxis is a rapid response towards or away from oxygen. Here we report on the use of computer-assisted motion analysis coupled to flash photolysis of caged oxygen to quantify aerotactic responses in bacteria. The caged compound (μ-peroxo)(μ-hydroxo)bis[bis(bipyridyl) cobalt(III)] perchlorate liberates molecular oxygen upon irradiation with near-UV light. A mixture of cells and the caged oxygen compound was placed in a capillary tube and challenged by discrete stimuli of molecular oxygen produced by photolysis. We then recorded the rate of change of direction (rcd) as an estimate of tumble frequency in response to liberated oxygen and measured the signal processing (excitation) times in Bacillus subtilis, Bacillus halodurans and Escherichia coli. This computer-assisted caged oxygen assay gives a unique physiological profile of different aerotaxis transducers in bacteria.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    ISSN: 1432-1432
    Schlagwort(e): Key words:Diphyllobothrium dendriticum— Cestode — Actin cDNA — Polyadenylation signal — Multigene family — Molecular evolution — Phylogeny
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract. Five cDNAs (pDidact2–pDidact6), representing different actin genes, were isolated from a Diphyllobothrium dendriticum cDNA library, and the DNA as well as the putative amino acid sequences were determined. The corresponding Didact2 and Didact4 genes code for peptides 376 amino acids long, with molecular weights 41,772 and 41,744 Da, respectively, while the deduced Didact3 protein is 377 amino acids long and weighs 41,912 Da. The pDidact5 and -6 cDNAs lack nucleotides corresponding to three to six amino acids at the amino-terminus. Two of the five cDNAs contain the conventional AATAAA as the putative polyadenylation signal, one has the common variant ATTAAA, whereas the hexanucleotide AATAGA is found 15 and 18 nucleotides, respectively, upstream of the poly(A) site in two of the cDNAs. Phylogenetic studies including 102 actin protein sequences revealed that there are at least four different types of cestode actins. In this study three of these types were found to be expressed in the adult D. dendriticum tapeworm. Structurally the cestode actin groupings differ from each other to an extent seen only among the metazoan actins between the vertebrate muscle and cytoplasmic isoforms. In the phylogenetic trees constructed, cestode actins were seen to map to two different regions, one on the border of the metazoan actins and the other within this group. It is, however, difficult to say whether the cestode actins branched off early in the metazoan evolution or if this position in the phylogenetic tree only reflects upon differences in evolutionary rate.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Journal of molecular evolution 30 (1990), S. 43-59 
    ISSN: 1432-1432
    Schlagwort(e): Phyletic trees from x-ray crystal structures ; Sequences ; Globins ; Cytochromes ; Immunoglobulins ; Serine proteinases ; Eye-lens gamma crystallins ; Dinucleotide-binding proteins
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary A distance measure that reflects the dissimilarity among structures has been developed on the basis of the three-dimensional structures of similar proteins, this being totally independent of sequence in the sense that only the relative spatial positions of mainchain alpha-carbon atoms need be known. This procedure leads to phyletic relationships that are in general correlated with the sequence phylogenies based on residue type. Such relationships among known protein three-dimensional structures are also a useful aid to their classification and selection in knowledge-based modeling using homologous structures. We have applied this approach to six homologous sets of proteins: immunoglobulin fragments, globins, cytochromesc, serine proteinases, eye-lens gamma crystallins, and dinucleotide-binding domains.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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