Note: Auch als Teil "Lernbuch" des "Lernpaket Chemie für Dummies". 1. Aufl. erschienen

Note: Front Cover -- Metalloproteins: Structural Aspects -- Copyright Page -- Contents -- Preface -- Chapter 1. Structural Aspects of Metal Liganding to Functional Groups in Proteins -- I. Metal-Binding Sites in Proteins -- II. Polarizabilities of Metals and Ligands -- III. Redox Behavior of Metal Ions -- IV. Number of Atoms Packed in First Coordination Sphere around Metal Ion -- V. Metal-Ligand Bond Distances -- VI. Asymmetry in Ionic Shape -- VII. Strengths of Bonds from Metal Ions to Ligands -- VIII. Selection of Metal Ions for Complexation -- IX. Metal Binding to Isolated Carboxylate Groups -- X. Metal Binding to Imidazole Groups -- XI. Metal Binding to Sulfur-Containing Groups. -- XII. Metal Binding to Main-Chain Carbonyl Groups -- XIII. Metal Binding to Two Groups -- XIV. Metals in Protein Crystal Structures -- XV. Electron Transfer in Metalloproteins -- XVI. Metal Competition and Replacement -- References -- Chapter 2. Calcium Binding Sites in Proteins: A Structural Perspective -- I. Introduction -- II. Functional and Structural Overview of Protein Ca2+-Binding Sites -- III. Regularities and Recurrent Themes in Ca2+-Binding Sites -- IV. Discussion and Summary -- References -- Chapter 3. Copper Protein Structures -- I. Introduction -- II. Cupredoxins: Proteins That Bind Only Type I Copper -- III. Proteins That Bind Only Type II Copper -- IV. Proteins That Bind Only Type III Copper -- V. Proteins That Bind More Than One Type of Copper -- VI. Summary and Conclusions -- References -- Chapter 4. Perspectives on Non-heme Iron Protein Chemistry -- I. Introduction -- II. Structures and Functions of Mononuclear Iron Proteins -- III. Structures and Mechanisms of Binuclear Octahedral Iron Proteins -- IV. Tetrahedral Iron: Fe:S Proteins -- V. Conclusions -- References -- Chapter 5. Structural Biology of Zinc -- I. Introduction. , II. Stereochemistry of Biological Zinc-Ligand Interactions -- III. Long-Range Protein-Metal Interactions -- IV. Examples of Zinc in Biological Catalysis and Regulation -- V. Protein Engineering of Zinc-Binding Sites -- VI. Summary -- References -- Author Index -- Subject Index.

Note: Front Cover -- Advances in Protein Chemistry, Volume 39 -- Copyright page -- CONTENTS -- PREFACE -- Chapter 1. Basement Membrane Proteins: Molecular Structure and Function -- I. Introduction -- II. Morphology and Ultrastructure -- III. Components -- IV. Self-Assembly and Interaction between Components -- V. Biological Aspects -- References -- Chapter 2. Design of Peptides and Proteins -- I. Introduction -- II. Design of Small Peptides -- III. Design of Medium-Sized Peptides -- IV. Protein Design -- References -- Chapter 3. Weakly Polar Interactions in Proteins -- I. Introduction -- II. Electrostatic Interactions in Proteins -- III. Weakly Polar Interactions in Proteins -- IV. Interactions: A Summary -- V. Hydrophobic Interactions in Proteins -- VI. Discussion -- VII. Conclusion -- References -- Chapter 4. Stability of Protein Structure and Hydrophobic Interaction -- I. Introduction -- II. Calorimetric Studies of Protein Denaturation -- III Studies of Dissolution of Nonpolar Substances into Water -- IV. Hydration of Nonpolar Molecules -- V. Comparison of Results on Protein Denaturation and Hydrocarbon Dissolution in Water -- VI. Mechanism of Stabilization of Compact Protein Structures -- References -- Chapter 5. Abstract of a Review on Chemistry of Peanut Proteins -- Abstract -- References -- AUTHOR INEDX -- SUBJECT INDEX.

Note: Front Cover -- Advances in Radiation Biology: Effects of Low Dose and Low Dose Rate Radiation -- Copyright Page -- Table of Contents -- Preface -- Chapter 1. Introduction and Overview -- References -- Chapter 2. Track Structure Considerations in Low Dose and Low Dose Rate Effects of Ionizing Radiation -- I. Introduction -- II. Features of Radiation Tracks -- III. Dose Responses and Extrapolation to Low Doses -- IV. Conclusions -- References -- Chapter 3. Dose-Time-Response Models for Radiation Carcinogenesis -- I. Introduction -- II. Descriptive Models -- III. Radiobiological Principles -- IV. Mechanistic Models -- V. Directions of Future Research -- VI. Conclusions -- References -- Chapter 4. Radiation-Induced Mutation in Mammalian Cells at Low Doses and Dose Rates -- I. Introduction -- II. Mutation Measurements -- III. Comment on Mutation Data -- IV. Novel Mutation Systems: Enhancing Mutant Detection -- V. The Bottom Line(s) -- Appendix 1: Mammalian Cell Line Sensitivities -- Appendix 2: A Brief Survey of the Nature of Radiation-Induced Mutations -- References -- Chapter 5. Commentary to Thacker: A Consideration of the Mechanisms of Induction of Mutations in Mammalian Cells by Low Doses and Dose Rates of Ionizing Radiation -- I. Introduction -- II. DNA Damage, Repair, and Mutations -- III. Mechanism of Induction of Chromosomal Mutations by Ionizing Radiations -- IV. Mutation Induction (Chromosomal and Point) by Ionizing Radiation -- V. Conclusion -- References -- Chapter 6. Oncogenic Cell Transformation in Vitro -- I. Introduction -- II. Cellular and Molecular Events in Oncogenic Transformation -- III. Choice of Cellular Systems: Criteria and Endpoints for Oncogenic Transformation -- IV. In Vivo Correlations of Transformation in Vitro -- V. Concluding Remarks: Future Research Directions -- References. , Chapter 7. Commentary 1 to Cox and Little: The Unbridged Gap between in Vivo and in Vitro Models for Evaluation of Low Dose, Low Dose Rate Radiation-Induced Oncogenic Transformation -- I. Introduction -- II. Stages of Neoplastic Development -- III. Model Systems for Studying Neoplastic Progression -- IV. Summary -- Acknowledgments -- References -- Chapter 8. Commentary 2 to Cox and Little: Radiation-Induced Oncogenic Transformation: The Interplay between Dose, Dose Protraction, and Radiation Quality -- I. Introduction -- II. Review of Pertinent Experimental Data -- III. Biophysical Modeling of Inverse Dose Rate Effects -- IV. Practical Consequences in the Field of Radiation Protection -- V. Conclusions -- Acknowledgments -- References -- Chapter 9. The Role of Animal Experiments in Estimates of Radiation Risk -- I. Introduction -- II. Stochastic Effects -- III. The Use of Experimental Data: Qualitative and Quantitative -- IV. Protracted and Low Dose Rate Studies -- V. Transfer to Risk Estimates across Populations -- VI. Summary -- Acknowledgments -- References -- Chapter 10. Commentary to Fry: Radiation Carcinogenesis Studies in Animals-Advantages, Limitations, and Caveats -- I. Introduction -- II. Random Processes and Carcinogenic Effects -- III. Molecular Biology of Radiation Carcinogenesis -- IV. The Grade of Malignancy and the Absorbed Dose -- V. The Relative Biological Effectiveness of High Linear Energy Transfer Radiation -- VI. Influence of the Time Factor for High Linear Energy Transfer Radiation -- VII. Caveats of Cancer Risks for Humans -- References -- Chapter 11. Radiation Carcinogenesis in Humans -- I. Introduction -- II. Carcinogenesis -- III. Conclusions -- References -- Chapter 12. Commentary 1 to Schull and Weiss: Low Dose Extrapolation, Time following Exposure, and Transport between Populations -- I. Low Dose Extrapolation. , II. Changes in Excess Risk over Time following Exposure -- III. Transport of Risk Estimates from One Population to Another -- References -- Chapter 13. Commentary 2 to Schull and Weiss: Human Cellular Radiosensitivity- The Search for the Diagnostic Holy Grail or a Poisoned Chalice -- I. Introduction -- II. The Response of Individuals -- III. Measurements of Cellular Radiosensitivity -- IV. Genetically Disposed Individuals -- V. Modifications to Survival Assays -- VI. Sensitivity of Tumor-Derived Cells -- VII. Other Assays -- VIII. Conclusions and the Future -- Acknowledgments -- References -- Chapter 14. Commentary 3 to Schull and Weiss: Increased Definition of Abnormal Radiosensitivity Using Low Dose Rate Testing -- I. Introduction -- II. Evidence for DNA Repair Involvement in Cases of Protection at Low Dose Rates -- III. Chronic Exposure Expands the Range of Radioresponse -- IV. Increased Resolution of Mildly Hypersensitive Responses Is Possible with Chronic Dose Delivery -- V. Possible Mechanisms of Protection on Dose Rate Protraction -- Acknowledgments -- References -- Chapter 15. Radiation Protection: Recent Recommendations of the ICRP and the NCRP and Their Biological Basis -- I. Introduction -- II. History of ICRP and NCRP Recommendations -- III. Deterministic Effects, Stochastic Effects, and Detriment -- IV. The Risk of Radiation-Induced Cancer to 1985 -- V. Recent Evaluations of the Risk of Radiation-Induced Fatal Cancer -- VI. Uncertainties in Risk Coefficients for Fatal Cancer -- VII. Tissue Weighting Factors (wT)and Detriment -- VIII. Radiations Other Than Low Linear Energy Transfer X and γ rays -- References -- Index.

Note: Intro -- Contents -- Part 1: Background -- Introduction -- 1. Flora -- 2. Environment -- 3. Plant communities and their distribution -- 4. Vegetation study methods -- Part 2: Southern Forests -- 5. Southern forests - general -- 6. Southern forests - mesic -- 7. Southern forests - xeric -- 8. Southern forests - lowland -- Part 3: Northern Forests -- 9. Northern forests - general -- 10. Northern forests - mesic -- 11. Northern forests - xeric -- 12. Northern forests - lowland -- 13. Boreal forest -- Part 4: Grasslands -- 14. Prairie -- 15. Sand barrens and bracken-grassland -- Part 5: Savanna and Shrub Communities -- 16. Savanna -- 17. Tall shrub communities -- Part 6: Lesser Communities -- 18. Fen, meadow, and bog -- 19. Aquatic communities -- 20. Beach, dune, and cliff communities -- 21. Weed communities -- Part 7: The Vegetation as a Whole -- 22. Postglacial history -- 23. The effect of man on the vegetation -- 24. Interrelations of communities -- Appendix -- Tables for Chapter 4 -- Tables for Chapter 5 -- Figures and tables for Chapter 6 -- Figures and tables for Chapter 7 -- Figures and tables for Chapter 8 -- Figures and tables for Chapter 10 -- Figures and tables for Chapter 11 -- Figures and tables for Chapter 12 -- Figures and tables for Chapter 13 -- Figures and tables for Chapter 14 -- Figures and tables for Chapter 15 -- Figures and tables for Chapter 16 -- Figures and tables for Chapter 17 -- Figures and tables for Chapter 18 -- Figures and tables for Chapter 19 -- Figures and tables for Chapter 20 -- Figure and tables for Chapter 21 -- Figure for Chapter 22 -- Glossary -- Bibliography -- Species list -- Index.

Note: Intro -- Foreword -- Preface -- References -- Contents -- Contributors -- Chapter 1: Short Peptide Vaccine Design and Development: Promises and Challenges -- 1 Introduction -- 2 Methodology -- 2.1 Structural Data -- 2.2 Structural Superposition of HLA Molecules -- 2.3 Molecular Overlay of HLA-Bound Peptides -- 2.4 Accessible Surface Area Calculations -- 2.5 Relative Binding Measure -- 3 Results and Discussion -- 3.1 HLA-Peptide Binding Prediction for T-Cell Epitope Design -- 4 Conclusion -- References -- Chapter 2: Human Papillomaviruses -- 1 Introduction -- 2 Virus Structure and Molecular Biology -- 3 Transmission and Immune Response -- 4 Epidemiology of Invasive Cervical Cancer -- 4.1 Natural History of Cervical HPV Infection -- 4.2 Risk Factors for Cervical HPV Infection, Persistence, and Progression to Invasive Cancer -- 5 Epidemiology of Anal Cancer -- 5.1 HPV Genotype Distribution -- 5.2 Natural History of Anal HPV Infection in Women and Men -- 5.3 Risk Factors for Anal HPV Infection -- 6 Epidemiology of Oropharyngeal Cancer -- 7 Coinfection with HIV and Associated Immunosuppression -- 7.1 Cervical Cancer in HIV-Infected Women -- 7.2 Anal Cancer in HIV-Infected Individuals -- 7.3 Oropharyngeal Cancer in HIV-Infected Individuals -- 7.4 Antiretroviral Therapy and HPV Infection -- 8 Prevention of HPV-Related Malignancies -- 8.1 Cervical Screening -- 8.1.1 Pap Cytology Screening -- 8.1.2 Screening Using HPV Nucleic Acid Testing -- 8.1.3 Cervical Screening Guidelines -- 8.2 Prevention of HPV-Related Anal and Oropharyngeal Cancers -- 8.3 Treatment of HPV-Related Disease -- 8.4 HPV Vaccination -- 8.4.1 Impact of HPV Vaccine and Barriers to Implementation -- 9 Conclusion -- References. , Chapter 3: Adaptation of Freshwater Mosquito Vectors to Salinity Increases Arboviral Disease Transmission Risk in the Context of Anthropogenic Environmental Changes -- 1 Human Arboviral Diseases and Their Mosquito Vectors -- 2 Salinity-Tolerant Mosquito Vectors of Human Arboviral Diseases -- 3 Recent Evidence Shows That Ae. aegypti and Ae. albopictus Can Undergo Pre-imaginal Development in Brackish Water -- 4 Significance of the Likely Role of Brackish Water Aedes Vectors in Dengue Transmission -- 5 Anthropogenic Environmental Changes That Expand Brackish Water Habitats Increase the Potential for Transmission of Arboviral Diseases -- 5.1 Rising Sea Levels -- 5.2 Expanding Coastal Populations and Beach Litter -- 5.3 Agriculture in Coastal Zones -- 5.4 Use of Insecticides and Larvicides in Inland Areas Can Drive the Adaptation of Freshwater Vector Mosquitoes to Coastal Brackish Water Habitats -- 5.5 Increased Coastal Arboviral Disease Transmission Will Impact on Inland Areas -- 6 Implications for Other Arboviral Diseases Transmitted by Mosquitoes -- 7 Strategies for Controlling the Transmission of Arboviral Diseases in Coastal Areas -- References -- Chapter 4: Epidemiology of Henipaviruses -- 1 Hendra Outbreaks -- 2 Nipah Virus Outbreaks -- 2.1 Malaysia/Singapore -- 2.2 NiV Epidemiology India/Bangladesh -- 2.2.1 NiV Transmission Through Date Palm Sap -- 2.2.2 NiV Transmission from Domestic Animals -- 2.2.3 NiV Person-to-Person Transmission -- 2.2.4 Other Plausible Pathways of NiV Transmission -- 3 Open Questions in Henipavirus Epidemiology -- 4 Conclusion -- References -- Chapter 5: Respiratory Syncytial Virus -- 1 Introduction -- 2 Epidemiology -- 2.1 Seasonality -- 2.1.1 USA -- 2.1.2 Europe -- 2.1.3 Southern Hemisphere -- 2.2 RSV in Developing Countries -- 3 RSV Biology: Host vs. Virus -- 3.1 Taxonomy and Structure of RSV. , 3.2 Viral Attachment, Fusion, and Entry -- 3.3 Cell Surface Receptors for RSV Infection -- 3.4 RSV Detection and Attack by the Host Immune System -- 3.4.1 RSV Subversion of the Host Antiviral Defense System -- 3.4.2 Dendritic Cells: Key Watchdogs in the Host Response to RSV Infections -- 3.5 Neurogenic Inflammatory Response to RSV -- 3.6 Persistent RSV Infections -- 4 Pathology of RSV Infection -- 4.1 Pathogenesis -- 4.2 Clinical Manifestations -- 4.2.1 Infants and Young Children -- 4.2.2 Adults and Elderly Individuals -- 4.3 Differential Pathology in Infants and the Elderly -- 5 Diagnosis, Prophylaxis, and Treatment of RSV Infection -- 5.1 New Targets for RSV Prophylaxis -- 5.2 Use of Animal and Three-Dimensional Cellular Models to Develop Anti-RSV Compounds -- 5.3 Immunoprophylaxis -- 5.4 siRNA-Based Prophylaxis -- 5.5 Modified Peptides for Blocking RSV Fusion and Entry -- 6 Conclusions and Future of Anti-RSV Strategies -- References -- Chapter 6: Surveillance for Hepatitis C -- 1 Importance and Aims of Hepatitis C Surveillance -- 2 Epidemiology -- 2.1 Characteristics -- 2.2 Geographic Distribution -- 2.3 Mode of Transmission -- 2.4 Complications of Chronic Infection -- 2.5 Laboratory Testing -- 2.6 Treatment -- 3 Assessment of Priorities -- 4 United States Surveillance Methods -- 4.1 Passive Surveillance -- 4.2 Active Surveillance -- 4.3 Enhanced Surveillance -- 4.4 Analysis of Specimens/Supplementary Data Sources -- 5 Sequence in Case-Based Surveillance Processes -- 5.1 Sequential Flow of Case Data for Hepatitis C Surveillance to CDC -- 5.2 Case Definitions in the USA, Europe, and Australia -- 5.3 Follow-Up Investigation and Case Management -- 5.4 Uses of Surveillance Data in the USA -- 5.5 Estimation of Hepatitis C Incidence in the USA -- 5.6 Security and Confidentiality -- 6 Limitations and Challenges of Surveillance. , 6.1 Distinguishing Acute and Chronic HCV Infection -- 6.2 Underreporting -- 6.3 Resources -- 6.4 Laboratory Issues -- 7 Future Directions -- 7.1 Health Information Technology -- 7.1.1 Electronic Integration -- 7.1.2 Health Information Exchanges -- 7.1.3 Electronic Laboratory Reporting -- 7.2 Lessons Learned from Enhanced Surveillance in the USA -- 7.3 Conclusions -- References -- Chapter 7: Nipah Virus Emergence, Transmission, and Pathogenesis -- 1 Nipah Virus Emergence -- 1.1 Nipah Virus Outbreaks -- 1.1.1 Malaysia and Singapore, 1998-1999 -- 1.1.2 India, 2001, 2007 -- 1.1.3 Bangladesh, 2001-Present -- 1.2 The Natural Reservoir of Nipah Virus -- 1.2.1 Fruit Bats of the Pteropus Genus Are the Natural Reservoir of Nipah Virus -- 1.2.2 Factors Affecting Zoonotic Transmission of Henipaviruses -- 1.2.3 Nipah Virus Infection of Bats -- 1.2.4 Geographic Spread of Henipaviruses in Bats -- 2 Nipah Virus Pathogenesis -- 2.1 Nipah Virus Disease in Humans -- 2.2 Nipah Virus Disease in Pigs -- 2.3 Animal Models -- 2.3.1 The Syrian Hamster Model: Elucidating Nipah Virus Pathogenesis and Transmission -- 2.3.2 The Ferret Model -- 2.3.3 The African Green Monkey Model -- 2.3.4 Other Animal Models -- 3 Outbreak Intervention Strategies and Treatment Options -- 3.1 Outbreak Intervention Strategies -- 3.1.1 Successful Implementation of Outbreak Intervention Strategies in Malaysia -- 3.1.2 Development of Outbreak Intervention Strategies in Bangladesh -- 3.2 The Search for Effective Antiviral Treatments -- 3.2.1 Ribavirin -- 3.2.2 Antibody Treatment -- 3.2.3 Other Antiviral Treatment Options -- 3.3 Vaccine Development -- 3.3.1 Viral Vector-Based Vaccine Candidates -- 3.3.2 Soluble Glycoprotein G-Based Vaccine Candidate -- 3.3.3 Other Vaccine Candidates -- 4 Concluding Remarks -- References. , Chapter 8: A Decade of Giant Virus Genomics: Surprising Discoveries Opening New Questions -- 1 The Nature of Viruses: A Traditional View -- 2 Discovery of Giant Viruses -- 3 Pandoraviruses -- 4 Are Viruses Alive? -- 5 Fourth Domain Hypothesis -- 6 Viral Origin of the Nucleus -- References -- Chapter 9: Expanded Host Diversity and Global Distribution of Hantaviruses: Implications for Identifying and Investigating Previously Unrecognized Hantaviral Diseases -- 1 Introduction -- 2 Reservoir Host Diversity -- 2.1 Hantaviruses in Rodents -- 2.2 Hantaviruses in Shrews -- 2.3 Hantaviruses in Moles -- 2.4 Hantaviruses in Bats -- 3 Geographic Distribution -- 4 Hantavirus Evolution -- 5 Hantaviral Diseases -- 5.1 HFRS and HCPS -- 5.2 Identifying and Investigating Previously Unrecognized Hantaviral Diseases -- 5.2.1 In Search of SANGV Infection and Disease -- 5.2.2 In Search of MJNV Infection and Disease -- 6 Concluding Remarks -- References -- Chapter 10: Family Bunyaviridae -- 1 Introduction -- 2 History and Classification -- 3 Physical Properties -- 4 Genome Structure -- 5 Protein Coding and Viral Replication Strategies -- 6 Ecology and Epidemiology -- 6.1 Orthobunyaviruses -- 6.2 Nairoviruses -- 6.3 Hantaviruses -- 6.4 Phleboviruses -- 7 Clinical Features of Human and Animal Bunyaviridae Infections -- 7.1 Orthobunyaviruses -- 7.2 Nairoviruses -- 7.3 Hantaviruses -- 7.4 Phleboviruses -- 8 General Features of Plant-Infecting Tospoviruses -- 9 Unclassified Bunyaviruses -- References -- Chapter 11: Viral Hemorrhagic Fevers of Animals Caused by Negative-Strand RNA Viruses -- 1 Introduction -- 2 Infectious Hematopoietic Necrosis Virus -- 2.1 Etiologic Agent and Natural History -- 2.1.1 Definition -- 2.1.2 Etiology and Evolution -- 2.1.3 Geographic Distribution and Economic Effects -- 2.1.4 Natural History, Transmission, and Host Range. , 2.2 Pathogenesis and Clinical Features.

Note: Intro -- Title Page -- Preface -- List of Contributors -- Part I: Kanti Mardia -- Chapter 1: A Conversation with Kanti Mardia -- 1.1 Family background -- 1.2 School days -- 1.3 College life -- 1.4 Ismail Yusuf College-University of Bombay -- 1.5 University of Bombay -- 1.6 A taste of the real world -- 1.7 Changes in the air -- 1.8 University of Rajasthan -- 1.9 Commonwealth scholarship to England -- 1.10 University of Newcastle -- 1.11 University of Hull -- 1.12 Book writing at the University of Hull -- 1.13 Directional data analysis -- 1.14 Chair Professorship of Applied Statistics, University of Leeds -- 1.15 Leeds annual workshops and conferences -- 1.16 High profile research areas -- 1.17 Center of Medical Imaging Research (CoMIR) -- 1.18 Visiting other places -- 1.19 Collaborators, colleagues and personalities -- 1.20 Logic, statistics and Jain religion -- 1.21 Many hobbies -- 1.22 Immediate family -- 1.23 Retirement 2000 -- Acknowledgments -- References -- Chapter 2: A Conversation with Kanti Mardia: Part II -- 2.1 Introduction -- 2.2 Leeds, Oxford, and other affiliations -- 2.3 Book writing: revising and new ones -- 2.4 Research: bioinformatics and protein structure -- 2.5 Research: not necessarily linked directly with bioinformatics -- 2.6 Organizing centers and conferences -- 2.7 Memorable conference trips -- 2.8 A select group of special colleagues -- 2.9 High honors -- 2.10 Statistical science: thoughts and predictions -- 2.11 Immediate family -- 2.12 Jain thinking -- 2.13 What the future may hold -- Acknowledgment -- References -- Chapter 3: Selected publications -- 1. Monographs -- 2. Edited Volumes -- 3. Journal Research Papers -- 4. Articles in Edited Volumes (other than edited by Mardia) -- Part II: Directional Data Analysis -- Chapter 4: Some advances in constrained inference for ordered circular parameters in oscillatory systems. , 4.1 Introduction -- 4.2 Oscillatory data and the problems of interest -- 4.3 Estimation of angular parameters under order constraint -- 4.4 Inferences under circular restrictions in von Mises models -- 4.5 The estimation of a common circular order from multiple experiments -- 4.6 Application: analysis of cell cycle gene expression data -- 4.7 Concluding remarks and future research -- Acknowledgment -- References -- Chapter 5: Parametric circular-circular regression and diagnostic analysis -- 5.1 Introduction -- 5.2 Review of models -- 5.3 Parameter estimation and inference -- 5.4 Diagnostic analysis -- 5.5 Examples -- 5.6 Discussion -- References -- Chapter 6: On two-sample tests for circular data based on spacing-frequencies -- 6.1 Introduction -- 6.2 Spacing-frequencies tests for circular data -- 6.3 Rao's spacing-frequencies test for circular data -- 6.4 Monte Carlo power comparisons -- Acknowledgments -- References -- Chapter 7: Barycentres and hurricane trajectories -- 7.1 Introduction -- 7.2 Barycentres -- 7.3 Hurricanes -- 7.4 Using k-means and non-parametric statistics -- 7.5 Results -- 7.6 Conclusion -- Acknowledgment -- References -- Part III: Shape Analysis -- Chapter 8: Beyond Procrustes: a proposal to save morphometrics for biology -- 8.1 Introduction -- 8.2 Analytic preliminaries -- 8.3 The core maneuver -- 8.4 Two examples -- 8.5 Some final thoughts -- 8.6 Summary -- Acknowledgments -- References -- Chapter 9: Nonparametric data analysis methods in medical imaging -- 9.1 Introduction -- 9.2 Shape analysis of the optic nerve head -- 9.3 Extraction of 3D data from CT scans -- 9.4 Means on manifolds -- 9.5 3D size-and-reflection shape manifold -- 9.6 3D size-and-reflection shape analysis of the human skull -- 9.7 DTI data analysis -- 9.8 MRI data analysis of corpus callosum image -- Acknowledgments -- References. , Chapter 10: Some families of distributions on higher shape spaces -- 10.1 Introduction -- 10.2 Shape distributions of angular central Gaussian type -- 10.3 Distributions without reflective symmetry -- 10.4 A test of reflective symmetry -- 10.5 Appendix: derivation of normalising constants -- References -- Chapter 11: Elastic registration and shape analysis of functional objects -- 11.1 Introduction -- 11.2 Registration in FDA: phase-amplitude separation -- 11.3 Elastic shape analysis of curves -- 11.4 Elastic shape analysis of surfaces -- 11.5 Metric-based image registration -- 11.6 Summary and future work -- References -- Part IV: Spatial, Image and Multivariate Analysis -- Chapter 12: Evaluation of diagnostics for hierarchical spatial statistical models -- 12.1 Introduction -- 12.2 Example: Sudden Infant Death Syndrome (SIDS) data for North Carolina -- 12.3 Diagnostics as instruments of discovery -- 12.4 Evaluation of diagnostics -- 12.5 Discussion and conclusions -- Acknowledgments -- References -- Chapter 13: Bayesian forecasting using spatiotemporal models with applications to ozone concentration levels in the Eastern United States -- 13.1 Introduction -- 13.2 Test data set -- 13.3 Forecasting methods -- 13.4 Forecast calibration methods -- 13.5 Results from a smaller data set -- 13.6 Analysis of the full Eastern US data set -- 13.7 Conclusion -- References -- Chapter 14: Visualisation -- 14.1 Introduction -- 14.2 The problem -- 14.3 A possible solution: self-explanatory visualisations -- References -- Chapter 15: Fingerprint image analysis: role of orientation patch and ridge structure dictionaries -- 15.1 Introduction -- 15.2 Dictionary construction -- 15.3 Orientation field estimation using orientation patch dictionary -- 15.4 Latent segmentation and enhancement using ridge structure dictionary -- 15.5 Conclusions and future work. , References -- Part V: Bioinformatics -- Chapter 16: Do protein structures evolve around 'anchor' residues? -- 16.1 Introduction -- 16.2 Exploratory data analysis -- 16.3 Are the anchor residues artefacts? -- 16.4 Effect of gap-closing method on structure shape -- 16.5 Alternative to multiple structure alignment -- 16.6 Discussion -- References -- Chapter 17: Individualised divergences -- 17.1 The past: genealogy of divergences and the man of Anekāntavāda -- 17.2 The present: divergences and profile shape -- 17.3 The future: challenging data -- References -- Chapter 18: Proteins, physics and probability kinematics: a Bayesian formulation of the protein folding problem -- 18.1 Introduction -- 18.2 Overview of the article -- 18.3 Probabilistic formulation -- 18.4 Local and non-local structure -- 18.5 The local model -- 18.6 The non-local model -- 18.7 The formulation of the joint model -- 18.8 Kullback-Leibler optimality -- 18.9 Link with statistical potentials -- 18.10 Conclusions and outlook -- Acknowledgments -- References -- Chapter 19: MAD-Bayes matching and alignment for labelled and unlabelled configurations -- 19.1 Introduction -- 19.2 Modelling protein matching and alignment -- 19.3 Gap priors and related models -- 19.4 MAD-Bayes -- 19.5 MAD-Bayes for unlabelled matching and alignment -- 19.6 Omniparametric optimisation of the objective function -- 19.7 MAD-Bayes in the sequence-labelled case -- 19.8 Other kinds of labelling -- 19.9 Simultaneous alignment of multiple configurations -- 19.10 Beyond MAD-Bayes to posterior approximation? -- 19.11 Practical uses of MAD-Bayes approximations -- Acknowledgments -- References -- Index -- Wiley Series in Probability and Statistics -- End User License Agreement.