Note: Intro -- Biocalorimetry 2 -- Contents -- Preface -- List of Contributors -- Part I General Introduction -- 1 Applications of Biocalorimetry: Binding, Stability and Enzyme Kinetics -- 1.1 Introduction -- 1.2 Principles of isothermal titration calorimetry (ITC) -- 1.3 Applications of ITC in the life sciences -- 1.4 Thermodynamic signatures of non-covalent interactions -- 1.5 Thermodynamic discrimination (TD) -- 1.6 ITC as a tool for studying drug-DNA interactions -- 1.7 ITC as a tool for studying protein-DNA interactions -- 1.8 The application of calorimetry for examining hydration effcts -- 1.9 The use of ITC for studying the kinetics and thermodynamics of enzyme catalysis -- 1.10 Principles of differential scanning calorimetry (DSC) -- 1.11 Applications of DSC in the life sciences -- 1.12 Thermodynamic stability -- 1.13 Shelf life versus thermodynamic stability -- 1.14 Specific and non-specific binding -- 1.15 Intrinsic and extrinsic macromolecular stability -- 1.16 Oligomerization -- 1.17 The use of DSC for examining nucleic acid helix coil transitions -- 1.18 Summary -- Acknowledgements -- References -- Part II Isothermal Titration Calorimetry -- 2 Isothermal Titration Calorimetry: A Tutorial -- 2.1 Introduction -- 2.2 Thermodynamic characterization -- 2.3 Instrumentation -- 2.4 Raw data -- 2.5 Basic considerations for experimental set-up -- 2.6 Data analysis -- 2.7 Summary -- Application notes -- Acknowledgement -- References -- 3 The Application of Isothermal Titration Calorimetry to Drug Discovery -- 3.1 Introduction -- 3.2 Overview of the drug discovery process -- 3.3 Experimental measurement of thermodynamic binding parameters -- 3.4 ITC in drug discovery -- 3.5 Summary -- References -- 4 Dissecting the Thermodynamics of DNA-Protein Interactions -- 4.1 Introduction -- 4.2 Model systems -- 4.3 Comparison with the hydrophobic effect. , 4.4 Protonation and charged-charged hydrogen bonds -- 4.5 Dissection of the binding entropy -- 4.6 Entropy contributions to the Sso7d-DNA interaction -- 4.7 Entropy contributions to the GCN4-DNA interaction -- 4.8 Discussion -- Acknowledgements -- References -- 5 Salt Effects in Ribonuclease-Ligand Interactions: Screening or Competitive Binding? -- 5.1 Introduction -- 5.2 Anion binding to a protein-protein complex -- 5.3 Charge-charge interactions in ribonuclease binding -- 5.4 Conclusions -- Acknowledgement -- References -- 6 Thermodynamics-Structure Correlations of Sulfonamide Inhibitor Binding to Carbonic Anhydrase -- 6.1 Introduction -- 6.2 Identification of protonation reactions occurring upon binding -- 6.3 Observed thermodynamics of inhibitor binding to CA -- 6.4 Energetics of inhibitor protonation -- 6.5 Sulfonamide 'anion' binding thermodynamics -- 6.6 Correlations between structures and the thermodynamics of sulfonamide binding to CA -- 6.7 Conclusions -- References -- 7 Energetics of the Interaction of Human Acidic Fibroblast Growth Factor with Heparin and the Functional Analogue Myo-Inositol Hexasulfate -- 7.1 Introduction -- 7.2 Thermodynamic parameter derived from ITC experiments -- 7.3 Discussion -- Acknowledgement -- References -- 8 Thermodynamics of SH2 Domain Binding -- 8.1 Introduction -- 8.2 SH2 domains and human pathologies -- 8.3 Structure and ligand binding -- 8.4 SH2-domain-binding inhibitors -- 8.5 Conclusions -- References -- 9 Titration Calorimetry as a Tool to Determine Thermodynamic and Kinetic Parameters of Enzymes -- 9.1 Introduction -- 9.2 ICT of enzyme catalysed reactions -- 9.3 Summary -- Acknowledgements -- References -- Part III Differential Scanning Calorimetry -- 10 Energetics of Site-Specific DNA Recognition by Integrase Tn916 -- 10.1 Introduction. , 10.2 Conformational stability of INT-DBD and the target DNA duplex -- 10.3 Thermodynamics of complex formation measured by titration calorimetry -- 10.4 Thermal dissociation and unfolding of the protein-DNA complex -- 10.5 The heat capacity change of protein-DNA association -- 10.6 Discussion -- References -- 11 Linkage Between Temperature and Chemical Denaturant Effects on Protein Stability: the Interpretation of Calorimetrically-Determined m Values -- 11.1 Introduction -- 11.2 Linkage between temperature and chemical denaturant effects on protein stability -- 11.3 Calorimetrically determined urea m values -- 11.4 Calorimetrically determined guanidine m values -- 11.5 Concluding remarks -- Acknowledgement -- References -- 12 Thermodynamic Indications of the Molten Globule State of Cytochrome c Induced by Hydrophobic Salts -- 12.1 Introduction -- 12.2 Thermodynamic description of molten globule state -- 12.3 Molten globule structure detection by isothermal titration calorimetry (ITC) -- 12.4 Enthalpic relationship with electronic transfer of molten globule state -- 12.5 Indication of molten globule state by differential scanning calorimetry (DSC) -- Acknowledgement -- References -- 13 Microcalorimetry as Applied to Psychrophilic Enzymes -- 13.1 Introduction -- 13.2 Cold adaptation -- 13.3 Uniformly unstable enzymes -- 13.4 Enzymes with local flexibility -- 13.5 Thermal inactivation recorded by isothermal titration calorimetry -- 13.6 Microcalorimetric determination of enzyme kinetic parameters -- 13.7 Conclusion -- References -- 14 An Autosampling Differential Scanning Calorimeter for Study of Biomolecular Interactions -- 14.1 Introduction to DSC -- 14.2 Description of instrument -- 14.3 Materials and methods -- 14.4 Results for ribonuclease binding to anionic inhibitors -- 14.5 Discussion -- References. , Appendix. Data analysis (reprinted from reference 10) -- Index.

Note: Cover -- Half Title -- Title Page -- Copyright Page -- Original Title Page -- Original Copyright Page -- Table of Contents -- Foreword -- Preface -- 1. Introduction -- I. A Definition of "Neurometrics -- II. Functional Insights Available from Scalp Recordings -- III. Limitations of Qualitative Analysis of Brain Electrical Activity -- IV. The Neurometric Alternative -- 2. Diagnostic Electrophysiology -- I. EEG Assessment of Neuropathology -- A. EEG Recording Methods -- 1. Electrode Placement -- 2. Recording Method -- 3. Recording Derivations or "Montages -- B. Principles of EEG Analysis -- C. The Accuracy of EEG Detection of Neuropathology -- 1. Incidence of Major Neurological Disease -- a. Head Injury -- b. Paroxysmal Disorders -- i. Migraine Headaches -- ii. Epilepsy -- c. Developmental and Degenerative Defects -- d. Cerebrovascular Disease -- e. Intracranial Tumors -- f. Infectious Diseases -- 2. Incidence of EEG Abnormalities in Major Neurological Diseases -- II. Detection of Neuropathology Using Symmetry of Average Evoked Responses (AER) -- III. Localization of Lesion Site by AER Methods -- IV. Assessment of Changes in Brain State -- V. AER Assessment of Sensory Acuity -- A. Evoked Response Audiometry -- B. AER Assessment of Visual Acuity -- C. AER Assessment of Color Vision -- VI. AER Assessment of Other Aspects of Brain Function -- A. Indices of Development and Maturation -- B. Perceptual and Cognitive Functions -- VII. Summary -- 3. Principles of Neurometric Analysis of Brain Electrical Activity -- I. Analysis of the Spontaneous EEG -- A. Frequency Analysis -- 1. Compressed Spectral Array -- 2. "Neurometric" Displays -- a. The "Canonogram -- b. The "Age Dependent Quotient -- B. Symmetry Analysis -- II. Average Evoked Response and Variance Computations: General Considerations -- A. The Average Evoked Response. , B. Variance of the Average Evoked Response -- C. t Test for the Significance of Differences between AERs -- III. Objective Comparisons Between AERs -- A. Symmetry of the AER -- B. Assessment of Effects of Altered Conditions -- IV. Pattern Recognition Methods -- A. Template Methods -- 1. Amplitude Sorting -- 2. Cross-Correlation Methods -- 3. Cross-Spectral Analysis -- 4. Adaptive Filtering -- B. Cluster Analysis -- C. Discriminant Analysis -- D. Multidimensional Scaling -- 1. Feasibility -- 2. Creating Non-Existent Structure -- V. Multivariate Factor Analysis -- A. Limitations -- B. Factor Analysis Methods -- C. Classification of Drugs -- D. Factor Analysis of AER in Humans -- E. "Normal Spaces" and Screening for Pathology -- F. Drug Subspaces -- G. Pathological Subspaces -- VI. Conclusions -- 4. Automatic Acquisition and Analysis of Electrophysiological Indices of Brain Functions -- I. An Automatic Digital Electrophysiological Data Acquisition and Analysis System (DEDAAS) -- 1. Amplifiers -- 2. 24-Channel Amplifying System -- 3. Display System -- 4. Impedance Testing -- 5. Variable Gain Analog-to-Digital Conversion -- 6. Automatic Artifact Control -- 7. Station Multiplexing -- 8. Digital Recording, Encoded Protocols and Automatic Analysis -- 9. Computation of all Bipolar Montages -- 10. Computer-Controlled Stimulator -- 11. Computer System -- 12. Plotter -- 13. Block Diagram of DEDAAS System -- 14. Economic Advantages of DEDAAS -- II. A Quantitative Electrophysiological Test Battery (NB) -- A. EEG Measures -- B. Evoked Potential Measures -- III. Quantitative Neurometric Indices Extracted from NB Challenges -- A. Neurometric Indices Extracted from EEG Measures -- B. Neurometric Indices Extracted from EP Measures -- IV. Concluding Comments -- 5. Neurometric Assessment of Brain Dysfunction in Patients with Neuropathology. , I. Neurometric Indices Extracted from Spontaneous EEG -- A. Indices Derived from Frequency Analysis -- 1. Abnormality Index -- 2. Age-Dependent Quotients -- B. Indices Derived from Symmetry Analysis -- 1. Discriminant Functions for Identification of Neuropathology Using Measures of EEG Symmetry -- 2. Numerical Taxonomy of Neuropathology: Neurometric Discrimination between Types of Neurological Diseases -- II. Neurometric Indices Extracted from AER -- A. Indices Derived from AER Symmetry Analysis -- 1. Discriminant Function Separating Normal Subjects from Neurological Patients on the Basis of AER Symmetry -- 2. Comparison of Effectiveness of AER Symmetry, EEG Symmetry, and Conventional EEG -- B. Neurometric Indices Derived by Varimax Factor Analysis of AER Waveshapes -- 1. Determination of the "Normal AER Space -- 2. Regression Factor Analysis of AERs from Patients with Tumors, Strokes, or Epilepsy -- 3. Multidimensional Scaling Applied to Discrimination between AERs from Normal Subjects and Patients with Tumors -- III. Conclusion -- 6. Neurometric Assessment of Sensory, Perceptual, and Cognitive Processes -- I. Introduction -- II. AER Assessment of Sensory Acuity -- III. AER Assessment of Perceptual Capability -- IV. AER Assessment of Shape Perception -- V. AER Assessment of Cognitive Processes -- A. Control of Afferent Input -- B. P-300 or the Late Positive Component of the Human AER -- C. Contingent Negative Variation -- D. Differential Anatomic Distribution of Exogenous and Endogenous Processes in Man -- 7. Assessment of Brain Dysfunction in Elderly Patients with Cognitive Impairment -- I. Cognitive Deterioration in the Elderly: The Organic Brain Syndrome -- II. Electrophysiological Studies of Changes with Aging, with Special Relevance to Organic Brain Syndrome -- A. EEC Studies -- 1. General Changes with Aging. , 2. Studies of Patients with Organic Brain Syndrome -- B. AER Studies -- 1. General Changes with Aging -- 2. Studies of Patients with Organic Brain Syndrome -- III. Neurometric Features that Discriminate Between Normal Elderly Subjects and Patients with Cognitive Impairment (OBS) -- A. Patient Selection -- 1. Normal Controls -- 2. Cognitively Impaired Group (OBS) -- B. Psychometric Evaluation -- C. Neurometric Evaluation -- 1. Recording Procedures -- 2. Test Conditions -- 3. Data Analysis -- a. Data Conversion and Editing -- b. Neurometric Indices -- D. Neurometric Findings -- 1. Frequency Analysis of Resting EEG -- 2. Bilateral EEG Synchrony -- 3. Comparison of Overall Interhemispheric Covariance of Resting EEG -- 4. Symmetry of AERs from Bilaterally Symmetric Derivations -- 5. Comparison of Overall Interhemispheric Covariance of AERs -- 6. Discriminant Functions on Individual Conditions -- 7. Multivariate Analysis -- a. Multiple Discriminant Function -- b. "Leave-One-Out" Replication of Discriminant Function -- 8. Cluster Analysis -- a. Method -- 9. Numerical Taxonomy of the Elderly -- IV. Conclusions -- 8. Neurometric Assessment of Brain Dysfunction in Children with Learning Disabilities -- I. Minimal Brain Damage -- A. The MBD Syndrome -- 1. "Learning Disability" and "Learning Disorder -- 2. Heterogeneity of Etiology -- 3. Estimates of Prevalence -- B. Relevant Electrophysiological Measures -- 1. Neonatal Status -- a. EEG Measures -- b. AER Measures -- 2. Indices of Maturation -- a. EEG Measures -- b. Age-dependent EEG Quotient and Maturational Lag -- c. AER Measures -- C. Electrophysiological Findings in Pharmacotherapy of MBD -- II. Neurometric Assessment of 50 Consecutive Children with Learning Difficulties referred to the Neurophysiology Clinic -- A. Deviation from EEG and AER Norms -- B. Age-Dependent Delta Quotient -- C. Abnormality Index. , D. Conclusions -- III. Comparison Between Previously Categorized Groups of "Normal" and "Learning Disabled" Children Using the Neurometric Test Battery (NB) -- A. Subjects, Behavioral Methods, and Criteria for Disability -- 1. Description of Subjects -- 2. Psychometric Battery and the Composite Dysfunction (3M) Score -- 3. The Criterion Problem -- 4. Need to Compress Measure Sets -- B. Factor Analysis of Psychometric Measures -- C. Factor Analysis of Neurometric Indices Extracted from the EEC Conditions of the NB -- 1. Factor Analysis of the Frequency Spectrum -- 2. Construction of a Compressed Set of Spectral Values -- 3. Factor Analyses of the 10/20 System -- a. Topography of Factors 1-6 -- b. Similar Factor Structure, Eyes Open or Closed -- 4. Construction of Set of Multivariate EEG Indices -- D. Psychometric Multiple Discriminant Function Separating Normal from Learning Disabled Children -- E. Neurometric Multiple Discriminant Function Separating Normal from Learning Disabled Children -- 1. Further Reduction of EEG Measure Set -- 2. Neurometric Multiple Discriminant Function -- F. Correction of Misclassified Subjects -- G. Comparison Between Psychometric and Neurometric Discriminant Functions -- 1. Canonical Correlations Between Psychometric and Neurometric Measures -- 2. Regression Analysis of Covariance for Psychometric and Neurometric Discriminant Scores -- 3. Density Distribution of Psychometric and Neurometric Discriminant Scores -- H. Analysis of Variance of EP Conditions of the NB -- I. Visual Display as a Method of Data Compression: The Density-Coded Z Transform -- J. Cluster Analysis -- 9. The Perspective for Neurometrics -- References -- Author Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- Y -- Z -- Subject Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J. , L.

Note: Air Quality Management -- Contents -- Improving Air Quality in the United Kingdom -- 1 Introduction -- 2 Pollution in Street Canyons -- 3 Motor Vehicle Contribution -- 4 Future Air Quality Objectives -- 5 Mapping an Air Quality Management Area -- 6 Quality Control -- 7 Other Approaches -- 8 Role of Air Quality Modelling -- 9 Conclusions -- Emission Inventories -- 1 Introduction -- 2 Urban Emission Inventory Procedures -- 3 West Midlands Atmospheric Emissions Inventory -- 4 Conclusions -- Ambient Air Quality Monitoring -- 1 Introduction -- 2 The Role of Monitoring in Air Quality Management -- 3 Monitoring Objectives -- 4 Quality Assurance and Control -- 5 Network Design -- 6 Instrument Selection -- 7 System Operation -- 8 Data Management -- 9 A Final Thought -- 10 Acknowledgements -- The European Auto-oil Programme: Scientific Considerations -- 1 The Modelling Framework for Regulatory Decisions -- 2 Urban and Regional Models for Air Quality Calculations -- 3 Characterization of Air Quality Data from Monitoring Stations -- 4 Construction and Disaggregation of Emission Inventories -- 5 Validation of Air Quality Modelling Simulations -- 6 Impact Assessment and Scenario Calculations -- 7 Coupling Air Quality with Cost Data and Optimization of Scenarios -- 8 Remarks and Conclusions -- 9 Acknowledgements -- Receptor Modeling for Air Quality Management -- 1 Introduction -- 2 Principle of Mass Balance -- 3 Currently Used Receptor Models -- 4 Secondary Aerosol Mass -- 5 Apportionment of Volatile Organic Carbon Compounds -- 6 Summary -- The Critical Load Approach to Air Pollution Control -- 1 Background -- 2 Definitions -- 3 Calculation of Critical Loads -- 4 Applications of the Critical Load Approach -- 5 Summary and Conclusions -- 6 Acknowledgements -- California's Approach to Air Quality Management -- 1 Introduction -- 2 Emissions and Air Quality Trends. , 3 Technical Basis and Approach to Emission Controls -- 4 Philosophy of Air Quality Management -- 5 On-road Vehicle Emissions -- 6 Cleaner Burning Fuels-Rationale and Implementation -- 7 Low Emission Vehicle Program -- 8 Economy of California and its Influence on Air Quality Management in the State -- 9 Summary -- 10 Acknowledgements -- Subject Index.

Note: Volatile Organic Compounds In The Atmosphere -- Contents -- Sources, Distributions, and Fates of VOCs in the Atmosphere -- 1 Introduction -- 2 Sources of VOCs -- 3 Ambient Concentrations of Organic Compounds -- 4 Fates of Organic Compounds -- 5 Acknowledgements -- Atmospheric VOCs from Natural Sources -- 1 Introduction -- 2 Measurement Methods -- 3 Sources of Natural VOCs in the Atmosphere -- 4 Air Concentrations and Emission Fluxes -- 5 Influence on Atmospheric Chemistry -- 6 Acknowledgements -- The UK Hydrocarbon Monitoring Network -- 1 Introduction -- 2 The United Kingdom Hydrocarbon Network -- 3 Data Summaries and Discussion -- 4 Acknowledgements -- Source Inventories and Control Strategies for VOCs -- 1 Introduction -- 2 Developing Inventories -- 3 Improving and Verifying Inventories -- 4 Uses for Inventories -- 5 Techniques for VOC Abatement -- 6 VOC Control Strategies -- 7 Acknowledgements -- Gas Phase Tropospheric Chemistry of Organic Compounds -- 1 Introduction -- 2 Chemical Loss Processes for Volatile Organic Compounds in the Troposhere -- 3 Tropospheric Chemistry of Alkanes -- 4 Tropospheric Chemistry of Alkenes -- 5 Tropospheric Chemistry of Aromatic Compounds -- 6 Tropospheric Chemistry of Oxygen-containing Compounds -- 7 Tropospheric Chemistry of Nitrogen-containing Compounds -- 8 Conclusions -- Alternatives to CFCs and their Behaviour in the Atmosphere -- 1 Introduction: Alternatives to CFCs -- 2 Reaction Chemistry and Atmospheric Lifetimes of HCFCs and HFCs -- 3 Environmental Effects of HCFCs and HFCs -- 4 Conclusions -- Volatile Organic Compounds in Indoor Air -- 1 Introduction -- 2 Sources of VOCs in Indoor Air -- 3 Measurement of VOCs -- 4 Concentration of VOCs in Indoor Air -- 5 Health Effects of VOCs -- 6 Control of Indoor Air Pollution due to VOCs -- 7 Emission Testing of Products. , Volatile Organic Compounds: The Development of UK Policy -- 1 Introduction -- 2 Effects of VOCs on Man and the Wider Environment -- 3 Current VOC Levels in the UK -- 4 Effects of Current UK VOC Levels -- 5 UK Policy Response -- 6 UK Policy Analysis -- 7 Conclusions -- Subject Index.

Note: Front Cover -- Fish in Research -- Copyright Page -- Table of Contents -- Invited Speakers -- Preface -- Welcoming Address -- PART 1: TOPICS IN CANCER -- CHAPTER 1. ENVIRONMENTAL ASPECTS OF NEOPLASIA IN FISHES -- INTRODUCTION -- HEPATOMA -- THYROID HYPERPLASIA AND NEOPLASIA -- EPIDERMAL PAPILLOMAS -- MESENCHYMAL TUMORS OF GOLDFISH -- SPINDLE CELL SARCOMAS OF PIKE-PERCH -- MULTIPLE OSTEOMAS OF THE RED TAI -- LYMPHOSARCOMAS OF ESOX -- EXPERIMENTALLY INDUCED CHORDOMAS IN EMBRYO TELEOSTS -- UNDIFFERENTIATED SARCOMAS IN LEBISTES AND PRISTELLA -- MELANOMAS OF SWORDTAIL-PLATYFISH HYBRIDS -- MULTIPLE NERVE SHEATH TUMORS -- TERATOMAS ASSOCIATED WITH ICHTHYOPHONUS INFESTATION -- DISCUSSION -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- COMMENTS -- CHAPTER 2. EXPERIMENTAL FISH NEOPLASIA -- INTRODUCTION -- LYMPHOCYSTIS -- MICROSPORIDIA -- MELANOMA -- SARCOMA -- HEPATOMA -- ECCHORDOMA -- CATARACT -- SUMMARY -- REFERENCES -- COMMENTS -- CHAPTER 3. COMPARATIVE ASPECTS OF NEOPLASIA IN FISH AND OTHER LABORATORY ANIMALS -- INTRODUCTION -- EPIDERMAL NEOPLASMS -- HEPATIC TUMORS -- MELANOMA -- THYROID TUMORS -- LYMPHOSARCOMA -- FIBROMA -- NEURILEMMOMA AND NEUROFIBROMA -- ADAMANTINOMA -- OSTEOMA -- ACKNOWLEDGMENT -- REFERENCES -- COMMENTS -- CHAPTER 4. CONTROL OF CHOLESTEROL SYNTHESIS IN NORMAL AND MALIGNANT TISSUE -- FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS IN NORMAL LIVER AND INTESTINE -- FEEDBACK CONTROL IN HEP ATOMAS OF MAMMALS -- DELETION OF THE CHOLESTEROL FEEDBACK SYSTEM IN LEUKEMIC CELLS -- FEEDBACK DELETION IN PRECANCEROUS TISSUE -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCES -- COMMENTS -- PART 2: TOPICS IN METABOLISM -- CHAPTER 5. THE BIOCHEMICAL ASPECTS OF SALT SECRETION -- INTRODUCTION -- METABOLIC ASPECTS: CATALYTIC PROCESSES ASSOCIATED WITH INTERMEDIARY METABOLISM WHICH ARE ALTERED BY EXTRACELLULAR SALT CONCENTRATIONS. , STRUCTURAL ASPECTS: CHEMICAL PROCESSES ASSOCIATED WITH THE CELLULAR DISTRIBUTION OF MACROMOLECULAR COMPLEXES WHICH ARE AFFECTED BY HALOPHILIC BEHAVIOR -- REPLICATIVE ASPECTS: CHEMICAL PROCESSES INVOLVED IN PERPETUATING THE CONTINUITY AND INTEGRITY OF MACROMOLECULAR COMPLEXES WITHIN THE CELLULAR FABRIC THAT ARE INFLUENCED BY HALOPHILISM -- REFERENCES -- COMMENTS -- CHAPTER 6. STEROIDOGENESIS IN FISH -- INTRODUCTION -- WHY USE FISH AS EXPERIMENTAL ANIMALS? -- 11-HYDROXYLATION OF C-19 STEROIDS: A TRANSFORMATION BY NORMAL FISH GONADS -- 1α-HYDROXYCORTICOSTERONE: A STEROID THUS FAR UNIQUE TO ELASMOBRANCH FISH -- PROTEIN-BINDING OF STEROIDS IN FISH BLOOD -- THE STATUS OF ALDOSTERONE IN FISH BLOOD -- REFERENCES -- COMMENTS -- CHAPTER 7. LIPID CATABOLISM IN FISH MUSCLE -- INTRODUCTION -- OXIDATION OF FATTY ACIDS BY FISH MUSCLE -- LIPOLYTIC ACTIVITY IN FISH MUSCLE -- RELEASE OF FREE FATTY ACIDS IN FISH IN VIVO -- THE FUNCTION OF THE RED MUSCLE IN ENERGY METABOLISM IN FISH -- FISH MUSCLE PHOSPHOLIPASES -- REFERENCES -- COMMENTS -- CHAPTER 8. CONTRASTS BETWEEN FISH AND WARM BLOODED VERTEBRATES IN ENZYME SYSTEMS OF INTERMEDIARY METABOLISM -- INTRODUCTION -- TEMPERATURE ACCLIMATION OF FISH AND WARM BLOODED ANIMALS -- ENZYMES INVOLVED IN INTERMEDIARY METABOLISM -- REFERENCES -- COMMENTS -- PART 3: TOPICS IN GENETICS -- CHAPTER 9. QUANTITATIVE INHERITANCE AND ENVIRONMENTAL RESPONSE OF RAINBOW TROUT -- INTRODUCTION -- FACTORS INFLUENCING A RESEARCH STOCK -- CONSIDERATIONS AFFECTING POPULATION -- OBSERVATIONS OF FOUR DOMESTIC LINES OF RAINBOW TROUT -- SUMMARY -- ACKNOWLEDGMENT -- REFERENCES -- COMMENTS -- CHAPTER 10. BLOOD GROUPS IN SALMONID FISHES -- INTRODUCTION -- BLOOD-TYPING STUDIES ON SALMON AND TROUT -- THE PRODUCTION OF ISOIMMUNE SERA IN RAINBOW TROUT -- SEROLOGICAL PROPERTIES OF RAINBOW TROUT -- EXTENT OF ANTIGENIC DIVERSITY IN SOCKEYE SALMON. , THE B-SYSTEM OF BLOOD GROUPS IN SALMON AND TROUT -- BLOOD GROUP FREQUENCY DIFFERENCES AMONG GEOGRAPHIC RACES OF SOCKEYE SALMON -- OPPORTUNITIES FOR FURTHER RESEARCH -- ACKNOWLEDGMENTS -- REFERENCES -- CHAPTER 11. ONTOGENY OF LACTATE DEHYDROGENASE ISOZYMESIN TROUT -- INTRODUCTION -- PROBLEMS OF GENE EXPRESSION -- LACTATE DEHYDROGENASE -- GENETIC STUDIES USING SPLAKE TROUT -- ONTOGENIC STUDIES USING LDH ISOZYMES -- TOTAL LDH ACTIVITY IN HYBRIDS -- REGULATION OF GENE OUTPUT -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- COMMENTS -- PART 4: TOPICS IN NUTRITION -- CHAPTER 12. VITAMIN REQUIREMENTS -- INTRODUCTION -- VITAMIN TEST DIETS -- THIAMINE -- RIBOFLAVIN -- PYRIDOXINE -- FOLIC ACID -- ASCORBIC ACID -- OTHER VITAMINS -- REFERENCES -- COMMENTS -- CHAPTER 13. AMINO ACID AND PROTEIN REQUIREMENTS OF FISH -- QUALITATIVE AMINO ACID REQUIREMENTS -- QUANTITATIVE AMINO ACID REQUIREMENTS -- BLOOD AMINO ACID LEVELS IN FISH -- SUMMARY -- REFERENCES -- COMMENTS -- CHAPTER 14. THE ROLE OF FATS -- INTRODUCTION -- COMPOSITION OF FISH OILS -- BIO-TRANSFORMATIONS OF FATTY ACIDS IN FISH -- ESSENTIAL FATTY ACIDS -- GROWTH -- EXPERIMENTAL PROCEDURES -- SEMI-PURIFIED DIETS -- PRACTICAL RATIONS -- CONCLUSION -- REFERENCES -- COMMENTS -- CHAPTER 15. NUTRITIONAL SCORE -- INTRODUCTION -- DIGESTIBILITY -- CHEMICAL EVALUATION -- UTILIZATION -- DISCUSSION -- REFERENCES -- CHAPTER 16. INORGANIC SALT EFFECTS ON GROWTH, SALT WATER ADAPTION, AND GILL ATPase OF PACIFIC SALMON -- INTRODUCTION -- EXPERIMENTAL METHODS -- EFFECT OF DIETARY SALT ON GROWTH -- DIETARY SALT AND ADAPTION TO SEA WATER -- DIETARY SALT AND ADENOSINETRIPHOSPHATASE ACTIVITY -- DISCUSSION -- CONCLUSIONS -- REFERENCES -- COMMENTS -- PARTICIPANTS.