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  • 1
    Online Resource
    Online Resource
    Dordrecht :Springer Netherlands,
    Keywords: Earth (Planet). ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (408 pages)
    Edition: 1st ed.
    ISBN: 9789401787895
    Series Statement: Space Sciences Series of ISSI Series ; v.46
    DDC: 551.48
    Language: English
    Note: Intro -- Contents -- Foreword: International Space Science Institute (ISSI) Workshop on the Earth's Hydrological Cycle -- References -- Review of Understanding of Earth's Hydrological Cycle: Observations, Theory and Modelling -- Abstract -- Introduction -- Clouds and Precipitation -- Soil Moisture -- Evapotranspiration -- Ground Water Observations -- Water Extent and Levels -- Vegetation Stage -- Water Vapour -- Snow -- Permafrost -- Glaciers and Ice Caps -- Ice Sheet -- Sea Ice -- Sea Level -- Sea-surface Salinity -- Freshwater Discharge for Large Mid-Latitude and Tropical Rivers -- Conclusions and Observational Needs for the Future -- Acknowledgments -- References -- Challenges and Opportunities in Water Cycle Research: WCRP Contributions -- Abstract -- Introduction -- The WCRP -- The Global Water Budget and Hydrological Cycle -- Grand Challenges -- Grand Challenge on Water Resources -- Grand Challenge on Water Extremes -- Conclusions -- Acknowledgments -- References -- Physically Consistent Responses of the Global Atmospheric Hydrological Cycle in Models and Observations -- Abstract -- Introduction -- Constraints upon Global Mean Precipitation Responses -- Simple Model of Global Precipitation -- Transient Response in Global Precipitation in CMIP5 Models -- Current Changes in the Global Atmospheric Water Cycle -- Water Vapor and Regional Constraints on Precipitation -- Moisture Flux into Tropical Wet Regions -- Precipitation Response in the Wet and Dry Regions of the Tropics -- Extremes of Precipitation -- Influence of Dynamical Changes on Precipitation and Its Extremes -- Conclusions -- Acknowledgments -- References -- Quantifying and Reducing Uncertainty in the Large-Scale Response of the Water Cycle -- Abstract -- Introduction -- Scientific Challenges in Modelling the Global Water Cycle -- Global Water Budget -- The Role of Model Resolution. , Influence of Resolution on Global Precipitation -- Resolved Versus Parametrised Processes in Models -- Representing Hydrological Processes and Phenomena -- Clouds, Humidity and Radiation -- Model Representations of Cloud and Precipitation and Their Evaluation -- Diurnal Cycle of Clouds and Precipitation -- Precipitation in Mid-latitude Cyclones -- Land--Atmosphere Interactions -- Ocean--Atmosphere Processes and Interactions -- The Role of the Cryosphere -- Global Monsoons -- Summary -- Acknowledgments -- References -- Connecting Satellite Observations with Water Cycle Variables Through Land Data Assimilation: Examples Using the NASA GEOS-5 LDAS -- Abstract -- Introduction -- Data and Methods -- GEOS-5 Land Data Assimilation System -- Assimilated Observations -- Validation Data and Approach -- Results -- Assimilation of Sparse and Coarse-Scale Observations -- Partitioning of Terrestrial Water Storage Observations -- Microwave Radiative Transfer Models for Radiance Data Assimilation -- Warm-Season, L-Band Radiative Transfer Modeling -- Predicting Microwave Brightness Temperatures over Snow -- Observation Selection for a Root Zone Soil Moisture Analysis -- Using Precipitation Observations -- Assimilating Surface Soil Moisture Retrievals -- Combining Precipitation Observations and Surface Soil Moisture Retrievals -- Summary and Discussion -- Conclusions and Outlook -- Acknowledgments -- References -- Initialisation of Land Surface Variables for Numerical Weather Prediction -- Abstract -- Introduction -- Snow Analysis -- Snow Forecast Models -- Snow Observations -- Snow Analysis Methods -- Results -- Soil Moisture Analysis -- History of Soil Moisture Analysis for NWP -- Comparison Between the OI and EKF Soil Moisture Analyses -- Use of Satellite Data to Analyse Soil Moisture -- Conclusion -- Acknowledgments -- References. , Closing the Gaps in Our Knowledge of the Hydrological Cycle over Land: Conceptual Problems -- Abstract -- Introduction -- Observations of the Hydrological Cycle -- Models of the Hydrological Cycle -- Data Assimilation of the Hydrological Cycle -- Introduction -- Data Assimilation Methods -- Representation of Errors -- Advantages and Disadvantages of Assimilation Methods -- Example of a Land Data Assimilation System -- Data Assimilation Research Applications -- Single-column Applications -- Distributed Applications -- Towards Operational Land Data Assimilation -- Conceptual Problems and Key Challenges -- Assimilated Observations -- Forward and Retrieval Models, with Particular Reference to Radiances and Backscatter Processes -- Land Surface Models -- Data Assimilation Challenges -- Validation -- Conclusions -- Acknowledgments -- Appendix: Sensor acronyms -- References -- Toward Improved Estimation of the Dynamic Topography and Ocean Circulation in the High Latitude and Arctic Ocean: The Importance of GOCE -- Abstract -- Introduction -- Ocean Dynamic Topography -- Surface Circulation -- Volume Transport -- Summary -- Acknowledgments -- References -- Sea Surface Salinity Observations from Space with the SMOS Satellite: A New Means to Monitor the Marine Branch of the Water Cycle -- Abstract -- Introduction -- Data -- SMOS SSS Data -- Ocean Surface Currents -- Rain, Evaporation and River Discharge Data -- Ocean Color Products -- In Situ Data -- SMOS Monitoring of the Major Tropical Atlantic River Plumes -- Amazon and Orinoco River Plume Monitoring -- Eastern Tropical Atlantic Freshwater Pools Monitoring -- Precipitation Signatures in SSS Data from Space -- SSS Temporal Variability Associated with Rain Events -- Systematically Fresher Skin SSS in Rainy Regions -- SSS as a Tracer of the Evaporation--Precipitation Budget in the Oceanic Mixed Layer. , Large-scale SSS Interannual Variability in Tropical Indian and Pacific Oceans -- Fresh Pool Interactions with Wind-driven Processes -- An Example of Fresh Pool Erosion by Wind-driven Upwelling -- Fresh Pool Interactions with Tropical Cyclones -- Conclusions and Perspectives -- Acknowledgments -- References -- Role of Ocean in the Variability of Indian Summer Monsoon Rainfall -- Abstract -- Introduction -- Monsoon Onset Over India -- Active--Break Cycle of Monsoon -- Inter-annual and Decadal Variability of Monsoon -- Rapid Warming of the Indian Ocean -- Summary and Conclusions -- References -- Perspectives in Modelling Climate--Hydrology Interactions -- Abstract -- Introduction -- Impact of Anthropogenic Land Use, Especially Irrigation, on Climate -- Impact of Irrigation on the South Asian Summer Monsoon (SASM) -- Conclusions and Perspectives for the Impact of Irrigation on Climate -- Permafrost -- Basic Hydrological Processes in Permafrost Areas -- Representation of Permafrost Processes in ESMs -- Wetlands -- Concluding Remark -- Acknowledgments -- References -- Downscaling Satellite Precipitation with Emphasis on Extremes: A Variational ell1-Norm Regularization in the Derivative Domain -- Abstract -- Introduction -- Precipitation Downscaling as a Regularized Inverse Problem -- Basic Concepts in the Continuous Space -- Discrete Representation -- Geometrical Versus Statistical Interpretation of the ell1-Norm Regularized Downscaling -- Working with an Unknown Downgrading Operator (H) -- Results from a Case Study -- Concluding Remarks -- Acknowledgments -- References -- Global Snow Mass Measurements and the Effect of Stratigraphic Detail on Inversion of Microwave Brightness Temperatures -- Abstract -- Introduction -- Current Snow Mass Estimation -- General Circulation Models and Reanalyses -- Products Which Prioritise Snow -- Surface Observations Only. , Land Surface Models Assimilating In Situ Observations -- Remote Sensing of Snow Mass -- Assimilation of Passive Microwave Observations to Improve Snow Mass Estimation -- Assimilation of Passive Microwave Brightness Temperatures -- Globsnow -- Methodology -- Limitations of Globsnow -- Methods -- The Cold Land Processes Experiment (CLPX) Resampled Snowpits -- Comparison: Layered HUT Scene Simulation Versus Observations -- Comparison: N-layer Versus Fewer Layers of Stratigraphic Information -- Results and Analysis -- Snow Properties at CLPX Sites -- Simulated Scene Brightness Temperatures -- Differences Due to Layering Detail -- Discussion and Conclusions -- Acknowledgments -- References -- Glaciers in the Earth's Hydrological Cycle: Assessments of Glacier Mass and Runoff Changes on Global and Regional Scales -- Abstract -- Introduction -- Assessing glacier mass balance on regional and global scales -- Assessments by in situ mass-balance measurements -- Assessments by geodetic method -- Assessments using satellite gravimetry -- Assessments by other approaches -- AAR method -- Multi-method approach -- Modeling glacier mass balance on regional and global scales -- Models based on mass-balance sensitivity -- Models of surface mass balance -- Model limitations -- Glacier runoff -- Effects of glaciers on streamflow -- What is glacier runoff? -- Assessing global-scale impacts of glaciers on the hydrological cycle -- Synthesis and discussion -- Conclusions -- Acknowledgments -- References -- Observing Global Surface Water Flood Dynamics -- Abstract -- Introduction: Surface Water Floods in the Earth System -- Observing Global Flood Dynamics -- Remote Measurements of Floodplain Topography -- Remote Measurements of Inundation Extent -- Remote Measurements of Water Elevation -- Remote Measurements of Water Storage -- The Proposed SWOT Satellite Mission. , Inferring Remaining Unknown Variables Using DA.
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  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Adult beagle dogs of either sex were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-HCl (2.5 mg/kg, i.v.) alone or after pretreatment with pargyline (5.0 mg/kg, s.c, twice), with pargyline alone, or were unin-jected. Groups were killed 2 h, 3 weeks, or 3 months after injection, and several brain areas were assayed for biogenic amines and their synthetic and degradative enzymes. MPTP caused a massive and permanent loss of striatal dopamine, tyrosine hydroxylase, and 3,4-dihydroxyphenylalanine decarboxylase activities and the loss of cells within the substantia nigra pars compacta. Dopamine and norepinephrine also were depleted to various degrees in cortex, olfactory bulb, and hypothalamus; however, dopamine β-hydroxylase activity in cortex was normal. There was no cell loss in the ventral tegmental area or locus ceruleus. The activities of monoamine oxidase (MAO)-A and MAO-B in cortex and caudate were not affected by MPTP. Despite a permanent loss of the ni-grostriatal system, the dogs exhibited only a transient hypokinesia lasting 1-2 weeks. Pargyline pretreatment prevented the loss of striatal dopamine and cells from the substantia nigra, but did not prevent a prolonged but reversible decrease in the concentration of dopamine metabolites. It is argued that this apparent inhibition of MAO is due not to suicide inactivation of the enzyme by MPTP, but to reversible inhibition by accumulation of the pyridinium metabolite, 1-methyl-4-phenylpyridinium, selectively in aminergic terminals.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish diseases 4 (1981), S. 0 
    ISSN: 1365-2761
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-1463
    Keywords: MPTP ; MPDP+ ; MPP+ ; substantia nigra ; nigrostriatal neurons ; neurotoxin ; dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unilateral intranigral administration of the oxidative metabolites of 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine (MPTP), 1-methyi-4-phenyl-dihydropyridine (MPDP+) or l-methyl-4-phenylpyridine (MPP+) produced dose-dependently a depletion of dopamine in the ipsilateral striatum of rats two weeks following treatment.d- Amphetamine and apomorphine induced circling toward the lesioned side in these unilaterally treated animals. No contralateral circling behavior was observed after challenging with apomorphine. This dopamine lesioning effect of MPP+ was not blocked by pretreatment of animals with a dopamine uptake blocker, GBR 12909. Furthermore, MPP+ increased the45Ca accumulation into cells at the site of injection and produced “nonspecific” cell membrane and/or cytotoxic damage seen by histological procedures. These results indicate that MPDP+ and MPP+ produced localized cytotoxic damage to nigrostriatal neurons, caused a decrease in striatal dopamine, and disrupted the nigrostriatal system's functioning following intranigral administration to rats. It is postulated that the cationic surfactant properties of MPDP+ and MPP+ might contribute to its neurotoxic effects.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Radiolabelled [1-14C]MPTP was prepared by reacting 14C-methyl iodide (2 mCi, 5.4 mg) with 4-phenylpyridine (10 mg) in dichloromethane at room temperature for 24 h, followed by reduction of the dried residue in aqueous solution with excess NaBH4, using the method of Lyle6. The product, [1-14C]MPTP, ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 8 (1981), S. 301-304 
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A gas chromatographic mass spectrometric assay for serotonin (5-hydroxytryptamine) has been developed. Serotonin is acylated in homogenized biological media, efficiently extracted into ethyl acetate, and further derivatized with pentafluoropropionic anhydride. Mass spectral characterization of derivatized serotonin using electron and positive or negative chemical ionization indicates that electron ionization mass spectrometry is useful for serotonin assay in most biological fluids and tissues, but that electron capture negative chemical ionization is required for samples containing less than 1-2 ng (cerebrospinal fluid). An assay limit of 10 pg per sample has been established. Examples of applications for the assay of serotonin in human platelets, rat spinal cord, and monkey cerebrospinal fluid are presented.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2020-02-24
    Description: Operational Oceanography (OO) has now emerged to a stage that allows the design, development and execution of marine core services tailored to user requirements. As such it is also feasible to provide routine production of environmental and climate indicators. Indicators are synthetic indices of environmental changes at various temporal and spatial scales. In this paper we outline the possible contribution and strengthening of existing indicator reporting based on OO products followed by a discussion of the relevance of such improved reporting for marine environmental policy implementation and regulation. In particular, it capitalizes on the main achievements of the Marine Environment and Security of the European Area (MERSEA) project, the outcome of a European Marine Monitoring and Assessment (EMMA) workshop on the connection between operational oceanography and the European Marine Strategy (EMS) Directive and the regular European Environmental Agency (EEA) assessment reports.
    Description: Financial support for our work was provided by the EU project 15 MERSEA (Marine Environment and Security for the European Area, Contract number: SIP3-CT-2003-502885), BOSS4GMES (Building Operational Sustainable Services for GMES, contract number: FP6-2005-SPACE-1-030966) and by the European Topic Center for Water (ETC-W).
    Description: Published
    Description: 121-141
    Description: 4.6. Oceanografia operativa per la valutazione dei rischi in aree marine
    Description: JCR Journal
    Description: open
    Keywords: operational oceanography ; indicators ; 03. Hydrosphere::03.01. General::03.01.05. Operational oceanography
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 8
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    In:  EPIC3Proceedings of OceanObs09: Sustained Ocean Observations and Information for Society (Vol. 2), Venice, Italy, 21-25 September 2009, Hall, J., Harrison D.E. & Stammer, D., Eds., ESA Publication WPP-306.
    Publication Date: 2019-07-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 9
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/conferenceObject
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  • 10
    Publication Date: 2021-06-14
    Description: In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion.
    Language: English
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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