Keywords:
Cells.
;
Molecular biology.
;
Electronic books.
Description / Table of Contents:
International Review of Cell & Molecular Biology presents current advances and comprehensive reviews in cell biology - both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Transgenic Mouse Models in Angiogenesis and Lymphangiogenesis, Morphogenesis in Giant-celled Algae, Plasmodium in the Post-Genomic Era: New Insight into the Molecular Cell Biology of Malaria Parasites, Role of Nuclear Lamins in Nuclear Organization, Cellular Signalling and Inherited Diseases, New Insights into the Mechanisms of Macroautophagy in Mammalian Cells. *Covers the latest on transgenic mouse models in angiogenesis and lymphangiogenesis. *Includes information on morphogenesis in giant-celled algae. *Provides new insights into the mechanisms of macroautophagy in mammalian cells.
Type of Medium:
Online Resource
Pages:
1 online resource (262 pages)
Edition:
1st ed.
ISBN:
9780080569468
Series Statement:
Issn Series ; v.Volume 266
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=338887
DDC:
611.0
Language:
English
Note:
Cover -- Contents -- Contributors -- Chapter 1: Transgenic Mouse Models of Angiogenesis and Lymphangiogenesis -- 1. Introduction -- 1.1. Angiogenesis -- 1.2. Lymphangiogenesis -- 2. Factors Involved in Abnormal Embryonic Vascular and Lymphatic Development -- 2.1. VEGF family -- 2.2. Growth factors -- 2.3. Angiopoietins, Tie-1, and Tie-2 -- 2.4. Hypoxia-inducible factor 1 -- 2.5. Other factors -- 3. Concluding Remarks -- Acknowledgments -- References -- Chapter 2: Morphogenesis in Giant-Celled Algae -- 1. Introduction -- 2. Biological Features of Giant-Celled Algae -- 2.1. Taxonomic and ecological aspects -- 2.2. Cellular organization -- 2.3. Motility of organelles -- 3. Cytoskeletal Organization During Morphogenesis -- 3.1. Vegetative morphogenesis -- 3.2. Reproductive morphogenesis -- 3.3. Wound-healing reaction -- 4. Physiological and Molecular Biological Aspects of Morphogenesis -- 4.1. Physiological factors controlling morphogenesis -- 4.2. Expression of genes controlling morphogenesis in Acetabularia -- 5. Concluding Remarks -- References -- Chapter 3: Plasmodium in the Postgenomic Era: New Insights into the Molecular Cell Biology of Malaria Parasites -- 1. Introduction -- 2. Cellular and Molecular Biology of Red Blood Cell Invasion -- 2.1. Structure of merozoites -- 2.2. Merozoite assembly -- 2.3. Merozoite exit from infected red blood cells -- 2.4. Invasion -- 3. Proteases -- 3.1. Invasion-related proteases -- 3.2. Proteases of intracellular stages -- 4. Protein Trafficking -- 4.1. Trafficking to intracellular compartments of parasites -- 4.2. Export to infected red blood cell cytoplasm and surface -- 4.3. Cytoadherence -- 5. Cellular Calcium Dynamics -- 5.1. Fluorescent and chemiluminescent probes to study Ca2+ in living cells -- 5.2. Calcium-handling mechanisms in Plasmodium -- 5.3. From genome to cell physiology.
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5.4. Parasite organelles as intracellular Ca2+ pools -- 5.5. Surviving in low-[Ca2+] parasitophorous vacuoles -- 5.6. Circadian rhythms, malarial infection, and Ca2+ signaling: modulation of Plasmodium cell cycle by tryptophan-related molecules -- 5.7. Signal transduction-handling machinery in Plasmodium -- 6. Molecular Biological Approaches to Plasmodium Studies -- 6.1. Transfection technology -- 6.2. Transfection in Plasmodium species -- 6.3. Knockout -- 6.4. Analysis of Transcription in Plasmodium -- 7. Concluding Remarks -- Acknowledgments -- References -- Chapter 4: Role of Nuclear Lamins in Nuclear Organization, Cellular Signaling, and Inherited Diseases -- 1. Introduction -- 2. Structure and Organization of Lamins -- 2.1. Genes and expression of lamin isoforms -- 2.2. Lamin structure, assembly, and dynamics -- 2.3. Lamin-binding proteins -- 3. Genetic Diseases Associated with Mutations in Lamins and Nuclear Envelope Proteins -- 3.1. Diseases caused by mutations in lamin A -- 3.2. Diseases caused by mutations in lamin B -- 3.3. Disorders associated with mutations in other nuclear envelope proteins -- 3.4. Animal models for laminopathies -- 4. Role of Lamins in Nuclear Organization and Cellular Functions -- 4.1. Nuclear morphology and chromatin organization -- 4.2. Regulation of mitosis -- 4.3. DNA replication -- 4.4. Transcription and gene regulation -- 4.5. Nuclear-cytoskeletal interactions -- 4.6. Apoptotic events involving lamins -- 5. Cellular Signaling Pathways Involving Lamins -- 5.1. Muscle differentiation -- 5.2. Adipocyte differentiation -- 5.3. DNA repair pathways -- 5.4. Transforming growth factor-beta-mediated signaling pathways -- 5.5. Cellular proliferation -- 6. Concluding Remarks -- Acknowledgments -- References -- Chapter 5: New Insights into the Mechanisms of Macroautophagy in Mammalian Cells -- 1. Introduction.
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2. Autophagy Proteins and Their Known Functions -- 2.1. Atg12-Atg5 -- 2.2. Atg8/LC3 -- 2.3. Beclin 1 and Vps34 -- 2.4. Atg9 -- 2.5. Atg15 -- 3. Maturation of Autophagosomes into Autolysosomes -- 3.1. Multistep maturation process -- 3.2. Factors required for autophagosome maturation in mammalian cells -- 4. Functions and Regulation of Autophagy -- 4.1. Functions -- 4.2. Regulation -- 5. Concluding Remarks -- Acknowledgments -- References -- Index.
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