Note: Front Cover -- Principles of Regenerative Medicine -- Copyright Page -- Contents -- Preface -- List of Contributors -- Part I: Introduction to Regenerative Medicine -- Chapter 1. Current and Future Perspectives of Regenerative Medicine -- REGENERATIVE MEDICINE: CURRENT AND FUTURE PERSPECTIVES -- CONCLUSIONS -- REFERENCES -- Chapter 2. Fundamentals of Cell-Based Therapies -- INTRODUCTION -- RATIONALE FOR CELL-BASED THERAPIES -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 3. Stem Cell Research -- INTRODUCTION -- STEM CELLS -- STEM CELL MODULATION IN VITRO -- REGENERATIVE MEDICINE -- CONCLUSION -- ACKNOWLEDGMENTS -- INTERNET RESOURCES -- REFERENCES -- Part II: Biologic and Molecular Basis of Regenerative Medicine -- Chapter 4. Molecular Organization of Cells -- INTRODUCTION -- CELLULAR MECHANISMS OF THE EMT -- MOLECULAR CONTROL OF THE EMT -- CONCLUSION -- REFERENCES -- Chapter 5. Cell-ECM Interactions in Repair and Regeneration -- INTRODUCTION -- COMPOSITION AND DIVERSITY OF THE ECM -- RECEPTORS FOR ECM MOLECULES -- SIGNAL TRANSDUCTION EVENTS DURING CELL-ECM INTERACTIONS -- CELL-ECM INTERACTIONS DURING HEALING OF SKIN WOUNDS -- CELL-ECM INTERACTIONS DURING REGENERATION -- IMPLICATIONS FOR REGENERATIVE MEDICINE -- REFERENCES -- Chapter 6. Developmental Mechanisms of Regeneration -- INTRODUCTION -- MECHANISMS OF REGENERATION -- STRATEGIES OF REGENERATIVE MEDICINE -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 7. The Molecular Basis of Pluripotency in Principles of Regenerative Medicine -- INTRODUCTION TO PLURIPOTENCY -- EXTRACELLULAR SIGNALING FACTORS AND SIGNAL TRANSDUCTION -- TRANSCRIPTIONAL NETWORKS -- EPIGENETIC AND ENVIRONMENTAL REGULATION -- SUMMARY AND PERSPECTIVES -- REFERENCES -- Chapter 8. How Do Cells Change Their Phenotype -- INTRODUCTION -- STEM CELLS -- PLASTICITY - TRANSDIFFERENTIATION AND TRANSDETERMINATION. , CELL FUSION -- CELL PHENOTYPE -- CONTROL OF GENE ACTIVITY -- EXTRINSIC CONTROLS -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 9. Somatic Cloning and Epigenetic Reprogramming in Mammals -- INTRODUCTION: SHORT HISTORY OF CLONING -- TECHNICAL ASPECTS OF SOMATIC NT -- SUCCESS RATES OF SOMATIC CLONING AND THE QUESTION OF NORMALITY OF CLONED OFFSPRING -- EPIGENETIC REPROGRAMMING -- APPLICATION OF SOMATIC NT -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 10. Transgenic Cloned Goats and Cows for the Production of Therapeutic Proteins -- INTRODUCTION -- GENERATION OF TRANSGENIC ANIMALS -- SCNT: DONOR CELL LINE DEVELOPMENT AND CHARACTERIZATION -- CAPRINE SCNT -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Part III: Cells and Tissue Development -- Chapter 11. Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives -- INTRODUCTION -- MAINTAINING UNDIFFERENTIATED HESCS -- GENETIC APPROACHES TO MANIPULATING HESCS -- DIFFERENTIATION OF HESCS INTO TISSUE-SPECIFIC LINEAGES AND TRANSPLANTATION OF HESC-DERIVED CELLS -- GENETIC MODIFICATIONS OF HESC-DERIVED PROGENIES -- POTENTIAL APPLICATIONS OF GENETICALLY MANIPULATED HESCS AND THEIR DERIVATIVES -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 12. Embryonic Stem Cells: Derivation and Properties -- INTRODUCTION -- DERIVATION OF ES CELLS -- CULTURE OF ES CELLS -- DEVELOPMENTAL POTENTIAL OF ES CELLS -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- Chapter 13. Stem Cells Derived from Amniotic Fluid and Placenta -- INTRODUCTION -- CVS AND AMNIOCENTESIS -- DIFFERENTIATED CELLS FROM AMNIOTIC FLUID AND PLACENTA -- MESENCHYMAL CELL FROM PLACENTA AND AMNIOTIC FLUID -- PLURIPOTENT STEM CELLS FROM PLACENTA AND AMNIOTIC FLUID -- FUTURE DIRECTION -- SUMMARY -- REFERENCES -- Chapter 14. Stem Cells Derived from Cord Blood -- INTRODUCTION -- PROCUREMENT AND PROCESSING OF CORD BLOOD. , CORD BLOOD STORAGE -- HEMATOPOIETIC AND TISSUE REGENERATION -- PLURIPOTENT CELLS FROM UMBILICAL CORD BLOOD CELLS -- NEUROLOGICAL REGENERATION -- CONCLUSION -- FUTURE DEVELOPMENTS -- REFERENCES -- Chapter 15. Multipotent Adult Progenitor Cells -- PLURIPOTENT STEM CELLS: EMBRYONIC STEM CELLS -- POSTNATAL TISSUE-SPECIFIC STEM CELLS: ARE SOME MORE THAN MULTIPOTENT? -- ISOLATION OF MAPCs -- DIFFERENTIATION ABILITY OF MAPC IN VITRO -- ENGRAFTMENT OF MAPC IN VIVO -- CONTRIBUTION OF MAPC TO CHIMERAS -- MECHANISM UNDERLYING GREATER POTENCY OF MAPC AND SIMILAR ADULT STEM CELLS WITH GREATER POTENCY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 16. Bone Marrow Stem Cells: Properties and Pluripotency -- INTRODUCTION -- BONE MARROW STEM CELLs -- BMSCS AND TISSUE REGENERATION -- IMPORTANT FACTORS REGULATING BMSC HOMING AND DIFFERENTIATION -- CLINICAL APPLICATIONS OF BMSCS FOR CARDIAC REGENERATION -- CONCLUSION -- REFERENCES -- Chapter 17. Hematopoietic Stem Cell Properties, Markers, and Therapeutics -- INTRODUCTION -- DEVELOPMENTAL ORIGIN OF HEMATOPOIESIS -- INTRINSIC REGULATORS OF SELF-RENEWAL -- MULTI-LINEAGE REPOPULATION -- PLAYERS IN HEMATOPOIESIS -- IN VITRO DIFFERENTIATION OF HEMATOPOIETIC LINEAGES -- IN VITRO EXPANSION OF SELF-RENEWING HSCs -- HSC NICHE -- PURIFICATION AND MOLECULAR SIGNATURE OF HSC -- PLASTICITY AND THERAPEUTICS -- CONCLUSIONS -- REFERENCES -- Chapter 18. Neural Stem Cells -- INTRODUCTION - HISTORICAL BACKGROUND -- THE NEURAL STEM CELL -- ANALYSIS OF NEUROGENESIS -- THERAPEUTICS AND CLINICAL APPROACHES -- CONCLUSION -- REFERENCES -- Chapter 19. Mesenchymal Stem Cells -- INTRODUCTION -- THE DEFINITION OF MSCS -- The Stem Cell Nature of MSCs -- SOURCE OF MSCS AND ISOLATION TECHNIQUES -- WHICH TISSUES CONTAIN MSCS? -- SKELETAL TISSUE REGENERATION BY MSCS -- IMMUNOMODULATORY EFFECTS OF MSCS -- NONSKELETAL TISSUE REGENERATION BY MSCS. , CONCLUSIONS -- REFERENCES -- Chapter 20. Hepatic Stem Cells: Lineage Biology and Pluripotency -- INTRODUCTION -- GENERAL ISSUES WITH RESPECT TO STEM CELLS AND MATURATIONAL LINEAGE BIOLOGY -- SOURCING OF HUMAN TISSUE -- THE LIVER AS A STEM CELL AND MATURATIONAL LINEAGE SYSTEM -- CLINICAL, COMMERCIAL, AND RESEARCH APPLICATIONS OF STEM CELLS (WITH A FOCUS ON LIVER) -- ETHICS AND LEGAL ISSUES IN THE USE OF STEM CELLS -- SUMMARY -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 21. Skeletal Muscle Stem Cells -- INTRODUCTION -- SKELETAL MUSCLE REQUIRES STEM CELL FUNCTION AFTER INJURY OR IN DISEASE -- MUSCLE STEM CELL CRITERIA -- HISTORICAL PERSPECTIVE ON MUSCLE STEM CELL BIOLOGY -- PUTATIVE MUSCLE STEM CELLS AND THEIR DEFINED CHARACTERISTICS -- MUSCLE STEM CELLS IN THEIR NATURAL ENVIRONMENTS IN VIVO -- THE MUSCLE STEM CELL NICHE -- CHALLENGES FACING THE POTENTIAL THERAPEUTIC USE OF MUSCLE STEM CELLS -- CONCLUSION -- REFERENCES -- Chapter 22. Islet Cell Therapy and Pancreatic Stem Cells -- INTRODUCTION -- BENEFITS OF & -- #946 -- -CELL REPLACEMENT THERAPY -- CURRENT LIMITATIONS TO & -- #946 -- -CELL REPLACEMENT THERAPY -- ALTERNATIVE SOURCES OF INSULIN-PRODUCING CELLS: STEM CELLS AND & -- #946 -- -CELL REGENERATION -- PANCREATIC DEVELOPMENT -- ISLET NEOGENESIS FROM ES CELLS -- ISLET NEOGENESIS FROM ADULT STEM CELLS -- TRANSDIFFERENTIATION -- WHAT THE FUTURE MAY HOLD -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 23. Regenerative Medicine for Diseases of the Retina -- INTRODUCTION -- EFTFs: SPECIFICATION OF THE EYE -- RETINAL PROGENITORS: FROM OPTIC CUP TO RETINA -- RETINAL STEM CELLS AND PERSISTENT PROGENITORS IN ADULT VERTEBRATES: THE CILIARY MARGINAL ZONE -- TRANSDIFFERENTIATION AND RETINAL REGENERATION -- CONCLUSION -- REFERENCES -- Chapter 24. Peripheral Blood Stem Cells -- INTRODUCTION -- TYPES AND SOURCE OF STEM CELLS IN THE PERIPHERAL BLOOD -- EPC. , MSC -- HSC -- THERAPEUTIC APPLICATIONS OF PERIPHERAL BLOOD STEM CELLS -- CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- Chapter 25. Prospects of Somatic Cell Nuclear Transfer-derived Embryonic Stem Cells in Regenerative Medicine -- INTRODUCTION -- BRIEF HISTORY -- STATE OF THE ART -- PROSPECTS AND CHALLENGES -- CONCLUSIONS AND FUTURE DIRECTIONS -- REFERENCES -- Chapter 26. Somatic Cells: Growth and Expansion Potential of T Lymphocytes -- INTRODUCTION -- T CELLS ARE KEY TO IMMUNITY TO INFECTIONS AND CANCER -- GROWTH AND EXPANSION POTENTIAL OF T CELLS -- CELL CULTURE MODELING OF T CELL REPLICATIVE SENESCENCE -- REPLICATIVE SENESCENCE ALSO AFFECTS GENE EXPRESSION AND FUNCTION -- SENESCENT CELLS ARE PRESENT IN VIVO -- SENESCENT CD8 T CELLS ARE ASSOCIATED WITH A VARIETY OF NEGATIVE HEALTH OUTCOMES -- RETARDING OR PREVENTING REPLICATIVE SENESCENCE IN AGING AND HIV DISEASE -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 27. Mechanical Determinants of Tissue Development -- INTRODUCTION -- MECHANICAL FORCES EXPERIENCED BY TISSUES -- THE CELL AS A SIGNAL RECEIVER AND PROCESSOR -- OVERVIEW OF BIOREACTORS -- PRACTICAL EXAMPLES OF MECHANICAL DETERMINANTS -- CONCLUSION -- REFERENCES -- Chapter 28. Morphogenesis and Morphogenetic Proteins -- INTRODUCTION -- BMPS -- STEM CELLS -- SCAFFOLDS OF BIOMIMETIC BIOMATERIALS -- CARTILAGE-DERIVED MORPHOGENETIC PROTEINS -- REGENERATIVE MEDICINE AND SURGERY -- ACKNOWLEDGEMENTS -- REFERENCES -- Chapter 29. Physical Stress as a Factor in Tissue Growth and Remodeling -- INTRODUCTION -- STRUCTURAL HIERARCHY AND THE CONTINUUM CONCEPT -- STRAIN AND STRESS DEFINITIONS -- TISSUE GROWTH, REPAIR, AND REMODELING -- MECHANOTRANSDUCTION MECHANISMS -- IN VITRO MECHANICAL CONDITIONING -- CONCLUSIONS -- REFERENCES -- Chapter 30. Engineering Cellular Microenvironments -- INTRODUCTION. , DEFINING THE CELLULAR MICROENVIRONMENT.

Note: Intro -- Timescales of Magmatic Processes From Core to Atmosphere -- Contents -- List of Contributors -- Introduction to the Timescales of Magmatic Processes -- 1 Extinct Radionuclides and the Earliest Differentiation of the Earth and Moon -- 2 Diffusion Constraints on Rates of Melt Production in the Mantle -- 3 Melt Production in the Mantle: Constraints from U-series -- 4 Formulations for Simulating the Multiscale Physics of Magma Ascent -- 5 Melt Transport from the Mantle to the Crust - Uranium-Series Isotopes -- 6 Rates of Magma Ascent: Constraints from Mantle-Derived Xenoliths -- 7 Time Constraints from Chemical Equilibration in Magmatic Crystals -- 8 Magma Cooling and Differentiation - Uranium-series Isotopes -- 9 Defining Geochemical Signatures and Timescales of Melting Processes in the Crust: An Experimental Tale of Melt Segregation, Migration and Emplacement -- 10 Timescales Associated with Large Silicic Magma Bodies -- 11 Timescales of Magma Degassing -- Index.

Note: Intro -- CONTENTS -- LIST OF CONTRIBUTORS -- LIST OF TABLES -- LIST OF FIGURES -- 1 Introduction -- BACKGROUND -- 2 Whales, Interaction Webs, and Zero-Sum Ecology -- 3 Lessons From Land: Present and Past Signs of Ecological Decay and the Overture to Earth's Sixth Mass Extinction -- 4 When Ecological Pyramids Were Upside Down -- 5 Pelagic Ecosystem Response to a Century of Commercial Fishing and Whaling -- 6 Evidence for Bottom-Up Control of Upper-Trophic-Level Marine Populations: Is it Scale-Dependent? -- WHALES AND WHALING -- 7 Evolutionary Patterns in Cetacea: Fishing Up Prey Size through Deep Time -- 8 A Taxonomy of World Whaling: Operations and Eras -- 9 The History of Whales Read from DNA -- 10 Changes in Marine Mammal Biomass in the Bering Sea/Aleutian Islands Region before and after the Period of Commercial Whaling -- 11 Industrial Whaling in the North Pacific Ocean 1952-1978: Spatial Patterns of Harvest and Decline -- 12 Worldwide Distribution and Abundance of Killer Whales -- 13 The Natural History and Ecology of Killer Whales -- 14 Killer Whales as Predators of Large Baleen Whales and Sperm Whales -- PROCESS AND THEORY -- 15 Physiological and Ecological Consequences of Extreme Body Size in Whales -- 16 Ecosystem Impact of the Decline of Large Whales in the North Pacific -- 17 The Removal of Large Whales from the Southern Ocean: Evidence for Long-Term Ecosystem Effects? -- 18 Great Whales as Prey: Using Demography and Bioenergetics to Infer Interactions in Marine Mammal Communities -- 19 Whales and Whaling in the North Pacific Ocean and Bering Sea: Oceanographic Insights and Ecosystem Impacts -- 20 Legacy of Industrial Whaling: Could Killer Whales be Responsible for Declines of Sea Lions, Elephant Seals, and Minke Whales in the Southern Hemisphere? -- 21 Predator Diet Breadth and Prey Population Dynamics: Mechanism and Modeling. , 22 Bigger Is Better: The Role of Whales as Detritus in Marine Ecosystems -- CASE STUDIES -- 23 Gray Whales in the Bering and Chukchi Seas -- 24 Whales, Whaling, and Ecosystems in the North Atlantic Ocean -- 25 Sperm Whales in Ocean Ecosystems -- 26 Ecosystem Effects of Fishing and Whaling in the North Pacific and Atlantic Oceans -- 27 Potential Influences of Whaling on the Status and Trends of Pinniped Populations -- SOCIAL CONTEXT -- 28 The Dynamic Between Social Systems and Ocean Ecosystems: Are There Lessons from Commercial Whaling? -- 29 Whaling, Law, and Culture -- OVERVIEW AND SYNTHESIS -- 30 Whales Are Big and It Matters -- 31 Retrospection and Review -- INDEX -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- Y -- Z.

Note: Cover -- Half Title Page, About the Series, Title Page, Copyright -- Contents -- Acknowledgments -- Editors' Introduction: A Language for Our Biotechnological Future: Rhetoric, Religion,Science, and Ethics -- 1. Faith in Science: Professional and Public Discourse on Regenerative Medicine -- 2. From Arrowsmith to Atwood: How Did We Cometo Disrespect Science? -- 3. The "Warfare" of Science and Religion and Science's Ethical Profile -- 4. Is There a Human Nature? An Argument Against Modern Excarnation -- 5. Crossing Frontiers of Science: Trespassing into a Godless Space or Fulfilling Our Manifest Destiny? -- 6. The Angels and Devils of Representing Prozac -- 7. "Leave your Medicine Outside": Bioethics, Spirituality, and the Rhetoric of Appalachian Serpent Handlers -- 8. Biovaluable Stories and a narrative Ethics of Reconfigurable Bodies -- 9. Blacks and the Language of Their Biotechnological Future -- 10. Bioethics, Economism, and the Rhetoric of Technological Innovation -- 11. Technologies of the Self at the End of Life: Pastoral Power and the Rhetoric of Advance Care Planning -- 12. Suffering and the Rhetoric of Care -- Notes -- Bibliography -- Contributors -- index.

Note: Intro -- DRUG-INDUCED MITOCHONDRIAL DYSFUNCTION -- CONTENTS -- CONTRIBUTORS -- PREFACE -- PART I BASIC CONCEPTS -- 1 Basic Mitochondrial Physiology in Cell Viability and Death -- 2 Basic Molecular Biology of Mitochondrial Replication -- 3 Drug-Associated Mitochondrial Toxicity -- 4 Pharmacogenetics of Mitochondrial Drug Toxicity -- PART II ORGAN DRUG TOXICITY: MITOCHONDRIAL ETIOLOGY -- 5 Features and Mechanisms of Drug-Induced Liver Injury -- 6 Cardiovascular Toxicity of Mitochondrial Origin -- 7 Skeletal Muscle and Mitochondrial Toxicity -- 8 Manifestations of Drug Toxicity on Mitochondria in the Nervous System -- 9 Lipoatrophy and Other Manifestations of Antiretroviral Therapeutics -- 10 Nephrotoxicity -- 11 Drug Effects in Patients with Mitochondrial Diseases -- PART III ASSESSMENT OF MITOCHONDRIAL FUNCTION IN VITRO AND IN VIVO -- 12 Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function -- 13 Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function -- 14 Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons -- 15 Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo -- 16 OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels -- 17 Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition -- 18 Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum -- 19 Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening -- 20 Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis. , 21 Clinical Assessment of Mitochondrial Function via [(13)C]Methionine Exhalation -- 22 Assessment of Mitochondrial Dysfunction by Microscopy -- 23 Development of Animal Models of Drug-Induced Mitochondrial Toxicity -- 24 Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy -- 25 Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations -- INDEX.

Note: FrontMatter -- Reviewers -- Contents -- Acronyms -- Letter Report -- REFERENCES -- Appendix A: Workshop Agenda and List of Participants -- Appendix B: Committee Biosketches.

Note: Front Cover -- The Role of Water in Agriculture -- Copyright Page -- Table of Contents -- Preface -- List of Publications (July, 1969) -- List of Figures -- List of Authors -- CHAPTER I. Definite rainfall measurements and their significance for Agriculture -- REFERENCES -- CHAPTER II. Sources of error in Agricultural water budgets -- 1. Introduction -- 2. Identifying the sources of error -- 3. Accidental errors -- 4. Systematic errors -- 5. Conclusion -- REFERENCES -- CHAPTER III. Evapotranspiration and the water balance in a small clay catchment -- INSTRUMENTATION AND EXPERIMENTAL DESIGN -- THE APPLICATION OF THE WATER BALANCE EQUATION -- Conclusions -- Acknowledgements -- REFERENCES -- CHAPTER IV. Variations in sediment production from three East Yorkshire catchments -- Techniques and Methods -- The Hodge Beck Catchment -- The Catchment Drain Catchment -- The Drewton Beck Catchment -- The Hodge Beck Catchment -- The Catchwater Drain Catchment -- Drewton Beck -- Conclusion -- Acknowledgements -- REFERENCES -- CHAPTER V. Sediment yields from Forested and Agricultural lands -- SEDIMENT YIELDS FROM BRITISH AGRICULTURAL AND FORESTED LANDS -- EVALUATION OF SEDIMENT YIELDS -- CONCLUSIONS -- REFERENCES -- CHAPTER VI. The effect of Agricultural treatment on quantity of water available in the soil -- Introduction -- Techniques -- Results -- Discussion and Conclusions -- Acknowledgements -- REFERENCES -- CHAPTER VII. The current trends in the use of water for Agriculture -- Uses other than for irrigation Quantities -- Quality of water -- Sources of water -- Future prospects -- Irrigation Development -- Irrigation water requirements -- Quality of water -- The Water Resources Act, 1963 -- Irrigation economics -- Charges for water - River Authorities -- Charges for public water supply -- Future prospects -- REFERENCES. , CHAPTER VIII. The water requirements of particular stock producing systems -- 1. Water required for drinking -- 2. Water required for production of stock feed -- 3. Water required for cleansing -- Conclusions -- REFERENCES -- CHAPTER IX. Water resource management and the needs of Agriculture -- Introduction -- Recent trends in water consumption -- The available resources -- Conservation and the Water Resources Act, 1963 -- Water resources and changing technology -- The problem of irrigation -- REFERENCES -- CHAPTER X. Limited Irrigation in crop production -- The need for limited irrigation -- Response of crops to limited irrigation -- The mechanism of the responses to altered water supply -- The limitation of water-need -- Results obtained by limited irrigation -- Irrigation in the future -- REFERENCES -- CHAPTER XI. The cumulative effects of irrigation on fruit crops -- Soft fruits -- Top fruit -- Discussion -- REFERENCES -- CHAPTER XII. Estimates of long-term irrigation needs -- Introduction -- Methods of obtaining estimates of long-term irrigation needs -- Use of the maps -- Discussion of accuracy and possible errors -- Acknowledgment -- REFERENCES -- CHAPTER XIII. The flexibility of land-use in relation to the water balance -- REFERENCES -- CHAPTER XIV. Edited summary of the discussions:conclusions and implications -- II IMPLICATIONS AND CONCLUSIONS -- REFERENCES -- LIST OF DISCUSSANTS -- Author Index -- Subject Index.