ISSN:
1573-9031
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Conclusions 1. Comparative study of the pharmacokinetics of HCA from a suspension and foam during rectal and intramuscular administration to rabbits showed that only the foam preparation introduced rectally ensures continuous and prolonged absorption of HCA from the foam for 5–6 h into the systemic blood flow and a considerable accumulation of HCA in the rectal tissue for the same period of time, and also the maximal degree of absorption of HCA (AUC0–8) in comparison with other forms due to prolonged action. 2. For prolonged accumulation of HCA in the rectal tissue, the content of PG in the foam emulsions should not exceed 15–20%. The PG may serve as a modulator of the bioavailability of foam preparations in aerosol packings containing corticosteroids.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00780575
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