ISSN:
1573-2568
Keywords:
zinc
;
zincl-carnosine
;
gastric mucosa
;
prostaglandin
;
indomethacin
;
cytoprotection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The effects of zincl-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosain vivo andin vivo. When given either intragastrically or intraperitoneally, zincl-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zincl-carnosine was not inhibited by indomethacin. Histological assessment showed that zincl-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl-prostaglandin E2. Zincl-carnosine (10−6 or 10−5 M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosain vivo; this effect was not inhibited by indomethacin. The results suggested that zincl-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01540402
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