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  • 1
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    White Blood Cell Count and Risk of Gastric Cancer Incidence in a General Japanese Population: The Hisayama Study (2012)
    Oxford University Press
    Details
    Publication Date: 2012-04-03
    Description: The authors examined the association between white blood cell (WBC) count and the development of gastric cancer in a 19-year follow-up study of 2,558 Japanese subjects aged ≥40 years (1988–2007). The subjects were stratified into 4 groups according to baseline WBC quartile (≤4.4, 4.5–5.2, 5.3–6.3, or ≥6.4 x 10 3 cells/μL). During follow-up, 128 subjects developed gastric cancer. The age- and sex-adjusted incidence of gastric cancer increased linearly with higher WBC level: 1.7, 2.6, 3.9, and 5.4 per 1,000 person-years, respectively, for the 4 quartile groups ( P for trend 〈 0.01). The risk of gastric cancer was 2.22-fold (95% confidence interval: 1.19, 4.14) higher in the highest WBC quartile group than in the lowest group after adjustment for confounding factors. With respect to Helicobacter pylori infection status, H. pylori -seropositive subjects in the highest WBC quartile group showed a significantly greater risk of gastric cancer than those in the lower 3 quartile groups, whereas such an association was not observed in H. pylori -seronegative subjects. There was no evidence of heterogeneity in the association ( P for heterogeneity = 0.65). The study findings suggest that higher WBC levels are a risk factor for gastric cancer, especially in subjects with H. pylori infection.
    Print ISSN: 0002-9262
    Electronic ISSN: 1476-6256
    Topics: Medicine
    Published by Oxford University Press
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  • 2
    Electronic Resource
    Electronic Resource
    Modulated photoconductivity study of electron drift mobility in amorphous silicon (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 2901-2909 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The modulated photoconductivity technique, a convenient means of measuring the drift mobility of photocarriers, has been applied to investigate carrier transport in hydrogenated amorphous silicon. The frequency resolved spectra of drift mobility that can be obtained from the measurements were analyzed in accordance with a generalized transport model that included possible carrier interactions between localized states through tunneling transitions. Theory suggests that a tunneling-assisted thermalization of nonequilibrium carriers appreciably affects the transport process. The experimental results are reasonably accounted for by the introduced model, leading to quantitative assessments for transport mechanisms. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372275
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  • 3
    Electronic Resource
    Electronic Resource
    Electron field emission from diamond-like carbon films deposited by electrolysis of methanol liquid (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 75 (1999), S. 2331-2333 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Electron field emission has been studied with diamond-like carbon (DLC) films deposited from a liquid phase. The DLC films were deposited on Si substrate by electrolysis of methanol liquid. The field emission measurements were carried out with a parallel plate configuration using the deposited DLC films on Si substrate as a cathode, and an indium tin oxide (ITO) coated glass plate as an anode. We found several bright spots on a luminescent screen mounted on the ITO anode, indicating that the electrons are emitted from the isolated emission sites on the deposited DLC film. The emission current density is more than 10−7 A/cm2 at the electric field as low as 1.2 V/μm. This result suggests that the DLC film deposited from the liquid phase has a potential advantage for field emitter applications. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.125006
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  • 4
    Electronic Resource
    Electronic Resource
    Sawtooth stabilization by localized electron cyclotron heating in the WT-3 tokamak (1992)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 4 (1992), S. 3675-3688 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effect on sawtooth oscillations (STO) by localized electron-cyclotron-resonance heating (ECH) on the WT-3 tokamak [Plasma Physics and Controlled Nuclear Fusion Research, 1988 (International Atomic Energy Agency, Vienna, 1989), Vol. 1, p. 563] is studied. STO are strongly modified or stabilized by ECH near the q=1 surface, where q refers to the safety factor. The effect of ECH is much stronger when it is applied on the high-field side as compared to the low-field side. Further, even when ECH is applied outside the q=1 surface, the amplitude of STO decreases and STO stabilizes. In the very high qL discharge, the excitation of STO can be obtained by applying ECH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.860375
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  • 5
    Electronic Resource
    Electronic Resource
    Sawtooth stabilization by electron cyclotron heating at the q=1 surface in the WT-3 tokamak (1991)
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 3 (1991), S. 2200-2204 
    Details
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Sawtooth oscillations (STO) in the Ohmically heated (OH) WT-3 tokamak [Plasma Physics and Controlled Nuclear Fusion Research 1988 (IAEA, Vienna, 1989), Vol. 1, p. 563] are strongly modified or suppressed by localized electron cyclotron resonance heating (ECH) near the q=1 surface, where q refers to the safety factor. The effect of ECH is much stronger when it is applied on the high-field side, as compared to the low-field side. Complete suppression of the STO is achieved for the duration of the ECH when it is applied on the high-field side, in a low-density plasma, provided the ECH power exceeds a threshold value. This threshold decreases with the increasing safety factor at the limiter qL and the complete stabilization of STO can be obtained even when ECH is applied on the low-field side in the high-qL region. It is noticeable that these complete stabilizations can be obtained only by the localized ECH with the elliptic antenna. The STO stabilization is attributed to a modification of the current density profile by high-energy electrons generated by ECH, which reduces the shear in the q=1 region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.859636
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  • 6
    Electronic Resource
    Electronic Resource
    Human mast cell progenitors in peripheral blood from atopic subjects with high IgE levels. (2001)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 31 (2001), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background It remains unclear whether the number of circulating mast cell progenitors is increased in patients with atopic diseases. Distinct genotypes are reported to affect mast cell/basophil activation.Objective We compared the number and function of mast cell progenitors present in the peripheral blood from donors with normal IgE (IgE 〈 400 U/mL) and those with atopic dermatitis accompanied by high serum IgE (IgE 〉 5000 U/mL).Methods Purified peripheral blood cells were cultured in serum-free methylcellulose containing stem cell factor (SCF), IL-6 plus IL-3. Fresh methylcellulose containing the cytokines was layered over every 2 weeks. The cultured mast cells were retrieved from the methylcellulose and were functionally analysed.Results Mast cell colonies were distinguished at 6 weeks of culture as other colony types had been degenerated. The number of mast cell colony-forming cells varied depending on donors and was not significantly increased in peripheral blood from the hyper-IgE atopic patients. A significant inversed correlation was found between the number of mast cells per one colony and the ages of donors. The cultured mast cells derived from atopic patients and those from normal IgE donors equally expressed FcεRI and released histamine through FcεRI, although IL-4 priming in vitro markedly enhanced the function of mast cells regardless of donors.Conclusions These results indicate that the number of circulating mast cell progenitors may be regulated by unknown individual factors unrelated to IgE levels. Mast cell function may be regulated largely by environmental factors, such as IL-4, but not determined by their progenitors' genotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2001.01181.x
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  • 7
    Electronic Resource
    Electronic Resource
    Relationship between obesity, glucose tolerance, and periodontal disease in Japanese women: the Hisayama study (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of periodontal research 40 (2005), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Recent studies have reported a relationship between obesity and periodontal disease. Obesity is the strongest risk factor for type 2 diabetes, which is, in turn, a risk factor for periodontal disease. An oral glucose tolerance test is necessary to diagnose diabetes; however, no study has examined the relationship between obesity and periodontal disease by taking oral glucose tolerance test results into consideration.Methods:  In all, 584 Japanese women aged between 40 and 79 years old, with at least 10 teeth, underwent health examinations. Body mass index, waist–hip ratio, body fat, and oral glucose tolerance test results were used as independent variables with known risk factors for periodontal disease. Mean probing pocket depth and mean attachment loss were used as the dependent variables.Results:  In all of the analyses, body mass index, body fat, and waist–hip ratio were significantly associated with the highest quintile of mean probing pocket depth, even when adjusted for oral glucose tolerance test results. In the multivariate analysis, the subjects with the highest quartile of body mass index had a significantly higher odds ratio (OR) for the highest quintile of mean probing pocket depth [OR, 4.3; 95% confidence interval (CI), 2.1–8.9; p 〈 0.001], whereas neither impaired glucose tolerance nor diabetes were significantly associated with deep pockets. The relationships between the obesity indexes and mean attachment loss did not reach statistical significance.Conclusion:  Obesity was associated with deep pockets in Japanese women, even after adjusting for oral glucose tolerance test.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.2005.00813.x
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  • 8
    Electronic Resource
    Electronic Resource
    Mucosal proinflammatory cytokine and chemokine expression of gastroduodenal lesions in Crohn's disease (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  The stomach and the duodenum are frequent sites of involvement by diminutive lesions in Crohn's disease (CD).Aim:  To assess mucosal proinflammatory cytokines and chemokines in gastroduodenal lesions of CD.Methods:  13C-Urea breath test and upper endoscopy were performed in 29 CD patients and seven control subjects, and biopsy specimens were obtained from the gastric cardia and the duodenum. Histology and mucosal levels of IL-1β, IL-8/CXCL8 and RANTES/CCL5 were assessed and compared according to the presence of gastric cardial lesion [bamboo joint-like appearance (BJA)] and duodenal lesion (notched appearance, aphthous erosion and polypoid lesion). In 11 CD patients, these procedures were repeatedly performed after administration of famotidine.Results:  H. pylori was less frequently positive in CD patients than in controls (10% vs. 71%, P = 0.003). Prevalence of cardial and duodenal lesion was significantly higher in CD than in controls (59% vs. 0%, P = 0.008 for gastric lesion; 45% vs. 0%, P =0.034 for duodenal lesion). There were no differences in IL-1β, IL-8 and RANTES between CD and controls. Duodenal mucosal IL-1β and IL-8 were significantly higher in positive duodenal lesion than in negative duodenal lesion. However, there were no such differences with respect to cardial lesions. Endoscopic findings remained unchanged after administration of famotidine, while there was a trend towards decreases in IL-1β and IL-8 in the gastric cardia.Conclusions:  The pathogenesis of diminutive lesions of CD may be different between the stomach and the duodenum. Famotidine may not have a therapeutic effect on duodenal lesion in CD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02480.x
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  • 9
    Electronic Resource
    Electronic Resource
    Lipopolysaccharide Primes Human Basophils for Enhanced Mediator Release: Requirement for Plasma Co-factor and CD14
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 203 (1994), S. 1295-1301 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1994.2323
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  • 10
    Electronic Resource
    Electronic Resource
    1H-Tetrazol-5(4H)-one (1998)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 1160-1162 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270198002108
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