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  • 1
    Electronic Resource
    Electronic Resource
    Measurement of AlInAsSb/GaInAsSb heterojunction band offset by photoluminescence spectroscopy (1999)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 75 (1999), S. 238-240 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have grown unstrained Al0.66In0.34As0.85Sb0.15/Ga0.64In0.36As0.84Sb0.16 multiple-quantum-well (MQW) structures on InP substrates by metalorganic vapor phase epitaxy. Low-temperature photoluminescence was performed for these MQW structures. By comparing the luminescence peak energies with the theoretical calculations, we estimated the conduction-band offset ratio to be 0.75±0.10 for the Al0.66In0.34As0.85Sb0.15/Ga0.64In0.36As0.84Sb0.16 heterostructure. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.124334
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    One-pot selective deuteriation of 5'-dimethoxytritylated deoxynucleotide derivatives.
    Amsterdam : Elsevier
    Bioorganic & Medicinal Chemistry Letters 4 (1994), S. 789-794 
    Details
    ISSN: 0960-894X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0960-894X(01)80849-0
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  • 3
    Electronic Resource
    Electronic Resource
    Application of the CMT algorithm to analog recordings of deep earthquakes
    Amsterdam : Elsevier
    Physics of the Earth and Planetary Interiors 83 (1994), S. 283-297 
    Details
    ISSN: 0031-9201
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0031-9201(94)90094-9
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A study of self-consistent particle and quasiparticle equations of motion
    Amsterdam : Elsevier
    Nuclear Physics, Section A 164 (1971), S. 422-438 
    Details
    ISSN: 0375-9474
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0375-9474(71)90226-0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A simple, sensitive, non-stimulated photon counting system for detection of superoxide anion in whole blood (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 141-144 
    Details
    ISSN: 1420-9071
    Keywords: Superoxide ; free radical ; reactive oxygen species ; chemiluminescence ; pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A simple, sensitive, non-stimulated assay was developed to measure the superoxide anion concentration in whole blood, using an ultra-sensitive chemiluminescence (CL) analyzer, and lucignin amplification. The assay system can be performed without leukocyte isolation or stimulant administration. The blood CL levels of healthy males (362.8±337.7 counts/10 sec) were not different from those of females (335±308.7 counts/10 sec) (p=0.64), whereas the CL levels in whole blood in patients with acute pancreatitis (2522±2014 counts/10 sec) were significantly higher than those of healthy controls (p〈0.001). This assay system may be valuable in the future for quantitative measurement of reactive oxygen species in various disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923359
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  • 6
    Electronic Resource
    Electronic Resource
    Reduction of calcium excretion in the stone-forming kidney in unilateral ureteral obstruction (1991)
    Springer
    Urological research 19 (1991), S. 193-198 
    Details
    ISSN: 1434-0879
    Keywords: Urolthiasis ; Obstructive uropathy ; Percutaneous nephrostomy ; Hypercalciuria ; Creatinine clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen urolithiasis patients with unilateral obstructive uropathy were treated with percutaneous nephrostomy (PCN) either for urinary diversion, endopyelotomy, nephrolithtotmy or chemolysis. After percutaneous nephrostomy, the indvidual urine volume, creatinine clearance (Ccr), urinary absolute and fractional excretions of sodium, potassium, calcium, magnesium and inorganic phosphate were measured separately in timed urine collections from a pigtail catheter and from the urethra. The data showed that Ccr and the absolute urinary excretions of sodium, potassium, calcium, magnesium and inorganic phosphate were significantly lower in the PCN kidney immediately or 2 days after relief of obstruction. The ratio of total urinary calcium excretion to urinary creatinine excretion in the obstructed kidney was significantly greater than that in the contralateral kidney. The fractional excretions of calcium and magnesium increased as renal function decreased. The results showed that when the total Ccr is below normal, the apparent excretion of urinary calcium will be underestimated. However, when the total Ccr of patients is within normal range, hypercalciuria may be detected adequately and thus favors early implementation of an appropriate therapeutic strategy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303749
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  • 7
    Electronic Resource
    Electronic Resource
    Menadione-induced cytotoxicity to rat osteoblasts (1997)
    Springer
    Cellular and molecular life sciences 53 (1997), S. 967-976 
    Details
    ISSN: 1420-9071
    Keywords: Key words. Menadione; oxidative stress; osteoblasts; superoxide dismutase (SOD); catalase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Oxygen-derived free radical injury has been associated with several cytopathic conditions. Oxygen radicals produced by chondrocytes is an important mechanism by which chondrocytes induce matrix degradation. In the present study, we extend these observations by studying oxidative processes against osteoblasts. Osteoblasts were mixed in in vitro culture with 200 μM menadione. The cytotoxic effect of menadione-induced oxidative stress was monitored by lucigenin- or luminol-amplified chemiluminescence, tetrazolium assay and immunocytochemical study. Results showed that adding menadione induces an oxidative stress on osteoblasts, via superoxide and hydrogen peroxide production, that can be eradicated by superoxide dismutase (SOD) and catalase in a dose-dependent manner. Catalase and the appropriate concentration of dimethyl sulfoxide have a protective effect on cytotoxicity induced by menadione, whereas SOD does not. Menadione-treated osteoblasts have a strong affinity for annexin V, and the nuclei are strongly stained by TUNEL (TdT-mediated dUTP nick-end labelling). The results suggest that menadione-triggered production of reactive oxygen species leads to apoptosis of osteoblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050118
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  • 8
    Electronic Resource
    Electronic Resource
    Early third-stage larvae of Gnathostoma hispidum in cyclops (1987)
    Springer
    Parasitology research 74 (1987), S. 69-72 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Surface structures of the early third-stage larae were examined by scanning electron microscopy. There were hemispherical head-bulbs at the apical ends. These bulbs could be clearly distinguished from the bodies. The head-bulbs (52 × 29 Μm) had four transverse rows of sharp booklets. The number of booklets in each row was 37, 36, 38, and 43, posteriorly. The larvae possessed a pair of lateral lips in the head-bulb. Each of the lips had two labial papillae and an amphid between the papillae. Small unidentate cuticular spines were present along the entire length of larvae on their transverse striations. The number of these cuticular striations was 175–217. A pair of cervical papillae and an excretory pore were present on the anterior part of the body. Another pair of papillae was detected laterally on the posterior one-third of the body. The shape of the posterior body papillae resembled that of cervical papillae. The cuticular spines were absent around the anus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00534935
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  • 9
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    Inhibiting Glycogen Synthase Kinase-3 Decreases 12-O-Tetradecanoylphorbol-13-Acetate-Induced Interferon-{gamma}-Mediated Skin Inflammation [Inflammation, Immunopharmacology, and Asthma] (2012)
    The American Society for Pharmacology and Experimental Therapeutics
    Details
    Publication Date: 2012-09-15
    Description: Glycogen synthase kinase-3 (GSK-3) facilitates interferon (IFN)- signaling. Because IFN- is involved in inflammatory skin diseases, such as psoriasis, the aim of this study was to investigate the pathogenic role of GSK-3 in 12- O -tetradecanoylphorbol-13-acetate (TPA)-induced IFN--mediated ear skin inflammation. TPA (3 μg per ear) induced acute skin inflammation in the ears of C57BL/6 mice, including edema, infiltration of granulocytes but not T cells, and IFN- receptor 1-mediated deregulation of intercellular adhesion molecule 1 (CD54). TPA/IFN- induced GSK-3 activation, which in turn activated signal transducer and activator of transcription 1. Inhibiting GSK-3 pharmacologically, by administering 6-bromoindirubin-3'-oxime (1.5 μg per ear), and genetically, with lentiviral-based short-hairpin RNA, reduced TPA-induced acute skin inflammation but not T-cell infiltration. It is noteworthy that inhibiting GSK-3 decreased TPA-induced IFN- production and the nuclear translocation of T-box transcription factor Tbx21, a transcription factor of IFN-, in CD3-positive T cells. In chronic TPA-induced skin inflammation, inhibiting GSK-3 attenuated epidermis hyperproliferation and dermis angiogenesis. These results demonstrate the dual role of GSK-3 in TPA-induced skin inflammation that is not only to facilitate IFN- signaling but also to regulate IFN- production. Inhibiting GSK-3 may be a potential treatment strategy for preventing such effects.
    Print ISSN: 0022-3565
    Electronic ISSN: 1521-0103
    Topics: Medicine
    Published by The American Society for Pharmacology and Experimental Therapeutics
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  • 10
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    Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies (2012)
    Oxford University Press
    Details
    Publication Date: 2012-04-06
    Description: Although formation of urothelial carcinoma of the bladder (UCB) requires multiple steps and proceeds along divergent pathways, the underlying genetic and molecular determinants for each step and pathway remain undefined. By developing transgenic mice expressing single or combinatorial genetic alterations in urothelium, we demonstrated here that overcoming oncogene-induced compensatory tumor barriers was critical for urothelial tumor initiation. Constitutively active Ha-ras (Ras*) elicited urothelial hyperplasia that was persistent and did not progress to tumors over a 10 months period. This resistance to tumorigenesis coincided with increased expression of p53 and all pRb family proteins. Expression of a Simian virus 40 T antigen (SV40T), which disables p53 and pRb family proteins, in urothelial cells expressing Ras* triggered early-onset, rapidly-growing and high-grade papillary UCB that strongly resembled the human counterpart (pTaG3). Urothelial cells expressing both Ras* and SV40T had defective G 1 /S checkpoint, elevated Ras-GTPase and hyperactivated AKT-mTOR signaling. Inhibition of the AKT-mTOR pathway with rapamycin significantly reduced the size of high-grade papillary UCB but hyperactivated mitogen-activated protein kinase (MAPK). Inhibition of AKT-mTOR, MAPK and STAT3 altogether resulted in much greater tumor reduction and longer survival than did inhibition of AKT-mTOR pathway alone. Our studies provide the first experimental evidence delineating the combinatorial genetic events required for initiating high-grade papillary UCB, a poorly defined and highly challenging clinical entity. Furthermore, they suggest that targeted therapy using a single agent such as rapamycin may not be highly effective in controlling high-grade UCB and that combination therapy employing inhibitors against multiple targets are more likely to achieve desirable therapeutic outcomes.
    Print ISSN: 0143-3334
    Electronic ISSN: 1460-2180
    Topics: Medicine
    Published by Oxford University Press
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