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  • 1
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    Time-Degenerative Factors and the Risk of Hepatocellular Carcinoma after Antiviral Therapy among Hepatitis C Virus Patients: A Model for Prioritization of Treatment (2017)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2017-04-04
    Description: Purpose: Age and hepatic fibrosis are the factors that increase the risk of hepatocellular carcinoma over time. We aimed to explore their impact at the initiation of antiviral therapy on hepatocellular carcinoma among chronic hepatitis C (CHC) patients. Experimental Design: A total of 1,281 biopsy-proven CHC patients receiving IFN-based therapy were followed for a mean period of 5.5 years. Results: The 5-year cumulative incidence of hepatocellular carcinoma did not differ between non–sustained virological response (SVR) and SVR patients who were 〈40 years old (7.7% vs. 0.5%, P = 0.1) but was significantly higher in non-SVR patients between 40 and 55 years old (18.0% vs. 1.3%, P 〈 0.001) and 〉55 years old (15.1% vs. 7.9%, P = 0.03). Compared with SVR, non-SVR was independently predictive of hepatocellular carcinoma in patients 40 to 55 years old [HR/95% confidence intervals (CI), 10.92/3.78–31.56; P 〈 0.001] and 〉55 years old (HR/CI, 1.96/1.06–3.63; P = 0.03) but not in patients 〈40 years old (HR/CI, 2.76/0.41–18.84; P = 0.3). The 5-year cumulative incidence of hepatocellular carcinoma did not differ between non-SVR and SVR patients whose fibrosis stage was F0–1 (4.6% vs. 1.9%, P = 0.25) but was higher in non-SVR patients with F2–3 (21.4% vs. 4.3%, P 〈 0.001) or F4 (33.5% vs. 8.4%, P = 0.002). Compared with SVR, non-SVR was independently predictive of hepatocellular carcinoma in patients with F2–3 (HR/CI, 4.36/2.10–9.03; P 〈 0.001) and F4 (HR/CI, 3.84/1.59–9.30; P = 0.03) but not in those with F0–1 (HR/CI, 1.53/0.49–4.74; P = 0.47). Conclusions: Delayed hepatitis C virus clearance for patients with CHC 〉40 years old or with a fibrosis stage 〉2 increases the risk of hepatocellular carcinoma over time. Clin Cancer Res; 23(7); 1690–7. ©2016 AACR .
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Nail infestation by Liposcelis bostrychophila Badonnel (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical and experimental dermatology 29 (2004), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report an unusual case of nail infestation by Liposcelis bostrychophila Badonnel in a 70-year-old woman with onychomycosis. Liposcelis spp., also known as booklouse, are tiny insects that feed on fungi, lichen and decaying materials. In this case, the loosened hyperkeratotic nail provided a favourable environment for these insects. This is the second report of human infestation by Liposcelis spp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.2004.01609.x
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  • 3
    Electronic Resource
    Electronic Resource
    Structure of [(1RS,4RS,7RS,8SR,11SR,14SR)-1,4,5,5,7,8,11,12,12,14-decamethyl-1,4,8,11-tetraazacyclotetradecane]nickel(II) perchlorate (1986)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 42 (1986), S. 1001-1004 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S010827018609371X
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  • 4
    Electronic Resource
    Electronic Resource
    Structure of [N,N'-bis(3-aminopropyl)-1,2-ethanediamine]perchloroatocopper(II) perchlorate hemihydrate (1986)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 42 (1986), S. 1316-1319 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270186092430
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  • 5
    Electronic Resource
    Electronic Resource
    Accurate determination of log k'"w in reversed-phase liquid chromatography - Implications for quantitative structure-retention relationships
    Amsterdam : Elsevier
    Journal of Chromatography A 631 (1993), S. 63-78 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0021-9673(93)80507-5
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  • 6
    Electronic Resource
    Electronic Resource
    Analysis of the N-Terminal Leucine Heptad and Hexad Repeats of Sigma 54
    Amsterdam : Elsevier
    Journal of Molecular Biology 239 (1994), S. 15-24 
    Details
    ISSN: 0022-2836
    Keywords: hydrophobic heptad repeats ; sigma 54
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/jmbi.1994.1347
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  • 7
    Electronic Resource
    Electronic Resource
    Improvement of health outcomes after continued implementation of a clinical pathway for radical nephrectomy (2000)
    Springer
    World journal of urology 18 (2000), S. 417-421 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The clinical pathway is an important tool for outcome management. We evaluated the overall effects of the continued implementation of a clinical pathway for radical nephrectomy on the length of hospital stay, admission charges, and the quality of medical care. The data obtained from the second-year implementation (group 3) of the clinical pathway were compared with the data from the first-year implementation (group 2) and the year preceding implementation (group 1). Thirty-seven consecutive patients with renal cell carcinoma underwent radical nephrectomy in group 1, 47 in group 2, and 55 in group 3; all were enrolled in this study. The length of hospital stay, average admission charges, and 8 quality indicators were measured in these patients. We also evaluated the variances in the implementation of the clinical pathway. The mean length of stay decreased by 14.0% (P=0.0048) in group 2, and by 15.8% (P=0.0014) in group 3, when compared to group 1. The total admission charges significantly decreased by 19.0% (P=0.001) in group 2, and by 27.9% (P 〈 0.0001) in group 3, compared to the charges for group 1. A continued decrease in charges for operation and anesthesia, laboratory, pharmacy, and others were found 2 years after implementation of the clinical pathway. Among the 8 quality indicators, 2 were continuously improved in the second-year implementation of the clinical pathway, 2 were improved significantly in the second-year implementation only, and 4 showed no significant change at all. Variances from the clinical pathway decreased significantly after continued implementation. Continued implementation of the clinical pathway for radical nephrectomy can improve a physician's practice continuously by decreasing the length of hospital stay, admission charges, and variances, and by improving quality. However, the improved results after implementation of the clinical pathway should be maintained carefully to assure good health care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003450000158
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  • 8
    Electronic Resource
    Electronic Resource
    Neuronal and endothelial nitric oxide synthase expression in outer medulla of streptozotocin-induced diabetic rat kidney (2000)
    Springer
    Diabetologia 43 (2000), S. 649-659 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Nitric oxide ; neuronal nitric oxide synthase ; endothelial nitric oxide synthase ; diabetic kidney ; outer medulla ; renin ; angiotensinogen.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Several investigations have shown that the renal medulla has a greater capacity to generate nitric oxide than the renal cortex. To further evaluate the changes of nitric oxide synthesis in the kidney, particularly in the outer medulla, in disorders involving fluid and electrolyte imbalances, we sought to determine renal nitric oxide synthase expression in the diabetic rats. Methods. We determined renal nitric oxide synthase mRNA and urinary nitrite/nitrate excretion in 12 normal and 12 streptozotocin-induced diabetic rats by reverse transcription-polymerase chain reaction with Southern blot hybridization and with Griess reaction, respectively. Nitric oxide synthase immunoreactivity was detected by immunohistochemistry in four normal and four diabetic rats. Results. Neuronal and endothelial nitric oxide synthase mRNA were 3.5-fold and 1.8-fold increased in the outer medulla of 12 diabetic rats with no difference found in the cortex and inner medulla when compared with 12 normal rats. Urinary nitrite/nitrate excretion was significantly increased from the first week after diabetic induction. In normal rats, immunohistochemical studies showed positive neuronal and endothelial nitric oxide synthase immunostaining in almost all segments of renal tubules. Diabetic rats had the greatest enhancement of immunostaining for neuronal and endothelial nitric oxide synthase in the proximal straight tubule and medullary thick ascending limb. Conclusion/interpretation. Our results indicate that increases in neuronal and endothelial nitric oxide synthase synthesis in the kidney, particularly in the outer medulla, possibly play an important part in the adaptation of renal function to hyperglycaemia and hyperosmolality in diabetes. [Diabetologia (2000) 43: 649–659]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051354
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  • 9
    Electronic Resource
    Electronic Resource
    Spontaneous variability of arterial oxygenation in critically ill mechanically ventilated patients (1999)
    Springer
    Intensive care medicine 25 (1999), S. 37-43 
    Details
    ISSN: 1432-1238
    Keywords: Key words Spontaneous variability ; Mechanical ventilation ; Arterial oxygenation ; Positive end-expiratory pressure ; Inverse ratio ventilation ; Venous admixture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To assess the magnitude of spontaneous variability of arterial oxygenation and oxygen tension-based indices over time in medical intensive care unit (ICU) patients and to study whether high positive end-expiratory pressure (PEEP) or inverse inspiratory-to-expiratory (I:E) ratio ventilation (IRV) results in a greater variability than low PEEP with conventiona l I:E ratio ventilation. Design: Prospective study. Setting: Medical ICU in a tertiary medical center. Participants: 23 patients requiring a pulmonary artery floating catheter for hemodynamic monitoring. Intervention: After being completely sedated, patients were randomized to receive pressure-control ventilation at setting A: high PEEP (15 cmH2O) with conventional I:E ratio (1:2) and setting B: inverse I:E ratio (2:1) with low PEEP (5 cmH2O) alternately, and then at setting C: low PEEP (5 cmH2O) with conventional I:E ratio (1:2). Each ventilation setting lasted 1 h. Measurements and results: The arterial and mixed venous blood samples were measured simultaneously at baseline (time 0), and at 15, 30, 45, and 60 min thereafter. The coefficient of variation (CV) of arterial oxygen tension (PaO2) over time was 5.9 % for setting A, 7.2 % for setting B, and 6.9 % for setting C. ANOVA showed no significant differences in CVs of PaO2 between the three settings. Oxygen tension-based indices, alveolar-arterial oxygen difference (A-aDO2) and PaO2/PAO2 (alveolar oxygen tension), displayed CV s equal to that of PaO2; the CV of A-aDO2/PaO2 was significantly greater than that of PaO2. Conclusions: In critically ill medical ICU patients, despite sedation, the spontaneous variability in PaO2 over time is substantial. A high PEEP or IRV does not contribute to the increased variation in PaO2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050784
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  • 10
    Electronic Resource
    Electronic Resource
    Suanzaorentang in cardiac patients with anxiety (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 481-484 
    Details
    ISSN: 1432-1041
    Keywords: suanzaorentang ; cardiac patients ; Chinese herb ; anxiolytic drug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 60 patients with cardiac symptoms and anxiety, the anxiolytic effect of the ancient Chinese remedy Suanzaorentang has been studied. It was a promising anxiolytic remedy, without apparent adverse effects on the cardiovascular system, and appearing not to interact with other drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607964
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