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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Water, air & soil pollution 70 (1993), S. 499-518 
    ISSN: 1573-2932
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Biomass can be grown to act as a carbon (C) store, or as a direct substitute for fossil fuels (with no net contribution to atmospheric CO2 if produced and used sustainably). There is great potential for the modernisation of biomass fuels to produce convenient energy carriers such as electricity and liquid fuels. Bioenergy accounts for about 15% of primary energy used throughout the world, and 4% of energy used in Western Europe. Several European countries plan to significantly increase their use of bioenergy and some already obtain over 10% of their energy from biomass fuels. The European Community (EC) is planning to implement policies which will more than double the use of biomass by 2005, with biofuels taking 5% of the motor vehicle fuel market, and a resultant reduction in CO2 emissions of about 180 million tonnes (Mt), equivalent to 50 Mt C/yr. The potential contribution of biofuels is even greater, especially with all the ‘setaside’ land being taken out of production. Use of 15–20 million hectares (Mha) of agricultural land for biomass crops could represent an annual sink of some 90–120 Mt C or else offset between 50 Mt C and 120 Mt C from fossil fuel emissions, depending on the fuel displaced (7–17% of total EC carbon emissions). Policies are needed that will encourage the penetration of biofuels into the market such as increased support for research, development and demonstration, subsidies for biofuels, and carbon taxes on fossil fuels.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 212 (1980), S. 173-186 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report presents our preliminary observations on the trabecular meshwork from human eyes up to 5 days post-mortem in tissue culture. Satisfactory primary cultures were obtained from about 20% of the 423 explants which were investigated. The period prior to growth was from 4 days to 4 weeks and from the appearance of the initial outgrowth it took 25 to 30 days to reach maximum cellular spread within the culture chambers. The progress of the explant and the spreading of the trabecular meshwork cells was monitored by phase-contrast microscopy, time-lapse cinephotomicrography, light microscopy, transmission electron microscopy, scanning electron microscopy and autoradiography (using tritiated thymidine). On the basis of their ultrastructural appearance the cultured meshwork cells seemed to be metabolically active. Their cytoplasm contained abundant rough endoplasmic reticulum, many mitochondria, a well developed Golgi apparatus and many coated and uncoated micropinosomes. However even in short-term culture the trabecular meshwork cells had adapted to the artificial environment of our system and no longer resembled “normal” trabecular meshwork cells as seen in vivo. Since trabecular meshwork cells can quickly adapt their morphology in a culture environment and because the adult human meshwork contains a significant population of non-trabecular cells, the value of long term culture as a means of investigating the cellular activity of the normal and glaucomatous outflow system must be open to question.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 208 (1978), S. 33-47 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The associations between the cells of the corneoscleral and trabecular walls of Schlemm's canal from the three primate species human, baboon and rhesus monkey were examined by transmission electron microscopy. Small gap junctions and occluding junctions modify the lateral borders between the canalicular endothelial cells. The endothelial monolayer on the corneoscleral aspect of Schlemm's canal is separated from several layers of fibroblasts by a continuous basement membrane. The fibroblasts are embedded in a dense collagenous matrix and at the regions of cellular association, modifications are restricted to simple maculae adhaerentes. The endothelial monolayer on the trabecular aspect of Schlemm's canal does not have a continuous basement membrane but maintains its association with the underlying endothelial meshwork by means of process connections. In the endothelial meshwork, the native meshwork cells link with each other by gap junctions and maculae adhaerentes.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2011-12-14
    Description: Plasmodium vivax (Pv) is a major cause of human malaria and is increasing in public health importance compared with falciparum malaria. Pv is unique among human malarias in that invasion of erythrocytes is almost solely dependent on the red cell's surface receptor, known as the Duffy blood-group antigen (Fy). Fy is an important minor blood-group antigen that has two immunologically distinct alleles, referred to as Fya or Fyb, resulting from a single-point mutation. This mutation occurs within the binding domain of the parasite's red cell invasion ligand. Whether this polymorphism affects susceptibility to clinical vivax malaria is unknown. Here we show that Fya, compared with Fyb, significantly diminishes binding of Pv Duffy binding protein (PvDBP) at the erythrocyte surface, and is associated with a reduced risk of clinical Pv in humans. Erythrocytes expressing Fya had 41–50% lower binding compared with Fyb cells and showed an increased ability of naturally occurring or artificially induced antibodies to block binding of PvDBP to their surface. Individuals with the Fya+b− phenotype demonstrated a 30–80% reduced risk of clinical vivax, but not falciparum malaria in a prospective cohort study in the Brazilian Amazon. The Fya+b− phenotype, predominant in Southeast Asian and many American populations, would confer a selective advantage against vivax malaria. Our results also suggest that efficacy of a PvDBP-based vaccine may differ among populations with different Fy phenotypes.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 5
    Publication Date: 2012-12-08
    Description: Mutations in the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a variety of tumor types, resulting in production of the proposed oncometabolite, 2-hydroxyglutarate (2-HG). How mutant IDH and 2-HG alter signaling pathways to promote cancer, however, remains unclear. Additionally, there exist relatively few cell lines with IDH mutations. To examine the effect of endogenous IDH mutations and 2-HG, we created a panel of isogenic epithelial cell lines with either wild-type IDH1/2 or clinically relevant IDH1/2 mutations. Differences were noted in the ability of IDH mutations to cause robust 2-HG accumulation. IDH1/2 mutants that produce high levels of 2-HG cause an epithelial-mesenchymal transition (EMT)-like phenotype, characterized by changes in EMT-related gene expression and cellular morphology. 2-HG is sufficient to recapitulate aspects of this phenotype in the absence of an IDH mutation. In the cells types examined, mutant IDH-induced EMT is dependent on up-regulation of the transcription factor ZEB1 and down-regulation of the miR-200 family of microRNAs. Furthermore, sustained knockdown of IDH1 in IDH1 R132H mutant cells is sufficient to reverse many characteristics of EMT, demonstrating that continued expression of mutant IDH is required to maintain this phenotype. These results suggest mutant IDH proteins can reversibly deregulate discrete signaling pathways that contribute to tumorigenesis.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
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  • 6
    Publication Date: 2017-02-08
    Description: Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization Translational Psychiatry 7, e1024 (February 2017). doi:10.1038/tp.2016.278 Authors: O D Howes & R McCutcheon
    Electronic ISSN: 2158-3188
    Topics: Medicine
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  • 7
    Publication Date: 2018-09-07
    Description: The key to controlling reactions of molecules induced with the current of a scanning tunneling microscope (STM) tip is the ultrashort intermediate excited ionic state. The initial condition of the excited state is set by the energy and position of the injected current; thereafter, its dynamics determines the reaction outcome. We show that a STM can directly and controllably influence the excited-state dynamics. For the STM-induced desorption of toluene molecules from the Si(111)-7x7 surface, as the tip approaches the molecule, the probability of manipulation drops by two orders of magnitude. A two-channel quenching of the excited state is proposed, consisting of an invariant surface channel and a tip height–dependent channel. We conclude that picometer tip proximity regulates the lifetime of the excited state from 10 femtoseconds to less than 0.1 femtoseconds.
    Keywords: Chemistry, Physics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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