ISSN:
1471-0528
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The effects of the 1–34 N-terminal parathyroid hormone-related protein fragment (0–10μM) and the 67–86 parathyroid hormone-related protein fragment (0–10μM) on trophoblast apoptosis, induced by TNFα and IFNγ or by the protein kinase inhibitor staurosporine, were investigated. TNFα/IFNγ and staurosporine significantly increased the rate of apoptosis by fivefold and by eightfold, respectively. Parathyroid hormone-related protein (1–34) evoked a dose-dependent rescue of both TNFα/IFNγ-induced and staurosporine-induced apoptosis, whereas parathyroid hormone-related protein (67–86) had no significant effect on staurosporine-induced apoptosis, and only significantly diminished TNFα/IFNγ-induced apoptosis at 10μM. Parathyroid hormone-related protein was thus found to be a cytotrophoblast apoptosis survival factor.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-0528.2002.01033.x
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