Note: Cover -- Half Title -- Title Page -- Copyright Page -- Preface -- Contents -- Introduction -- Chapter 1 Experimental Methods and Analytical Techniques -- Chapter 2 Theoretical Consideration of Solubility -- 2.1 Intermolecular Forces -- 2.2 Polar and Nonpolar Fluids -- 2.3 Association of Molecules -- 2.4 Hydrogen Bonding -- 2.5 Liquid and Dissolved States -- 2.6 Structure and Properties of Water and Halogenated Hydrocarbons -- 2.7 Prediction, Estimation, and Correlation of Solubility Data -- 2.8 Temperature and Pressure Dependence of Solubility Data -- Chapter 3 Sources of Information on Solubility -- Chapter 4 Methods of Collection and Compilation of Solubility Data -- Chapter 5 Discrepancies and Critical Evaluation of Data -- Chapter 6 Accuracy and Reliability of Solubility Data -- Chapter 7 Graphs -- Chapter 8 Tabulated Data -- Chapter 9 Expressions, Units, and Conversions of Solubility Data -- Glossary -- Appendix -- References -- Subject Index.

Note: Front Cover -- Principles and Applications of Clinical Mass Spectrometry -- Principles and Applications of Clinical Mass Spectrometry -- Copyright -- Contents -- Contributors -- Preface -- 1 - Chromatography -- BASIC PRINCIPLES OF CHROMATOGRAPHY -- General Terms and Components of Chromatography -- Retention and Selectivity -- Band-Broadening and Efficiency -- Resolution and Peak Capacity -- Analyte Identification and Quantification -- GAS CHROMATOGRAPHY -- Types of Gas Chromatography -- Gas-Solid Chromatography -- Gas-Liquid Chromatography and Bonded Phases -- Gas Chromatography Instrumentation -- Carrier Gas Sources and Flow Control -- Injection Systems and Sample Derivatization -- Columns and Supports -- Temperature Control -- Gas Chromatography Detectors -- Flame Ionization Detector -- Nitrogen-Phosphorus Detector -- Electron Capture Detector -- Mass Spectrometry -- Other Gas Chromatography Detectors -- Data Acquisition and System Control -- Laboratory Safety in Gas Chromatography -- LIQUID CHROMATOGRAPHY -- Types of Liquid Chromatography -- Adsorption Chromatography -- Partition Chromatography -- Ion-Exchange Chromatography -- Size-Exclusion Chromatography -- Affinity Chromatography and Chiral Separations -- Hydrophilic Interaction Liquid Chromotography and Mixed-Mode Methods -- Liquid Chromatography Instrumentation -- Mobile Phase Reservoirs and Delivery Systems -- Injection Systems and Sample Derivatization -- Columns and Supports -- Temperature Control -- Liquid Chromatography Detectors -- Absorbance Detectors -- Fluorescence Detectors -- Electrochemical and Conductivity Detectors -- Refractive Index Detectors -- Mass Spectrometry -- Other Liquid Chromatography Detectors -- Data Acquisition and System Control -- Laboratory Safety in Liquid Chromatography -- OTHER CHROMATOGRAPHIC METHODS -- Supercritical Fluid Chromatography. , Planar Chromatography -- Multidimensional Separations -- REFERENCES -- 2 - Mass Spectrometry -- BASIC CONCEPTS AND DEFINITIONS -- INSTRUMENTATION -- Ion Source -- Electron Ionization -- Chemical Ionization -- Electrospray Ionization -- Atmospheric Pressure Chemical Ionization -- Atmospheric Pressure Photoionization -- Inductively Coupled Plasma -- Matrix-Assisted Laser Desorption Ionization -- Ionization Methods of Potential Interest -- Ionization Methods of Historical Interest -- Vacuum System -- Mass Analyzers, Tandem Mass Spectrometers, and Ion Detectors -- General Classes of Mass Spectrometers -- Beam-Type Designs -- Quadrupole -- Magnetic Sector -- Time-of-Flight -- Trapping Mass Spectrometers -- Quadrupole Ion Trap -- Linear Ion Trap -- Ion Cyclotron Resonance -- Orbitrap -- Tandem Mass Spectrometers -- Ion Mobility -- Detectors -- Computer and Software -- CLINICAL APPLICATIONS -- Gas Chromatography-Mass Spectrometry -- Liquid Chromatography-Mass Spectrometry -- Matrix-Assisted Laser Desorption Ionization Mass Spectrometry -- Inductively Coupled Plasma Mass Spectrometry -- Proteomics, Genomics, and Metabolomics -- Practical Aspects of Mass Spectrometry: Logistics, Operations, and Quality -- OPTIMIZATION OF INSTRUMENT CONDITIONS -- Selection of Mass Transitions and Operating Conditions -- Online Two-Dimensional Separations -- Conventional Versus Microflow Separations -- Ion Suppression -- Noise Reduction Techniques -- REFERENCES -- 3 - Sample Preparation for Mass Spectrometry Applications -- BACKGROUND -- GENERAL TECHNIQUES -- Dilution -- Centrifugation -- Sonication -- Homogenization -- SEPARATION TECHNIQUES -- Filtration -- Dialysis and Microdialysis -- Desalting and Buffer Exchange -- Enzymatic Hydrolysis -- Phase II Metabolic Conjugation -- Tissue Digestion -- Proteolysis -- Acid-Base Digestion -- PRECIPITATION TECHNIQUES. , Protein Precipitation -- ENRICHMENT TECHNIQUES -- Evaporation and Solvent Exchange -- Derivatization -- EXTRACTION TECHNIQUES -- Liquid-Liquid Extraction -- Solid-Supported Liquid-Liquid Extraction -- Solid-Phase Extraction -- Methodology -- Sorbents and Sorbent Chemistries -- High-Throughput Methods -- Processing Approaches: Off-Line Versus Online -- CHROMATOGRAPHIC TECHNIQUES -- Column-Switching: Single Column Mode -- Turbulent Flow Chromatography -- Monolithic Columns -- Immunoaffinity Extraction -- Restricted Access Media -- Column-Switching: Dual Column Mode -- EVOLVING TECHNIQUES -- Dried Blood Spots -- Capillary Microsampling -- REFERENCES -- 4 - Mass Spectrometry Applications in Infectious Disease and Pathogens Identification -- MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY -- History and Development of Commercial Systems -- ANALYSIS OF MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY DATA -- Performance -- Identification of Aerobic Bacteria -- Identification of Anaerobic Bacteria -- Identification of Mycobacteria -- Identification of Fungi -- Laboratory Workflow and Cost -- Antimicrobial Susceptibility Testing -- Direct Testing of Clinical Samples -- Testing of Positive Blood Culture Bottles -- Typing -- Limitations -- Future Perspectives -- ELECTROSPRAY IONIZATION MASS SPECTROMETRY -- The Polymerase Chain Reaction and Electrospray Ionization-Mass Spectrometry Method -- Bacterial Diagnostics -- Fungal Diagnostics -- Application to Mycobacterial Testing -- Performance for Viral Diagnostics -- Limitations and Future Perspectives -- CONCLUSIONS -- REFERENCES -- 5 - Development and Validation of Small Molecule Analytes by Liquid Chromatography-Tandem Mass Spectrometry -- PRACTICAL CONSIDERATIONS FOR LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY ASSAYS -- Calibration Standard and Matrix. , Internal Standard Selection and Utility -- Mass Spectrometry Source Setup and Tuning -- Solvent Chemistry Optimization -- Liquid Chromatography Development -- Additional High-Performance Liquid Chromatography Optimization -- Adsorptive Loss Evaluation -- On-Column Detection Limits -- Final Development Stage 2 Considerations -- SAMPLE PREPARATION -- Tools and Considerations -- Protein Precipitation -- Liquid-Liquid Extraction -- Supported Liquid Extraction -- Solid-Phase Extraction -- Online Extraction (Online Solid-Phase Extraction and Turbulent Flow Chromatography) -- Assay Calibration and Carryover Assessment -- Selectivity -- Final Method Refinement -- Assay Prevalidation Studies -- Assay Validation -- General Validation Rules -- Accuracy -- Precision -- Carryover -- Analytical Interferences -- Ion Suppression and Enhancement -- Matrix Effects -- Spike and Recovery -- Selectivity -- Calibration Curve Fit and Linearity -- Dilutional Linearity -- Preprocessing Stability -- Hydrolysis and Derivatization -- Postprocessing Stability -- Ruggedness and Maximum Batch Size -- Long-Term Stability -- Interassay Comparison and Correlation -- External Quality Assessments, Certified Reference Materials, and Reference Intervals -- REFERENCES -- 6 - Proteomics -- HISTORICAL PERSPECTIVE -- Early Proteomics -- Biomarker Discovery in the Post-Two-Dimensional Gel Era -- BIOMARKER PIPELINE -- Discovery Experiment -- Requirement for Separations -- Data Acquisition Strategies -- Processing of Discovery Proteomics Data -- Variations and Details -- Targeted Quantitative Experiment -- Bottom-Up and Top-Down Experiments -- BOTTOM-UP TARGETED PROTEOMICS -- Workflow Overview -- Peptide Selection -- Denaturation -- Reduction and Alkylation -- Protease Selection and Activity -- Digestion Optimization -- Internal Standards and Peptide Quality -- Calibration. , Protein or Peptide Enrichment -- Multiplexing -- Polymorphisms -- Chromatography -- Summary -- TOP-DOWN PROTEOMICS -- Workflow Overview -- Assay Specificity -- Calibration -- Internal Standards -- Protein Enrichment -- PREANALYTICAL AND OTHER TECHNICAL CONSIDERATIONS -- Specimen Collection Considerations -- Urine as a Matrix for Proteomics Assays -- Tissues -- Posttranslational Modifications -- Stability -- Interferences -- Instruments -- CONCLUSIONS -- Current Clinical Proteomics Assays -- New Directions -- REFERENCES -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y -- Z -- Back Cover.