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  • 1
    Online Resource
    Online Resource
    Tenth Scandinavian Conference on Artificial Intelligence : Scai 2008. (2008)
    Amsterdam :IOS Press, Incorporated,
    Details
    Keywords: Electronic books.
    Description / Table of Contents: The Scandinavian Conference on Artificial Intelligence continues a tradition of being one of the most important regional AI conferences in Europe for ten years now. The topics of this year's contributions have a broad range, from machine learning, knowledge representation, robotics, planning and scheduling, natural language, computer vision, search algorithms, industrial applications, to philosophical foundations. These contributions exemplify the diversity of research in artificial intelligence today and confirm the achievement and magnitude of 25 years AI research in Scandinavia. In this tenth edition there will be an overview of the past, present and future of artificial intelligence. Furthermore, attention will be paid to the industrial aspects of artificial intelligence and the impressions from Swedish AI through the years. Other topics discussed are biosurveillance and an elaboration on probalistic modelling and learning in a relational world.
    Type of Medium: Online Resource
    Pages: 1 online resource (228 pages)
    Edition: 1st ed.
    ISBN: 9781607503354
    Series Statement: Frontiers in Artificial Intelligence and Applications Series ; v.173
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=363212
    Language: English
    Note: Title page -- Preface -- Contents -- Presented Papers -- The Observer Algorithm for Visibility Approximation -- Efficient AUC Maximization with Regularized Least-Squares -- Fast Learning in an Actor-Critic Architecture with Reward and Punishment -- Explanatory Capabilities in the CREEK Knowledge-Intensive Case-Based Reasoner -- Case-Based Reasoning for Ontology Engineering -- Defect Prediction in Hot Strip Rolling Using ANN and SVM -- A Framework for Human-Aware Robot Planning -- The Problem of Object Recognition in the Presence of Noise in Original Data -- Troubleshooting when Action Costs Are Dependent with Application to a Truck Engine -- A Sparse Regularized Least-Squares Preference Learning Algorithm -- Supporting Maritime Situation Awareness Using Self Organizing Maps and Gaussian Mixture Models -- Better Safe than Sorry - Optimal Troubleshooting Through A* Search with Efficiency-Based Pruning -- Combining Measurement Data and Erlang-B Formula for Blocking Prediction in GSM Networks -- Load Prediction Using Combination of Neural Networks and Simple Strategies -- Towards Automatic Model Generation by Optimization -- A Heuristic-Based Approach for a Betting Strategy in Texas Hold'em Poker -- Chipper - A Novel Algorithm for Concept Description -- A Novel Framework for Case-Based Decision Analysis -- Poster Presentations -- Bayesian Inference Under Probability Constraints -- Acting Under Interference by Other Agents with Unknown Goals -- Sharing Moral Responsibility with Robots: A Pragmatic Approach -- Foundation for Program Understanding -- Looking for Planning Problems Solvable in Polynomial Time via Investigation of Structures of Action Dependencies -- Reducing Temporal Delays in a Real Time Train Management System -- Invited Talks -- The Many Faces of Biosurveillance. , Probabilistic-Logic Models: Reasoning and Learning with Relational Structures -- CBR for Advice Giving in a Data-Intensive Environment -- Modeling Habituation in the Cnidarian Hydra -- Subject Index -- Author Index.
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    GEOMAR EBL
  • 2
    Electronic Resource
    Electronic Resource
    Appraisal of skin tests with food extracts for diagnosis of food hypersensitivity (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 8 (1978), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Seventy-six children aged 5 months to 15 years who exhibited a net weal of 3.0 mm or greater to a puncture skin test with one or more of fourteen foods were subjected to double-blind food challenge. Confirmed reactions to double-blind food challenge were found to occur only with peanut, milk, egg and soybean. Puncture skin tests with 1:20 w/v concentration of food extracts identified all subjects who exhibited an adverse reaction during the double-blind food challenge. Performance of intradermal skin tests did not identify any additional subjects who reacted clinically to double-blind food challenge.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1978.tb01509.x
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  • 3
    Electronic Resource
    Electronic Resource
    Immunologischer Status permanent überlebender Rattennierenallotransplantant-Empfänger nach kurzer initialer ALS-Therapie (1976)
    Springer
    Research in experimental medicine 167 (1976), S. 171-183 
    Details
    ISSN: 1433-8580
    Keywords: Rat renal allograft ; GvHR ; allorosette ; blocking factor ; Rattennierentransplantation ; GvHR ; Allorosettenformation ; blockierender Serumfaktor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 53 LBNF1-Nieren wurden auf L-Ratten transplantiert: 24 unbehandelte Empfänger überlebten durchschnittlich 16,1 ± 1,7 Tage. 14 Empfänger bekamen je 4 ml Alloantiserum (ADS, Gruppe 2), die restlichen 15 je 4 ml ALS (Gruppe 3). Davon überlebten 9 bzw. 10 Empfänger mehr als 4 Monate. Mit Milzzellen dieser permanent überlebenden 19 Ratten wurde eine GvHR durchgeführt. Grad und Index der GvHR ergaben eine normale, zellgebundene Immunantwort der Empfänger. Nach der Splenektomie erhielten sie erstmalig, 18 Tage später zum zweiten Mal Haut von LBNF1, 18 Tage danach Haut von LBufF1 transplantiert. Das erste Transplantat überlebte in der ADS-Gruppe 13,1 ± 1,9 Tage, in der ALS-Gruppe 12,2 ± 1,2 Tage. Das zweite wurde bei Gruppe 2 ebenfalls verzögert, bei Gruppe 3 fast gleich wie bei unbehandelten L-Ratten, das unspezifische Transplantat in beiden Gruppen regelrecht abgestoßen. Lymphozytotoxin und Hämagglutinin wurden vor und nach der Hauttransplantation bis zum 53. Tag nicht nachgewiesen. Die Seren beider Gruppen inhibierten die Allorosettenformation auf 46,0 ± 4,4% (ADS-Gruppen) bzw. 37,7 ± 9,2% (ALS-Gruppe), somit war ein blockierender FAktor im Serum der Empfänger vorhanden. Höchstwahrscheinlich hatten sich also bei diesen Empfängern nach der ALS-Therapie blockierende Antikörper gebildet, woraus sich ein Enhancement der Nierentransplantate entwickelte.
    Notes: Summary 53 LBNF1 kidneys were grafted into L-rats. 24 untreated recipients served as control and survived 16.1 ± 1.7 days. 14 recipients were treated with 4 ml alloantiserum (ADS) each, and the other 15 animals with 4 ml ALS each. 9 and 10 of these 14 and 15 animals survived for more than 4 months. We performed GvH-reaction with spleen cells of these 19 animals. It showed normal cellular immune response. After splenectomy first donor specific skin was transplanted, 18 days later second skin of same origin (LBNF1) and 18 days after third party skin (LBufF1). The first grafts survived 13.1 ± 1.9 days in the recipients of ADS treatment and 12.2 ± 1.2 days in the recipients of ALS. Second skin grafts were rejected delayed in the former recipients as the first grafts, in the later more accelerated than the first grafts. The third grafts survived as the controls. Before and after skin grafting we could not detect lymphocytotoxin and hemagglutinin. The sera of animals with ADS therapy inhibited the spontaneous allorosette formation to 46.0 ± 4.4% and of ALS therapy 37.7 ± 9.2%. Our results suggest that after ALS treatment blocking antibodies were produced in the recipients and they cause the enhancement of kidney allograft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851598
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  • 4
    Electronic Resource
    Electronic Resource
    Der Effekt der spenderspezifischen Antigen-Typen auf aktives Enhancement der Rattennierenallotransplantate bei histoinkompatibilen Inzucht-Ratten (1975)
    Springer
    Research in experimental medicine 165 (1975), S. 175-179 
    Details
    ISSN: 1433-8580
    Keywords: Rat renal transplantation ; active enhancement ; antigen ; Rattennierentransplantation ; aktives Enhancement ; Antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 49 Nieren männlicher LBNF1-Ratten wurden auf männliche Lewis-Ratten transplantiert. BN-Ratten wurden als Antigenquelle verwendet. Kontrolltiere überlebten 16,1 ± 1,8 Tage. Bei 5 Empfängern erfolgte die Vorbehandlung mit spenderspezifischen lebenden Zellen, bei 7 mit halblöslichem und bei weiteren 5 mit niedrigerer Dosis löslichen Antigens. Die lebenden Zellen zeigten den besten Effekt; die löslichen Antigene den schlechtesten. Die Vorbehandlung mit 6 mg Protein/kg KGW verursachte bei den Empfängern Sensibilisierung. Am Tage der Transplantation wurde nur bei den mit lebenden Zellen vorbehandelten Empfängern lymphozytotoxische Antikörpertiter festgestellt, nicht dagegen bei den anderen Gruppen. Die Nierenallotransplantate mit erhöhtem postoperativem Titer wurden schnell abgestoßen.
    Notes: Summary 49 kidneys of male LBNF1-rats were transplanted into male Lewis-rats. BN-rats were used as a source of antigen. Control animals survived 16.1 ± 1.8 days. 5 recipients were pretreated with donorspecific living cells, 7 with semisoluble and 5 with low dosage of soluble antigen. The living cell-pretreatment showed the best effect for the active enhancement, the soluble antigen the least. The pretreatment with 6 mg protein/kg bw. caused the sensibilization of recipients. At the time of transplantation lymphcytotoxic antibody titers were detected in all recipients with pretreatment of living cells, but no titer in other groups. Renal allografts with elevated postopertive titer were rejected rapidly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01854844
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  • 5
    Electronic Resource
    Electronic Resource
    Epiphyseal separation of the coracoid process without acromioclavicular dislocation (1998)
    Springer
    Skeletal radiology 27 (1998), S. 461-462 
    Details
    ISSN: 1432-2161
    Keywords: Key words Shoulder trauma ; Coracoid process ; Epiphyseal separation ; Acromioclavicular sprain ; CT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A patient with an epiphyseal separation through the base of the coracoid process of the shoulder associated with a grade I acromioclavicular sprain is reported. The epiphyseal separation was not visible on conventional roentgenograms. A CT scan demonstrated the abnormality. In patients with considerable intractable pain due to contusion of the shoulder, early use of CT should be considered to determine whether symptoms are caused by epiphyseal separation of the coracoid process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050419
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  • 6
    Electronic Resource
    Electronic Resource
    Aktives Enhancement von Hundeleberallotransplantaten Vorbehandlung mit polyspezifischem semisolublen Milzalloantigen (1977)
    Springer
    Langenbeck's archives of surgery 344 (1977), S. 15-26 
    Details
    ISSN: 1435-2451
    Keywords: Liver transplantation ; Active enhancement ; Polyspecific antigen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Aktives Enhancement mit spenderspezifischem Antigen ist bei der klinischen Kadaver-Organtransplantation nicht praktikabel. Deshalb wurde der Versuch gemacht, ein aktives Enhancement von orthotopen Hundeleberallotransplantaten mit polyspezifischem Antigen zu erzielen. Die 17 Tiere der Kontrollgruppe überlebten durchschnittlich 6,9 ± 1,5 Tage. 6 Empfänger (Gruppe 3) erhielten 750 mg/kg polyspezifisches halblösliches (PSEA 20) Antigen, welches aus 20 Milzen hergestellt wurde, zusammen mit 10 mg/kg Prednisolon 15, 8 und 1 Tag vor der Transplantation. Die durchschnittliche Überlebensdauer in dieser Gruppe betrug 10,1 ± 2,0 Tage (P 〈 0,01, gegen die Kontrollgruppe). Weitere 6 Hunde (Gruppe 4) wurden wie die Tiere de Gruppe 3 vorbehandelt; jedoch wurde das Antigen hier aus 70 Nilzen hergestellt (PSEA 70). Die Überlebensdauer war sehr unterschiedlich: 3 Tiere überlebten mehr als 3 Wochen, die anderen 3 starben 1, 7 und 8 Tage nach der Transplantation unter Zeichen der beschleunigten Abstoßung. Spender und Empfänger waren in keinem Fall LD-identisch, aber ein nahezu identisches Spender-Empfänger-Paar zeigte einen besseren Enhancement-Effekt. Die Empfänger mit der beschleunigten Abstoßung zeigten ungewöhnlich hohe Lymphocytotoxin-und Hämagglutinin-Präsenz, länger überlebende Tiere niedrige Antikörper-Titer. Bei allen Empfängern mit starker Rejektion war die Leukocyten-Migration inhibiert. Rosetten-bildende Lymphocyten waren nach dreimaliger Antigenapplikation vermehrt im Blut nachweisbar und blieben danach konstant.
    Notes: Summary Because it is not possible to use donor specific antigens for the induction of immunological enhancement in cadaveric organtransplantation, attempts were made to use polyspecific antigens in the enhancement of orthotopic canine liver allotransplants. Of 34 mongrel recipients, 17 controls survived for 6.9 ± 1.5 days. Six recipients (group 3) were given 750 mg/kg polyspecific, semisoluble antigen prepared from 20 spleens (PSEA 20) together with 10 mg/kg prednisolone on days 15, 8 and 1 before transplantation. The mean survival time of this group was 10.1 ± 2.0 days (P 〈 0.01 compared with the control group). Six other recipients (group 4) were treated similiarly, except that the antigen had been prepared from a pool of 70 spleens (PSEA 70). Survival was variable here: 3 survived for more than 3 weeks and the other 3 died on days 1, 7 and 8 postoperatively, with signs of accelerated rejection. Donors and recipients were not identical for LD determinants, but one donor recipient pair with near identity showed a higher degree of enhancement. The recipients displaying accelerated rejection had markedly higher lymphocytotoxic and haemagglutinating antibodies. Animals surviving for longer periods had low antibody titres. In addition, all recipients progressive rejection were found to show inhibition of leucocyte migration. After three antigen doses rosette-forming lymphocytes were present in increased numbers in peripheral blood, and remained unchanged thereafter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01259349
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  • 7
    Electronic Resource
    Electronic Resource
    Die Prüfung der pharmaceutischen Extracte (1890)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 29 (1890), S. 228-238 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01367138
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  • 8
    Electronic Resource
    Electronic Resource
    N-o-Nitrobenzolsulfenyl-aminosäuren und -aminosäureester (1959)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 71 (1959), S. 775-775 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19590712403
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  • 9
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    High Prevalence of Long QT Syndrome-Associated SCN5A Variants in Patients With Early-Onset Lone Atrial Fibrillation [Original Articles] (2012)
    American Heart Association (AHA)
    Details
    Publication Date: 2012-08-15
    Description: Background— Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, Na V 1.5, plays a pivotal role in setting the conduction velocity and the initial depolarization of the cardiac myocytes. We hypothesized that early-onset lone AF was associated with genetic variation in SCN5A . Methods and Results— The coding sequence of SCN5A was sequenced in 192 patients with early-onset lone AF. Eight nonsynonymous mutations (T220I, R340Q, T1304M, F1596I, R1626H, D1819N, R1897W, and V1951M) and 2 rare variants (S216L in 2 patients and F2004L) were identified. Of 11 genopositive probands, 6 (3.2% of the total population) had a variant previously associated with long QT syndrome type 3 (LQTS3). The prevalence of LQTS3-associated variants in the patients with lone AF was much higher than expected, compared with the prevalence in recent exome data (minor allele frequency, 1.6% versus 0.3%; P =0.003), mainly representing the general population. The functional effects of the mutations were analyzed by whole cell patch clamp in HEK293 cells; for 5 of the mutations previously associated with LQTS3, patch-clamp experiments showed an increased sustained sodium current, suggesting a mechanistic overlap between LQTS3 and early-onset lone AF. In 9 of 10 identified mutations and rare variants, we observed compromised biophysical properties affecting the transient peak current. Conclusions— In a cohort of patients with early-onset lone AF, we identified a high prevalence of SCN5A mutations previously associated with LQTS3. Functional investigations of the mutations revealed both compromised transient peak current and increased sustained current.
    Keywords: Arrythmias-basic studies
    Print ISSN: 1942-325X
    Electronic ISSN: 1942-3268
    Topics: Medicine
    Published by American Heart Association (AHA)
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    PAPER CURRENT
  • 10
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    Unknown
    A novel KCND3 gain-of-function mutation associated with early-onset of persistent lone atrial fibrillation (2013)
    Oxford University Press
    Details
    Publication Date: 2013-05-18
    Description: Aims Atrial fibrillation (AF) is the most common cardiac arrhythmia, and early-onset lone AF has been linked to mutations in genes encoding ion channels. Mutations in the pore forming subunit K V 4.3 leading to an increase in the transient outward potassium current ( I to ) have previously been associated with the Brugada Syndrome. Here we aim to determine if mutations in K V 4.3 or in the auxiliary subunit K + Channel-Interacting Protein (KChIP) 2 are associated with early-onset lone AF. Methods and results Two hundred and nine unrelated early-onset lone AF patients (〈40 years) were recruited. The entire coding sequence of KCND3 and KCNIP2 was bidirectionally sequenced. One novel non-synonymous mutation A545P was found in KCND3 and was neither present in the control group ( n = 432 alleles) nor in any publicly available database. The proband had onset of persistent AF at the age of 22, and no mutations in genes previously associated with AF were found. Electrophysiological analysis of K V 4.3-A545P expressed in CHO-K1 cells, revealed that peak-current density was increased and the onset of inactivation was slower compared with WT, resulting in a significant gain-of-function both in the absence and the presence of KChIP2. Conclusion Gain-of-function mutations in K V 4.3 have previously been described in Brugada Syndrome, however, this is the first report of a K V 4.3 gain-of-function mutation in early-onset lone AF. This association of K V 4.3 gain-of-function and early-onset lone AF further supports the hypothesis that increased potassium current enhances AF susceptibility.
    Print ISSN: 0008-6363
    Electronic ISSN: 1755-3245
    Topics: Medicine
    Published by Oxford University Press
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    PAPER CURRENT
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