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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 30 (1989), S. 0 
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A study of 121 melanoma patients and 139 control subjects was conducted among whites to examine and compare the distribution of non-dysplastic and dysplastic naevi and other pigmented lesions in each group. Melanoma patients had a mean of 97 melanocytic naevi which were greater than 2 mm in diameter and controls had a mean of 36 such naevi, while the medians were 58 and 22 respectively (p〈0.0001). 55% of melanoma patients and 17% of controls had at least one clinically determined dysplastic naevus, and 26% of melanoma patients and 6% of controls had at least 5 dysplastic naevi. Men were found to have more naevi on the trunk than women in both melanoma cases (p=0.01), and controls (p=0.005). Dysplastic naevi were most often found on the trunk and were present at this location in 51% of cases and 77% of controls. Melanoma patients and control subjects with dysplastic naevi, when compared to those without these lesions, had larger number of non-dysplastic naevi. Lentigines were more common among melanoma patients that among control subjects (p = 0.02). There were no differences in the number of non-dysplastic naevi among cases with light and dark hair and eyes, or among controls with these characteristics. There also was little variation in the number of naevi according to number of blistering sunburns.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1530-0358
    Keywords: Anus ; Squamous intraepithelial lesion ; Colposcopy ; Human immunodeficiency virus ; Anal cancer ; Anal intraepithelial neoplasia ; Anoscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: The incidence of anal cancer is increased in men with a history of anal receptive intercourse. Analogous to cervical cancer, whose precursor is cervical high-grade squamous intraepithelial lesion (HSIL), anal cancer may be preceded by anal HSIL. Although not yet proven, detection, follow-up, and treatment of HSIL may prevent development of anal cancer. Cervical colposcopic methodology was used to describe anal lesions and to determine if HSIL could be distinguished from low-grade squamous intraepithelial lesion (LSIL). METHODS; The colposcopic characteristics of 385 biopsied anal lesions were described and correlated with results of histopathology in a cohort of 121 human immunodeficiency virus-positive and 31 human immunodeficiency-negative homosexual/bisexual men with anal lesions followed as part of a longitudinal study of anal squamous intraepithelial lesions. Color, contour, surface, and vascular patterns of anal lesions were analyzed and correlated with histologic diagnosis. RESULTS: Sixty-seven percent of biopsies showed LSIL and 26 percent showed HSIL. The positive predictive value for anal HSIL in lesions with characteristics typical of cervical LSIL was 7.7 percent (95 percent confidence interval, 1.8–14), whereas the positive predictive value for anal HSIL in lesions with characteristics typical of cervical HSIL was 49 percent (95 percent confidence interval, 40–58). CONCLUSIONS: The colposcopic appearance of different grades of anal squamous intraepithelial lesions was similar to those described for the cervix. Incorporation of colposcopy into assessment of anal disease could aid in distinguishing anal LSIL from HSIL.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0350
    Keywords: Key words Brain neoplasms ; Childhood neoplasms ; Prenatal exposures ; Vitamin supplements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An international case-control study of primary pediatric brain tumors included interviews with mothers of cases diagnosed from 1976–1994 and mothers of population controls. Data are available on maternal vitamin use during pregnancy for 1051 cases and for 1919 controls in eight geographic areas of North America, Europe and Israel. While risk estimates varied by study center, combined results suggest that maternal supplementation for two trimesters may decrease risk of brain tumor [odds ratio (OR)=0.7; 95% confidence interval (CI)=0.5– 0.9], with a trend toward less risk with longer duration of use (P trend= 0.0007). The greatest risk reduction was among children diagnosed under 5 years of age whose mothers used supplements during all three trimesters (OR=0.5; CI=0.3– 0.8). This effect did not vary by histology and was seen for supplementation during pregnancy rather than during the month before pregnancy or while breast feeding. These findings are largely driven by data from the US, where most mothers took vitamins. The proportion of control mothers who took vitamins during pregnancy varied tremendously, from 3% in Israel and in France through 21% in Italy, 33% in Canada, 52% in Spain to 86–92% at the three US centers. The composition of the various multivitamin compounds taken also varied: daily dose of vitamin C ranged from 0 up to 600 mg; vitamin E from 0 to 70 mg; vitamin A from 0 to 30,000 IU and folate from 0 to 2000 mg. Mothers also took individual micronutrient supplements (e.g., vitamin C tablets), but most mothers who took these also took multivitamins, making it impossible to determine potential independent effects of these micronutrients.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7225
    Keywords: Melanoma ; incidence ; race ; site ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cutaneous malignant melanoma occurs less frequently among non-Whitepopulations than among Whites. As a result, little is known about theincidence and epidemiology of melanoma among other race/ethnicity groups.Data from the California Cancer Registry (United States) among 879 Hispanic,126 Asian, and 85 Black men and women diagnosed with melanoma in 1988-93 wereanalyzed and compared with data for 17,765 non-Hispanic White cases. Average,annual, age-adjusted incidence rates per 100,000 population were 17.2 for men(M) and 11.3 for women (W) for non-Hispanic Whites; 2.8 (M), 3.0 (W) forHispanics; 0.9 (M), 0.8 (W) for Asians; and 1.0 (M), 0.7 (W) for non-HispanicBlacks. Among men, melanoma occurred on the lower extremity for 20 percent ofHispanics, 36 percent of Asians, and 50 percent of Blacks compared with ninepercent of non-Hispanic Whites, with similar but less pronounced differencesin site distribution by race/ethnicity for women. Among men, melanoma wasdiagnosed after it had metastasized to a remote site for 15 percent ofHispanics, 13 percent of Asians, and 12 percent of Blacks, compared with sixpercent of non-Hispanic Whites. Among women, seven percent of Hispanics, 21percent of Asians, and 19 percent of Blacks were diagnosed with late-stagemelanoma compared with four percent of non-Hispanic Whites. Althoughhistologic type was not specified for nearly half of the cases, Hispanic,Asian, and Black patients were more likely than non-Hispanic White patientsto have been diagnosed with acral lentiginous melanoma. MelanomaamongHispanics, Asians, and Blacks differs in incidence, site distribution,stage at diagnosis, andhistologic type from melanoma among non-HispanicWhites, and identification of risk factors for melanoma in theserace/ethnicity groups would elucidate further the role of sun and otherfactors in the etiology of melanoma.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-7225
    Keywords: Incidence of melanoma ; melanoma ; reporting bias ; trends in melanoma ; United States
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Temporal changes in the incidence of cutaneous malignant melanoma (CMM) were examined in the San Franscisco-Oakland (California, United States) Metropolitan Statistical Area (MSA) between 1976 and 1987, using data from the population-based cancer registry. This analysis was conducted after the completion of a project designed to eliminate bias in the reporting of CMM due to changes in medical practice. The incidence of CMM is higher in the San Francisco-Oakland MSA than nationally. From 1976 through 1987, the incidence of invasive CMM increased from 9.8±0.9 to 16.5±1.1 per 100,000 (P=0.0001) among men and from 9.3±0.8 to 12.7±0.9 per 100,000 (P=0.001) among women. Age-specific, histologic-specific, and anatomic site-specific trends were also evaluated. The temporal patterns of CMM suggest that the recent increases are not accounted for solely by ascertainment bias due to reporting practices. The observed trends are consistent with early detection efforts and with changes in the prevalence of risk factors.
    Type of Medium: Electronic Resource
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