ISSN:
1438-8359
Keywords:
Endotoxin
;
Selective thromboxane synthetase inhibitor
;
Blood viscosity
;
Erythrocyte deformability
;
Plasma fluidity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Effects of a selective thromboxane synthetase inhibitor, (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY-046), were studied hemorheologically in endotoxin shocked-rabbits. The animals were intravenously administrated with 0.1 mg of endotoxin 3 times at intervals of 3 days. At 7 days after the last endotoxin injection, endotoxin (0.2 mg·kg−1) was intravenously administrated to induce a shock. OKY-046 (30 mg·kg−1) was administrated after hypotension was developed by the endotoxin treatment and, then, it was continuously injected at 0.03 mg·kg−1·min−1. Blood pressure remained unchanged and hypotensive was maintained during the treatment with OKY-046. Blood was sampled from the femoral artery 15 (before the administration of OKY-046), 45, and 120 minutes after the final administration of endotoxin. PaO 2 increased, and PaCO 2, arterial pH, and base excess (BE) decreased during the endotoxin shock. The decrease of pH and BE was prevented by the administration of OKY-046. In the endotoxin-shocked animals, hematocrit, whole blood viscosity, erythrocyte deformability, plasma fluidity, and the ratio of hematocrit to whole blood viscosity showed no significant differences between the OKY-046 treated animals and non-treated ones. These data show that a selective thromboxane synthetase inhibitor (OKY-046) does not improve the blood rheology during endotoxin shock, although it seems to prevent the acidosis in some extent. (Kato T, Hayashi K, Takamizawa K, et al.: A selective thromboxane synthetase inhibitor, OKY-046, fails to improve blood rheology in exdotoxin-shocked rabbits. J Anesth 5: 247–254, 1991)
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s0054010050247
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