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  • 1
    Online Resource
    Online Resource
    Target Detection and Tracking by Bionanosensor Networks. (2016)
    Singapore :Springer Singapore Pte. Limited,
    Details
    Keywords: Biotechnology. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (73 pages)
    Edition: 1st ed.
    ISBN: 9789811024689
    Series Statement: SpringerBriefs in Computer Science Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=4697464
    Language: English
    Note: Intro -- Preface -- Contents -- 1 Introduction -- 1.1 Background -- 1.2 Bionanosensor Networks for Target Detection and Tracking -- 1.2.1 Monitoring Environment -- 1.2.2 Targets -- 1.2.3 Bionanosensors -- 1.2.4 External Devices -- 1.3 Related Areas -- 1.3.1 Wireless Sensor Networks (WSNs) -- 1.3.2 Molecular Communication and Nanonetworks -- 1.3.3 Drug Delivery Systems -- 1.3.4 Systems/Synthetic Biology -- 1.4 Book Organization -- References -- 2 Static Bionanosensor Networks for Target Detection -- 2.1 Overview -- 2.2 Problem Formulation -- 2.3 Sensor Placement Schemes -- 2.4 Numerical Experiments -- 2.4.1 Parameter Configurations -- 2.4.2 Results -- 2.5 Summary -- References -- 3 Dynamic Bionanosensor Networks for Target Tracking -- 3.1 Overview -- 3.2 Model Equations -- 3.2.1 Dynamics of Bionanosensor Concentration -- 3.2.2 Dynamics of Attractant Concentration -- 3.2.3 Dynamics of Repellent Concentration -- 3.3 Numerical Experiments -- 3.3.1 Numerical Methods -- 3.3.2 Impact of Attractants -- 3.3.3 Impact of Repellents -- 3.3.4 Target Tracking -- 3.4 Summary -- References -- 4 Controllability of Mobile Bionanosensors -- 4.1 Overview -- 4.2 Problem Formulation -- 4.3 Numerical Experiments -- 4.4 Summary -- References -- 5 Conclusion -- 5.1 Summary -- 5.2 Current and Future Work -- 5.2.1 Robust Molecular Communication Methods -- 5.2.2 Protocols and Architectures -- 5.2.3 Interfaces with External Devices -- 5.2.4 Wet Laboratory Experiments -- 5.2.5 Noise Handling -- References -- Index.
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    GEOMAR EBL
  • 2
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    Helium anomalies suggest a fluid pathway from mantle to trench during the 2011 Tohoku-Oki earthquake (2014)
    Nature Publishing Group
    In:  Nature Communications, 5 . p. 3084.
    Details
    Publication Date: 2015-07-24
    Description: Geophysical evidence suggests that fluids along fault planes have an important role in generating earthquakes; however, the nature of these fluids has not been well defined. The 2011 magnitude 9.0 Tohoku-Oki earthquake ruptured the interface between the subducting Pacific plate and the overlying Okhotsk plate. Here we report a sharp increase in mantle-derived helium in bottom seawater near the rupture zone 1 month after the earthquake. The timing and location indicate that fluids were released from the mantle on the seafloor along the plate interface. The movement of the fluids was rapid, with a velocity of ~4 km per day and an uncertainty factor of four. This rate is much faster than what would be expected from pressure-gradient propagation, suggesting that over-pressurized fluid is discharged along the plate interface.
    Type: Article , PeerReviewed
    DOI: 10.1038/ncomms4084
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 3
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    The Evidence of Glioblastoma Heterogeneity (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-01-28
    Description: Cancers are composed of heterogeneous combinations of cells that exhibit distinct phenotypic characteristics and proliferative potentials. Because most cancers have a clonal origin, cancer stem cells (CSCs) must generate phenotypically diverse progenies including mature CSCs that can self-renew indefinitely and differentiated cancer cells that possess limited proliferative potential. However, no convincing evidence exists to suggest that only single CSCs are representative of patients' tumors. To investigate the CSCs' diversity, we established 4 subclones from a glioblastoma patient. These subclones were subsequently propagated and analyzed. The morphology, the self-renewal and proliferative capacities of the subclones differed. Fluorescence-activated cell sorting and cDNA-microarray analyses revealed that each subclone was composed of distinct populations of cells. Moreover, the sensitivities of the subclones to an inhibitor of epidermal growth factor receptor were dissimilar. In a mouse model featuring xenografts of the subclones, the progression and invasion of tumors and animal survival were also different. Here, we present clear evidence that a brain tumor contains heterogeneous subclones that exhibit dissimilar morphologies and self-renewal and proliferative capacities. Our results suggest that single cell-derived subclones from a patient can produce phenotypically heterogeneous self-renewing progenies in both in vitro and in vivo settings. Scientific Reports 5 doi: 10.1038/srep07979
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 4
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    Optimized Dosing Schedule Based on Circadian Dynamics of Mouse Breast Cancer Stem Cells Improves the Antitumor Effects of Aldehyde Dehydrogenase Inhibitor (2018)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2018-07-03
    Description: Although malignant phenotypes of triple-negative breast cancer (TNBC) are subject to circadian alterations, the role of cancer stem cells (CSC) in defining this circadian change remains unclear. CSC are often characterized by high aldehyde dehydrogenase (ALDH) activity, which is associated with the malignancy of cancer cells and is used for identification and isolation of CSC. Here, we show that the population of ALDH-positive cells in a mouse 4T1 breast tumor model exhibits pronounced circadian alterations. Alterations in the number of ALDH-positive cells were generated by time-dependent increases and decreases in the expression of Aldh3a1. Importantly, circadian clock genes were rhythmically expressed in ALDH-negative cells, but not in ALDH-positive cells. Circadian expression of Aldh3a1 in ALDH-positive cells was dependent on the time-dependent release of Wingless-type mmtv integration site family 10a (WNT10a) from ALDH-negative cells. Furthermore, antitumor and antimetastatic effects of ALDH inhibitor N,N-diethylaminobenzaldehyde were enhanced by administration at the time of day when ALDH activity was increased in 4T1 tumor cells. Our findings reveal a new role for the circadian clock within the tumor microenvironment in regulating the circadian dynamics of CSC. These results should enable the development of novel therapeutic strategies for treatment of TNBC with ALDH inhibitors.Significance: This seminal report reveals that circadian dynamics of CSC are regulated by the tumor microenvironment and provides a proof of principle of its implication for chronotherapy in TNBC. Cancer Res; 78(13); 3698–708. ©2018 AACR.
    Print ISSN: 0008-5472
    Electronic ISSN: 1538-7445
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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  • 5
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    Free-surface molecular command systems for photoalignment of liquid crystalline materials (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-02-20
    Description: Article Molecular alignment in liquid crystals is conventionally achieved by surface mediation from the substrate side. Fukuhara et al. develop a method to photocontrol the orientation of liquid crystalline polymer films from the air side, which is guided by a photoresponsive skin layer. Nature Communications doi: 10.1038/ncomms4320 Authors: Kei Fukuhara, Shusaku Nagano, Mitsuo Hara, Takahiro Seki
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    CORRIGENDUM: The Evidence of Glioblastoma Heterogeneity (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-05-27
    Description: Scientific Reports 5 doi: 10.1038/srep09630
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 7
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    Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-06-13
    Description: Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous Journal of Investigative Dermatology 135, 1829 (July 2015). doi:10.1038/jid.2015.83 Authors: Hitomi Aoki, Hiroyuki Tomita, Akira Hara & Takahiro Kunisada
    Print ISSN: 0022-202X
    Electronic ISSN: 1523-1747
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 8
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    Light-melt adhesive based on dynamic carbon frameworks in a columnar liquid-crystal phase (2016)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2016-07-06
    Description: Article Liquid crystals are used in many applications, such as removable adhesives, but this requires both good bonding strength, and its rapid disappearance under an external stimulus. Here, Saito and others report a dynamic liquid crystal material that loses is bonding strength under photo irradiation. Nature Communications doi: 10.1038/ncomms12094 Authors: Shohei Saito, Shunpei Nobusue, Eri Tsuzaka, Chunxue Yuan, Chigusa Mori, Mitsuo Hara, Takahiro Seki, Cristopher Camacho, Stephan Irle, Shigehiro Yamaguchi
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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