ISSN:
1432-2196
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Conclusions In summary, the LOS of B. pertussis lacks the long-chain polysaccharide O antigen, and is resolved electrophoretically into two distinct bands designated LOS A and LOS B. Mice administered with anti-LOS A mAbs can be protected from fatal B. pertussis infection. These observations may indicate potential for oligosaccharides as a component of new acellular pertussis vaccines. Studies performed thus far also suggest that idiotypic profiles influence the protective value of antibodies and that several antibody-mediated effector functions may participate in the protection. Further research investigating the factors inducing protective immunity is needed for a better definition of new vaccine formulations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00201101
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