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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 10 (1999), S. 0 
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Locating Ectopic Foci. Introduction: Successful radiofrequency of an ectopic focus requires accurate localization of the region of enhanced automaticity. Present localization techniques require detailed electrical mapping that is time-consuming and involves much trial and error. Here, we propose two new localization techniques which were used to locate a pacemaker in a computer simulation. Methods and Results: We suggest that an ectopic focus can he located by measuring the activation sequence of three or more intracardiac electrodes subsequent to an ectopic depolarization. Furthermore, the resetting response of an ectopic pacemaker can be used to estimate the distance from the stimulation electrode to the ectopic focus. We derive simple geometric localization strategies based on these ideas and examine the sensitivity of the strategies with respect to measurement uncertainties and electrode arrangements. Our localization strategies were tested using a numerical simulation of a pacemaker in a sheet of excitable media described by modified FitzHugh-Nagumo equations. The strategy based on electrode activation sequences located the pacemaker region in a homogeneous isotropic sheet after an average of 2.2 ± 0.8 iterates in 10 out of 10 trials starting from random initial catheter positions. In the case of an inhomogeneous anisotropic sheet, the pacemaker was located after an average of 4 ± 3 iterates in 9 out of 10 trials. The localization strategy based on resetting successfully found the pacemaker in a homogeneous isotropic sheet after an average of 1.2 ± 0.4 iterates in 5 out of 5 trials and localized the pacemaker in an inhomogeneous anisotropic sheet after an average of 1.4 ± 0.5 iterates in 5 out of 5 trials. Conclusions: Simple geometric strategies can be used to locate an ectopic focus. Although our basic localization strategies are sensitive to the electrode arrangement and measurement uncertainties, we show that iteration of our techniques quickly locates the pacemaker.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 7 (1996), S. 0 
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: AV Nodal Conduction Time Alternation. Introduction: Alternation of atrial cycle length and AV nodal conduction time (NCT) is often observed during AV reentrant tachycardia. Both AV nodal dual pathway and rate-dependent function have been postulated to be involved in this phenomenon. This study was designed to determine the respective role of these two mechanisms in the alternation observed in an in vitro model of orthodromic AV reentrant tachycardia. Methods and Results: The tachycardia was produced by detecting each His-bundle activation and stimulating the atrium after a retrograde delay, thereby simulating retrograde pathway conduction, in six isolated rabbit heart preparations. After a 5-minute stabilization period at a fast rate, the retrograde delay was decremented by 2 msec every minute until nodal blocks occurred. We observed a sequential alternation of the cycle length and NCT in four preparations in the short retrograde delay range. The magnitude of the alternation gradually increased as the retrograde delay was decreased and reached 4.6 ± 0.5 msec during 1:1 conduction. The alternation increased further just prior to termination of the tachycardia by an AV nodal block. None of the preparations showed discontinuous AV nodal recovery curves. Moreover, an electrode positioned over the endocardial surface of the node showed that the alternation developed distally to the nodal inputs, which are believed to constitute a major component of dual pathways. A mathematical model predicted the alternation from known characteristics of rate-dependent nodal functional properties. Conclusions: NCT and cycle length alternation can arise during orthodromic AV reentrant tachycardia when the retrograde delay is sufficiently short. The characteristics of the alternation, presence of continuous recovery curves, intranodal location of the alternation, and mathematical modeling suggest that the alternation is predictahle from the known functional properties of the AV node without postulating dual pathway physiology.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2018-08-10
    Description: The Weddell Sea sector is one of the main formation sites for Antarctic Bottom Water and an outlet for about one fifth of Antarctica’s continental ice volume. Over the last few decades, studies on glacialegeological records in this sector have provided conflicting reconstructions of changes in ice-sheet extent and ice-sheet thickness since the Last Glacial Maximum (LGM at ca 23e19 calibrated kiloyears before present, cal ka BP). Terrestrial geomorphological records and exposure ages obtained from rocks in the hinterland of the Weddell Sea, ice-sheet thickness constraints from ice cores and some radiocarbon dates on offshore sediments were interpreted to indicate no significant ice thickening and locally restricted grounding-line advance at the LGM. Other marine geological and geophysical studies concluded that subglacial bedforms mapped on theWeddell Sea continental shelf, subglacial deposits and sediments over-compacted by overriding ice recovered in cores, and the few available radiocarbon ages from marine sediments are consistent with major ice-sheet advance at the LGM. Reflecting the geological interpretations, different icesheet models have reconstructed conflicting LGM ice-sheet configurations for the Weddell Sea sector. Consequently, the estimated contributions of ice-sheet build-up in the Weddell Sea sector to the LGM sealevel low-stand of w130 m vary considerably. In this paper, we summarise and review the geological records of past ice-sheet margins and past icesheet elevations in the Weddell Sea sector. We compile marine and terrestrial chronological data constraining former ice-sheet size, thereby highlighting different levels of certainty, and present two alternative scenarios of the LGM ice-sheet configuration, including time-slice reconstructions for post- LGM grounding-line retreat. Moreover, we discuss consistencies and possible reasons for inconsistencies between the various reconstructions and propose objectives for future research. The aim of our study is to provide two alternative interpretations of glacialegeological datasets on Antarctic Ice- Sheet History for the Weddell Sea sector, which can be utilised to test and improve numerical icesheet models
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 4
    Publication Date: 2022-03-24
    Description: The Alpine Fault zone in New Zealand marks a major transpressional plate boundary that is late in its typical earthquake cycle. Understanding the subsurface structures is crucial to understand the tectonic processes taking place. A unique seismic survey including 2D lines, a 3D array, and borehole recordings, has been performed in the Whataroa Valley and provides new insights into the Alpine Fault zone down to ∼2 km depth at the location of the Deep Fault Drilling Project (DFDP)‐2 drill site. Seismic images are obtained by focusing prestack depth migration approaches. Despite the challenging conditions for seismic imaging within a sediment filled glacial valley and steeply dipping valley flanks, several structures related to the valley itself as well as the tectonic fault system are imaged. A set of several reflectors dipping 40°–56° to the southeast are identified in a ∼600 m wide zone that is interpreted to be the minimum extent of the damage zone. Different approaches image one distinct reflector dipping at ∼40°, which is interpreted to be the main Alpine Fault reflector located only ∼100 m beneath the maximum drilled depth of the DFDP‐2B borehole. At shallower depths (z 〈 0.5 km), additional reflectors are identified as fault segments with generally steeper dips up to 56°. Additionally, a glacially over‐deepened trough with nearly horizontally layered sediments and a major fault (z 〈 0.5 km) are identified 0.5–1 km south of the DFDP‐2B borehole. Thus, a complex structural environment is seismically imaged and shows the complexity of the Alpine Fault at Whataroa.
    Description: Plain Language Summary: The Alpine Fault in New Zealand is a major plate boundary, where a large earthquake will likely occur in the near future. Thus, it is important to understanding the detailed processes of how and where such an earthquake occurs. Many scientists are involved in this work, particularly in the attempt of drilling through the fault zone with a ∼900 m deep borehole. We analyzed new seismic data from this area using sensors in the borehole and at the surface to record small ground movements caused by a vibrating surface source causing waves that travel through the ground. From these data, we obtained a detailed image of the structures in the subsurface, for the first time in 3D, by applying advanced analysis methods. Hence, we can better understand the shape of the glacial valley and of the fault zone, that is, the local structures of the continental plate boundary. We interpret at least 600 m wide zone of disturbed rocks and identify a potential major fractured plane down to about 1 km depth. Our studies may help to understand structures that host earthquakes in this area.
    Description: Key Points: We use focusing prestack depth migration with detailed seismic data to analyze the complex subsurface environment of the Alpine Fault zone. Seismic images show Alpine Fault zone related reflectors at a depth of ∼0.2–1 km dipping ∼40°–56° around the DFDP‐2B borehole. Complex structures within the glacial Whataroa Valley are imaged showing steep valley flanks, faults, and internal sedimentary horizons.
    Description: German Research Foundation (DFG)
    Description: Earthquake Commission (EQC) http://dx.doi.org/10.13039/100012181
    Description: NSERC discovery and Canada Research Chairs Program
    Description: Canadian Foundation for Innovation
    Keywords: ddc:622.1592 ; ddc:551.8
    Language: English
    Type: doc-type:article
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  • 5
    Publication Date: 2017-04-13
    Description: The crown-of-thorns starfish genome as a guide for biocontrol of this coral reef pest Nature 544, 7649 (2017). doi:10.1038/nature22033 Authors: Michael R. Hall, Kevin M. Kocot, Kenneth W. Baughman, Selene L. Fernandez-Valverde, Marie E. A. Gauthier, William L. Hatleberg, Arunkumar Krishnan, Carmel McDougall, Cherie A. Motti, Eiichi Shoguchi, Tianfang Wang, Xueyan Xiang, Min Zhao, Utpal Bose, Chuya Shinzato, Kanako Hisata, Manabu Fujie, Miyuki Kanda, Scott F. Cummins, Noriyuki Satoh, Sandie M. Degnan & Bernard M. Degnan The crown-of-thorns starfish (COTS, the Acanthaster planci species group) is a highly fecund predator of reef-building corals throughout the Indo-Pacific region. COTS population outbreaks cause substantial loss of coral cover, diminishing the integrity and resilience of reef ecosystems. Here we sequenced genomes of COTS from the Great Barrier Reef, Australia and Okinawa, Japan to identify gene products that underlie species-specific communication and could potentially be used in biocontrol strategies. We focused on water-borne chemical plumes released from aggregating COTS, which make the normally sedentary starfish become highly active. Peptide sequences detected in these plumes by mass spectrometry are encoded in the COTS genome and expressed in external tissues. The exoproteome released by aggregating COTS consists largely of signalling factors and hydrolytic enzymes, and includes an expanded and rapidly evolving set of starfish-specific ependymin-related proteins. These secreted proteins may be detected by members of a large family of olfactory-receptor-like G-protein-coupled receptors that are expressed externally, sometimes in a sex-specific manner. This study provides insights into COTS-specific communication that may guide the generation of peptide mimetics for use on reefs with COTS outbreaks.
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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