ISSN:
1432-2196
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Conclusions In the future, the development of an effective immunopharmacology will service clinical immunotherapy by removing the current empiricism in which the latter is steeped. By dissection of critical features of the cell targets of action and intracellular mechanisms of action and relating these to primary effects to modify host immune responses, in a predictable, consistent manner, the primary goal will be achieved. Once achieved and appropriate nonimmunologic aspects of host resistance and status are taken into account, the second goal of effective delivery of a restored or enhanced immune system to combat the invading tumor or pathogen can be made. Finally, by overcoming the resistance and suppressor mechanisms derived from the pathogen or tumor, immunotherapy will achieve an efficacy and safety which will ultimately justify a more general use. To date, cyclic nucleotide pharmacology and in vitro analysis of cellular targets and function have provided important first steps towards achieving these goals. Once achieved, the clinical potential for therapeutic benefit in cancer, immunodeficiency, aging, chronic infections, and autoimmune disorders seems great.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00201972
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