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  • 1
    Electronic Resource
    Electronic Resource
    The anaplastic variant of centrocytic lymphoma is marked by frequent rearrangements of the bcl-1 gene and high proliferation indices (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 24 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ten cases of classic centrocytic lymphoma as defined in the Kiel classification system were investigated for their immunophenotype, their proliferation activity and by means of molecular diagnostics. The findings were compared to those obtained from a group of nine cases of anaplastic centrocytic lymphoma. Both groups showed virtually identical immunohistochemical characteristics with positivity for CD5 and negativity for CD10 and CD23. In the group of anaplastic centrocytic lymphoma, there were considerably higher proliferation indices as documented by staining for the Ki-67 antigen, up to 80% of the tumour cells being positive. Moreover, the cases of anaplastic centrocytic lymphoma had bcl-1 gene rearrangements in eight out of nine cases compared with three out of 10 cases of classic centrocytic lymphoma. DNA analysis was not able to detect bcl-2 gene rearrangement in any case, pointing to a difference compared with lymphomas of germinal centre origin. The coincidence of anaplastic and sometimes blast-like morphology of the tumour cells, high proliferation index and a rearranged bcl-1 gene in nearly all cases of anaplastic centrocytic lymphoma support their classification as high-grade malignant variants of centrocytic lymphoma and suggest a possible role for the bcl-1 locus not only in the origin but also in the progression of centrocytic lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb00533.x
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  • 2
    Electronic Resource
    Electronic Resource
    Postheparin-diamine oxidase (histaminase) in anaphylaxis (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 285-287 
    Details
    ISSN: 1432-1440
    Keywords: Postheparin-diamine oxidase ; histaminase ; heparin ; anaphylaxis ; Postheparin-Diamino-Oxidase ; Histaminase ; Heparin ; Anaphylaxie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Postheparin-Diamino-Oxidase wurde im Plasma bei zwei Patienten drei Tage nach einem anaphylaktischen Schock bestimmt und vier Wochen bzw. sechs Monate später kontrolliert. Ein Abfall des Enzymspiegels auf ca. 10%, verglichen mit einer Kontrollgruppe, wurde festgestellt, und ein langsamer Wiederanstieg der Enzymaktivität bis auf etwa 40% der Kontrollen wurde nach sechs Monaten gefunden. Wahrscheinlich erfolgt in der Anaphylaxie eine Enzymverarmung der Leber und des Dünndarmes, wie dies nach Heparinbelastung bei Normaltieren bekannt ist.
    Notes: Summary The level of plasma postheparin-diamine oxidase was determined in two patients three days after an anaphylactic shock and was controlled four weeks, and also six months later. A decrease of the enzyme levels to about 10% of a control group was found and a slow enzyme increase to about 40% observed six months later. It seems probable that in anaphylaxis a depletion of the enzyme in liver and small intestine occurs as could be shown in animals after heparin load.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469122
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  • 3
    Electronic Resource
    Electronic Resource
    Germinal center cell lymphomas: Prognostic significance of their histopathological differentiation (1981)
    Springer
    Annals of hematology 43 (1981), S. 193-200 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; Centrocytic lymphoma ; Centroblastic-centrocytic lymphoma ; Centroblastic lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical data of 48 patients with centrocytic, 83 patients with centroblastic/centrocytic and 64 patients with centroblastic lymphoma who had entered a prospective multicenter study of the Kiel Lymphoma Study Group since October 1975 were compared. Advanced (stage IV) disease at time of diagnosis, predominantly due to bone marrow infiltration, was most frequent in centrocytic (69% of patients) and in centroblastic/centrocytic (51% of patients) lymphomas as compared to only 28% of patients with centroblastic lymphoma. High survival probability of patients with localized centrocytic and centroblastic/centrocytic lymphomas after radiotherapy, contrasting with a worse prognosis of corresponding patients with centroblastic lymphoma, is compatible with the classification of these lymphoma entities as neoplasias of low-grade malignancy. However, as shown by this prospective and previous retrospective trials overall survival probability of patients with advanced centrocytic lymphoma was inferior to that observed in corresponding patients with centroblastic/centrocytic lymphoma. These findings suggest the possibility that patients with advanced centrocytic lymphoma occupy an intermediate position between typical low-grade and typical high-grade malignant non-Hodgkin lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363889
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  • 4
    Electronic Resource
    Electronic Resource
    Principles and present status of a prospective multicenter study on the clinical relevance of the kiel classification (1981)
    Springer
    Annals of hematology 43 (1981), S. 155-166 
    Details
    ISSN: 1432-0584
    Keywords: Non-Hodgkin lymphoma ; Kiel classification ; Low-grade malignancy ; High-grade malignancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On the basis of the retrospective analysis of 405 patients, suggesting the clinical relevance of the Kiel classification of non-Hodgkin lymphomas (NHL), a prospective multicenter study was started on October 1st, 1975, by the Kiel Lymphoma Study Group in order to further clarify the clinical and prognostic features of the different lymphoma entities defined by this histopathologic scheme. Diagnostic protocol provides initial staging evaluation according to a modification of the Ann Arbor classification. Therapeutic approach is based on the hypothesis that, like Hodgkin's disease, NHL originate, at least in part, as localized lymphatic or extralymphatic tumors. Thus, extended field irradiation is performed in stages I and II (except for lymphoblastic lymphoma in children and young adults) whereas in the more advanced stages III and IV (except for stage III of centroblastic-centrocytic lymphoma) chemotherapy with additional radiotherapy is applied. Until June 1979, 815 patients entered the study (69.7% with NHL of low-grade malignancy). For the interim evaluation underlying the present and the other papers of this series data of 511 patients were available. Survival of patients with NHL of low-grade malignancy significantly exceeds that of patients with NHL of high-grade malignancy. NHL with good prognosis such as chronic lymphocytic leukaemia and centroblastic-centrocytic lymphoma can be differentiated from NHL with a poor course such as lymphoblastic and immunoblastic lymphomas. In addition, the existence of a third group with an intermediate prognosis comprising centrocytic and centroblastic lymphomas and, possibly, also LP immunocytoma is suggested. However, different initial slope of survival curves shows that this latter group of NHL is not homogeneous with regard to prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00363886
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