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  • 1
    Electronic Resource
    Electronic Resource
    Lipid abnormalities in stable liver transplant recipients – effects of cyclosporin, tacrolimus, and steroids (1998)
    Springer
    Transplant international 11 (1998), S. 137-142 
    Details
    ISSN: 1432-2277
    Keywords: Key words Lipoproteins ; liver transplantation ; immunosuppression ; Liver transplantation ; lipoproteins ; immunosuppression ; Immunosuppression ; liver transplantation ; lipoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dyslipidemia is common after liver transplantation, but the underlying mechanisms are largely unknown. We studied the lipid profile of 27 liver transplant recipients randomized to receive either cyclosporin (CyA, n = 14) or tacrolimus (n = 13) and compared them with 20 healthy, matched controls. Before transplantation, patients presented low total and low-density lipoprotein (LDL) cholesterol (as compared to controls) that increased shortly, i. e., 3 months, after transplantation. Eighteen months post-transplantation, total and LDL cholesterol levels decreased to pretransplant values but tended to remain higher in CyA-treated patients. However, at that time, prednisone treatment was more prevalent among CyA-treated than tacrolimus-treated patients and fully accounted for the difference in cholesterol levels. Indeed, regardless of therapy, patients not receiving prednisone exhibited lower cholesterol levels than prednisone-treated patients and controls. We conclude that prednisone therapy, rather than CyA or tacrolimus immunosuppression, seems to be the major determinant of increased cholesterol levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050117
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    Paper (German National Licenses)
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  • 2
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    Extension of summer climatic conditions into spring in the Western Mediterranean area (2016)
    Wiley-Blackwell
    Details
    Publication Date: 2016-07-21
    Description: ABSTRACT From a local point of view, in May/June, there is an important and positive 2 m temperature trend at Palma (Mallorca), which is simultaneous and highly correlated with a strong increase in the 500 hPa geopotential height. This study analyses this fact as well as the observed tendencies in a wider seasonal and geographical context. We confirm the particularly high correlation between 2 m temperature and 500 hPa geopotential during the warm months as opposed to the much weaker correlation in winter. This suggests that mechanisms for thermal changes act differently throughout the year in this region. Besides the direct radiative effect, warm season near-surface temperatures are linked to the presence of deep anticyclones, which effectively determine the northern edge of the Hadley cell. Accordingly, the strong warming trend in the area of Palma during the warm months of the year is purportedly related to the poleward extension of the Hadley cell. The fact that May/June shows the highest low-level temperature trend among all bi-monthly series is a common regional feature over a relatively wide area over the Western Mediterranean. Different geographical patterns emerge in other periods of the year. In July/August, the strongest low-level warming area drifts to the east-northeast, towards Ukraine and Russia. Coincidentally, the 500 hPa geopotential tendencies show a coherent pattern, with an intense positive trend ridge over the Western Mediterranean area in May/June, and a displacement of this ridge to the north-east in July/August. We show the connection between 500 hPa geopotential height and near-surface temperature by means of a multiple lineal regression that attributes half of the local temperature tendency in Palma to the intensification of a 500 hPa ridge centred over the Western Mediterranean and surroundings.
    Print ISSN: 0899-8418
    Electronic ISSN: 1097-0088
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell
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