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  • 1
    Electronic Resource
    Electronic Resource
    Neurogenesis and Plasticity of the Olfactory Sensory Neurons (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 457 (1985), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1985.tb20802.x
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  • 2
    Electronic Resource
    Electronic Resource
    Low-grade MALT lymphoma involving multiple mucosal sites and bone marrow (1998)
    Springer
    Annals of hematology 76 (1998), S. 81-83 
    Details
    ISSN: 1432-0584
    Keywords: Key words Non-Hodgkin's lymphoma ; Mucosa-associated lymphoid tissue ; Clinical findings ; Pathological findings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Mucosa-associated lymphoid tissue (MALT) lymphomas are indolent neoplasms which tend to remain localized for a long time before spreading. We describe here the case of a 36-year-old woman with a low-grade MALT lymphoma involving the lung, stomach, lingual tonsil, and bone marrow at the time of diagnosis. The clonal origin of the pulmonary and bone marrow neoplastic infiltrates was assessed by means of gene rearrangement analysis. All of the involved sites were infiltrated by centrocyte- and monocytoid-like cells expressing the B-cell-associated antigens CD19 and CD20 and showed IgM λ chain restriction; no CD5, CD10, or CD43 expression was detectable. As the patient had a history of recurrent bronchitis, and computed tomography performed 3 years before the lymphoma diagnosis had already revealed a lesion of the left lung, we conclude that the present case probably represents a pulmonary low-grade MALT lymphoma characterized by an early and unusual involvement of different mucosal sites and bone marrow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050367
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  • 3
    Electronic Resource
    Electronic Resource
    Olfactory epithelium ofNecturus maculosus andAmbystoma tigrinum (1976)
    Springer
    Journal of neurocytology 5 (1976), S. 11-32 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The morphological study presented here provides a general description of the elements of the olfactory epithelium in the mud puppy and tiger salamander, and gives evidence about their dynamic activity and interrelationships. There are morphological indications of local bursts of reduplication and a continual line of differentiation of receptor cells from basal cell progenitors through stages of mature development to senescence (indicated by the accumulation of pigment granules) and cell death and disposal (by expulsion of pycnotic cell nuclei and by phagocytosis by macrophages). The supporting cells probably play several roles: a secretory role which supplements the activity of Bowman's glands, a minor insulating role in which some dendrites are shielded from the surrounding milieu, and a skeletal role in which they facilitate the efficient displacement of dendrites. The dendrites are regularly arranged in organized relationships with one another and are for the most part in direct apposition, separated only by a 200 Å intercellular gap, thus suggesting the possibility of functional interrelationships. This study emphasizes the fact that efficient planning of experimental investigations must include knowledge and consideration of the thickness of the particular olfactory epithelium under study. It also suggests that because of the large receptor-cell size, the mud puppy and/or tiger salamander would make good model systems for single cell recording. Further, the olfactory epithelia of these species are suggested as favorable targets for studies of the aging process in nerve cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01176180
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  • 4
    Electronic Resource
    Electronic Resource
    Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy (1979)
    Springer
    Journal of neurocytology 8 (1979), S. 197-213 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes the retrograde degeneration affecting olfactory sensory neurons of rats after severance of their axons and illustrates the reconstitution of new neurons originating from stem cells located at the base of the olfactory neuroepithelium. Degeneration of the mature, axotomized neurons, signalled by an increased electron density of their cytoplasmic matrix and by the appearance of lipofuscin-like granules, can be detected in the neuroepithelium as early as 24 h after surgery and becomes conspicuous between the second and the third day. Degenerating neurons can be observed in decreasing number up to the tenth post-operative day. They are removed by macrophages which invade the epithelium. The reconstitution of new neurons begins to occur after eight days, when the stem cells undergo vigorous mitotic activity and differentiate into neurons. The morphology of the reconstituted neurons has been described in detail at different stages of their maturation. After 30 days, the olfactory epithelium appears similar to controls. On the basis of both morphological (in rats) and autoradiographic (in mice) observations, the basal cells have been recognized as stem cells of the olfactory neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01175561
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  • 5
    Electronic Resource
    Electronic Resource
    Neurogenesis and neuron regeneration in the olfactory system of mammals. III. Deafferentation and reinnervation of the olfactory bulb following section of thefila olfactoria in rat (1980)
    Springer
    Journal of neurocytology 9 (1980), S. 145-162 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Axotomy at the level of thelamina cribrosa in rat induces rapid degeneration of the olfactory sensory axons in the bulb. The phenomenon, which is limited to the layer of olfactory fibres and to the glomeruli of the bulb, can be observed as early as 15–24 h after surgery, and peaks at 3–4 days. The glomeruli located in the rostro-ventral portion of the bulb are affected first, and the process extends to the dorso-caudal portion with a delay of 12–24 h. Reactive hypertrophy of the glia coincides with removal of the degenerating terminals, and is maximal 48 h after axotomy. Axotomy does not preclude reinnervation of the bulb by axons originating from new, reconstituted neurons in the olfactory neuroepithelium. These new axons begin to reach the periphery of the bulb approximately at the 20th day post-operative and then reinnervate the glomeruli. The rostro-ventral portion of the bulb is the first to be reinvaded by the new axons. The glomeruli reacquire a morphological pattern similar to controls between 20 and 30 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01205155
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  • 6
    Electronic Resource
    Electronic Resource
    Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons (1979)
    Springer
    Journal of neurocytology 8 (1979), S. 1-18 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The neurogenetic process leading to the formation of primary sensory neurons persists into adult life in the olfactory epithelium of mammals. The morphological stages of maturation and ageing of this exceptional neuron have been described both at light and electron microscopical levels. For descriptive purposes the neural elements have been classified as: (1) basal cells proper, (2) globose basal cells, and (3) neurons. Intermediate stages, however, have been identified. Autoradiographic observations complement the morphological studies and provide a time sequence of the morphological stages leading to the mature neurons. A typical columnar arrangement of the sensory neurons has been described. Furthermore, active and quiescent zones have been recognized in the neuroepithelium. In the active zones the neurogenetic process is vigorous, and the zones are characterized by the presence of immature elements. However, in the quiescent zones there exists a population of mature elements while immature neurons are sparse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01206454
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