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  • 1
    Online Resource
    Online Resource
    Milton :Taylor & Francis Group,
    Keywords: Aromatic compounds -- Metabolism. ; Electronic books.
    Description / Table of Contents: This book examines 20,000 aromatic compounds researched since 1972 and assembled from all relevant journals. The author focuses on biotransformation in animals, plants, and microbes while remaining in the scope of aromatic compounds that contain at least one aromatic C6 ring. He lists each compound and its forward and reverse mechanisms in Part One and characterizes the different types of organic reactions and the enzymes associated with those reactions in Part Two. A searchable CD-ROM covering aromatic compounds researched from 1900 through 1972 is included. The most complete resource of its kind, this book is a user-friendly handbook for professionals, policymakers, and researchers.
    Type of Medium: Online Resource
    Pages: 1 online resource (2126 pages)
    Edition: 1st ed.
    ISBN: 9780203641965
    DDC: 572.5
    Language: English
    Note: Front cover -- Contents -- Author Biography -- Introduction -- Part 1: Reactions of Individual Compounds -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z -- Part 2: Enzymes and Reactions -- 1. Reactions involving the formation and degradation of the aromatic nucleus -- 2. Oxidations and reductions involving the aromatic nucleus and non-organic substituents -- 3. Oxidations and reductions of substituent side chains and non-aromatic ring systems (without altering chain length) -- 4. Formation and degradation of side-chains -- 5. Conjugation and substitution reactions -- 6. Elimination of substituents -- 7. Transfer reactions -- 8. Formation and reactions of non-aryl double and triple bonds -- 9. Hydration of epoxides -- 10. Light-forming reactions -- Bibliography -- Part 2 Index -- Back cover.
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 51 (1988), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin. A gas chromatographic-mass spectrometric assay for isatin has been developed and used to measure its relatively high concentrations in unpurified human urine, and in rat heart and brain. Isatin is a known compound with a broad range of biological activity; this is the first report of its presence in the animal body. Isatin is a potent inhibitor of MAO, particularly of MAO B (IC50, 3 μM), and also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 229 (1971), S. 414-416 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Urine samples (24 h) obtained from six patients with idiopathic Parkinsonism during a previous investigation2 were stored at -15 C before assay. All patients were on their maximum tolerated oral dosage of L-dopa (Fig. 1). Collections had been made before taking neomycin and on day 3 of a short ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 278 (1979), S. 357-358 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Thirteen females (mean age, 56.9±3.2yr) and 10 males (mean age, 57.6±2.8yr) suffering from primary depressive illness6 were studied. They had no history of mania or of significant physical illness. On admission, all were withdrawn from antidepressant or neuroleptic medication and ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 213 (1967), S. 882-883 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The first article deals with the problem of using the response to injected phenylalanine to determine whether or not the subject is heterozygous for phenylketonuria. The second article suggests a third allele on the phenylketonuria locus, the corresponding enzyme having a higher affinity for ...
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the L-Dopa treated rat, a decreased urinary output of free and conjugated dopamine and an increase in free and conjugated L-Dopa excretion after administration of decarboxylase-inhibiting drugs provide a goodin vivo index of Dopa decarboxylase inhibition. With the exception of free dopamine output, which showed an equivocal change, these measurements appear to provide a good yardstick of decarboxylase status in man also. Using this approach, it was not possible to find any evidence of facilitation of decarboxylase action, in L-Dopa-treated parkinsonians given pyridoxine supplements, to account for the ability of this compound to neutralize the beneficial effect of L-Dopa.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-1463
    Keywords: Tribulin ; monoamine oxidase inhibition ; benzodiazepine receptor binding inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A low molecular weight fraction of human urine (〈500 daltons) which both inhibits monoamine oxidase and benzodiazepine binding to central and peripheral receptors has been purified by ethyl acetate extractions, HPLC and thin layer chromatography. This material extracted equally well at acid and basic pH and was insoluble in heptane. It competitively inhibited binding of3H-clonazepam, a central benzodiazepine receptor agonist and, in addition, displaced3H-Ro 5-4864, a specific peripheral benzodiazepine receptor ligand, from its binding sites. It showed no GABA shift with the benzodiazepine receptor antagonist, Ro-15 1788. MAO A and B were inhibited approximately equipotently and the material competitively inhibited tyramine oxidation by rat liver. It was stable on boiling and is unlikely to be a peptide.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 29 (1973), S. 523-525 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die Hemmung der Phenylpyruvat- undp-Hydroxyphenylpyruvat-Oxydasen durch Chelat-Wirkstoffe wurde offenbar durch die Bildung eines Enzym-Wirkstoff-Komplexes verursacht, der bei Behandlung mit Kationen oder mit Sephadex trennbar ist. Die Reinigung des Enzyms führt zur Kupferanreicherung des Präparates, welches eine scheinbar funktionelle Einheit mit dem Enzym bildet.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 28 (1972), S. 1298-1299 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Chez le rat, les injections dedl-thréo-3,4-dihydroxyphénylsérine, un précurseur pharmacologique synthétique de la noradrénaline, provoquent une conversion de moins de 1% au 4-hydroxy-3-méthoxyphényl-glycol, le métabolite urinaire majeur de la noradrénaline dans cette espèce. Un nouveau cheminement qui entraîne une coupure latérale de la chaîne prit environ 10% de la dose et un autre 10% fût excrété comme un amino-acideO-méthylé; le sort de quelque 80% est inconnu.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-2072
    Keywords: Selegiline (deprenyl) ; Tyramine ; Monoamine oxidase ; Pressor response ; 4-Hydroxy-3-methoxyphenylglycol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood pressure and heart rate responses to oral tyramine have been measured in healthy volunteers before and after administration of the selective monoamine oxidase B inhibitor selegiline at high dosage (30 mg/day). Treatment brought about a 2 to 4-fold increase in tyramine sensitivity and a concomitant small but significant reduction in plasma 4-hydroxy-3-methoxyphenylglycol concentration, pointing to the emergence of some degree of monoamine oxidase A inhibition. It is suggested that patients treated with selegiline 30 mg/day or more should be placed on a tyramine-free diet.
    Type of Medium: Electronic Resource
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