ISSN:
1573-8353
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The action of sodiomalonic ester on 4-bromomethylbenzo-2,1,3-thiadiazole forms a malonate which is converted by acid hydrolysis into 4-(β-carboxyethyl)benzo-2,1,3-thiadiazole. When this reaction is carried out with 5-bromomethylbenzo-2,1,3-thiadiazole, mono- and disubstituted malonic esters are formed the acid hydrolysis of which gives the corresponding acids. The nitration of 4-and 5-(β-carboxyethyl)benzo-2,1,3-thiadiazoles forms, respectively, 4-(β-carboxyethyl)-5,7-dinitrobenzo-2,1,3-thiadiazole and 5-(β-carboxyethyl)4-nitrobenzo-2,1, 3-thiadiazole. The reaction of 4-bromomethylbenzo-2,1, 3-thiadiazole with potassium cyanide forms two products: 4-cyanomethylbenzo-2,1, 3-thiadiazole and 1,2-di(benzo-2,1, 3-thiadiazole-4′-yl)-2-cyanoethane.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00470257
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