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  • 1
    Electronic Resource
    Electronic Resource
    Deuterium–tritium plasmas in the Joint European Torus (JET): Behavior and implications : The 39th annual meeting of division of plasma physics of APS (1998)
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 5 (1998), S. 1839-1847 
    Details
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This paper reports the first deuterium–tritium (D-T) fusion experiments in the geometry of the International Thermonuclear Experimental Reactor (ITER) [R. Aymar, V. Chuyanov, M. Huguet, R. Parker, Y. Shimamura, and the ITER Joint Central Team and Home Teams, Proceedings of the 16th International Conference on Fusion Energy (International Atomic Energy Agency, Vienna), Fusion Energy 1, 3 (1996)], with long pulse length and an ITER-like divertor. Physics aspects, such as the isotope dependence of confinement, the H-mode (high confinement) threshold, shear optimisation, heating methods, high fusion performance and alpha particle heating, are discussed together with their implications. The technology aspects of tritium wall loading and clean-up, the close coupled tritium plant and the future remote handling divertor target exchange are also mentioned. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.872854
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  • 2
    Electronic Resource
    Electronic Resource
    A new K-matrix approach to N-body scattering (1991)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 32 (1991), S. 3117-3124 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The Chandler–Gibson theory of N-body scattering is used to define a new K matrix for N-body quantum scattering systems. The half-on-shell K matrix has the proper channel thresholds and may be computed using a K-matrix form of the CG equations. The on-shell K matrix is an Hermitian matrix for all energies and is related to a unitary scattering matrix via a Cayley transform. A B-spline solution method is developed and applied to a two-body and a three-body test problem. The three-body numerical calculations are within 0.5% of the exact solution both below and above the breakup threshold.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.529059
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  • 3
    Electronic Resource
    Electronic Resource
    N-body quantum scattering theory in two Hilbert spaces. V. Computation strategy (1989)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 30 (1989), S. 1533-1544 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: In this paper the development of our previously published theory of approximations for the Chandler–Gibson (CG) equations is continued. In particular, our approximation theory is rigorously brought to the point where N-particle scattering calculations can begin. This is accomplished by mapping the CG operator equations into a function equation form, where the unknowns belong to a new (third!) computational Hilbert space L. This mapping is facilitated by rescaling the Jacobi momentum variables for the relative free motion of the asymptotic clusters so that surfaces of constant kinetic energy are hyperspheres. The input terms to the resulting equations are expanded in a basis on the surface of the kinetic energy hypersphere. This leads to a system of infinitely many coupled one-dimensional integral equations with the kinetic energy as the continuous variable. The half-on-shell variant of these equations is then transformed to a K-matrix form. Our approximations result from truncating this system to a finite number of equations, which is equivalent to using a finite basis approximation of the original input terms. The basis sets could be hyperspherical harmonics, but the use of hyperspherical spline functions is also proposed. Our method generalizes the well-known method of partial waves for channels with two clusters, and it accommodates breakup channels in a straightforward way.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.528286
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  • 4
    Electronic Resource
    Electronic Resource
    Purification and Characterization of Two Soluble C1−-Activated Arginyl Aminopeptidases from Human Brain and Their Endopeptidase Action on Neuropeptides (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 50 (1988), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Two closely related Cl− -activated arginyl aminopeptidases (I and II) were purified from a soluble extract of postmortem human cerebral cortex by anion-exchange chromatography and preparative gel electrophoresis. The electrophoretic mobility of II was approximately 80% that of I; the molecular mass of both enzymes was approximately 70 kilodaltons (kDa) (gel filtration). The aminopeptidase action of 1 and II on aminoacyl-7-amido-4-methyl-coumarin (AMC) substrates was restricted to the Arg and Lys derivatives. Both enzymes had significant endopeptidase activity, hydrolysing several biologically active peg tides including neurotensin, bradykinin, angiotensin-I, substance P, luliberin, and somatostatin at internal bonds. Other peptides [Leu-enkephalin, proctolin, thyroliberin, adrenocorticotropin18–39 (ACTH18–39), ACTH11–24, and dynorphin (1–13)] were not appreciably hydrolysed. The amino- and endopeptidase activities had pH optima at 6.5 and 7, respectively, and were both inhibited by metal ion chelators and sulphydryl group blocking agents. The ami-nopeptidase activity was stimulated 20-fold by Cl− ions, whereas the endopeptidase activity was unaffected by the latter. Km values for neurotensin degradation were 20 μM (I) and 37 μM (II) and for Arg-AMC hydrolysis they were 167 μM (I) and 125 μM (II). The endopeptidase activity was not inhibited by the aminopeptidase inhibitors arphame-nine or bestatin (IC50= 9 nM and 0.1 μM, respectively, with Arg-AMC substrate).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb13246.x
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  • 5
    Electronic Resource
    Electronic Resource
    Raised Thyrotrophin-Releasing Hormone, Pyroglutamylamino Peptidase, and Proline Endopeptidase Are Present in the Spinal Cord of Wobbler Mice but Not in Human Motor Neurone Disease (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 49 (1987), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The Wobbler mouse (wr) is a mutant that exhibits loss of anterior horn ceils in the spinal cord and brainstem and subsequent muscle wasting, particularly of the fore-limbs and neck. The wr mice, 2–3 months of age, were found to have increased levels of immunoreactive-thyrotrophin-releasing hormone (ir-TRH) in the spinal cord and pons and medulla, but not in other CNS areas. This increase was observed in dorsal and ventral cord and at cervical, thoracic, and lumbar levels and was confirmed by HPLC to be authentic TRH. The levels of immunoreactive-somatostatin,-neurotensin, and-substance P were not raised in the CNS of wr mice. The activities of two peptidases capable of degrading TRH, pyroglutamylaminopeptidase (PGAP, EC 3.4.11.8) and proline endopeptidase (PEP, EC 3.4.21.26), and the level of 5-hydroxyindoleacctic acid were also raised in the spinal cord of 2–3-month-old wr mice although the activities of alanine aminopeptidase and lactate dehydrogenase and the level of 5-hydroxytrypt-amine were not. Increased spinal cord levels of ir-TRH and PGAP and PEP activities were not observed in the 1-month-old wr mice. In addition, a pilot study using spinal cord obtained at autopsy from three patients with motor neurone disease and 12 control subjects indicated no increase in spinal cord ir-TRH, PGAP, or PEP in human motor neurone disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1987.tb09997.x
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  • 6
    Electronic Resource
    Electronic Resource
    Multicatalytic, High-Mr Endopeptidase from Postmortem Human Brain (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 56 (1991), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The main high molecular weight (650K) multica-talytic endopeptidase has been purified from postmortem human cerebral cortex. As in other tissues and species, this enzyme is composed of several subunits of 24-3 IK and has three distinct catalytic activities, as shown by the hydrolysis of the fluorogenic tripeptide substrates glutaryl-Gly-GIy-Phe-7-amido-4-methylcoumarin, benzyloxycarboxyl - Gly - Gly -Arg-7-amido-4-methylcoumarin, and benzyloxycarboxyl-Leu-Leu-Glu-2-naphthylamide with hydrophobic (Phe), basic (Arg), and acidic (Glu) residues in the P, position, respectively. These activities are distinguishable by their differential sensitivity to peptidase inhibitors. The enzyme hydrolysed neu-ropeptides at pH 7.4 at multiple sites with widely differing rates, ranging from 113 nmol/min/mg for substance-P, down to 2 nmol/min/mg for bradykinin. The enzyme also had pro-teinase activity as shown by the hydrolysis of casein. For the hydrolysis of the Tyr5-Gly6 bond in luteinizing hormone-releasing hormone, the Km was 0.95 mM and the specificity constant (kcat/Km) was 4.7 ± 103 M-l s-1. The bond specificity of the enzyme at neutral pH was determined by identifying the degradation products of 15 naturally occurring peptide sequences. The bonds most susceptible to hydrolysis had a hydrophobic residue at P1, and either a small (e.g., -Gly or -NH2) or hydrophobic residue at P1. Hydrolysis of -Glu-X bonds (most notably in neuropeptide Y) and the Arg6-Arg7 bond in dynorphin peptides was also seen. Thus the three activities identified with fluorogenic substrates appear to be expressed against oligopeptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1991.tb02045.x
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  • 7
    Electronic Resource
    Electronic Resource
    REPLY (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 53 (1989), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb04464.x-i1
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  • 8
    Electronic Resource
    Electronic Resource
    Detection by ultrasound of abnormality in twin pregnancies during the second trimester (1982)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 89 (1982), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Five cases of abnormality in twin pregnancies, detected by ultrasound examination during the second trimester, are reported. In four pregnancies there was a fetal malformation: discordant anencephaly, a monozygotic, heterokaryotypic twin pregnancy with coexistant Turner's syndrome and intrauterine death, concordant body stalk syndrome, and a dicephalus monster. In the other pregnancy one fetus dies in utero to become a fetus papyraceous. Four of the pregnancies were associated with raised levels of maternal serum α-fetoprotein, by singleton standards. Ultrasound examination proved of value in each case. Three pregnancies were terminated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1982.tb04660.x
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  • 9
    Electronic Resource
    Electronic Resource
    Erratum: Precision measurement of nuclear susceptibility by pulsed NMR [Rev. Sci. Instrum. 55, 1111 (1984)] (1985)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 56 (1985), S. 2178-2178 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138535
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  • 10
    Electronic Resource
    Electronic Resource
    Erratum: N-body quantum scattering theory in two Hilbert spaces. V. Computation strategy [J. Math. Phys. 30, 1533 (1989)] (1993)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 34 (1993), S. 886-886 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.530231
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