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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 49 (1977), S. 1880-1881 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 49 (1977), S. 1885-1886 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Circadian rhythms are entrained by light and by several neurochemical stimuli. In hamsters housed in constant darkness, i.c.v. administration of nerve growth factor (NGF) at various times in their circadian cycle produced phase shifts of locomotor activity rhythms that were similar in direction and circadian timing to those produced by brief pulses of light. Moreover, the effect of NGF and light were not additive, indicating signalling points in common. These points include the immediate-early gene c-fos and ERK1/2, a component of the mitogen-activated protein kinases (MAPK) family. NGF activates c-FOS and ERK1/2-MAPK in the suprachiasmatic nuclei, the site of a circadian clock in mammals, when administered during the subjective night but not during the day. The effect of NGF on ERK1/2 activation was not inhibited by the administration of MK-801, a glutamate/NMDA receptor antagonist. These results suggest that NGF, acting through MAPK activation, plays a role in photic entrainment of the mammalian circadian clock.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 10 (1988), S. 9-10 
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Les conclusions pratiques qui nous paraissent pouvoir être déduites de cette étude anatomique et des quelques cas pathologiques cités ou rapportés sont les suivantes: au cours des investigations angiographiques, il faut souligner la nécessité de rechercher l'artère du renflement lombaire qui naît parfois très haut en dorsal, chaque fois que l'on cherche à injecter une lésion du FT. 11 faut aussi penser à étudier les branches des artères hypogastriques et l'artère sacrée moyenne, en cas de négativité des explorations artérielles thoraco-lombaires pour rechercher une malformation vasculaire dure-mérienne ou une tumeur adhérant à la méninge lombaire basse ou sacrée (fig. 10). Sur le plan physiopathologique, il faut souligner l'importance de la veine du FT comme structure de drainage vers la moelle sus-jacente de shunts artério-veineux lombo-sacrés dure-mériens expliquant ainsi, par un mécanisme d'hyperpression veineuse, la possibilité dans de tels cas de myélopathies à distance [1, 7, 16, 19, 20].
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0533
    Keywords: Monstrocellular brain tumor ; Malignant glioma ; Foamy cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A man of 32 years was admitted with a 3-month history of temporal lobe epilepsy. CT-Scan showed a well-circumscribed area of heterogenous contrast enhancement in the right temporal lobe. Gross total resection was performed but the tumor recurred: the patient died 6 months after the onset of symptoms. There was no autopsy. Histology revealed a highly pleomorphic neoplasm with extensive zones of necrosis. Monster cells, up to several hundred micrometers in diameter, with multiple and/or multilobed nuclei were numerous and showed emperipolesis for polymorphonuclear, mononuclear, and small tumor cells. Abundant mitoses were observed. Tumor cells of all sizes had ground-glass or vacuolated cytoplasm which obscured their glial nature. GFAP was demonstrated in some neoplastic cells. Reticulin fibers were confined to perivascular areas where mononuclear inflammatory cells were sometimes noted. Vascular proliferation was mild. Electronmicroscopic study revealed that the cytoplasms of the tumor cells contained abundant lipid droplets, numerous mitochondria, and glio-filaments. Such a tumor has been reported recently as “malignant glioma with heavily lipidized tumor cells”. This rare entity, previously reported as xanthosarcoma of the brain, represents a subgroup of primitive monstrocellular cerebral tumors.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0533
    Keywords: Human immunodeficiency virus ; Acquired immune deficiency syndrome (AIDS) ; Encephalopathy ; Cortical atrophy ; Morphometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 25-year-old homosexual AIDS patient presented with progressive cognitive, motor and behavioral disturbances consistent with HIV encephalopathy. CT scans demonstrated progressive diffuse brain atrophy. Neuropathology showed predominant cortical changes including severe neuronal loss corroborated by morphometry. Only minimal changes were found in the white matter and basal ganglia. Immunocytochemistry for HIV stained occasional microglial cells more markedly in the cerebral cortex. This suggests that HIV infection of the brain may cause predominant cortical nerve cell loss, and that HIV encephalopathy is not necessarily due to white matter lesions.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of environmental contamination and toxicology 33 (1997), S. 430-435 
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract. Thick-billed murres (Uria lomvia) originating from breeding colonies in the Canadian Arctic were collected on their wintering grounds off the coast of Newfoundland. Murres had been previously banded such that the age of each bird could be determined upon collection. This allowed us to explore the possible relationships between age and contaminant levels in the thick-billed murre. Samples of breast muscle were analyzed for organochlorines (chlorobenzenes, hexachlorocyclohexanes, DDTs, chlordanes, mirex, dieldrin, and PCBs) and metals (selenium, cadmium, mercury, and lead). Levels of both organochlorine and metal residues were sufficiently low so that toxic effects were unlikely. First-year birds contained lower levels of DDTs, mirex, dieldrin, and PCBs compared with older birds, reflecting lower levels of contamination of these compounds in food chains at breeding colonies located at higher latitudes. Higher levels of chemical residues in older birds may reflect greater direct input of those organochlorines into the wintering grounds via the highly contaminated St. Lawrence River. Levels of chlorobenzenes, hexachlorocyclohexanes, and chlordanes, which reflect atmospheric deposition, were not detected at higher levels in older birds. Of the metals, only cadmium was detected at higher levels in older birds.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0584
    Keywords: Protein C ; Protein S ; Stroke ; Inflammatory bowel disease ; Ulcerative colitis ; Vitamin K
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thromboembolic complications may occur in inflammatory bowel disease. Recently, we had the opportunity to observe a case of a cerebral arterial thrombosis in a young patient with active ulcerative colitis. Investigation of blood coagulation revealed a temporary Protein C, Protein S and Factor II deficiency. To our knowledge, this is the first reported case of a temporary Protein C and S deficiency in a patient with thrombosis and inflammatory bowel disease.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 10 (1988), S. 201-209 
    ISSN: 1279-8517
    Keywords: Filum terminale ; Spinal cord angio graphy ; Cauda equina ; Arteriovenous malformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La vascularisation artérielle et veineuse du filum terminale intradural a été étudiée sur 18 cadavres frais, sous microscope, après prélèvement en monobloc de la moelle épinière dorso-lombaire, des racines et du filum dans leur étui dural. L'examen des artères a été fait après injection manuelle de l'artère du renflement lombaire, tandis que l'étude des veines s'est faite sans injection compte tenu d'une coloration bleu-noir spontanée qui les rendent aisément identifiables. Après étude macroscopique, chaque pièce a été fixée, puis coupée à 12 niveaux différents depuis le cône médullaire jusqu'au fond du cul-de-sac dure-mérien, pour étude histologique. La distribution de la vascularisation du FT apparaît constante. Une artère unique, l'artère du FT, naît de la terminaison de l'axe spinal antérieur, soit par trifurcation, soit de la partie proximale d'une des 2 branches de l'anse anastomotique du cône. L'artère chemine devant le FT; son calibre diminue rapidement; rarement, elle a pu être suivie jusque dans le canal sacré. Une veine, la veine du FT, chemine en avant du FT mais en arrière de l'artère, comme au niveau médullaire. Son calibre est uniforme mais variable d'un sujet à l'autre. Elle traverse la dure-mère en bas; elle se continue avec la veine spinale antérieure en haut. Aucun vaisseau n'a été retrouvé à la face dorsale du FT. Si l'artère du FT a un calibre qui est proportionnel à celui du filum et apparaît comme un vaisseau nourricier, la veine a un calibre sans aucun rapport avec le volume de celui-ci et apparaît davantage comme une voie de drainage intradural en continuité avec la veine spinale antérieure. Quelques cas de pathologie du FT confirment cet aspect anatomique et montrent aussi qu'en raison de l'hyperpression veineuse régnant dans la veine du FT, la veine spinale postérieure participe également au drainage de celle-ci et que l'ensemble peut fonctionner dans les 2 sens ascendant ou descendant.
    Notes: Summary The arterial and venous blood-supply of the intradural filum terminale was studied microscopically in 18 fresh cadavers after removing the dorsolumbar spinal cord in one piece, with the roots and the filum in their dural sheath. The arteries were examined after manual injection of the artery of the lumbar enlargement, while study of the veins was made without injection since their bluish-black color made them easily identifiable. After gross examination, each specimen was fixed and then sectioned at 12 different levels from the medullary conus to the bottom of the dural sac for histologic study. The distribution of the vascularization the filum terminale appeared constant. A single artery, the artery of the filum, arises from the termination of the anterior spinal axis, either by trifurcation or from the proximal part of one of the 2 branches of the anastomotic ansa of the conus. The artery travels in front of the filum, with rapidly diminishing caliber; rarely, it can be followed into the sacral canal. The vein of the filum travels in front of that structure but behind the artery, as in the cord; its caliber is uniform but varies from subject to subject. It traverses the dura below and continuous with the anterior spinal vein above. No vessels were found on the dorsal aspect of the filum. While the artery of the filum is of a caliber proportional to that of the filum and appears to be a nutrient vessel, the vein has a caliber unrelated to that of the filum and appears rather as an intradural drainage route continuous with the anterior spinal vein. Several cases of disease of the filum terminale confirm this anatomic appearance and also show that, because of the existing hyperpressure in the vein of the filum, the posterior spinal vein also shares in the drainage of the latter and that entire system may function in both ascending and descending directions.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 17 (1995), S. 171-172 
    ISSN: 1279-8517
    Keywords: Bronchial artery ; Subclavian artery ; Arteriography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'origine des artères bronchiques est très variable ; nous rapportons un cas exceptionnel d'un tronc artériel bronchique commun naissant d'une artère subclavière gauche de découverte angiographique fortuite, chez une patiente indemne de toute pathologie pulmonaire. Nous proposons une explication embryologique à cette variation anatomique.
    Notes: Summary The origin of the bronchial arteries is very variable. An exceptional case is reported of a common bronchial arterial trunk arising from a left subclavian artery discovered incidentally during angiography in a patient without any pulmonary disease. An embryologic explanation is proposed for this anatomic variant.
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