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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 562 (1989), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 87 (1987), S. 4042-4047 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The functional methods developed by Yvon, Bogoliubov, Lebowitz, and Percus in the theory of fluids are applied to the derivation of new integral equations for dense fluids with an a priori knowledge of their range of validity in some sense. In particular, we find conditions in order that the resulting radial distribution function contains, at least, all the diagrams in the density (n) expansion up to order n2, n3,..., and present a method to obtain systematic corrections to familiar approximations such as the Percus–Yevick and the hypernetted-chains equations.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 938-946 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The problem of removing the characteristic parasitic errors of the high-accuracy universal polarimeter method in a linearly birefringent and optically active crystal section is examined. The use of constant parasitic errors typical of each particular polarimetric system is shown to be inappropriate. The parasitics should preferably be determined in each measurement process, since the instrumental parasitics depend not only on the optical and mechanical elements of the experimental system (polarizers, rotators, detection unit etc.), but on sample quality, alignment of the system, and even in many cases on exactly where the light beam passes through the sample. Thus, measurements with different samples give different values of parasitic errors. Such instrumental parasitics can be held within the same order of magnitude for different samples (∼10−4) if they are of good optical quality. However, the parasitics are increased by an order of magnitude (∼10−3) when the samples are of moderate or bad optical quality. Optical anisotropy properties as coefficients of thermal variation of the birefringence of KDC and KDP single crystals and the optical activity of KDP at 632.8 nm wavelength are obtained, in the ranges from room temperature to 353 K and to 373 K, respectively.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1216 (1993), S. 329-331 
    ISSN: 0167-4781
    Keywords: (Rat) ; Gene family ; Gene sequencing ; PAP III ; Pancreatitis ; mRNA cloning
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0843
    Keywords: Key words Gastric cancer ; Chemotherapy ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/ vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0843
    Keywords: Gastric cancer ; Chemotherapy ; Toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A phase II study was performed to assess the efficacy and toxicity of the combination of 5-fluorouracil (5-FU), leucovorin (LV), etoposide, and cisplatin (FLEP) in patients with advanced gastric carcinoma. A total of 46 consecutive, previously untreated patients with unresectable, measurable gastric carcinoma were treated with 300 mg/m2 LV, 100 mg/m2 etoposide, 500 mg/m2 5-FU, and 30 mg/m2 cisplatin on days 1–3 every 28 days. All courses were given on an outpatient basis. A total of 169 courses of treatment were given. In all, 18 of the 46 patients (39%) had an objective response [95% confidence interval (CI), 25%–54%] and 2 (4%) patients experienced a clinical complete response. The median duration of response was 5 months. The main side effects were hematological and gastrointestinal. Grade 3–4 toxicity was encountered as follows: leukopenia, in 9.5% of the courses; anemia, in 3%; thrombocytopenia, in 3%; nausea/vomiting, in 4%; and diarrhea, in 5%. Hospitalization due to fever and granulocytopenia was required in 5 patients, 3 of whom died of sepsis. In conclusion, FLEP shows moderate activity in patients with advanced gastric carcinoma, albeit at the cost of a high degree of toxicity. For this reason we do not recommend its use.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 88 (1997), S. 807-824 
    ISSN: 1572-9613
    Keywords: Billiards ; Kolmogorov–Sinai entropy ; Lyapunov exponents ; ergodic theory ; chaos ; numerical experiments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We perform new experiments on the Kolmogorov–Sinai entropy, Lyapunov exponents, and the mean free time in billiards. We study their dependence on the geometry of the scatterers made up of two interpenetrating square lattices, each one with circular scatterers with different radius. We find, in particular, that the above quantities are continuous functions of the ratio of the scatterer radius. However, it seems that their derivative is discontinuous around the radius ratio which separates the diffusive and nondiffusive types of geometries.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 96 (1999), S. 303-324 
    ISSN: 1572-9613
    Keywords: nonequilibrium systems ; driven lattice gases ; Langevin equations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We define a soft-spins approach to the driven lattice gas model (C-DLG) at the level of a master equation. As a result, we obtain a Langevin equation for the C-DLG which depends on the microscopic transition probabilities. We then show how this dependence affects the critical behavior of the the C-DLG, placing the finite- and the infinite-driving-field cases into different universality classes. In the same vein, we propose a continuum description of two other well-known anisotropic, conservative, nonequilibrium models: the two-temperature model (C-TT) and the randomly driven model (C-RDLG). We show that the C-RDLG with infinite averaged field and the C-TT with T ‖=∞ fall in the same universality class as the infinitely driven C-DLG. A Langevin equation for the driven bilayer lattice gas model is also presented.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of statistical physics 49 (1987), S. 551-568 
    ISSN: 1572-9613
    Keywords: Stationary nonequilibrium states ; Ising model ; competing temperatures ; nonequilibrium phase transitions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We study kinetic one- and two-dimensional Ising models whose transition probabilities occur according to two (or more) locally competing temperatures. The model is solved analytically and studied numerically on different assumptions to reveal a variety of stationary nonequilibrium states and phase transitions; we also investigate the system relaxation in some typical cases.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0843
    Keywords: Key words Malignant melanoma ; Chemotherapy ; Cisplatin ; Tamoxifen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A phase II study was performed to assess the efficacy and toxicity of the combination of cisplatin (CDDP) and tamoxifen (TAM) in patients with metastatic malignant melanoma (MM). A total of 31 consecutive previously untreated patients with unresectable measurable MM were given 100 mg/m2 CDDP every 21 days and 60 mg TAM every 12 h daily. All courses were given on an outpatient basis. A total of 119 courses of treatment were given. In all, 5 of the 31 patients (16%) had an objective response (95% confidence interval 5.3 – 34%) and 2 (6%) achieved a clinical complete response. The median duration of response was 7 months. The main side effect was gastrointestinal: 13% of the patients experienced grade 3/4 nausea/vomiting. Hematological or neurological toxicities were mild and rare. In conclusion, the combination CDDP-TAM has limited activity in MM, although its toxicity is tolerable. Our results do not allow us to recommend its use for the treatment of MM.
    Type of Medium: Electronic Resource
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