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  • 1
    Online Resource
    Online Resource
    Bark and Wood Boring Insects in Living Trees in Europe, a Synthesis. (2007)
    Dordrecht :Springer Netherlands,
    Details
    Keywords: Forest insects-Control-Europe. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (569 pages)
    Edition: 1st ed.
    ISBN: 9781402022418
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6484606
    DDC: 634.967094
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Reliable Models of Severe Coronary Stenosis in Porcine Coronary Arteries: Lesion Induction by High Temperature or Copper Stent (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of interventional cardiology 10 (1997), S. 0 
    Details
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Severe, chronic, and nonfatal stenoses in coronary arteries have been difficult to induce consistently in large animals. Availability of such a model would have practical applications, including understanding the pathophysiology of coronary stenoses and testing new interventional devices. Current methods of producing stenosis typically require an open chest preparation, are time-consuming, and expensive. The purpose of this study was to report two reliable methods for creating severely stenotic lesions percutaneously in a porcine model without the need for an atherogenic diet. Two methods for producing severe coronary stenoses in pigs were found: (1) thermal balloon angioplasty at high temperature (80°C), and (2) implantation of elemental copper stents. Both were performed using a carotid artery cutdown. Pigs were euthanized, the hearts perfusion fixed, and arteries examined histologically. Thermal balloon angioplasty injury produced lesions with mean histopathological stenosis of 67%± 27% and mean angiographic stenosis of 70%± 21%. Histopathological examination showed medial necrosis, adventitial fibrosis, and occasional calcification of the external elastic lamina. Copper stent deployment created a mean histopathological stenosis of 81%± 22% and mean angiographic stenosis of 84%± 17%. Histopathological evaluation revealed inflammatory lesions with destruction of the elastic laminas and gross enlargement of vessel diameter. Two practical methods that reliably create severe coronary artery stenoses use intracoronary heat or copper stent implant. These lesions can be used for testing coronary interventional and diagnostic devices. These models generate lesions that form rapidly, use standard percutaneous techniques, and do not require intrathoracic surgery or atherogenic diets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8183.1997.tb00006.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Orientation ofRhizophagus grandis (Coleoptera: Rhizophagidae) to oxygenated monoterpenes in a species-specific predator-prey relationship (1992)
    Springer
    Chemoecology 3 (1992), S. 14-18 
    Details
    ISSN: 1423-0445
    Keywords: specificity ; predation ; long-range orientation ; windtunnel ; Coleoptera ; Rhizophagidae ; Scolytidae ; Rhizophagus grandis ; Dendroctonus micans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The predator,Rhizophagus grandis, is linked to its specific prey,Dendroctonus micans, by semiochemical signals regulating oviposition and long range orientation. A mixture of simple oxygenated monoterpenes [(−)—fenchone, (−)—pinocamphone, rac. camphor, terpinene-4-ol, borneol, fenchol and verbenone], identified from the frass ofD. micans has been found to be extremely active in a flight windtunnel as a long—range attractant for the predator. The mixture elicited 84 % of the response to larval frass of the prey. Excluding pinocamphone from the mixture did not influence its activity. Also, changing the absolute configurations of some of the components (fenchol, terpinene-4-ol and borneol) did not influence the predators' response. However, the addition of (−)—α-terpineol increased the attractivity of the synthetic blend to almost that of larval frass of the prey. Ecological implications of the identified semiochemicals and their use in pest management are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261451
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Reliability of mechanical and phased-array designs for serial intravascular ultrasound examinations (2000)
    Springer
    The international journal of cardiovascular imaging 16 (2000), S. 365-375 
    Details
    ISSN: 1573-0743
    Keywords: atherosclerosis ; coronary ; intravascular ultrasound ; stenting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Both mechanical and multi-element intravascular ultrasound designs have potential advantages and limitations that may impact on their value for clinical and research purposes. Determination of the reproducibility of measurements is critical before a given system can be used in studies such as regression of atherosclerosis trials. Methods: We performed serial intravascular ultrasound imaging with catheters using mechanical and phased-array designs in stented and non-stented coronary arteries in dogs and in patients. Results: Both systems correlated well for areas (r ≥ 0.90, p 〈 0.0001) and diameters (r ≥ 0.84, p 〈 0.0001) in dogs and in patients. There was a slight difference between multi-element and mechanical designs for measurements of area (mean difference in dogs and in patients: −0.24 and 0.96 mm2, p 〈 0.055) and diameter (−0.08 and 0.16 mm, p 〈 0.0001). The reproducibility of the multi-element system for reanalysis of the same frames and for analysis of serial pullbacks was similar to the same measurements with the mechanical system (r ≥ 0.96 for all measurements). The differences in absolute and relative variability between the mechanical and phased-array designs, both for reanalysis of same frames and serial pullbacks, were very small. Conclusions: Although multi-element and mechanical intravascular ultrasound designs are not strictly interchangeable, their similar reproducibility and the small differences in measurements demonstrate that both designs are acceptable alternatives for trials of regression of atherosclerosis. Determination of the variability for serial pullbacks of both designs was also important to assess the statistical power of such trials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026558824664
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Technetium-99m antimyosin antibody (3–48) myocardial imaging: human biodistribution, safety and clinical results in detection of acute myocardial infarction (1995)
    Springer
    European journal of nuclear medicine 22 (1995), S. 453-464 
    Details
    ISSN: 1619-7089
    Keywords: Technetium-99m antimyosin ; Myocardial infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Technetium-99m antimyosin (99mTc-AM) antibody imaging may have significant advantages over indium-111 antimyosin in clinical practice. The purpose of this study was to determine the human biodistribution, the safety profile and the sensitivity of99mTc-AM (3–48) imaging in the detection of both Q-wave and non-Q-wave myocardial infarction (MI). Biodistribution and safety parameters were mainly determined in 12 normal healthy volunteers while 40 patients with proven MI (22 Q-wave, 18 non-Q-wave) were injected with99mTc-AM (20–25 mCi) between 5 h and 7 days after the onset of acute chest pain. Three standard planar views were performed at 6 h and at 24 h post injection. Both sets of images were completed in 33 patients while two patients were imaged only at 6 h, three patients only at 18 h and one at 18 and 24 h. One patient was not imaged. Vital signs and ECG were recorded and blood samples for haematology, biochemistry and human antimurine antibodies (HAMA) and urinalysis were obtained in all volunteers and patients. No serious adverse reactions or side-effects attributable to99mTc-AM have been reported. No volunteers or patients developed allergic reactions or significant increases in HAMA titres. Reading of99mTc-AM imaging was performed by two blinded experienced observers. The sensitivity of99mTc-AM in the detection of MI was 100% (21/21) for Q-wave and 83.3% (15/18) for non-Q-wave infarctions. The overall sensitivity was 92.3% (36/39). The three false-negative cases were inferoposterior MI. A certain degree of uptake focalization was seen in 26 out of 35 (74.2%) at 6 h. At 24 h, two patients (5.8%) did not show99mTc-AM uptake while 22 (64.7%) showed intense focal uptake, seven (20.6%) moderate uptake and 3 (8.9%) slight uptake. It is concluded that99mTc-AM (3–48) imaging is safe and shows high sensitivity in the detection of both Q-wave and non-Q-wave MI even with early imaging (6 h post injection). These promising results warrant further clinical investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00839060
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Same day injections of Tc-99m methoxy isobutyl isonitrile (hexamibi) for myocardial tomographic imaging: Comparison between rest-stress and stress-rest injection sequences (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 113-117 
    Details
    ISSN: 1619-7089
    Keywords: 99mTc-hexamibi myocardial imaging ; Radionuclide myocardial perfusion imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been shown that both rest and stress 99mTc-hexamibi myocardial perfusion imaging can be performed on the same day using two different doses injected within few hours (the first one at rest followed by a second at stress). In order to evaluate and compare 2 sequences (rest-stress and stress-rest) of 99mTc-hexamibi injections performed the same day, 18 patients with either abnormal 201Tl myocardial scan or abnormal coronary angiography were studied with 2 99mTc-hexamibi injections protocols. The rest-stress study was performed as follows: 7 mCi 99mTc-hexamibi was injected at rest. Single photon emission computed tomography (SPECT) was performed 60 min later. Immediately after the rest study, patients were injected at peak stress with 25 mCi 99mTc-hexamibi. Tomographic imaging was repeated 1 h later. Patients were submitted to the stress-rest protocol within 3 days. Tomographic imaging was done 1 h after a 7 mCi injection at stress. This study was followed by an injection of 25 mCi 99mTc-hexamibi at rest, a tomographic study was performed 60 min later. Myocardial sections were reconstructed in horizontal long, vertical long, and short axes. Data analysis also included polar map representation. A total of 324 segments were interpreted blind by 3 observers, there was an agreement in 283/324 (87.3%) segments between the 2 protocols. However, 24 segments (7.4%) judged ischemic on rest-stress were called scars on stress-rest. In three patients, myocardial segments were judged normal on the rest image of the rest-stress protocol while they were found abnormal (false positive images) on the stress-rest sequence. Stress images from both protocols were judged similar in 17 patients. In conclusion, when using a short time interval (less than 2 h) between two 99mTc-hexamibi injections, it is preferable to do a rest-stress sequence since the rest image performed initially represents a true rest study, which is not necessarily the case with the stress-rest sequence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00254621
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Clinical comparison between thallium-201 and Tc-99m-methoxy isobutyl isonitrile (hexamibi) myocardial perfusion imaging for detection of coronary artery disease (1989)
    Springer
    European journal of nuclear medicine 15 (1989), S. 280-286 
    Details
    ISSN: 1619-7089
    Keywords: Myocardial perfusion imaging ; Thallium-201 thallous chloride ; Tc-99m-methoxy isobutyl isonitrile ; Tc-99m-hexamibi
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 99mTc-hexamibi (methoxy isobutyl isonitrile) is a new 99mTc-hexakis analog that can be used as a myocardial perfusion imaging agent. The purposes of this study were to compare 99mTc-hexamibi to 201Tl-thallous chloride myocardial stress scintigraphy in patients referred for investigation of chest pain and to evaluate the sensitivity of 99mTc-hexamibi in detection of coronary artery disease. One hundred patients were prospectively studied with both 201Tl and 99mTc-hexamibi planar imaging. Sixty five patients had a current coronary angiography. There was a total of 97 significantly (≤70%) stenosed major coronary arteries. 99mTc-hexamibi (25 mCi) study was done within a week of the 201Tl scan with similar double products upon standard treadmil stress testing. Rest studies with 99mTc-hexamibi were obtained 24–48 h after the stress test using the same acquisition parameters and dose. Analysis was performed blind by three observers. The left ventricle was divided into five segments in each image. Analysis of 201Tl and 99mTc-hexamibi results in 1500 left ventricle segments showed an overall agreement in 1326/1500 (88.4%) segments. Correlation between the patient diagnosis on the 201Tl and 99mTc-hexamibi studies showed an agreement in 89 patients (89%). 201Tl revealed myocardial uptake defects in 526 segments, detecting 72 out of 97 (74.2%) significantly stenosed coronary arteries and 99mTc-hexamibi detected 513 segments corresponding to 68 (70.1%) stenosed arteries (no significant statistical difference). In conclusion, these results show a good correlation between 201Tl and 99mTc-hexamibi myocardial imaging in the detection of significant coronary artery disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00435466
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  • 8
    Electronic Resource
    Electronic Resource
    Selective predation on chemically defended chrysomelid larvae (1984)
    Springer
    Journal of chemical ecology 10 (1984), S. 1693-1700 
    Details
    ISSN: 1573-1561
    Keywords: Coleoptera ; Chrysomelidae ; leaf-beetle larva ; Phratora vitellinae ; Plagiodera versicolora ; Hymenoptera ; Tenthredinidae ; sawfly ; Tenthredo olivacea ; predation ; conditioning ; defensive secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Laboratory experiments showed that femaleTenthredo olivacea prefer to prey upon insects of a previously encountered species, instead of upon unknown ones. This has been observed when comparing two natural prey of the sawfly, the larvae ofPhratora vitellinae and those ofPlagiodera versicolora. The two species secrete copious amounts of defensive secretion, the first salicylaldehyde, and the latter a mixture of cyclopentanic monoterpenes. The predator appears less reluctant when encountering a species whose secretion has been previously experienced. A selective pressure might thus exist favoring rare secretions, which is consistant with the well-known diversity of defensive compounds among sympatric insects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00987355
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    Paper (German National Licenses)
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  • 9
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    Downregulation of MUC1 expression and its recognition by CD8+ T cells on the surface of malignant pleural mesothelioma cells treated with HDACi (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-04-05
    Description: Research into new treatments against malignant pleural mesothelioma (MPM) is of great interest, as this aggressive cancer is often resistant to conventional therapies. One potential strategy is the use of epigenetic drugs, such as 5-aza-2′-deoxycytidine (5-azaCdR), a DNA-hypomethylating drug, and valproate (VPA), a histone deacetylase inhibitor (HDACi). Indeed, these drugs not only trigger MPM cell death, but also induce the expression of cancer testis antigens recognized by CD8 + T cells, such as New York-esophageal cancer-1 (NY-ESO-1). The objective of this study was to assess effects of these drugs on the expression and recognition by CD8 + T cells of Mucin1 (MUC1), a tumor-associated antigen that is overexpressed by MPM. MPM tumor cell lines were treated with epigenetic drugs, alone or in combination. MUC1 expression by MPM cells, and its recognition by a MUC1-specific CD8 + T-cell clone, was downregulated by HDACi when used alone or in combination with 5-azaCdR. This effect was not due to a blocking of the HLA class I presentation pathway in treated MPM cells, as NY-ESO-1 induced by 5-azaCdR alone, or with VPA, was recognized by a NY-ESO-1-specific T-cell clone. This study suggests that the choice of tumor antigens could be critical for strategies combining epigenetic drugs with immunotherapy.
    Print ISSN: 0014-2980
    Electronic ISSN: 1521-4141
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 10
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    Self-assembled naphthalenediimide derivative films for light-assisted electrochemical reduction of oxygen (2011)
    Royal Society of Chemistry (RSC)
    Details
    Publication Date: 2011-04-05
    Description: Electrochemically self-assembled N,N[prime or minute]-(ethyl-N[double prime],N[double prime],N[double prime]-dimethyloctadecane ammonium)-1,4,5,8-naphthalene diimide bromide films produce photocurrent with oxygen in water. Evandro Castaldelli, Eduardo Rezende Triboni, Gregoire Jean-Francois Demets ( from Chem. Commun.) Evandro Castaldelli, Chem. Commun., 2011, DOI: 10.1039/C1CC10139K To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
    Print ISSN: 1359-7345
    Electronic ISSN: 1364-548X
    Topics: Chemistry and Pharmacology
    Published by Royal Society of Chemistry (RSC)
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