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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 110 (1929), S. 9-66 
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Morbus Osler ; Epistaxis ; Argon-Plasma- Koagulation ; Nasenschleimhaut ; Key words Osler-Rendu-Weber disease ; Epistaxis ; Argon plasma coagualtion ; Nasal mucosa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Patients with hereditary hemorrhagic telangiectasia (M. Osler-Rendu-Weber disease) often suffer from recurrent epistaxis that poses considerable therapeutic problems. Dermoplasty, electrocoagulation, laser coagulation, iridium brachytherapy and systemic administration of estrogens have been proposed for treatment. Until recently argon plasma coagulation (APC) was not used in ENT surgery, but theoretical considerations render APC a promising therapeutic method for controlling nasal bleeding. Coagulation of tissue is limited to 1–2 mm of penetration and therefore risk of damage to adjacent tissue is low. Effects are best in tissues with high electric conductivity, especially for coagulating bleeding lesions and blood vessels. We have now treated four patients with telangiectasias in the nasal mucosa who had long histories of treatment for epistaxis. The patients were satisfied with the postoperative results and the frequency and intensity of bleeding were significantly reduced. Initial clinical experiences show that APC is a useful alternative for the treatment of bleeding telangiectasias in the nasal mucosa.
    Notes: Zusammenfassung Bei der hereditären hämorrhagischen Teleangiektasie (Morbus Osler-Rendu-Weber) stellt die rezidivierende Epistaxis für den Patienten eine große Belastung und ein oft nur schwer therapeutisch angehbares Problem dar. Bisherige beschriebene Therapieformen beinhalten die Dermoplastik, die Elektro- und Laserkoagulation, die Brachytherapie mit Iridium sowie die systemische Gabe von Östrogenen. Ein Therapieansatz mit der Argon-Plasma-Koagulation (APC) erscheint aufgrund theoretischer Überlegungen in hohem Maße erfolgversprechend. Bei diesem in der HNO bislang noch nicht angewendeten Koagulationsverfahren ist die Tiefenwirkung durch den Desik-kationseffekt auf die Schleimhaut auf ca. 1–2 mm beschränkt, wodurch das Risiko einer Schädigung benachbarter Gewebe minimal ist. Die APC enfaltet ihre koagulierende Wirkung bevorzugt am Ort der höchsten elektrischen Leitfähigkeit, demzufolge insbesondere an frischen Blutungsherden sowie an Blutgefäßen. Vier multipel vorbehandelte Patienten mit rezidivierender Hb-relevanter Epistaxis bei Teleangiektasien in beiden Nasenhaupthöhlen wurden mit der APC therapiert und der prä- und postoperative Befund makroskopisch und histologisch dargestellt. Die Patienten waren postoperativ mit dem Ergebnis sehr zufrieden. Die Frequenz und Intensität der Blutungen hatte deutlich abgenommen. Die ersten klinischen Erfahrungen bestätigen die theoretischen Erwägungen, welche die APC als eine sinnvolle Alternative zu bisherigen Behandlungsformen bei der hämorrhagischen Teleangiektasie erscheinen lassen.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 256 (1999), S. 10-15 
    ISSN: 1434-4726
    Keywords: Key words Hereditary hemorrhagic telangiectasia ; Epistaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) remains a challenge for all clinicians, as in about 80% of cases nasal bleeding is the first manifestation of this disease, which is characterized by a clinical triad of multiple telangiectasias, recurrent hemorrhages and familial occurrence. Although in the last few years there has been diagnostic and therapeutic progress, a cure for this rarely life-threatening but often burdening and handicapping disease is still not possible. We have reviewed head and neck presentations, diagnostic and therapeutic features, as well as new insights into the molecular genetics of the disease and local treatment now available.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 257 (2000), S. 263-269 
    ISSN: 1434-4726
    Keywords: Key words Recurrent respiratory papillomatosis ; Pediatric laryngeal disease ; Human papilloma virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Juvenile-onset recurrent respiratory papillomatosis is a relatively uncommon disease that presents clinically with symptoms ranging from hoarseness to severe dyspnea. Human papilloma viruses type 6 and 11 are important in the etiology of the papillomata and are most probably transmitted from mother to child during childbirth. Although spontaneous remission is frequent, a rare fatal course because of pulmonary spread or malignant transformation has occurred. CO2 laser evaporation of papillomas and adjuvant drug therapy using lymphoblastoid α-interferon are the most common treatment modalities at present. However, several other treatment modalities have been tried with varying success. Recent advances in basic research and different therapeutic approaches are reviewed.
    Type of Medium: Electronic Resource
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