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  • 1
    Electronic Resource
    Electronic Resource
    Extended strictureplasty for multiple short skipped strictures of Crohn's disease (1996)
    Springer
    Diseases of the colon & rectum 39 (1996), S. 342-344 
    Details
    ISSN: 1530-0358
    Keywords: Crohn's disease ; Strictureplasty ; Surgical technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: We will describe a new procedure for treatment of multiple short strictures involving a short segment of Crohn's disease. METHODS: This procedure involves the following: 1) stay sutures at the mid portion of the two strictures; 2) an antimesenteric longitudinal enterotomy of 12 cm or more; 3) two or three interrupted transmural sutures in the four lateral portions of the two stenoses; 4) a transverse running suture, according to Heineke-Mikulicztype strictureplasty; and 5) interrupted seromuscular sutures. RESULTS: We performed four such “double HeinekeMikulicz”-type strictureplasties in three patients with Crohn's disease without postoperative complications. CONCLUSION: This type of double Heineke-Mikulicz-type strictureplasty is suitable for multiple short skipped strictures of Crohn's disease in selected patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02049479
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  • 2
    Electronic Resource
    Electronic Resource
    Turcot syndrome with colonic obstruction and small intestinal invagination: Report of a case (1999)
    Springer
    Surgery today 29 (1999), S. 785-788 
    Details
    ISSN: 1436-2813
    Keywords: Turcot syndrome ; small intestinal invagination ; colonic obstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report herein the case of a 16-year-old boy diagnosed as having turcot syndrome, otherwise known as glioma-polyposis syndrome. The patient was transferred from the Department of Neurosurgery where he was undergoing investigation of a brain tumor, to the Department of Medicine for investigation of gastrointestinal symptoms. The patient was diagnosed as having Turcot syndrome, and was then transferred to the Department of Surgery for treatment of an obstruction in the sigmoid colon and small intestinal invagination. A subtotal colectomy with side-to-end ileoproctostomy and release of the invaginations was carried out. Multiple polyps were found in the colon, two of which, including a large polyp that obstructed the colonic lumen, were confirmed histologically to be adenocarcinoma. The remaining polyps were adenomas. A biopsy of the brain tumor confirmed a diagnosis of astrocytoma (WHO grade II). This case report describes the characteristic features of Turcot syndrome presented by this patient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02482328
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  • 3
    Electronic Resource
    Electronic Resource
    Management of Urinary Complications in Crohn's Disease (1999)
    Springer
    Surgery today 29 (1999), S. 713-717 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: urinary complication ; Crohn's disease ; urolithiasis ; ureteral obstruction ; urinary fistula
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050497
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  • 4
    Electronic Resource
    Electronic Resource
    Colonization of microflora in mice: mucosal defense against luminal bacteria (1999)
    Springer
    Journal of gastroenterology 34 (1999), S. 54-60 
    Details
    ISSN: 1435-5922
    Keywords: Key words: inflammatory bowel disease ; germ-free conventionalization ; mucosal defense
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: To investigate the pathogenesis of inflammatory bowel disease, it is critical to develop a system that uses simple and reproducible models for analyzing the "normal" mucosal defense mechanism. In the present study, germ-free mice were conventionalized by the oral administration of microorganisms prepared from the feces of genetically identical mice. Histological assessment and mucin characterization of small intestine and colon were then carried out. Histological findings in the gut were site-dependent and clearly time-dependent. Acute inflammation was most evident in the cecum. The cecal mucosa exhibited hyperplastic changes in epithelial cells, infiltration of polymorphonuclear cells, crypt abscesses, and epithelial projections on the epithelial surface 7 days after conventionalization. Some of the changes were similar to those seen in human ulcerative colitis. The histological findings in the conventionalized mice were comparable to those in specific pathogen-free mice after 28 days. Mucin histochemistry revealed that bacterial colonization altered the number of rectal goblet cells and the mucin composition in a time-dependent fashion. Although this model shares only some characteristics of human inflammatory bowel disease, it is unique in demonstrating the acquisition of mucosal defense. Understanding of this process is critical for the elucidation of inflammatory bowel disease pathogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005350050216
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  • 5
    Electronic Resource
    Electronic Resource
    Management of urinary complications in Crohn's disease (1999)
    Springer
    Surgery today 29 (1999), S. 713-717 
    Details
    ISSN: 1436-2813
    Keywords: urinary complication ; Crohn's disease ; urolithiasis ; ureteral obstruction ; urinary fistula
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Among the 127 patients who underwent surgical treatment for Crohn's disease at Tohoku University Hospital, urinary complications were noted in 13 patients (10.2%), including urolithiasis in 6 patients (4.7%), a ureteral obstruction in 4 (3.1%), and urinary fistula in 3 (2.4%). In patients with urolithiasis, conservative therapy was effective. An ureteral obstruction was detected on the right side in all 4 of these cases because of the inflamed terminal ileum. In 2 of the 4 cases, the symptoms improved by either preoperative total parenteral nutrition or elemental diet therapy. A resection of the inflamed intestine was necessary in all cases. In patients with urinary fistulas, a resection of the inflamed intestine combined with a reconstruction of the urinary tract was carried out after total parenteral nutrition. In conclusion, conservative therapy with preoperative total parenteral nutrition or elemental diet therapy proved to be effective for a ureteral obstruction since it improved the intestinal inflammation. As a definitive treatment, surgery is still necessary for the management of urinary fistulas and ureteral obstruction. Based on our findings, patients with urolithiasis in Crohn's disease should thus be treated conservatively in the same way as patients without Crohn's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02482314
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  • 6
    Electronic Resource
    Electronic Resource
    Light and electron microscopic immunolocalization of endothelial leucocyte adhesion molecule-1 in inflammatory bowel disease (1992)
    Springer
    Virchows Archiv 420 (1992), S. 403-409 
    Details
    ISSN: 1432-2307
    Keywords: Inflammatory bowel disease ; ELAM-1 ; Endothelial cells ; Immunoelectron microscopy ; Neutrophils
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Endothelial leucocyte adhesion molecule-1 (ELAM-1) is a rapidly inducible adhesion molecule for neutrophils in vascular endothelial cells. We investigated its immunohistochemical localization in 17 cases of inflammatory bowel disease. ELAM-1 was preferentially expressed in venules in actively inflamed mucosa and granulation tissue. Most capillaries were negative for ELAM-1. In areas with mild inflammation its expression diminished markedly and in normal mucosa of the colon and small intestine its expression was sparse. Electron microscopically, venules in active inflammation had swollen endothelial cells with well-developed rough endoplasmic reticulum. Immunoelectron microscopy revealed ELAM-1 localization along the luminal plasma membrane and in rough endoplasmic reticulum and round granules, findings suggestive of active production in endothelial cells. Furthermore, exocytosis of immuno-reactive substance into the lumen was confirmed. Our study suggests that venules in actively inflamed area play an important role in eliciting and/or maintaining acute inflammatory processes by active permeation of neutrophils from the blood stream into the tissue, and that ELAM-1 may be a secretory protein as well as a transmembrane receptor protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600511
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  • 7
    Electronic Resource
    Electronic Resource
    Turcot Syndrome with Colonic Obstruction and Small Intestinal Invagination: Report of a Case (1999)
    Springer
    Surgery today 29 (1999), S. 785-788 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: Turcot syndrome ; small intestinal invagination ; colonic obstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050511
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  • 8
    Electronic Resource
    Electronic Resource
    Adequacy of mucosal biopsies for evaluation of intestinal cytokine-specific mRNA (1995)
    Springer
    Digestive diseases and sciences 40 (1995), S. 1498-1505 
    Details
    ISSN: 1573-2568
    Keywords: ulcerative colitis ; Crohn's disease ; inflammatory bowel disease ; interleukin-1β ; interleukin-2 ; quantitative reverse transcription-polymerase chain reaction ; biopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endoscopic biopsies are being increasingly utilized to investigate cytokine profiles in normal and diseased intestine. To evaluate the adequacy of mucosal biopsies as a source of cytokine-specific mRNA, we measured their content of interleukin-1β (IL-1β) and interleukin-2 (IL-2) mRNA by reverse transcription-polymerase chain reaction and compared it to that of autologous lamina propria mononuclear cells in control and inflammatory bowel disease-involved specimens. High-quality total RNA was recovered more consistently from cell isolates than from biopsies. Interleukin-1β mRNA was reliably detected in both cell and biopsy samples, whereas IL-2 mRNA was measurable in all lamina propria cells but not always in biopsies. Compared to controls, levels of IL-1β were significantly elevated in Crohn's disease and ulcerative colitis cells and biopsies, and a weak but significant correlation existed between values derived from the two sources. In contrast, only ulcerative colitis cell isolates but not biopsies contained significantly reduced concentrations of IL-2 mRNA compared to those of control and Crohn's disease samples, and no correlation was found between cell and biopsy contents. Widely different levels of cytokine-specific mRNA were present in closely adjacent biopsies, particularly for IL-2. These results suggest that mucosal biopsies are suitable to assess some but not all cytokine-specific mRNA due to variation in RNA recovery, intrinsic level of cytokine gene expression, and substantial variability of cytokine transcripts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02285198
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  • 9
    Electronic Resource
    Electronic Resource
    Sodium Butyrate-Induced Liver-Type Alkaline Phosphatase Activity in a Small Intestinal Epithelial Cell Line, IEC6 (1998)
    Springer
    Digestive diseases and sciences 43 (1998), S. 1116-1123 
    Details
    ISSN: 1573-2568
    Keywords: SODIUM BUTYRATE ; ALKALINE PHOSPHATASE ACTIVITY ; INTESTINAL EPITHELIAL CELLS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sodium butyrate is a well-recognizeddifferentiating agent inducing alkaline phosphataseactivity, one of the epithelial differentiation markers.When IEC6 cells, a nontransformed, small intestinalepithelial cell line, were cultured with butyrate, thissubstrate induced alkaline phosphate activity in a time-and dose-dependent fashion. However, the type ofisoenzyme involved was a liver-type, not anintestinal-type. Electron microscopy revealed that the inducedactivity was strictly localized in the cytosol and noton the plasma membrane. However, disaccharidaseactivities, another kind of differentiation marker, were also enhanced by sodium butyrate. In addition,the positive cells demonstrating the presence ofalkaline phosphatase activity were preferentiallyobserved in tubular structures. These data show thatbutyrate-induced alkaline phosphatase activity is closelyassociated with differentiation-like phenomena in IEC6cells, although the type of isoenzyme and cellularlocalization of the activity are different from thoseobserved in mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018807524075
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  • 10
    Electronic Resource
    Electronic Resource
    Induction of Mineralocorticoid Receptor by Sodium Butyrate in Small Intestinal (IEC6) and Colonic (T84) Epithelial Cell Lines (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 1571-1578 
    Details
    ISSN: 1573-2568
    Keywords: MINERALOCORTICOID RECEPTOR ; BUTYRIC ACID ; SMALL INTESTINAL CELLS ; COLON CELLS ; DIFFERENTIATION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mineralocorticoid action is essential forcolonic sodium and water absorption and is mediated viamineralocorticoid receptors in the upper half of coloniccrypts. On the other hand, it has been established that sodium butyrate inducesdifferentiation-like phenomenon in vitro. The aim ofthis study is to investigate whether this bacterialproduct participates in the regulation of gene andprotein expression of mineralocorticoid receptor in vitro. IEC6and T84 cells were stimulated by sodium butyrate andRNAs extracted. Gene expression of mineralocorticoidreceptor was evaluated by northern blotting orsemiquantitative RT-PCR. Protein expression was determined inT84 cells using immunohistochemistry. To investigatewhether MR induction was associated with cellulardifferentiation, we also measured alkaline phosphatase in situ. The mineralocorticoid receptor genewas induced by sodium butyrate in both IEC6 and T84cells. Immunoreactivity increased in butyrate-treatedT84 cells, but receptorcontaining cells were notuniformly distributed and often formed clusters.Induction of alkaline phosphate activity was alsodemonstrated in both IEC6 and T84 cells. Double stainingby immunoreactivity and alkaline phosphatase activityclearly demonstrated the colocalization of both afterbutyrate treatment. In conclusion, sodium butyrateup-regulates gene and protein expression of thefunctionally important mineralocorticoid receptor inepithelial cells, after induction by differentiation-likecondition in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026606809171
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