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  • 1
    Electronic Resource
    Electronic Resource
    Specific distribution patterns of hCDC47 expression in cutaneous diseases (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 25 (1998), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: hCDC47 is a human member of the MCM family, which has been implicated to be concerned with the regulatory machinery causing DNA to replicate once per cell cycle. In a previous paper, we described hCDC47 expression as being localized in the proliferative component of normal tissues, and showed greater expression in squamous cell skin carcinomas than in seborrheic keratosis. In the present study, we compared its expression in another type of skin tumor and variotis non-neoplastic cutaneous proliferative diseases. Two patterns of distribution of hCDC47-positive cells were observed. Keratoacanthomas showed a peripheral pattern in which only the cells located the basal cell layers were positive. Psoriasis vulgaris also showed this peripheral type of location, with the cells in the suprabasal layers also occasionally expressing hCDC47. Verruca vulgaris demonstrated a diffuse pattern, with positive epithelial cells distributed throughout the layers. Basal cell carcinomas also showed a similar pattern. The keratoacanthomas showed the highest hCDC47 positive cell rate (43.1%), followed by verruca vulgaris (42.5%). psoriasis vulgaris (23.4%), and basal cell carcinoma (17.3%). Our results suggest participation of hCDC47 in these proliferative disorders involving keratinocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1998.tb01747.x
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in coronary flow following repeated brief coronary occlusion in the conscious dog (1986)
    Springer
    Heart and vessels 2 (1986), S. 87-90 
    Details
    ISSN: 1615-2573
    Keywords: Collateral development ; Coronary occlusions ; Coronary perfusion territory ; Doppler flowmeter ; Myocardial regional function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies were conducted in 12 conscious, unsedated dogs instrumented for measurements of subendocardial segment length in the area perfused by the left circumflex coronary artery, blood flow velocity of this artery, and left ventricular pressure. An externally inflatable pneumatic occluder was placed to occlude the circumflex coronary artery for selected durations at selected intervals. Resting coronary blood flow velocity was measured before and after collateral development induced by repeated brief coronary occlusion. Under conditions of comparable myocardial oxygen consumption, shown by the similar pressure-rate product, preocclusion resting coronary blood flow velocity of the repeatedly occluded artery decreased by 21.3% (P〈0.001) in association with collateral growth. These findings strongly suggest that the perfusion territory of the collateralized artery decreases considerably secondary to the periodic ischemic stimulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02059961
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of nonischemic segment shortening during variable extent of myocardial ischemia in conscious dogs (1987)
    Springer
    Heart and vessels 3 (1987), S. 122-128 
    Details
    ISSN: 1615-2573
    Keywords: Coronary artery occlusion ; Ejection phase shortening ; Isovolumic contraction ; Myocardial regional function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Studies were performed on seven conscious dogs chronically instrumented for measurement of subendocardial segment length in the central area perfused by the left circumflex coronary artery (LCCA) and left anterior descending coronary artery, LCCA flow, and left ventricular pressure. We occluded the LCCA for 2 min using an externally inflatable pneumatic occluder placed around the proximal LCCA. Two-minute LCCA occlusions were repeated hourly for 8 h, 5 days/week. The first LCCA occlusion decreased the ejection phase shortening in the ischemic area from 22.2%±2.5% (SEM) to 3.1%±0.7% (P〈0.001). Concomitantly, heart rate increased from a resting rate of 76±4 to 117±6 beats/min (P〈0.001) after 2 min of LCCA occlusion, and ejection phase shortening in the nonischemic area decreased from 25.5%±1.3% to 21.6%±1.1% (P〈0.001) despite increases in end-diastolic segment length (15.31±1.46 mm to 15.69±1.52 mm,P〈0.01). These changes in non-ischemic segment shortening and heart rate during LCCA occlusion were attenuated progressively with improvement in the regional myocardial function at jeopardy due to the development of collateral circulation, and a significant (P〈0.001) correlation between both the reduced nonischemic segment shortening and the increased heart rate with the degree of dysfunction in the ischemic region was obtained by linear regression analysis with Fisher's Z transformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058787
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  • 4
    Electronic Resource
    Electronic Resource
    Cineangiographic evaluation of changes in regional left ventricular wall motion after acute myocardial infarction (1987)
    Springer
    Heart and vessels 3 (1987), S. 152-158 
    Details
    ISSN: 1615-2573
    Keywords: Coronary collateral circulation ; Isovolumic contraction ; Myocardial hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the natural course of changes in regional left ventricular function after acute myocardial infarction, we compared cineventriculograms taken during the acute and chronic stages of myocardial infarction in ten patients who had sustained coronary occlusion despite intracoronary thrombolysis. Three ventricular silhouettes (end diastole, aortic valve opening, and closure) were superimposed using external reference markers, and 36 radial grids were drawn from the center of gravity of the end-diastolic silhouette to the endocardial margin of each silhouette. Measurement of the length of each radial grid provided quantitative details of segmental centripetal wall motion. In the infarcted area, percentage total systolic shortening (%ΔLTOT), isovolumic shortening (%ΔLISO), and ejection phase shortening (%ΔLEJ) remained unchanged. In the nonischemic area, %ΔLTOT tended to increase from 34%±6% to 41%±6%. Although %ΔLISO was unchanged (9%±4% vs. 8%±1%), %ΔLEJ increased from 25%±4% to 37%±6% (P〈0.05). Thus, progressive increases in ejection phase shortening in normal regions may contribute to the functional recovery of the left ventricle after myocardial infarction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058792
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  • 5
    Electronic Resource
    Electronic Resource
    Usefulness of intracoronary injection of acetylcholine as a provocative test for coronary artery spasm in patients with vasospastic angina (1991)
    Springer
    Heart and vessels 6 (1991), S. 96-101 
    Details
    ISSN: 1615-2573
    Keywords: Vasospastic angina ; Variant angina ; Acetylcholine ; Coronary artery spasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to examine both the sensitivity and specificity of coronary artery spasm induced by intracoronary injection of acetylcholine in patients with vasospastic angina, incremental doses of acetylcholine (20, 30, and 50 µg) were injected directly into each coronary artery in 21 patients with variant angina (group A), in 28 patients with other types of vasospastic angina (group B), and in 20 patients without any significant coronary artery disease (group C). Coronary artery spasm was defined as severe vasoconstriction (≥90% of reduction in luminal diameter) with chest pain and/or ischemic changes in the electrocardiogram. Intracoronary injection of acetylcholine induced spasm of at least one coronary artery in 20 patients (95%) of group A, in 27 patients (96%) of group B, and in only 2 patients (10%) of group C. The low dose of acetylcholine (20 µg) induced coronary spasm more frequently in group A patients (81%) than in group B patients (43%) (P〈0.05). ST-segment elevation associated with anginal attacks was significantly (P〈0.05) more frequent in group A (71%) than in group B (39%). When acetylcholine was injected separately into the left and right coronary arteries, spasm of both coronary arteries was observed in 7 out of 14 of group A (50%), in 8 out of 22 of group B (36%), and in none of the 20 of group C. We concluded that intracoronary injection of acetylcholine is a sensitive and reliable method for the induction of coronary spasm in patients with vasospastic angina as well as in those with variant angina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058755
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  • 6
    Electronic Resource
    Electronic Resource
    Heparin exercise treatment following percutaneous transluminal coronary angioplasty in a patient with effort angina (1991)
    Springer
    Heart and vessels 6 (1991), S. 181-183 
    Details
    ISSN: 1615-2573
    Keywords: Percutaneous transluminal coronary angioplasty ; Heparin exercise treatment ; Collateral circulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 63-year-old female with chronic stable effort angina underwent percutaneous transluminal coronary angioplasty (PTCA) for a donating coronary artery of the collateral circulation to the jeopardized region. Because of the inefficacy of the procedure in increasing the collateral flow reserve, the patient was then put on an exercise regimine and also received heparin pretreatment. Her exercise tolerance improved remarkably with the development of improved collateral circulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058284
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  • 7
    Electronic Resource
    Electronic Resource
    Determinants of collateral development in a canine model with repeated coronary occlusion (1994)
    Springer
    Heart and vessels 9 (1994), S. 292-299 
    Details
    ISSN: 1615-2573
    Keywords: Collateral circulation ; Myocardial ischemia ; Myocardial regional function ; Reactive hyperemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is now accepted that repetitive 2-min coronary occlusion can develop collateral vessels to the area perfused by the occluded coronary artery. However, which factors influence collateral development has yet to be fully elucidated. The goal of the present study was to identify the determinants of the rate of coronary collateral development in dogs undergoing repeated coronary occlusion. The study was conducted in 19 conscious dogs instrumented for measurements of a subendocardial segment length in the area perfused by the left circumflex coronary artery (LCCA), LCCA flow, and left ventricular pressure. An externally inflatable pneumatic occluder was placed around the LCCA. After the recovery from surgery, 2-min LCCA occlusions were conducted eight times daily. Following 141 ± 61 (SD) LCCA occlusions (20 ± 7 days), an LCCA occlusion produced no reduction in segment shortening and negligible reactive hyperemia. The total number of LCCA occlusions needed for adequate collateral development (the rate of collateralization) correlated well with the severity of myocardial ischemia during the first occlusion, which was determined mainly by the extent of postsurgical initial collateral circulation. On the other hand, the response to the ischemic stimulus in the later stage of collateral development was independent of the extent of development of the initial postsurgical collaterals. It is concluded that the overall rate of collateral development is slower in dogs with initially poorer collaterals; however, the response of each dog to the ischemic stimulus in the later stage of collateral development was similar among dogs regardless of the extent of the initial collaterals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745094
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  • 8
    Electronic Resource
    Electronic Resource
    Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris (1998)
    Springer
    Angiogenesis 2 (1998), S. 105-108 
    Details
    ISSN: 1573-7209
    Keywords: Angiogenesis ; collateral circulation ; coronary artery bypass graft surgery ; stable angina ; unstable angina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia. Using an enzyme-linked immunosorbent assay, we measured the concentrations of VEGF and bFGF in pericardial fluid of 51 patients with open heart surgery. Patients were divided into group A (n=10) with class III unstable angina (Braunwald's classification), group B (n=24) with class I or II unstable angina or stable angina and group C (n=17) with non-ischemic heart disease. The VEGF level in pericardial fluid in group A was 83±7 pg/ml, being significantly (p〈0.001) higher than the 27±3 pg/ml in group B and the 28±5 pg/ml in group C. The concentrations of bFGF in pericardial fluid in groups A and B were 1461±579 and 1224±161 pg/ml, respectively, significantly (p〈0.05) higher than the 292±97 pg/ml in group C. The level of VEGF in pericardial fluid was increased only in patients with severe rest angina within 2 days before emergency coronary artery bypass graft surgery (CABG), while bFGF was increased in all patients undergoing CABG for coronary artery disease. Thus VEGF and bFGF may play important roles in mediating collateral growth in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009062712441
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  • 9
    Electronic Resource
    Electronic Resource
    Basic kinetics of 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid (BMIPP) in canine myocardium (1999)
    Springer
    The international journal of cardiovascular imaging 15 (1999), S. 11-20 
    Details
    ISSN: 1573-0743
    Keywords: infarction ; ischemia ; mitochondrial function ; triglyceride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract BMIPP is a radioiodinated fatty acid analogue used for myocardial single photon emission CT (SPECT) imaging based on high cardiac fatty acid metabolism. In normal dogs, 74% of the injected BMIPP was instantly extracted and was then retained in 65.3%. The washout of the retained radioactivity was low, and most of the washout was alpha- and beta-oxidation metabolites. ATP concentration plays an important role in the myocardial uptake and retention of BMIPP. The ATP-dependent BMIPP uptake at the TG pool was strongly regulated by etomoxir with modifying mitochondrial β-oxidation and subsequent ATP production. Thus, myocardial viability was reflected on the BMIPP uptake in acute ischemia. In spite of in-significant changes in early extraction and retention, BMIPP back diffusion (r=−0.92) and full-oxidation metabolite (r=0.78) were correlated with the severity of ischemia. Mismatched region of BMIPP with flow (Tl-201) showed decreased metabolic enzymes such as citrate synthase and 3-hydroxyacyl-CoA dehydrogenase. These data suggest that BMIPP would be feasible for detecting cellular energy state from lipid metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006167713330
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  • 10
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    Surface-site-selective study of valence electronic states of a clean Si(111)-7×7 surface using Si L_{23} VV Auger electron and Si 2p photoelectron coincidence measurements (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-01-25
    Description: Author(s): Takuhiro Kakiuchi, Masashi Tahara, Shogo Hashimoto, Narihiko Fujita, Masatoshi Tanaka, Kazuhiko Mase, and Shin-ichi Nagaoka Valence electronic states of a clean Si(111)-7×7 surface are investigated in a surface-site-selective way using high-resolution coincidence measurements of Si pVV Auger electrons and Si 2p photoelectrons. The Si L_{23} VV Auger electron spectra measured in coincidence with energy-selected Si 2p pho... [Phys. Rev. B 83, 035320] Published Mon Jan 24, 2011
    Keywords: Semiconductors II: surfaces, interfaces, microstructures, and related topics
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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