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  • 1
    Online Resource
    Online Resource
    Dordrecht :Springer Netherlands,
    Keywords: Magnetosphere. ; Electronic books.
    Description / Table of Contents: This volume fulfils the need for an overview of the field, rather than offering a topical focus. Its chapters, written by leading scientists, cover the latest results in many areas such as magnetospheric substorms and transport phenomena in the plasma sheet.
    Type of Medium: Online Resource
    Pages: 1 online resource (366 pages)
    Edition: 1st ed.
    ISBN: 9789400705012
    Series Statement: IAGA Special Sopron Book Series ; v.3
    DDC: 538.766
    Language: English
    Note: Intro -- Foreword by the Series Editor -- Preface -- Contents -- Contributors -- Part I Solar Wind-Magnetosphere Interaction -- 1 The Magnetopause, Its Boundary Layers and Pathways to the Magnetotail -- 1.1 Introduction -- 1.2 Magnetic Reconnection at the Magnetopause -- 1.2.1 Basics of Magnetopause Reconnection -- 1.2.1.1 Concept of Reconnection -- 1.2.1.2 Signatures of Magnetic Reconnection -- 1.2.2 Quantifying Magnetic Reconnection -- 1.2.2.1 Bulk Plasma Heating at the Magnetopause -- 1.2.2.2 Measurement of the Hall Term in the Generalized Ohms Law -- 1.2.2.3 Anti-parallel Versus Component Magnetic Reconnection -- 1.2.2.4 Estimates of the Magnetic Reconnection Rate -- 1.2.2.5 Determination of the Local Magnetic Topology -- 1.2.3 Continuous and Intermittent Magnetic Reconnection -- 1.2.3.1 Continuous Magnetic Reconnection -- 1.2.3.2 Intermittent or Unsteady Magnetic Reconnection: Flux Transfer Events -- 1.2.4 Magnetic Reconnection for Northward IMF -- 1.3 KelvinHelmholtz Instability and Diffusive Processes -- 1.3.1 Location and Signatures of the KelvinHelmholtz Instability -- 1.3.2 KelvinHelmholtz and Secondary Processes -- 1.3.2.1 KelvinHelmholtz and Secondary Diffusive Processes -- 1.3.2.2 KelvinHelmholtz and Localized Magnetic Reconnection -- 1.3.3 Other Diffusive Processes -- 1.4 Global Coupling and Pathways for Solar Wind Plasma -- 1.4.1 Global Coupling and Magnetic Reconnection -- 1.4.2 Pathways to the Magnetotail -- Conclusions -- References -- 2 Quantifying Energy Transfer at the Magnetopause -- 2.1 Introduction -- 2.2 Methodology -- 2.2.1 GUMICS-4 Simulation -- 2.2.2 Magnetopause Energy Transfer -- 2.2.3 Dayside Reconnection Line -- 2.2.4 Magnetopause Reconnection and Dynamo -- 2.3 Hysteresis in Energy Transfer -- 2.4 Discussion and Conclusions -- References -- 3 Long-Period ULF Waves Driven byINTtie. , Periodic Solar Wind Disturbances -- 3.1 Introduction -- 3.2 Numerical Results -- 3.2.1 The Numerical Model -- 3.2.2 Waveforms of the Plasma Pressure in the Magnetosphere -- 3.2.3 Force Balance in the Dayside Magnetopause -- 3.2.4 Nature of the Magnetospheric Current -- 3.3 Discussion and Summary -- References -- Part II Magnetotail Dynamics -- 4 Magnetotail Dynamics: Survey of Recent Progress -- 4.1 Introduction -- 4.2 Thin Current Sheets -- 4.2.1 Formation and Structure -- 4.2.2 Stability -- 4.2.2.1 Observations -- 4.2.2.2 Theory: Ballooning and Interchange -- 4.2.2.3 Theory: Tearing -- 4.2.3 Active Modes: Flapping -- 4.2.4 Conclusions -- 4.3 Onset Timing -- 4.4 Bursty Bulk Flows and Dipolarization -- 4.4.1 Observations -- 4.4.2 Source Mechanism -- 4.4.3 Conclusions -- 4.5 Summary and Conclusions -- 4.5.1 Formation and Stability of Thin Current Sheets -- 4.5.2 Substorm Onset Timing -- 4.5.3 BBFs and Dipolarization -- References -- 5 Physical Processes for Magnetospheric Substorm Expansion Onsets -- 5.1 Introduction -- 5.2 External Conditions -- 5.2.1 Northward Turning of IMF as a Substorm Trigger -- 5.2.2 Interplanetary Shock as a Substorm Trigger -- 5.2.3 Overall Assessment -- 5.3 Activity Prior to Onset -- 5.3.1 Magnetic Field Reconfiguration -- 5.3.2 Plasma Sheet Thinning and Poynting Flux Consideration -- 5.3.3 Ion Temperature Drop -- 5.3.4 Neutral-Sheet-Pointing Electric Field -- 5.3.5 Dimming of Auroral Arcs -- 5.3.6 Auroral Activity Poleward of Breakup Arc -- 5.3.7 Azimuthal Auroral Forms and Waves -- 5.4 Activity After Onset -- 5.4.1 Magnetic Field Dipolarization and Current Disruption -- 5.4.2 Plasma Flows -- 5.4.3 Mid-Tail Plasma Sheet Thinning and Rarefaction Wave -- 5.4.4 Plasma Waves and Turbulence -- 5.5 Time History Analysis -- 5.5.1 2008 February 26 Event -- 5.5.2 2008 February 16 Event -- 5.5.3 2008 February 25 Event. , 5.5.4 Weaknesses in the Time History Approach -- 5.6 System-Wide Approach -- 5.7 Implications on Substorm Onset Theories -- 5.8 Concluding Remarks -- References -- 6 Cluster Observations of Plasma Bubbles, BBFs and Their Wakes -- 6.1 Introduction -- 6.2 Case Study One: 21 September 2005 -- 6.3 Case Study Two: 25 August 2003 -- 6.4 Case Study Three: 24 September 2004 -- 6.5 Discussion -- 6.6 Summary and Conclusions -- References -- 7 A Statistical Study of Pressure Changes in the Near-Earth Magnetotail Associated with Substorm Expansion Onsets -- 7.1 Introduction -- 7.2 Superposed Epoch Analysis -- 7.3 Discussion -- References -- 8 Categorization of the Time Sequence of Events Leading to Substorm Onset Based on THEMIS All-Sky Imager Observations -- 8.1 Introduction -- 8.2 Case Study -- 8.2.1 15 February 2008 Auroral Breakup -- 8.2.2 4 February 2008 Auroral Breakup -- 8.2.3 11 February 2008 Pseudo-breakup -- 8.3 Statistical Study -- Conclusion -- References -- Part III Inner Magnetospheric Processes -- 9 Dynamic Inner Magnetosphere: A Tutorial and Recent Advances -- 9.1 Preface -- 9.2 Plasmasphere -- 9.2.1 Structure of Plasmasphere -- 9.2.2 Formation of Plasmasphere -- 9.2.3 Fate of Plasmaspheric Plasma -- 9.3 Warm Plasma -- 9.4 Ring Current -- 9.4.1 Carrier of Ring Current -- 9.4.2 Structure of Ring Current -- 9.4.3 Transport and Acceleration of Ring Current Particles -- 9.4.3.1 Convection -- 9.4.3.2 Substorm -- 9.4.3.3 Compression of Magnetosphere -- 9.4.3.4 Wave-Particle Interaction -- 9.4.4 Source of Ring Current Particles -- 9.4.5 Loss of Ring Current Ions -- 9.4.5.1 Charge Exchange -- 9.4.5.2 Coulomb Drag -- 9.4.5.3 Coulomb Scattering -- 9.4.5.4 Wave-Particle Interaction -- 9.4.5.5 Adiabatic Loss Cone Loss -- 9.4.5.6 Violation of First Adiabatic Invariant -- 9.4.5.7 Magnetopause Loss. , 9.4.6 Influence on Other Regions and Other Energy Regimes -- 9.4.6.1 Ring Current-Ionosphere Coupling -- 9.4.6.2 Ring Current-Thermosphere Coupling -- 9.4.6.3 Ring Current-Plasmasphere Coupling -- 9.4.6.4 Ring Current-Ring Current Coupling -- 9.4.6.5 Ring Current-Radiation Belt Coupling -- 9.5 Proton Radiation Belt -- 9.5.1 Time Variation of Proton Radiation Belt -- 9.5.2 Source and Loss of Relativistic Protons -- 9.6 Electron Radiation Belt -- 9.6.1 Time Variation of Electron Radiation Belt -- 9.6.1.1 Storm-Time Variations -- 9.6.1.2 Semiannual Variations -- 9.6.1.3 Solar Cycle Variations -- 9.6.2 Response to Solar Wind and IMF -- 9.6.2.1 Solar Wind Speed -- 9.6.2.2 IMF -- 9.6.2.3 Solar Wind Density and Dynamic Pressure -- 9.6.3 Transport and Acceleration of Relativistic Electrons -- 9.6.3.1 Radial Diffusion -- 9.6.3.2 In Situ Accelerations by Wave-Particle Interactions -- 9.6.3.3 Which Mechanism Is Important -- 9.6.4 Loss of Relativistic Electrons -- 9.6.4.1 Adiabatic Effect -- 9.6.4.2 Precipitation into Atmosphere -- 9.6.4.3 Magnetopause Loss -- 9.6.4.4 Which Mechanism Is Important -- 9.6.5 Cross-Energy Couplings for Acceleration of Relativistic Electrons -- 9.7 Concluding Remarks -- References -- 10 Self-Consistent Simulations of Plasma Waves and Their Effects on Energetic Particles -- 10.1 Introduction -- 10.2 Global Simulations of Electromagnetic Ion Cyclotron Waves -- 10.2.1 Effects of Heavy Ions on EMIC Wave Generation and Propagation -- 10.2.2 Observations and Modeling of Subauroral Proton Arcs -- 10.2.3 Scattering of Radiation Belt Electrons by EMIC Waves -- 10.3 Global Simulations of Whistler Mode Chorus Waves -- 10.3.1 Evolution of Ring Current Electrons -- 10.3.2 Observations and Modeling of Chorus Waves -- 10.4 Summary and Conclusions -- References -- 11 Topology of High-Latitude Magnetospheric Currents -- 11.1 Introduction. , 11.2 Auroral Oval and Plasma Distribution in the High Latitude Magnetosphere -- 11.3 Transverse Currents at Geocentric Distances 7RE -- 11.4 Auroral Oval and Field-Aligned Currents -- 11.5 Discussion and Conclusions -- References -- 12 Detection of Dynamical Complexity Changes in Dst Time Series Using Entropy Concepts and Rescaled Range Analysis -- 12.1 Introduction -- 12.2 Theoretical Background -- 12.2.1 Fundamentals of Symbolic Dynamics -- 12.2.2 The Concept of Dynamical (Shannon-Like) Block Entropy -- 12.2.3 T-complexity -- 12.2.4 Principles of Non-extensive Tsallis Entropy -- 12.2.5 Approximate Entropy -- 12.2.6 Rescaled Range Analysis -- 12.3 Results -- 12.4 Discussion and Conclusions -- References -- Part IV Waves and Turbulence in Magnetosphere-Ionosphere Coupling -- 13 Magnetospheric ULF Waves: A Review -- 13.1 ULF Wave Sources -- 13.1.1 Sources in the Solar Wind -- 13.1.2 Instabilities at the Magnetopause -- 13.1.3 Interactions within the Magnetosphere -- 13.2 Wave Generation and Propagation Mechanisms -- 13.2.1 Global Cavity Modes -- 13.2.2 Field Line Resonances (FLRs) -- 13.2.3 Other Alfvn Modes -- 13.3 Electromagnetic Ion-Cyclotron Waves (EMICWs) -- 13.3.1 Observational Studies -- 13.3.2 Modeling and Simulation Studies -- 13.4 The Ionosphere Boundary -- 13.4.1 Effects of the Ionosphere on ULF Waves -- 13.4.2 Effects of ULF Waves on the Ionosphere -- 13.5 Consequences and Applications of ULF Waves -- 13.5.1 Magnetospheric Remote Sensing -- 13.5.2 Energization of Magnetospheric Particles -- 13.5.3 Precipitation of Magnetospheric Particles -- 13.5.4 New Techniques -- 13.5.5 Other Effects -- References -- 14 ULF Waves in the Topside Ionosphere: Satellite Observations and Modeling -- 14.1 Introduction: Simultaneous Observations of ULF Waves by Low-Altitude Satellites and Ground Stations -- 14.1.1 Pc3 Waves -- 14.1.2 Pi2 Waves. , 14.1.3 Pc1 Wave Packets.
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  • 2
    Publication Date: 2021-07-21
    Description: Observations of the magnetization state of asteroids indicate diverse properties. Values between 1.9  × 10 −6 Am 2/kg (Eros) and 10 −2 Am 2/kg (Braille) have been reported. A more detailed understanding of asteroidal magnetic properties allows far-reaching conclusions of the magnetization mechanism as well as the strength of the magnetic field of the solar system regions the asteroid formed in. The Hayabusa2 mission with its lander Mobile Asteroid Surface Scout is equipped with a magnetometer experiment, MasMag. MasMag is a state-of-the-art three-axis fluxgate magnetometer, successfully operated also on Philae, the Rosetta mission lander. MasMag has enabled, after Eros for the second time ever, to determine the magnetic field of an asteroid during descent and on-surface operations. The new observations show that Ryugu, a low-albedo C-type asteroid, has no detectable global magnetization, and any local magnetization is either small ( 〈10−6 Am 2/kg) or on very small (subcentimeter) scales. This implies, for example, that energetic solar wind particles could reach and alter the surface unimpeded by strong asteroidal magnetic fields, such as minimagnetospheres in case of the Moon.
    Keywords: 523 ; asteroids ; magnetization ; MASCOT ; Hayabusa2 ; magnetic field ; Ryugu
    Language: English
    Type: article
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  • 3
    Publication Date: 2014-09-19
    Description: The aim of this study was to clarify the participation of expression of chimeric transcripts in renal carcinogenesis. Whole transcriptome analysis (RNA sequencing) and exploration of candidate chimeric transcripts using the deFuse program were performed on 68 specimens of cancerous tissue (T) and 11 specimens of non-cancerous renal cortex tissue (N) obtained from 68 patients with clear cell renal cell carcinomas (RCCs) in an initial cohort. As positive controls, two RCCs associated with Xp11.2 translocation were analyzed. After verification by reverse transcription (RT)-PCR and Sanger sequencing, 26 novel chimeric transcripts were identified in 17 (25%) of the 68 clear cell RCCs. Genomic breakpoints were determined in five of the chimeric transcripts. Quantitative RT-PCR analysis revealed that the mRNA expression levels for the MMACHC, PTER, EPC2, ATXN7, FHIT, KIFAP3, CPEB1, MINPP1, TEX264, FAM107A , UPF3A, CDC16, MCCC1, CPSF3 , and ASAP2 genes, being partner genes involved in the chimeric transcripts in the initial cohort, were significantly reduced in 26 T samples relative to the corresponding 26 N samples in the second cohort. Moreover, the mRNA expression levels for the above partner genes in T samples were significantly correlated with tumor aggressiveness and poorer patient outcome, indicating that reduced expression of these genes may participate in malignant progression of RCCs. As is the case when their levels of expression are reduced, these partner genes also may not fully function when involved in chimeric transcripts. These data suggest that generation of chimeric transcripts may participate in renal carcinogenesis by inducing dysfunction of tumor-related genes. © 2014 The Authors. Genes, Chromosomes & Cancer Published by Wiley Periodicals, Inc.
    Print ISSN: 1045-2257
    Electronic ISSN: 1098-2264
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 4
    Publication Date: 2012-12-06
    Description: Background: Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) phosphorylates and activates particular downstream protein kinases --- including CaMKI, CaMKIV, and AMPK--- to stimulate multiple Ca2+-signal transduction pathways. To identify previously unidentified CaMKK substrates, we used various nucleotides as phosphate donors to develop and characterize an in vitro phosphorylation assay for CaMKK. Results: Here, we found that the recombinant CaMKK isoforms were capable of utilizing Mg-GTP as a phosphate donor to phosphorylate the Thr residue in the activation-loop of CaMKIalpha (Thr177) and of AMPK (Thr172) in vitro. Kinetic analysis indicated that the Km values of CaMKK isoforms for GTP (400-500 muM) were significantly higher than those for ATP (~15 muM), and a 2- to 4-fold decrease in Vmax was observed with GTP. We also confirmed that an ATP competitive CaMKK inhibitor, STO-609, also competes with GTP to inhibit the activities of CaMKK isoforms. In addition, to detect enhanced CaMKI phosphorylation in brain extracts with Mg-GTP and recombinant CaMKKs, we found potential CaMKK substrates of ~45 kDa and ~35 kDa whose Ca2+/CaM-induced phosphorylation was inhibited by STO-609. Conclusions: These results indicated that screens that use STO-609 as a CaMKK inhibitor and Mg-GTP as a CaMKK-dependent phosphate donor might be useful to identify previously unidentified downstream target substrates of CaMKK.
    Electronic ISSN: 1471-2091
    Topics: Chemistry and Pharmacology
    Published by BioMed Central
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