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  • 1
    Online Resource
    Online Resource
    Potsdam : Astrophysikalisches Inst.
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: Online Ressource, 8 p. = 251 Kb., text and images , graphs
    Edition: [Elektronische Ressource]
    Series Statement: Preprint series / Astrophysikalisches Institut Potsdam 2001,03
    Language: English
    Note: nIndex p. 7. - Differences between the printed and electronic version of the document are possible , Also available as printed version , Systemvoraussetzungen: Acrobat Reader.
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  • 2
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Keywords: Noise control. ; Engineering. ; Soundproofing. ; Civil engineering. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (219 pages)
    Edition: 1st ed.
    ISBN: 9783662098035
    Series Statement: VDI-Buch Series
    DDC: 534.208
    Language: German
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature genetics 36 (2004), S. 961-968 
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] A new class of dominant dark skin (Dsk) mutations discovered in a screen of ∼30,000 mice is caused by increased dermal melanin. We identified three of four such mutations as hypermorphic alleles of Gnaq and Gna11, which encode widely expressed Gαq subunits, act in an additive and ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth) mouse mutant and a missense mutation in Tmc1 (transmembrane cochlear-expressed gene 1). ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large number of mutants similar to the collections available from other model organisms such as Drosophila melanogaster and Caenorhabditis elegans. Here we report on a ...
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. The Munich ENU Mouse Mutagenesis Screen is a large-scale mutant production, phenotyping, and mapping project. It encompasses two animal breeding facilities and a number of screening groups located in the general area of Munich. A central database is required to manage and process the immense amount of data generated by the mutagenesis project. This database, which we named MouseNet©, runs on a Sybase platform and will finally store and process all data from the entire project. In addition, the system comprises a portfolio of functions needed to support the workflow management of the core facility and the screening groups. MouseNet© will make all of the data available to the participating screening groups, and later to the international scientific community. MouseNet© will consist of three major software components: • Animal Management System (AMS) • Sample Tracking System (STS) • Result Documentation System (RDS) MouseNet© provides the following major advantages: • being accessible from different client platforms via the Internet • being a full-featured multi-user system (including access restriction and data locking mechanisms) • relying on a professional RDBMS (relational database management system) which runs on a UNIX server platform • supplying workflow functions and a variety of plausibility checks.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have undertaken a phenotypic approach in the mouse to identifying molecules involved in inner ear function by N-ethyl-N-nitrosourea mutagenesis followed by screening for new dominant mutations affecting hearing or balance. The pathology and genetic mapping of the first of these new mutants, tailchaser (Tlc), is described here. Tlc/+ mutants display classic behavioural symptoms of a vestibular dysfunction, including head-shaking and circling. Behavioural testing of ageing mice revealed a gradual deterioration of both hearing and balance function, indicating that the pathology caused by the Tlc mutation is progressive, similar to many dominant nonsyndromic deafnesses in humans. Based on scanning electron microscopy (SEM) studies, Tlc clearly plays a developmental role in the hair cells of the cochlea since the stereocilia bundles fail to form the characteristic V-shape pattern around the time of birth. By young adult stages, Tlc/+ outer hair bundles are grossly disorganised although inner hair bundles appear relatively normal by SEM. Increased compound action potential thresholds revealed that the Tlc/+ cochlear hair cells were not functioning normally in young adults. Similar to inner hair cells, the hair bundles of the vestibular hair cells also do not appear grossly disordered. However, all types of hair cells in the Tlc/+ inner ear eventually degenerate, apparently regardless of the degree of organisation of their hair bundles. We have mapped the Tlc mutation to a 12 cM region of chromosome 2, between D2Mit164 and D2Mit423. Based on the mode of inheritance and map location, Tlc appears to be a novel mouse mutation affecting both hair cell survival and stereocilia bundle development.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 60 (1971), S. 569-588 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Abstract In a period of 2 years the area of the Southern Bawanthari River has been mapped. In the following paper the results concerning the structure are presented. In the mapped area only one trend of foliation has been recognised, of which only locally, depending on the type of rock, degree of deformation (and degree of metamorphism), different types (S1, S2, Sx) can be distinguished. In the south the foliation (S1) is usually parallel to the original bedding (S1 = SS). To the north this foliation gradually changes to a typical axial plane foliation (S2) and S1 disappears competely. Further north this schistosity becomes a typical gneissic lamination (Sx). Two generations of folds have been recognised. The general trend of the first generation folds is west-east, but their style changed from south to north. In the south similar folds dominate, which further north gradually change to concentric isoclinal shear folds. These are first slightly and then more and more overturned to the north. The overturned, lying isoclinal folds resemble flow folds. The folds of the second generation are cross folds (B ⊥ B′); they plunge to the south and generally are flow folds. They are slightly younger than the folds of the first generation. The macroscopic fold pattern is identical to the pattern observed in hand specimens. The macroscopic synclines and anticlines show no regular synclinorium, but a system of folds, which follow each other to the north in an “en échelon” fashion. In contrast to the fold structures of the first generation, which can be recognised every where in the area studied, the macroscopic folds of the second generation are developed only in the northern part of the area, where they form two irregular anticlines. In contrast to the opinion of earlier workers the mapped area cannot be divided into different fold belts along major fault zones. It is shown that a gradual increase of deformation to the north exists, which parallels the increase of metamorphism.
    Abstract: Résumé La géologie de la région située au sud du fleuve Bawanthari a été étudiée de nouveau au cours de deux années. C'est dans ce résumé que les résultats des recherches structurales seront présentés. Dans la région en question, on peut toujours observer un clivage principal qui représente toute fois selon les types différents de roche, leur dégré de déformation (et leur dégré de métamorphisme) des plans de séparation différents: au sud, le clivage est en général parallèle à la stratification originale (S1=SS). Vers le nord, le clivage (S1) est transformé en un clivage de plan axial (S2=schistosité) tandis que (S1) disparaÎt entièrement. Plus au nord, enfin, la schistosité se développe en une structure rubanée gneissique (Sx). On peut constater deux générations de plissements: la direction des plissements de la lère génération est ouest-est tandis que le style de plissement varie du sud au nord. Au sud, les plissements véritables dominent. Plus au nord, les plis se transforment d'abord en plis de cisaillement qui sont fort comprimés et déversés, adoptant en partie le caractère de plis de fluage. Les plis de la 2ème génération sont toujours des plis repliés (B ⊥ B′) qui plongent vers le sud et qui sont presque sans exception des plis de fluage couchants. Ceux-ci sont un peu plus jeunes que les plis de la lère génération. Le type de plissement macroscopique ressemble au type mésoscopique. Les synclinaux et anticlinaux macroscopiques ne sont toutefois pas des synclinoriums régulièrement formés, mais des systemes de plis qui, à la manière de plis »en échelon«, se composent de plusieurs plis particuliers. Outre ce type de plissement de la lère génération développé dans toute la région, les plis macroscopiques de la 2ème génération ne forment au nord que deux anticlinaux irréguliers. à l'opposé des opinions d'autres auteurs, la région étudiée ne peut Être divisée en zones de plissement séparées par des zones de faille de caractère régional. Le résultat de ces recherches montre que, du sud vers le nord, une augmentation continuelle de déformation est accompagnée d'un métamorphisme intensifié.
    Notes: Zusammenfassung Das Gebiet des südlichen Bawanthari-Flusses wurde in zwei Jahren geologisch neu aufgenommen, wobei in dem vorliegenden Bericht die Ergebnisse der tektonischen Bearbeitung dargelegt werden. In dem gesamten Arbeitsgebiet ist immer nur eine „Hauptschieferung“ S1, S2, Sx) erkennbar, die aber in den untersehiedlichen Gesteinstypen und in Abhängigkeit von deren Deformationsgrad (und Metamorphose) verschiedenartige Trennflächen darstellt. Im Süden herrscht eine hauptsächlich der ursprünglichen Schichtung folgende (S1=SS) und dem metamorphen S entsprechende Schieferung vor. Nördlich daran anschließend wird das Schieferungsgefüge vor allem durch eine Achsenebenenschieferung (S2) geprägt, die gewöhnlich nicht vom metamorphen S (S1) getrennt werden kann. Die Trennflächen Sx in den Gneisen sind uneinheitlicher ausgebildet und verlaufen meist parallel zu einer ausgeprägten Bänderung. Zwei Faltengenerationen sind erkennbar. Der Verlauf der Falten der ersten Generation ist prinzipiell West-Ost. Der Faltenstil ändert sich jedoch von Süden nach Norden. Im Süden herrschen Biegefalten vor. Nördlich davon gehen diese zuerst in eng zusammengepreßte, nach Norden überkippte isoklinale Scherfalten über, die schon teilweise den Charakter von Fließfalten haben. Die Falten der zweiten Generation sind stets Querfalten (B ⊥ B′), fallen nach Süden ein und sind fast ausschließlich liegende Fließfalten. Letztere sind etwas jünger als die Falten der ersten Generation. Der regionale Faltenbau verhält sich wie der im Handstückbereich. Die regional entwickelten Syn- und Antiklinen sind jedoch keine einheitlich verlaufenden Großfalten, sondern Faltensysteme, die sich in der Art von „en-échelon“-Falten, aus mehreren, immer mehr nach Norden verschobenen Einzelfalten zusammensetzen. Neben diesem Faltenbau der ersten Generation, der im ganzen Gebiet verfolgt werden kann, bilden die Großfalten der zweiten Generation nur im Norden zwei unregelmäßige Antiklinen aus. Abweichend von der Auffassung früherer Bearbeiter kann das Untersuchungsgebiet nicht in mehrere, durch regional verfolgbare Störungszonen getrennte Faltengürtel gegliedert werden. Es wird der Nachweis erbracht, daß eine kontinuierliche Intensivierung der Verformung (parallel der ansteigenden Metamorphose) von Süden nach Norden festzustellen ist.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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