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  • 1
    Electronic Resource
    Electronic Resource
    Modifying factors on repair phenomena
    Amsterdam : Elsevier
    Advances in Space Research 9 (1989), S. 187-195 
    Details
    ISSN: 0273-1177
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0273-1177(89)90437-7
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  • 2
    Electronic Resource
    Electronic Resource
    Post-irradiation induced sensitization of inhibition of oxidative phosphorylation by iodoacetamide (1966)
    Springer
    Cellular and molecular life sciences 22 (1966), S. 666-667 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Zugabe von Iodazetamid während und nach der Bestrahlung von isolierten Lebermitochondrien der Ratte sensibilisiert die strahleninduzierte Hemmung der oxydativen Phosphorylierung. Die Nachbehandlung lässt einen latenten Strahlenschaden sichtbar werden, der selber vermutlich in einer Produktion latenter ATPase besteht. Es ist wahrscheinlich, dass die bekannte strahlensensibilisierende Wirkung von Iodacetamid bei Lebewesen und Zellen auf dieser Hemmung der ATP-Produktion beruht, welche Erholungsprozesse erschwert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01902432
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  • 3
    Electronic Resource
    Electronic Resource
    Role of the germinal centre of Drosophila melanogaster: the presence of a master cell
    Amsterdam : Elsevier
    Mutation Research Letters 192 (1987), S. 47-53 
    Details
    ISSN: 0165-7992
    Keywords: (Drosophila melanogaster) ; Apical centre ; Germinal centre ; Master cell, presence of
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0165-7992(87)90124-2
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  • 4
    Electronic Resource
    Electronic Resource
    Teratogenic interactions between cadmium and radiation in mice (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 80-81 
    Details
    ISSN: 1420-9071
    Keywords: Embryonic development ; mice ; teratogenic interaction ; cadmium ; X-irradiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mouse embryos were exposed to various doses of cadmium and/or X-rays on day 8 of gestation. The combined treatment exerted an antagonistic effect regarding the teratogenic action of the two agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975905
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  • 5
    Electronic Resource
    Electronic Resource
    Chemische Sensibilisierung der Strahlenschädigung bei Rattenembryonen (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 1135-1136 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A combined treatment involving a radio-sensitizing chemical and low doses of X-rays was investigated. Small quantities of iodoacetamide can cause an increase in the radiation damages of rat embryos. The possibility of inhibition of postirradiation repair mechanisms is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01900231
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  • 6
    Electronic Resource
    Electronic Resource
    Induzierte Strahlenresistenz bei Zellkulturen des Chinesischen Hamsters: Entwicklung und Art der Resistenz (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 844-846 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mutations-induction followed by selection is a suitable method for developing a cell line with resistance to low doses of X-rays. In comparison with the original cell line, the derived resistant line is characterized by an enhanced variability of the chromosome number, and no higher level of cellular repair, limited to the two repair types described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01938498
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  • 7
    Electronic Resource
    Electronic Resource
    100 years of radiobiology: Implications for biomedicine and future perspectives (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 652-664 
    Details
    ISSN: 1420-9071
    Keywords: Radiation chemistry ; radiation biochemistry ; cellular radiobiology ; mutation induction ; cancer induction ; repair ; space radiobiology ; Chernobyl accident ; hormesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The development of radiobiology from the very early detection of the biological action of X-rays to the knowledge of today is described in sections on radiation chemistry and biochemistry, mutation and cancer induction, and embryonic damage, as well as the dependence of radiation response on radiation quality and temporal dose distribution (repair) and the interaction with other factors. For medicine radiobiology serves as a basis for radiotherapy and radiological protection. The effect of very low doses, and their possible biopositive effect (hormesis and adaptive response), is also discussed, as are the health hazard of radon, health risks after the Chernobyl accident, and space radiobiology. The radiobiology of the future will be concerned with biomolecular and genetic implications, problems of damage and repair, and connected problems like hormesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01941263
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  • 8
    Electronic Resource
    Electronic Resource
    Preclinical Radiobiology with Pions: RBE — Values for Mouse Skin Damage as a Function of Single Doses of Pions (1979)
    Springer
    Radiation and environmental biophysics 16 (1979), S. 289-294 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The macroscopic reaction of the mouse skin was used to derive RBE values for negativeπ-Mesons. Hind limbs of mice were irradiated with pions or X-rays. The pions were produced by the 590 MeV accelerator of the Schweizerisches Institut für Nuklearforschung (SIN). Early skin reaction was assessed over a period of 6–30 days after irradiation with single doses (20–45 Gy). The radiation damage was scored using an arbitrary scale of effect. The time pattern of development of the skin reaction and the subsequent healing after exposure both to pions and X-rays were similar, indicating that depletion and repopulation of the basal cells of the skin were comparable, both after pions and X-rays. RBE values as a function of pion doses at the peak (dose maximum), plateau and at the postpeak (12 mm downstream of the dose maximum) were computed with nonparametric statistical methods. The RBE at the peak and at the plateau relative to X-rays of the same dose rate was 1.15–1.25 and 0.85, respectively. The RBE of peak pions manifested a marked dependence on dose, when plateau pions were chosen as reference radiation. In this experiment there was no significant difference in RBE between peak and postpeak. The importance of some experimental condition (dose rate, irradiation volume) is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01358292
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of negative pions, relative to 140 kV - 29 MeV photons and 20 MeV electrons, on proliferation of Ehrlich ascites carcinoma cells (1979)
    Springer
    Radiation and environmental biophysics 16 (1979), S. 261-265 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The effect of negative pions (peak and plateau), photons (140 kV and 29 MeV), and 20 MeV electrons on the proliferative capacity of Ehrlich ascites carcinoma cells was investigated. Proliferative survival curves plotted for the modalities employed are presented. Under the experimental conditions used, the peak pions were more effective than plateau pions by a factor of about 1.4. For 50% survival, 140 kV X-rays had the same effect as peak pions but the latter was more effective (factor 1.2) at 10% survival level. When 140 kV X-rays were taken as the standard, following are the RBE values calculated at 50% survival level: plateau pions -0.73; peak pions -about 1.0; 29 MeV photons -0.73 and 20 MeV electrons -0.6. The results obtained are compared with those reported on other tumor systems and biological test objects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01358287
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of negative pi mesons on vascular permeability of brain in neonatal rats (1979)
    Springer
    Radiation and environmental biophysics 16 (1979), S. 303-308 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary Neonatal rats and their radiation-induced cerebral petechial hemorrhages were used as an experimental system for evaluating the effects of negative pions on healthy tissue and especially on the microvasculature. Dose response curves for peak and plateau pions (dose range 150–250 rad and 100–400 rad, respectively) were obtained and compared with those of 200 kV X-rays of corresponding dose rates. The RBE of the peak pions was 1.1, that of the plateau pions 0.6 resulting in a peak/plateau ratio of 1.8. Implications were made as to the importance of this favorable peak/plateau relationship since the response of the capillary endothelium to pion-irradiation might be one of the limiting factors in radiotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01358295
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