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  • 1
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (36 Seiten, 1,04 MB) , Illustrationen, Diagramme
    Language: German
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  • 2
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: Online-Ressource (36 S., 2,95 MB) , graph. Darst.
    Language: German
    Note: Systemvoraussetzungen: Acrobat reader.
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing AG,
    Keywords: Water resources development. ; Water resources development-Government policy. ; Water-supply-Management. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (344 pages)
    Edition: 1st ed.
    ISBN: 9783030467692
    Series Statement: Palgrave Studies in Water Governance: Policy and Practice Series
    DDC: 363.61
    Language: English
    Note: Intro -- Acknowledgement -- Contents -- Notes on Contributors -- List of Figures -- List of Tables -- 1: Introduction -- Why This Book? -- Summary of Case Study Chapters -- Comparative Overview of Case Study Chapters -- Structure of the Book -- References -- 2: Conceptual Reflections About Water, Governance, and Networks -- Introduction -- Water Governance: Challenges and Approaches to Deal with Them -- Challenges of Dynamic Interdependencies in Water Governance -- First Challenge: Water Issues Are Questioning Established Organization Within Borders, Sectors, and Levels -- Second Challenge: Integrating Broad Ranges of Interests and Expertise -- Water Policies and Regulation -- From Early Development Until Today -- Integrated Water Resource Management -- Collaborative Environmental Governance -- Networks and Network Analysis -- Nodes and Ties in Water Governance Networks -- Network Nodes -- Network Ties -- Key Variables in Network Analysis -- Micro-Level Network Measures: Centralities -- Meso-Level Network Measures: Clustering, Cliques, and Modularity -- Macro-Level Network Measures: Density, Centralization, Reciprocity, Transitivity, Core-Periphery -- Statistical Models of Network Data -- Common Limitations of Network Analytic Approaches -- References -- 3: Network Segregation and Water Governance: The Case of the Spiny Lobster Initiative -- Introduction -- Theory -- Geography -- Policy Beliefs and Preferences -- Social Group Identity -- Sectoral Affiliations -- Trust and Reciprocity -- Empirical Case Study: The Spiny Lobster Initiative in Honduras -- The Spiny Lobster Initiative as Collaborative Governance -- Hypotheses: Geographic and Sectoral Function Segregation -- Methods and Analysis -- Survey and Network Data Collection -- Network Visualization and Community Detection -- Stochastic Actor Oriented Models -- Model Results -- Conclusions. , References -- 4: Network Embeddedness and the Rate of Water Cooperation and Conflict -- Introduction -- Theory -- Theories of Political Networks -- Theories of Political Geography -- Theories of Political Economy -- Theories of Political Institutions -- Case -- Methods -- Analysis -- Conclusions -- References -- 5: Identifying Subsystems and Crucial Actors in Water Governance: Analysis of Bipartite Actor-Issue Networks -- Introduction -- Theory -- Subsystems in an Overall Governance System -- Dynamics of Subsystem Structures -- The Importance of Cross-subsystem Dynamics -- Two Types of Crucial Actors -- Case, Data, and Methods -- Water Governance in General -- The Case of Swiss Water Governance -- Data Gathering: Swiss Water Governance Issues and Actor Survey -- Bipartite Actor-Issue Networks -- Inductively Identifying Subsystems Through Bipartite Modularity -- Crucial Actors: Exploring a Measure Developed in Ecology -- Results and Discussion -- Subsystem Identification -- Crucial Actors-Within- and Between-Subsystem Connectors -- Conclusions -- References -- 6: What Drives the Formation and Maintenance of Interest Coalitions in Water Governance Forums? -- Introduction -- Theory -- Hypotheses -- Methods -- Data Collection -- Data Analysis -- Quadratic Assignment Procedure -- Exponential Random Graph Models -- Case -- Results of the Quantitative Analysis -- Discussion -- Conclusion -- Appendix -- References -- 7: Modeling Environmental Governance in the Lake Tahoe Basin: A Multiplex Network Approach -- Introduction -- Theory -- Case: Policy Change in the Lake Tahoe Basin -- Methods -- Data Collection and Processing -- Step 1: Coding with Discourse Network Analyzer -- Step 2: Coding Coalition Membership -- Network Data Analysis -- Results -- Beliefs Network -- Interaction Network -- Policy Positions Network -- Multiplex Network. , Discussion and Conclusion -- Appendix -- References -- 8: Collaboration in Water Quality Management: Differences in Micro-Pollutant Management Along the River Rhine -- Introduction -- Literature -- Case Description and Data Gathering -- Three Case Study Areas and Research Design -- Policy Network and Actor Identification Therein -- Collecting Network Data Through Surveys -- Methods of Descriptive Social Network Analysis (SNA) -- Edges and Vertices That Make a Graph -- Cohesion and Fragmentation: Macro-, Meso-, and Micro-level Statistics -- Macro Level -- Meso Level -- Micro Level -- Analysis -- The Macro Level: Density, Reciprocity, and Connectedness Statistics -- The Meso Level: Components and Factions -- The Micro Level: Actors in Between: Building Bridges Across Factions -- Discussion and Conclusion -- References -- 9: Analyzing Stakeholders' Network to Water Resources Co-management at a Watershed Scale: A Case Study from the Taleghan Watershed in Iran -- Introduction -- Theory -- Material and Methods -- Case Study -- Data Collection -- Social Network Analysis (SNA) -- Network Context -- Micro-Level Indicators -- Meso-Level Indicators -- Macro-Level Indicators -- Results and Discussion -- Micro-Level Indicators -- Results for Degree Centrality -- Results for Betweenness Centrality -- Meso-Level Indicators -- Results of Core/Periphery Structure -- Results of E-I Indictor -- Macro-Level Indicators -- Results of Density -- Results of Transitivity -- Results of Reciprocity -- Conclusion -- References -- 10: Institutional Design and Complexity: Protocol Network Structure in Response to Different Collective-Action Dilemmas -- Introduction -- Theory -- Empirical Setting -- Data -- Methods -- Protocols as Hypergraph, Bipartite, and Unipartite Networks -- Subcomponents and Clustering in Actor-Actor Hypergraphs. , Connectivity and Clustering in Actor-Rule Bipartite Networks -- Connectivity in Rule-Rule Networks -- Results -- Spectral Clustering of Protocol Hypergraphs -- Redundancy in Bipartite Actor-Rule Networks -- Connectivity in Rule-to-Rule Networks -- Discussion -- Conclusion -- References -- 11: Comparing Centrality Across Policy Networks and Media Narratives -- Introduction -- Theory: Network Centrality and Actor Importance -- Policy Brokers -- Policy Entrepreneurs -- Discovering Important Policy Actors through Network Analysis -- Challenges of Network Measurement -- Data: Networks in Urban Water Governance in Arizona, USA -- Data Collection -- The Tucson Water Governance Network -- Measurement of Actor Importance -- Data Analysis -- Discussion -- Circumstances in the Policy Setting -- Bias in Reporting and Content Type -- Limits of Event-Based Analysis -- Conclusion -- References -- 12: Conclusions -- Key Findings per Chapter -- Learnings from and for the Application of Network Concepts and Measures to Water Governance -- Recommendations for Academia and Practice -- References.
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  • 4
    Online Resource
    Online Resource
    Cham : Springer International Publishing AG
    Description / Table of Contents: Intro -- Preface -- Introduction -- Contents -- About the Authors -- Chapter 1: Why Sustainability? -- 1.1 The Anthropocene -- 1.2 The Ecological Challenges: Planetary Boundaries -- 1.3 Adding the Social Dimension -- 1.4 The Role of Economic Growth -- Literature -- Further Reading -- Chapter 2: The Concept of Sustainable Development -- 2.1 ``Our Common Future´´ or The Brundtland Report -- 2.2 Three Dimensions of Sustainable Development -- 2.3 Three Approaches to Sustainable Systems -- 2.4 Policy Action and SDGs -- 2.5 Knowledge and Tackling Sustainability Challenges -- Literature -- Further Reading -- Chapter 3: Challenges of Managing Common Resources -- 3.1 What Is Meant by Tragedy of the Commons? -- 3.2 The Logic of Collective Action or the Prisoner Dilemma -- 3.3 Social Dilemma -- 3.4 How to Cope with the ``Tragedy of the Commons,´´ Prisoners or Social Dilemma? -- Literature -- Further Reading -- Chapter 4: Corporate Sustainability -- 4.1 Sustainability as the New Management Paradigm in Business Administration -- 4.1.1 Sustainability as Innovative Business Concept -- 4.1.2 Strategic Management -- 4.1.3 New Business Administration Model -- 4.2 Three Levels of Corporate Sustainability -- 4.2.1 Production Level -- 4.2.2 Product Level -- 4.2.3 Organizational Level -- 4.3 Technological Change: The Role of Green Innovation -- 4.3.1 Where Is the Largest Impact Reduction Possible? -- 4.3.2 The Speed of Technological Change -- 4.3.3 What Hampers Green Innovation? -- 4.3.4 The Importance of Policy Instruments -- 4.3.5 Green Innovation in a Spatial Context -- 4.4 Sustainability and Corporate Values -- 4.4.1 Functions of Corporate Values -- 4.4.2 Scope of Application -- 4.4.3 Vision, Mission, and Corporate Values -- 4.4.4 Definition of Corporate Values -- 4.5 Sustainability Reporting -- 4.5.1 Why Sustainability Reporting?.
    Type of Medium: Online Resource
    Pages: 1 online resource (156 pages)
    Edition: 1st ed.
    ISBN: 9783031253973
    Series Statement: SpringerBriefs in Business Series
    Language: English
    Note: Description based on publisher supplied metadata and other sources
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  • 5
    Publication Date: 2016-01-29
    Description: A genome-wide exome association study has identified the transmembrane 6 superfamily member 2 ( TM6SF2) rs58542926 variant encoding an E167K substitution as a genetic determinant of hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). The role of this variant across a spectrum of liver diseases and pathologies and on serum lipids comparing viral hepatitis to NAFLD, and viral load in chronic viral hepatitis, and its intrahepatic molecular signature, have not been well characterized. We undertook detailed analyses in 3,260 subjects with viral and non-viral liver diseases and in healthy controls. Serum inflammatory markers and hepatic expression of TM6SF2 and genes regulating lipid metabolism were assessed in a subset with chronic hepatitis C (CHC). The rs58542926 T allele was more prevalent in 502 NAFLD patients than controls (p=0.02), but not different in cohorts with CHC (n = 2,023) and CHB (n = 507). The T allele was associated with alterations in serum lipids and hepatic steatosis in all diseases, and with reduced hepatic TM6SF2 and MTTP expression expression. Interestingly, the substitution was associated with reduced CHC viral load, but increased HBV-DNA. The rs58542926 T allele had no effect on inflammation, impacted on ≥F2 fibrosis in CHC and NAFLD assessed cross-sectionally (OR: 1.39 (95% CI = 1.04-1.87 and OR: 1.62, 95% CI: 1.03-2.52, respectively, p〈0.03 for both), but had no effect on fibrosis progression in 1174 patients with CHC and a known duration of infection. We conclude that the TM6SF2 E167K substitution promotes steatosis and lipid abnormalities in part by altering TM6SF2 and MTTP expression and differentially impacts CHC and CHB viral load, while effects on fibrosis are marginal. This article is protected by copyright. All rights reserved.
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
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