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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Therapy of chronic hepatitis C non- responders to interferon monotherapy with standard doses of interferon plus ribavirin is usually ineffective.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To evaluate the efficacy and tolerability of high-dose prolonged combination retreatment in non- responder patients.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Patients were retreated for 6 months with 6 MU αIFN on alternate days and 1000 or 1200 mg/day ribavirin. HCV-RNA negative patients continued therapy for an additional 6 months.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Forty patients (29 males, mean age 49.7 years, 34 genotype 1b, 11 with F3 fibrosis) were treated. At 6 months, 20 (50%) patients were HCV-RNA negative but six of them discontinued therapy because of adverse events. A sustained response was achieved in 28% of patients (11/40). A sustained response was more frequent among patients with genotype non-1b than in those with genotype 1b (67 vs. 21%, P=0.005) and clearance of HCV-RNA in the first 3 months had a high predictive value for sustained response (100% of sustained responders vs. 24% of non-responders, P=0.0001).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:High-dose prolonged combination therapy in non-responders to IFN monotherapy leads to a higher rate of sustained response than the standard combination regimen. Tolerability may be a rate-limiting factor. Maximal effectiveness can be predicted in patients with non-1b genotype and in those who clear HCV-RNA soon after starting retreatment.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0309-1651
    Keywords: chromatin ; differentiation ; neurons
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 242 (1973), S. 119-120 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Most of our recent marijuana-behaviour studies have been performed with a delayed matching to sample task. The experimental paradigm involves presenting one of six sample stimuli on a translucent key mounted on a stimulus-response panel fixed to the chimpanzee's cage. The chimpanzee must press this ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  108 rotavirus strains obtained from children with diarrhea hospitalized in Palermo, Italy, in the years 1990–1994, were examined by seminested PCR to study the relative frequency and distribution of the four most common alleles of the gene 4. Such strains were selected from 344 human rotavirus strains recovered in Palermo during those years after characterization by electropherotyping, subgrouping and G serotyping. One hundred and seven of the 108 strains could be classified into P types, the P[8], G1 (38.3%) and the P[8], G4 (52.3%) types being predominant. The unique strain whose P genotype could not be identified showed an unusual combination of long migration electrophoretic pattern and subgroup I specificity.
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  • 5
    ISSN: 1590-3478
    Keywords: Rat CNS cell culture ; multiple sclerosis ; gliogenesis ; neurons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario L'aggiunta di siero prelevato da pazienti affetti da sclerosi multipla (SM) in colture primarie di cellule da S.N.C. di feto di ratto, determina un ritardo della proliferazione gliale ed un incremento della sopravvivenza dei neuroni. Tale effetto non si verifica se alle colture viene aggiunto siero prelevato da soggetti normali od affetti da altre malattie neurologiche. I dati presentati vengono interpretati come il risultato di una inibizione della gliogenesi in vitro.
    Notes: Abstract The addition of serum from multiple sclerosis (MS) patients to the culture medium of dissociated cells from cerebral hemispheres of rat embryos caused a delay in glial proliferation and an enhancement of neuronal survival. Sera from normal individuals and patients with other neurological diseases failed to show this effect. These morphological observations are interpreted as the outcome of inhibition of in vitro gliogenesis.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 4 (1983), S. 323-326 
    ISSN: 1590-3478
    Keywords: cell culture ; neurons ; glial cells ; chemically defined medium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene descritto un terreno chimicamente definito che facilita la sopravvivenza di neuroni di cervello di feto di ratto in coltura primaria. Più del 90% delle cellule in coltura vengono identificate come neuroni mediante immunofluorescenza con anticorpi antineurofilamenti. Il terreno, arricchito con siero, invece, stimolando la proliferazione delle cellule nonneuronali, ostacola la sopravvivenza dei neuroni.
    Notes: Abstract A Chemically Defined Medium is described which facilitates the survival of neurons in primary cultures of rat cerebral hemispheres. More than 90% of all cells were identified as neurons using neurofilament as a marker in an immunocytochemical assay. In contrast, serumsupplemented medium, by stimulating nonneuronal cell proliferation, hinders the survival of neurons in culture.
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  • 7
    Publication Date: 2012-10-30
    Description: 4,4'-dihydroxy-trans-stilbene (DHS) is a synthetic analog of resveratrol, a phytoalexin known for its biological activities. We previously demonstrated that DHS exerts an antiproliferative effect on normal human fibroblasts that is higher than that of the natural parent molecule. No evidence regarding its role in human cancer cell lines has been found thus far. In this study, we investigated the effects of DHS both on chemical-induced transformation of BALB/c 3T3 mouse fibroblasts and on the proliferation and invasion of human breast cancer MCF-7 cells. The results showed that DHS markedly suppresses the two-stage (3-methylcholanthrene plus 12- O -tetradecanoylphorbol-13-acetate) cell transformation. Compared with resveratrol, DHS inhibited both anchorage-dependent and -independent MCF-7 growth more efficiently. In addition, a reduction in the number of cells in S-phase, characterized by a concomitant increase in the levels of p21 and p53 proteins, together with a strong inhibition of pRb protein phosphorylation, was observed in DHS-treated cells. Furthermore, DHS effected a strong reduction in matrix metalloproteinase-2 and -9 activities, concomitantly with a marked inhibition of cell adhesion to the extracellular matrix components as well as inhibition of cell migration and invasion. Importantly, modulation of the adhesion molecule E-cadherin was also found in DHS-treated cells. Taken together, these results demonstrate that the two 4,4'-hydroxyl groups on the stilbenic backbone make DHS a more active molecule than resveratrol in inhibiting neoplastic transformation, cancer cell proliferation and invasion. In conclusion, this study suggests that DHS could be a promising anticancer agent.
    Print ISSN: 0143-3334
    Electronic ISSN: 1460-2180
    Topics: Medicine
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  • 8
    Publication Date: 2013-01-30
    Description: Breast tumors lacking expression of human epidermal growth factor receptor 2 (HER2) and the estrogen and the progesterone receptors (triple negative; TNBC) are more aggressive than other disease subtypes, and no molecular targeted agents are currently available for their treatment. Because TNBC commonly displays EGF receptor (EGFR) expression, and combinations...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 9
    Publication Date: 2016-10-12
    Description: The walleye (Sander vitreus) is a golden yellow fish that inhabits the Northern American lakes. The recent sightings of the blue walleye and the correlation of its sighting to possible increased UV radiation have been proposed earlier. The underlying molecular basis of its adaptation to increased UV radiation is the...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 10
    Publication Date: 2016-10-28
    Description: The growth of a tearing mode is described by reduced MHD equations. For a cylindrical equilibrium, tearing mode growth is governed by the modified Rutherford equation, i.e., the nonlinear Δ ′ ( w ) . For a low beta plasma without external heating, Δ ′ ( w ) can be approximately described by two terms, Δ ′ q l ( w ) ,   Δ A ′ ( w ) [White et al ., Phys. Fluids 20 , 800 (1977); Phys. Plasmas 22 , 022514 (2015)]. In this work, we present a simple method to calculate the quasilinear stability index Δ q l ′ rigorously, for poloidal mode number m ≥ 2 . Δ q l ′ is derived by solving the outer equation through the Frobenius method. Δ ′ q l is composed of four terms proportional to: constant Δ ′ 0 , w , w ln w , and w 2 . Δ A ′ is proportional to the asymmetry of island that is roughly proportional to w . The sum of Δ q l ′ and Δ A ′ is consistent with the more accurate expression calculated perturbatively [Arcis et al ., Phys. Plasmas 13 , 052305 (2006)]. The reduced MHD equations are also solved numerically through a 3D MHD code M3D-C1 [Jardin  et al ., Comput. Sci. Discovery 5 , 014002 (2012)]. The analytical expression of the perturbed helical flux and the saturated island width agree with the simulation results. It is also confirmed by the simulation that the Δ A ′ has to be considered in calculating island saturation.
    Print ISSN: 1070-664X
    Electronic ISSN: 1089-7674
    Topics: Physics
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