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  • 1
    Publication Date: 2022-05-25
    Description: Author Posting. © Acoustical Society of America, 2018. This article is posted here by permission of Acoustical Society of America for personal use, not for redistribution. The definitive version was published in Journal of the Acoustical Society of America 143 (2018): 1223, doi:10.1121/1.5025042.
    Description: The ocean acoustic noise floor (observed when the overhead wind is low, ships are distant, and marine life silent) has been measured on an array extending up 987 m from 5048 m depth in the eastern North Pacific, in what is one of only a few recent measurements of the vertical noise distribution near the seafloor in the deep ocean. The floor is roughly independent of depth for 1–6 Hz, and the slope (∼ f−7) is consistent with Longuet-Higgins radiation from oppositely-directed surface waves. Above 6 Hz, the acoustic floor increases with frequency due to distant shipping before falling as ∼ f−2 from 40 to 800 Hz. The noise floor just above the seafloor is only about 5 dB greater than during the 1975 CHURCH OPAL experiment (50–200 Hz), even though these measurements are not subject to the same bathymetric blockage. The floor increases up the array by roughly 15 dB for 40–500 Hz. Immediately above the seafloor, the acoustic energy is concentrated in a narrow, horizontal beam that narrows as f−1 and has a beam width at 75 Hz that is less than the array resolution. The power in the beam falls more steeply with frequency than the omnidirectional spectrum.
    Description: The OBSANP cruise was funded by the Office of Naval Research under Grant Nos. N00014-10-1-0987, N00014-14- 1-0324, N00014-10-1-0510, and N00014-10-1-0990.
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Publication Date: 2022-05-25
    Description: Author Posting. © American Meteorological Society, 2016. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Physical Oceanography 46 (2016): 1705-1716, doi:10.1175/JPO-D-15-0221.1.
    Description: A rapid and broadband (1 h, 1 〈 f 〈 400 Hz) increase in pressure and vertical velocity on the deep ocean floor was observed on seven instruments comprising a 20-km array in the northeastern subtropical Pacific. The authors associate the jump with the passage of a cold front and focus on the 4- and 400-Hz spectra. At every station, the time of the jump is consistent with the front coming from the northwest. The apparent rate of progress, 10–20 km h−1 (2.8–5.6 m s−1), agrees with meteorological observations. The acoustic radiation below the front is modeled as arising from a moving half-plane of uncorrelated acoustic dipoles. The half-plane is preceded by a 10-km transition zone, over which the radiator strength increases linearly from zero. With this model, the time derivative of the jump at a station yields a second and independent estimate of the front’s speed, 8.5 km h−1 (2.4 m s−1). For the 4-Hz spectra, the source physics is taken to be Longuet-Higgins radiation. Its strength depends on the quantity , where Fζ is the wave amplitude power spectrum and I the overlap integral. Thus, the 1-h time constant observed in the bottom data implies a similar time constant for the growth of the wave field quantity behind the front. The spectra at 400 Hz have a similar time constant, but the jump occurs 25 min later. The implications of this difference for the source physics are uncertain.
    Description: The OBSANP cruise was funded by the Office of Naval Research under Grants N00014-10-1-0987, N00014-14-1-0324, N00014-10-1-0510, and N00014-10-1-0990.
    Keywords: Atm/Ocean Structure/ Phenomena ; Atmosphere-ocean interaction ; Cold fronts ; Marine boundary layer ; Sea state
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 1034-1035 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Gromme, Merrill and Verhoogen2 critically examined the palaeomagnetic data for the Cretaceous of North America, presenting the results in the conventional manner as virtual geomagnetic poles (a VG-P is the pole of that unique axial dipole field which gives the observed magnetization at a given ...
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2013-04-20
    Description: Retinoic acid (RA)-induced expression of bone morphogenetic protein-4 (BMP-4) inhibits in vitro and in vivo cell proliferation and ACTH synthesis in corticotroph-derived tumor cells. Reduced expression of BMP-4 in this adenoma subtype is associated with epigenomic silencing, and similar silencing mechanisms are also associated with the RA-responsive dopamine D2 receptor (D2R) in somatolactotroph cells. We now show that preincubation with the epidrugs zebularine and trichostatin A is obligate and permissive for RA-induced expression of the BMP-4 and the D2R genes in pituitary tumor cells. Combined epidrug challenges are associated with marginal reduction in CpG island methylation. However, significant change to histone tail modifications toward those associated with expression-competent genes is apparent, whereas RA challenge alone or in combined incubations does not have an impact on these modifications. Epidrug-mediated and RA-augmented expression of endogenous BMP-4 increased or decreased cell proliferation and colony-forming efficiency in GH3 and AtT-20 pituitary tumor cells, respectively, recapitulating recent reports of challenges of these cells with exogenous ligand. The specificity of the BMP-4–mediated effects was further supported by knock-down experiments of the BMP-4 antagonist noggin (small interfering RNA [siRNA]). Knock-down of noggin, in the absence and the presence of epidrugs, induced and augmented BMP-4 expression, respectively. In cell proliferation assays, challenge with either epidrugs or siRNA led to significant increase in cell numbers at the 72-hour time point; however, in siRNA-treated cells coincubated with epidrugs, a significant increase was apparent at the 48-hour time point. These studies show the potential of combined drug challenges as a treatment option, where epidrug renders silenced genes responsive to conventional therapeutic options.
    Print ISSN: 0013-7227
    Topics: Medicine
    Published by Oxford University Press on behalf of The Endocrine Society.
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  • 5
    Publication Date: 2012-07-21
    Description: Bone morphogenetic protein (BMP)-4 is a key mediator of anterior pituitary organogenesis. However, through inappropriate expression patterns, BMP-4 is also pathogenic in a pituitary adenoma subtype-specific context. In these cases, increase or decrease in BMP-4 in lactotroph- and corticotroph-derived adenomas, respectively, is consistent with a bifunction role for this protein toward either promotion or inhibition of cell proliferation and hormone secretion. To gain insight into the aberrations responsible for differential expression, we examined BMP-4 transcript and protein expression patterns in the major adenomas subtypes. BMP-4 transcript and protein are differentially expressed and show increase in the majority of prolactinomas relative to normal pituitary, whereas the majority of other adenoma subtypes show reduced expression relative to both prolactinoma and normal pituitaries. Reduced expression of BMP-4 is not associated with change in CpG island methylation status. However, histone tail modifications are apparent, as enrichment for a modification associated with silent genes, H3K27me3, and depletion of a modification associated with active genes, H3K9Ac. In pituitary cell lines, reduced BMP-4 expression is also associated with similar histone tail modifications and contemporaneous increase in CpG island methylation. In these cells, coincubation with the demethylating agent zebularine and histone deacetylase inhibitor, trichostatin A, reversed epigenetic changes and restored expression of BMP-4. These studies show that, in contrast to prolactinomas, other adenoma subtypes show reduced expression of BMP-4 where epidrug induced reexpression, alone or in combination with conventional therapies, may offer new treatment strategies.
    Keywords: TRANSLATIONAL RESEARCH IN ENDOCRINOLOGY AND METABOLISM, Translational Highlights from ENDO
    Print ISSN: 0013-7227
    Topics: Medicine
    Published by Oxford University Press on behalf of The Endocrine Society.
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